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1. 发明申请

WO2011153449A1 FILAMENTOUS FUNGAL HOST STRAINS AND DNA CONSTRUCTS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：真菌真菌宿主菌和DNA构建体及其使用方法
公开(公告)号：WO2011153449A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/039092
申请日：2011-06-03
申请人： DANISCO US INC. , BOWER, Benjamin, S. , KAPER, Thijs , KELEMEN, Bradley, R.
发明人： BOWER, Benjamin, S. , KAPER, Thijs , KELEMEN, Bradley, R.
IPC分类号： C12N15/81 , C12N15/00 , C12N5/00
CPC分类号： C12N15/80 , C12N9/2437 , C12P21/02 , C12Y302/01091 , Y02P20/52
摘要： The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for achieving reliable expression of recombinant enzymes and variants.
摘要翻译：本公开涉及丝状真菌宿主菌株和用于其产生和使用的重组DNA构建体。丝状真菌宿主菌株对于实现重组酶和变体的可靠表达特别有用。

2. 发明申请

WO2009149202A2 COMPOSITIONS AND METHODS COMPRISING CELLULASE VARIANTS WITH REDUCED AFFINITY TO NON-CELLULOSIC MATERIALS 审中-公开
标题翻译：包含具有减少对非细胞材料的亲和力的纤维素酶变体的组合物和方法
公开(公告)号：WO2009149202A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046159
申请日：2009-06-03
申请人： DANISCO US INC., GENENCOR DIVISION , CASCAO-PEREIRA, Luis, G. , KAPER, Thijs , KELEMEN, Bradley, R. , LIU, Amy
发明人： CASCAO-PEREIRA, Luis, G. , KAPER, Thijs , KELEMEN, Bradley, R. , LIU, Amy
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01004 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.
摘要翻译：本公开涉及纤维素酶变体。特别地，本公开涉及具有减少的与非纤维素材料结合的纤维素酶变体。还描述了编码纤维素酶的核酸，包含所述纤维素酶的组合物，鉴定纤维素变体的方法和使用该组合物的方法。

3. 发明申请

WO2008079227A1 STORAGE-STABLE GLUCOSE OXIDASE 审中-公开
标题翻译：储存稳定的葡萄糖氧化酶
公开(公告)号：WO2008079227A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/025923
申请日：2007-12-18
申请人： DANISCO US, INC., GENENCOR DIVISION , KELEMEN, Bradley, R. , LANTZ, Suzanne, E.
发明人： KELEMEN, Bradley, R. , LANTZ, Suzanne, E.
IPC分类号： C12N9/04 , A61K8/66
CPC分类号： C12Y101/03004 , A61K8/66 , A61Q19/00 , C12N9/0006 , C12N9/96
摘要： The present invention provides methods and compositions comprising at least one glucose oxidase enzyme, wherein the glucose oxidase has improved storage stability. In some preferred embodiments, the glucose oxidase enzyme is stable after exposure to elevated temperatures. In some alternative preferred embodiments, the glucose oxidase has improved storage stability in liquid formulations. In some particularly preferred embodiments, the present invention provides methods and compositions comprising glucose oxidase(s) obtained from Aspergillus sp. In some more particularly preferred embodiments, the glucose oxidase is obtained from A. niger. The present invention finds use in applications involving cleaning, including personal care applications.
摘要翻译：本发明提供包含至少一种葡萄糖氧化酶的方法和组合物，其中葡萄糖氧化酶具有改善的储存稳定性。在一些优选的实施方案中，葡萄糖氧化酶在暴露于升高的温度之后是稳定的。在一些替代的优选实施方案中，葡萄糖氧化酶在液体制剂中具有改善的储存稳定性。在一些特别优选的实施方案中，本发明提供了包含从曲霉属（Aspergillus sp。）获得的葡萄糖氧化酶的方法和组合物。在一些更特别优选的实施方案中，葡萄糖氧化酶得自黑曲霉。本发明用于涉及清洁的应用，包括个人护理应用。

4. 发明申请

WO2009131799A2 ORAL CARE COMPOSITION CONTAINING OXIDASE ENZYME 审中-公开
标题翻译：含有氧化酶的口腔护理组合物
公开(公告)号：WO2009131799A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/038777
申请日：2009-03-30
申请人： DANISCO US INC., GENENCOR DIVISION , KELEMEN, Bradley, R. , WOLGER, Erin
发明人： KELEMEN, Bradley, R. , WOLGER, Erin
IPC分类号： A61Q11/00 , A61K8/66 , A61K8/84
CPC分类号： A61Q11/00 , A61K8/345 , A61K8/66 , A61K8/84 , A61Q17/005
摘要： Oral care compositions comprising an oxidase, polyethyleneimine, and an orally acceptable carrier are described, along with methods of use thereof. The oral care composition may be applied to a tooth surface to produce peroxide.
摘要翻译：描述了包含氧化酶，聚乙烯亚胺和口服可接受的载体的口腔护理组合物及其使用方法。口腔护理组合物可以施用于牙齿表面以产生过氧化物。

5. 发明申请

WO2004063326A2 PROTEORHODOPSIN MUTANTS WITH IMPROVED OPTICAL CHARACTERISTICS 审中-公开
标题翻译：具有改进的光学特性的防腐剂
公开(公告)号：WO2004063326A2
公开(公告)日：2004-07-29
申请号：PCT/US2003/038194
申请日：2003-11-26
申请人： GENENCOR INTERNATIONAL, INC. , DOW CORNING CORPORATION , JENSEN, Rasmus, B. , KELEMEN, Bradley, R.
发明人： JENSEN, Rasmus, B. , KELEMEN, Bradley, R.
IPC分类号： C12N
CPC分类号： C07H21/04 , B42D2035/24 , C07K14/195 , C07K14/705 , G11B7/245 , G11B7/246 , G11B7/2531 , G11B7/2532 , G11B7/2533 , G11B7/2539
摘要： The present invention is directed to a protoeorhodopsin mutant having improved optical characteristics. One improved optical characteristic is having a lower pH(p K rh ) at which equal concentrations of the acidic and basic spectral form of the proteorrhodopsin molecules are present. Another improved optical characteristic is having a smaller difference in maximum absorption wavelength between the basic and the acidic form. The mutant comprises a mutation in a conserved amino acid residue of a proteorhodopdin variant, which auses spectral shifts. A preferred mutation site is a conserved histidine residue at amino acid position 75 of Bac31A8, or position 77 of Hot75m1, or its equivalent position of a proteorhodopsin variant. Another preferred mutation site is a conserved arginine residue at amino acid position 94 of Bac31A8, or position 96 of Hot75m1, or its equivalent position of a proteorhodopsin variant.
摘要翻译：本发明涉及具有改善的光学特性的原生eor视蛋白突变体。一个改进的光学特征是具有较低的pH（pKrh），在该pH下存在等同浓度的蛋白质视紫红质分子的酸性和碱性光谱形式。另一改进的光学特性在碱性和酸性形式之间的最大吸收波长的差异较小。突变体包含蛋白质多巴胺变体的保守氨基酸残基中的突变，其导致光谱偏移。优选的突变位点是Bac31A8的氨基酸位置75处的保守的组氨酸残基，或Hot75m1的77位或其蛋白质视紫红质变体的等同位置。另一个优选的突变位点是Bac31A8的氨基酸位置94的保守精氨酸残基，或Hot75m1的位置96或其蛋白质视紫红质变体的等同位置。

6. 发明申请

WO2006074005A2 NOVEL VARIANT HYPOCREA JECORINA CBH2 CELLULASES 审中-公开
标题翻译：新型变异胶原蛋白CBH2细胞
公开(公告)号：WO2006074005A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/047266
申请日：2005-12-22
申请人： GENENCOR INTERNATIONAL, INC. , AEHLE, Wolfgang , CALDWELL, Robert, M. , DANKMEYER, Lydia , GOEDEGEBUUR, Frits , KELEMEN, Bradley, R. , MITCHINSON, Colin , NEEFE, Paulien , TEUNISSEN, Pauline
发明人： AEHLE, Wolfgang , CALDWELL, Robert, M. , DANKMEYER, Lydia , GOEDEGEBUUR, Frits , KELEMEN, Bradley, R. , MITCHINSON, Colin , NEEFE, Paulien , TEUNISSEN, Pauline
IPC分类号： C12N9/42 , C11D3/386 , A23K1/165 , C12P7/10
CPC分类号： C11D3/38645 , C12N9/2437 , C12P19/14 , C12Y302/01091 , Y02E50/16
摘要： Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
摘要翻译：本文描述了H.cecorina CBH2，Cel6A酶的变体。本发明提供了具有改变的热稳定性的新型纤维二糖水解酶。

7. 发明申请

WO2004048451A2 OPTICAL INFORMATION CARRIER COMPRISING IMMOBILIZED PROTEORHODOPSIN 审中-公开
标题翻译：包含固定保护膜的光信息载体
公开(公告)号：WO2004048451A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/038157
申请日：2003-11-26
申请人： GENENCOR INTERNATIONAL, INC. , DOW CORNING CORPORATION , JENSEN, Rasmus, B. , KELEMEN, Bradley, R. , McAULIFFE, Joseph, C , SMITH, Wyatt, C.
发明人： JENSEN, Rasmus, B. , KELEMEN, Bradley, R. , McAULIFFE, Joseph, C , SMITH, Wyatt, C.
IPC分类号： C08K
CPC分类号： G11B7/245 , B42D25/378 , B42D2035/24 , C07H21/04 , C07K14/195 , C07K14/705 , C09D11/037 , G11B7/246 , G11B7/2531 , G11B7/2532 , G11B7/2533 , G11B7/2539 , Y10S430/146
摘要： The present invention relates to materials comprising hydrophilic polymersand immobilized proteorhodopsin and the use of such materials as an optical information carrier. The material comprises one or more hydrophilic polymersthat are capable to form a homogeneous phase with proteorhodopsin prior to solidification to a solid form. The hydrophilic polymer, for example, is silica sol-gel,gelatin, polyvinylalcohol, agarose, agar, methyl cellulose, polyvinyl acetate, polyvinyl pyrrolidone, polyethylene glycol, or a mixture thereof. The solid material having immobilized proteorhodopsin is deposited on a substrate selected from the group consisting of glass, paper, metal, fabric material, plastic material, and used as an optical data storage material or a fraud-proof carrier. The present invention further provides a security ink comprising proteorhodopsin and one or more hydrophilicpolymers.
摘要翻译：本发明涉及包含亲水性聚合物和固定化蛋白质视紫红质的材料以及这种材料作为光学信息载体的用途。该材料包含一种或多种在固化成固体形式之前能与蛋白质视紫质形成均相的亲水性聚合物。亲水性聚合物例如是硅溶胶 - 凝胶，明胶，聚乙烯醇，琼脂糖，琼脂，甲基纤维素，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙二醇或它们的混合物。具有固定化蛋白质视紫红质的固体材料沉积在选自玻璃，纸，金属，织物材料，塑料材料的基材上，并用作光学数据存储材料或防欺负载体。本发明还提供了包含蛋白质视紫红质和一种或多种亲水性聚合物的安全油墨。

8. 发明申请

WO2014093282A1 VARIANTS OF CELLOBIOHYDROLASES 审中-公开
标题翻译：纤维水解物的变体
公开(公告)号：WO2014093282A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074014
申请日：2013-12-10
申请人： DANISCO US INC.
发明人： BOTT, Richard, R. , FOUKARAKI, Maria , HOMMES, Ronaldus , KAPER, Thijs , KELEMEN, Bradley, R. , KRALJ, Slavko , NIKOLAEV, Igor , SANDGREN, Mats , VAN LIESHOUT, Johannes , VAN STIGT THANS, Sander
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/2402 , C12N9/2434 , C12P19/02 , C12P19/14 , C12Y302/01004
摘要： Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1 ), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
摘要翻译：公开了Hypocrea jecorina Cel7A（以前称为里氏木霉纤维二糖水解酶I或CBH1）的许多同系物和变体，编码它们的核酸和生产方法。同系物和变体纤维素酶具有家族7A的糖基水解酶的氨基酸序列，其中一个或多个氨基酸残基被取代和/或缺失。

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