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1. 发明申请

WO2012149333A9 DETERGENT COMPOSITIONS CONTAINING BACILLUS SP. MANNANASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有BACILLUS SP的洗涤剂组合物曼尼诺酶及其使用方法
公开(公告)号：WO2012149333A9
公开(公告)日：2013-08-01
申请号：PCT/US2012035472
申请日：2012-04-27
申请人： DANISCO US INC , JONES BRIAN E , KOLKMAN MARC , QIAN ZHEN , LAURSEN BRIAN SOGAARD , KRAGH KARSTEN M , PRICELIUS SINA , YU ZHEYONG , BABE LILIA MARIA , ESTABROOK MELODIE , HUA LING
发明人： JONES BRIAN E , KOLKMAN MARC , QIAN ZHEN , LAURSEN BRIAN SOGAARD , KRAGH KARSTEN M , PRICELIUS SINA , YU ZHEYONG , BABE LILIA MARIA , ESTABROOK MELODIE , HUA LING
IPC分类号： C12N9/42
CPC分类号： C11D3/38636 , C12C5/004 , C12N9/2405 , C12N9/2491 , C12N9/2494 , C12Y302/01078
摘要： The present compositions and methods relate to an endo-B-mannanase cloned from a Bacillus sp., polynucleotides encoding the endo-B-mannanase, and methods of use thereof. Formulations containing the endo-beta-mannanase are highly suitable for use as detergents.
摘要翻译：本发明的组合物和方法涉及从Bacillus sp。，编码内切-B-甘露聚糖酶的多核苷酸克隆的内切-B-甘露聚糖酶及其使用方法。含有β-内酰基β-甘露聚糖酶的制剂非常适合用作洗涤剂。

2. 发明申请

WO2010065455A3 ENZYMES WITH LIPASE ACTIVITY 审中-公开
标题翻译：具有脂肪酶活性的酶
公开(公告)号：WO2010065455A3
公开(公告)日：2010-07-29
申请号：PCT/US2009066106
申请日：2009-11-30
申请人： DANISCO US INC , ADAMS CHRISTIAN D , BAO KAI , COLLIER KATHERINE D , LEE EDWIN , MIASNIKOV ANDREI , QIAN ZHEN , SCHMIDT BRIAN F , SONG DANFENG
发明人： ADAMS CHRISTIAN D , BAO KAI , COLLIER KATHERINE D , LEE EDWIN , MIASNIKOV ANDREI , QIAN ZHEN , SCHMIDT BRIAN F , SONG DANFENG
IPC分类号： C11D3/386
CPC分类号： C11D3/38627
摘要： Described are detergent compositions comprising at least one lipase enzyme selected from SriII, ScoIIA, ScoIIB, CefII, and variants, thereof. The compositions are useful for removing oily stains from fabric.
摘要翻译：描述了包含至少一种选自SriII，ScoIIA，ScoIIB，CefII及其变体的脂肪酶的洗涤剂组合物。该组合物可用于从织物中除去油性污渍。

3. 发明申请

WO2006086607A2 NOVEL PROTEINS WITH ENHANCED FUNCTIONALITY AND METHODS OF MAKING NOVEL PROTEINS USING CIRCULAR PERMUTATION 审中-公开
标题翻译：具有增强功能的新蛋白质和使用圆形透明制备新蛋白质的方法
公开(公告)号：WO2006086607A2
公开(公告)日：2006-08-17
申请号：PCT/US2006004675
申请日：2006-02-10
申请人： UNIV EMORY , LUTZ STEFAN , QIAN ZHEN
发明人： LUTZ STEFAN , QIAN ZHEN
IPC分类号： C12P21/06
CPC分类号： C12P21/00 , C12N9/20
摘要： The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and protein engineering.
摘要翻译：本公开涉及具有关于天然蛋白质或肽的新颖和/或增强的功能和/或行为的新型蛋白质和肽以及使用循环置换和蛋白质工程技术制备新型蛋白质和肽的方法。

4. 发明申请

WO2008097630A3 3D SEGMENTATION OF THE COLON IN MR COLONOGRAPHY 审中-公开
标题翻译：在分层结构中对结肠的3D分割
公开(公告)号：WO2008097630A3
公开(公告)日：2008-10-16
申请号：PCT/US2008001664
申请日：2008-02-06
申请人： SIEMENS MEDICAL SOLUTIONS , QIAN ZHEN , WOLF MATTHIAS , BOGONI LUCA
发明人： QIAN ZHEN , WOLF MATTHIAS , BOGONI LUCA
IPC分类号： G06T7/00 , G06T5/00
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10088 , G06T2207/20101 , G06T2207/20116 , G06T2207/20168 , G06T2207/30032 , Y10S128/922
摘要： A method for segmenting a tubular structure includes providing a three-dimensional image including the tubular structure, providing at least one seed point within the tubular structure (101), fitting an initial cylinder into the tubular structure at the seed point (102), adding cylinder segments to the initial cylinder in forward and backward directions within the three-dimensional image of the tubular structure by tracking the cylinder model over the tubular structure (103), modeling each cylinder segment using parameters to account for a three-dimensional orientation, a radius, a length and a curvature, describing an intensity image of the tubular structure using a second model to represent an edge and intensity distribution of the tubular structure, fitting the parameters as the cylinder segment is added to the intensity image, and outputting cylinder segments as a segmentation of the tube (104). (Figure 1)
摘要翻译：一种用于分割管状结构的方法包括提供包括管状结构的三维图像，在管状结构（101）内提供至少一个种子点，在种子点（102）处将初始圆柱体装配到管状结构中，添加通过跟踪所述管状结构（103）上的所述圆柱体模型在所述管状结构的所述三维图像内在所述管状结构的三维图像内沿前后方向将所述圆柱体段分成初始圆柱体，使用参数来对每个圆柱体分段进行建模以考虑三维取向，半径，长度和曲率，使用第二模型描述管状结构的强度图像以表示管状结构的边缘和强度分布，当将圆柱段添加到强度图像时将参数拟合，并输出圆柱段作为管（104）的分割。（图1）

5. 发明申请

WO2010071896A3 SYSTEM AND METHOD FOR LESION-SPECIFIC CORONARY ARTERY CALCIUM QUANTIFICATION 审中-公开
标题翻译：用于特定冠状动脉钙质量的系统和方法
公开(公告)号：WO2010071896A3
公开(公告)日：2010-08-12
申请号：PCT/US2009069081
申请日：2009-12-21
申请人： PIEDMONT HEALTHCARE INC , VOROS SZILARD , QIAN ZHEN
发明人： VOROS SZILARD , QIAN ZHEN
IPC分类号： A61B5/02 , G06F19/00 , G06T15/08
CPC分类号： A61B6/504 , A61B5/02007 , A61B6/032 , A61B6/5288 , G06F19/321 , G06T7/0012 , G06T15/08 , G06T2200/24 , G06T2207/10081 , G06T2207/30048 , G16H50/30
摘要： Methods and systems utilizing the data provided by a non-contrast-enhanced CAC scan that is left unused by the "whole-heart" Agatston or volume scores. Agatston and volume scores summarize overall coronary calcium burden, but do not show the number of vessels involved, the geographic distribution of the lesions, the size and shape of the individual lesions and the distance of the lesions from the coronary ostium. The methods and systems described herein extract and use the enhanced information provided by 3-D CAC scan data and significantly increases its clinical predictive value by providing vessel and lesion specific CAC scores which are superior to the whole-heart Agatston and volume scores in predicting obstructive Coronary artery disease (CAD).
摘要翻译：使用由“全心脏”阿格斯顿或体积分数未使用的非对比度增强型CAC扫描提供的数据的方法和系统。阿格斯顿和体积分数总结了总体冠状动脉钙负荷，但不显示所涉及的血管数量，病变的地理分布，个体病变的大小和形状以及病变与冠状动脉口的距离。本文所述的方法和系统提取并使用3-D CAC扫描数据提供的增强信息，并通过提供优于全心脏阿格斯顿的血管和病变特异性CAC评分并预测阻塞性体积评分来显着提高其临床预测价值冠状动脉疾病（CAD）。

6. 发明申请

WO2016054163A8 COMPOSITIONS COMPRISING BETA MANNANASE AND METHODS OF USE 审中-公开
标题翻译：包含β-甘露聚糖酶的组合物和使用方法
公开(公告)号：WO2016054163A8
公开(公告)日：2017-05-04
申请号：PCT/US2015053147
申请日：2015-09-30
申请人： DANISCO US INC
发明人： LE STEVEN , QIAN ZHEN
IPC分类号： C12N9/24
CPC分类号： C12N9/2491 , C12P19/02 , C12P19/14 , C12Y302/01025
摘要： The present compositions and methods relate to a beta-mannanase from Mahella australiensis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).
摘要翻译：本发明的组合物和方法涉及来自Mahella australiensis的β-甘露聚糖酶，编码β-甘露聚糖酶的多核苷酸，以及制备和/或使用它们的方法。含有β-甘露聚糖酶的制剂适用于水解木质纤维素生物质底物，特别是包含可测量水平的半乳糖葡甘露聚糖（GGM）和/或葡甘露聚糖（GM）的那些。

7. 发明申请

WO2016007929A2 PAENIBACILLUS AND BACILLUS SPP. MANNANASES 审中-公开
标题翻译： PAENIBACILLUS和BACILLUS SPP。甘露聚糖
公开(公告)号：WO2016007929A2
公开(公告)日：2016-01-14
申请号：PCT/US2015040057
申请日：2015-07-10
申请人： DANISCO US INC
发明人： ADAMS CHRISTIAN D , GHIRNIKAR ROOPA , HUANG VICTORIA , JIN LILING , KOLKMAN MARC , QIAN ZHEN
CPC分类号： C12N9/2494 , A23K20/189 , A23L29/06 , A23V2002/00 , C11D3/38636 , C11D3/38681 , C12C5/004 , C12N9/2488 , C12Y302/01078
摘要： The present disclosure relates to endo-beta-mannanases from Paenibacillus and Bacillus spp., polynucleotides encoding such endo-beta-mannanases, compositions containing such mannanases, and methods of use thereof. Compositions containing such endo-beta-mannanases are suitable for use as detergents and cleaning fabrics and hard surfaces, as well as a variety of other industrial applications.
摘要翻译：本公开涉及来自类芽孢杆菌属和芽孢杆菌属的内源β-甘露聚糖酶，编码此类内切-β-甘露聚糖酶的多核苷酸，包含此类甘露聚糖酶的组合物及其使用方法。含有这种内β-甘露聚糖酶的组合物适合用作洗涤剂和清洁织物以及硬表面，以及各种其他工业应用。

8. 发明申请

WO2014088935A2 COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：组合物和使用方法
公开(公告)号：WO2014088935A2
公开(公告)日：2014-06-12
申请号：PCT/US2013072576
申请日：2013-12-02
申请人： DANISCO US INC
发明人： HUA LING , LAU ROSALYN , LE STEVEN , QIAN ZHEN , YU ZHEYONG
IPC分类号： C07K14/32 , C12N9/24
CPC分类号： C12P19/14 , C12N9/2494 , C12P19/02 , C12Y302/01078 , G01N2333/924
摘要： The present compositions and methods relate to a beta-mannanase from Bacillus licheniformis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).
摘要翻译：本发明组合物和方法涉及来自地衣芽孢杆菌的β-甘露聚糖酶，编码β-甘露聚糖酶的多核苷酸，及其制备和/或使用方法。含有β-甘露聚糖酶的制剂适用于水解木质纤维素生物质底物，特别是含有可测量水平的半乳甘露聚糖（GGM）和/或葡甘露聚糖（GM）的那些。

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