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1. 发明申请

WO2005021771A3 PROCESS FOR THE PRODUCTION OF L-LYSINE 审中-公开
标题翻译：生产L-赖氨酸的方法
公开(公告)号：WO2005021771A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004009385
申请日：2004-08-23
申请人： DEGUSSA , PETERSEN SOEREN , GERIGK MARC , HERMANN THOMAS , BATHE BRIGITTE
发明人： PETERSEN SOEREN , GERIGK MARC , HERMANN THOMAS , BATHE BRIGITTE
IPC分类号： C12P13/08
CPC分类号： C12P13/08
摘要： The invention relates to an improved process for the production of L-lysine by fermentation using L-lysine-producing coryneform bacteria.
摘要翻译：本发明涉及通过使用L-赖氨酸生产的棒状细菌发酵生产L-赖氨酸的改进方法。

2. 发明申请

WO03023016A2 METHOD FOR PRODUCING FINE CHEMICALS 审中-公开
标题翻译：生产精细化学品的方法
公开(公告)号：WO03023016A2
公开(公告)日：2003-03-20
申请号：PCT/EP0210174
申请日：2002-09-11
申请人： DEGUSSA , FARWICK MIKE , HERMANN THOMAS
发明人： FARWICK MIKE , HERMANN THOMAS
IPC分类号： C12N1/15 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/88 , C12P13/08 , C12N1/00
CPC分类号： C12N9/93 , C12N9/0006 , C12N9/88 , C12P13/08
摘要： The present invention relates to genetically modified microorganisms, in particular coryneform bacteria and Escherichia coli, in which the phosphorylation state of proteins or polypeptides has been changed such that the bacteria produce a larger amount of a desired fine chemical or a metabolite than the wild type, and to a method for the production of fine chemicals or metabolites.
摘要翻译：本发明涉及基因修饰的微生物，特别是棒状杆菌和大肠杆菌，其中蛋白质或多肽的磷酸化状态已经改变，使得细菌产生比野生型更大量的期望的精细化学品或代谢物，并涉及生产精细化学品或代谢物的方法。

3. 发明申请

WO2005014843A3 A PROCESS FOR PREPARING L-THREONINE 审中-公开
标题翻译：一种制备L-苏氨酸的方法
公开(公告)号：WO2005014843A3
公开(公告)日：2005-05-19
申请号：PCT/EP2004008470
申请日：2004-07-29
申请人： DEGUSSA , KRUSE DANIELA , HERMANN THOMAS , THIERBACH GEORG , RIEPING MECHTHILD
发明人： KRUSE DANIELA , HERMANN THOMAS , THIERBACH GEORG , RIEPING MECHTHILD
IPC分类号： C12P13/08 , C12N15/00
CPC分类号： C12P13/04 , C12P13/08 , C12R1/19
摘要： The invention provides an improved process for the fermentative preparation of L-threonine using L-threonine-producing bacteria from the family Enterobacteriaceae.
摘要翻译：本发明提供了使用来自肠杆菌科的L-苏氨酸生产菌来发酵制备L-苏氨酸的改进方法。

4. 发明申请

WO03008603A3 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERI ACEA FAMILY WHICH CONTAIN AN ATTENUATED ASPA GENE 审中-公开
标题翻译：使用含有ASPA基因的肠内寄生虫家系的菌株制备L-氨基酸的方法
公开(公告)号：WO03008603A3
公开(公告)日：2003-07-31
申请号：PCT/EP0207351
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/22 , C12P13/24
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the aspA gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及一种制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物发酵，其中所述aspA基因或其编码的核苷酸序列被减弱，特别是被消除，b）所述L-氨基酸在培养基中或细菌中的浓度，和c）L-氨基酸的分离。

5. 发明申请

WO03008616A2 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH CONTAIN AN ATTENUATED aceK GENE 审中-公开
标题翻译：使用含有减毒的aceK基因的肠杆菌属家族的菌株制备L-氨基酸的方法
公开(公告)号：WO03008616A2
公开(公告)日：2003-01-30
申请号：PCT/EP0207353
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the aceK gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物的发酵，并且其中 aceK基因或编码它的核苷酸序列被减弱，特别是被消除，b）L-氨基酸在培养基或细菌细胞中的浓度，以及c）分离L-氨基酸。

6. 发明申请

WO03008604A2 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH CONTAIN AN ATTENUATED ACEB GENE 审中-公开
标题翻译：使用含有ACEB基因的肠杆菌家族的菌株制备L-氨基酸的方法
公开(公告)号：WO03008604A2
公开(公告)日：2003-01-30
申请号：PCT/EP0207352
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08 , C12P13/00
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the aceB gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及一种制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物发酵，其中 aceB基因或其编码的核苷酸序列被减弱，特别是消除，b）L-培养基或细菌细胞中L-氨基酸的浓度，和c）L-氨基酸的分离。

7. 发明申请

WO0222799A3 METHOD FOR THE MICROBIAL PRODUCTION OF METABOLIC PRODUCTS, POLYNUCLEOTIDES FROM CORYNEFORM BACTERIA AND USE THEREOF 审中-公开
标题翻译：用于生产微生物代谢产物，从杆状菌及其用途多核苷酸
公开(公告)号：WO0222799A3
公开(公告)日：2003-03-13
申请号：PCT/DE0103485
申请日：2001-09-08
申请人： FORSCHUNGSZENTRUM JUELICH GMBH , DEGUSSA , BOTT MICHAEL , NIEBISCH AXEL , BATHE BRIGITTE , MARX ACHIM , HERMANN THOMAS
发明人： BOTT MICHAEL , NIEBISCH AXEL , BATHE BRIGITTE , MARX ACHIM , HERMANN THOMAS
IPC分类号： C07K14/34 , C12N1/21 , C12N9/02 , C12N15/31 , C12N15/52 , C12N15/53 , C12P1/04 , C12P7/04 , C12P7/40 , C12P13/04 , C12P19/38 , C12Q1/68
CPC分类号： C12N9/0036 , C07K14/34 , C12N9/0038 , C12N9/0053 , C12N15/52 , C12P1/04
摘要： The invention relates to a method for the microbial production ofmetabolic products, polynucleotides from coryneform bacteria and use thereof. According to the invention, by means of said method and polynucleotides it is possible to influence the synthesis of ATP in a controlled manner and also to control the synthesis of metabolic products. The invention relates to genes from Corynebacterium glutamicum coding for cytochrome aa3 oxidase and the cytochrome bcl complex. The monocistronic ctaD gene codes for a 65 kDa protein, the primary structure of which displays all the typical properties of the sub-unit I of cytochrome aa3 oxidase. The genes which code for the sub-unit III of the cytochrome aa3 (ctaE) and the three characteristic sub-units of the cytochrome bc1 complex (qcrABC) are arranged in a group with the sequence ctaE-qcrCAB.
摘要翻译：本发明涉及一种用于从棒状细菌和它们的使用的微生物生产的代谢产物，多核苷酸的方法。本发明的方法和多核苷酸，它是现在可以影响ATP的合成目标，从而控制代谢产物的合成。本发明涉及一种细胞色素氧化酶AA3和谷氨酸棒杆菌细胞色素BC1复杂的编码基因。单顺反子基因编码CTAD大的蛋白质，其主要结构具有细胞色素氧化酶AA3的亚基我为65 kDa的所有的典型特征。编码细胞色素BC1络合物（qcrABC）被布置的顺序ctaE-qcrCAB一组中的特性编码细胞色素AA3（ctaE）的亚基III的基因和三个亚基。

8. 发明申请

WO03008602A3 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY WHICH CONTAIN AN ATTENUATED UGPB GENE 审中-公开
标题翻译：使用含有减毒的UGPB基因的肠杆菌属家族的菌株制备L-氨基酸的方法
公开(公告)号：WO03008602A3
公开(公告)日：2003-07-31
申请号：PCT/EP0207350
申请日：2002-07-03
申请人： DEGUSSA , HERMANN THOMAS
发明人： HERMANN THOMAS
IPC分类号： C12N1/21 , C12N9/12 , C12N9/16 , C12N15/31 , C12N15/52 , C12N15/54 , C12N15/55 , C12N15/74 , C12P13/04 , C12P13/08 , C07K14/245
CPC分类号： C12N9/1205 , C12N9/16 , C12N15/52 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which the ugpB gene, or the nucleotide sequence which codes for this, is attenuated, in particular eliminated, b) concentration of the L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.
摘要翻译：本发明涉及制备L-氨基酸，特别是L-苏氨酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的肠杆菌科的微生物的发酵，并且其中 ugpB基因或编码它的核苷酸序列被减毒，特别是被消除，b）L-氨基酸在培养基或细菌细胞中的浓度，和c）分离L-氨基酸。

9. 发明申请

WO2010017328A3 CYCLODEXTRIN CONJUGATES FOR SIRNA DELIVERY 审中-公开
标题翻译： CYCLODEXTRIN联合SIRNA交付
公开(公告)号：WO2010017328A3
公开(公告)日：2011-01-13
申请号：PCT/US2009052898
申请日：2009-08-05
申请人： RGO BIOSCIENCES LLC , CHUCHOLOWSKI ALEXANDER , HERMANN THOMAS , AYIDA BENJAMIN , WANG TINGMIN , KHASANOV ALISHER
发明人： CHUCHOLOWSKI ALEXANDER , HERMANN THOMAS , AYIDA BENJAMIN , WANG TINGMIN , KHASANOV ALISHER
IPC分类号： C12N15/88 , A61K47/48 , C08B37/00
CPC分类号： A61K48/0041 , A61K47/62 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015 , C12N15/111 , C12N2310/351 , C12N2320/32
摘要： It has been discovered that the uptake of anionic charged species into cells can be enhanced by noncovalently associating such species with specifically modified forms of cyclodextrin. The invention modified forms of cyclodextrin form well defined stoichiometric complexes with anionic charged molecules. This discovery enables one to produce various compositions containing anionic charged molecules and facilitates methods for enhancing the cellular uptake of double-stranded or hairpin nucleic acid.
摘要翻译：已经发现，通过非特异性地将这些物质与特定的修饰形式的环糊精缔合，可以增强阴离子带电物质进入细胞的摄取。本发明改性形式的环糊精与阴离子带电分子形成了明确的化学计量络合物。该发现使得人们可以生产含有阴离子带电分子的各种组合物，并且有利于增强双链或发夹核酸的细胞摄取的方法。

10. 发明申请

WO2011124311A3 MOBILE MEASURING AND CALIBRATING UNIT 审中-公开
标题翻译：移动测量和校准
公开(公告)号：WO2011124311A3
公开(公告)日：2012-03-15
申请号：PCT/EP2011001276
申请日：2011-03-16
申请人： KHS GMBH , BUCHKREMER WOLFGANG , ZORN TAMMO , HERMANN THOMAS
发明人： BUCHKREMER WOLFGANG , ZORN TAMMO , HERMANN THOMAS
IPC分类号： G01D18/00 , G07C5/08
CPC分类号： G01D18/00 , G01D18/006 , G07C3/00
摘要： The invention relates to a mobile measuring and calibrating unit (1) for calibrating machines having at least one interface for establishing a connection for transferring data signals and/or measurement signals between the measuring and calibrating unit and a machine, wherein the measuring and calibrating unit is coupled to a data store (10) and comprises means for generating and reproducing information and at least one measuring module, and the measuring and calibrating unit (1) is configured to determine and document a deviation of a current operating state of the machine from a normal state of the machine by measuring current operating parameters of the machine. The invention further relates to a method for operating such a mobile measuring and calibrating unit (1) and to a suitable computer program having program code means for using such a measuring and calibrating unit (1) functionally if the computer program is executed on a computing unit coupled to the measuring and calibrating unit (1).
摘要翻译：本发明涉及一种移动测量和校准单元（1）具有用于建立用于传输所述测量和校准单元和机器，测量和校准之间的数据和/或测量信号的连接的至少一个接口的机器校准被耦合到数据存储器（10）和包括用于生成和的信息和至少一个测量模块重放并且测量和校准装置（1）被配置为，通过测量机的当前操作参数，从该机器的实际操作状态的偏差建立机和记录的标准条件。此外，本发明涉及一种用于操作这样的移动的测量和校准单元（1）的方法，并与程序代码的合适的计算机程序是指以使这样的测量和校准单元（1）功能性地，当在一个与计算机程序的使用耦合到所述计算单元的测量和校准单元（1）被执行。

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