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1. 发明申请

WO2007117110A3 SUSTAINED-RELEASE PELLETS CONTAINING TAMSULOSIN HYDROCHLORIDE AND PROCESSES FOR PREPARING THE SAME 审中-公开
公开(公告)号：WO2007117110A3
公开(公告)日：2007-10-18
申请号：PCT/KR2007/001732
申请日：2007-04-10
申请人： DAEWOONG PHARMACEUTICAL CO., LTD. , KANG, Bok Ki , CHANG, Hee Chul , LEE, Min Suk
发明人： KANG, Bok Ki , CHANG, Hee Chul , LEE, Min Suk
IPC分类号： A61K9/28
摘要： The present invention relates to a sustained-release pellet containing tamsulosin hydrochloride, which comprises (a) a pellet core; (b) a drug-coating layer wherein a water insoluble polymer and tamsulosin hydrochloride are coated on said pellet core; (c) a semi-permeable membrane layer wherein cellulose acetate is coated on said drug-coating layer; and (d) an enteric coating layer wherein an enteric polymer is coated on said semi-permeable membrane layer, and a process for preparing the same.

2. 发明申请

WO2013058496A1 TASTE-MASKED PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：用于口服给药的香味化学药物组合物及其制备方法
公开(公告)号：WO2013058496A1
公开(公告)日：2013-04-25
申请号：PCT/KR2012/008230
申请日：2012-10-11
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： CHANG, Hee Chul , PARK, Sang Han , KANG, Bok Ki
IPC分类号： A61K9/20 , A61K9/48 , A61K47/02
CPC分类号： A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077
摘要： A pharmaceutical composition for oral administration, wherein taste of the pharmaceutically active ingredient is masked, prepared by wet granulation of a mixture of a pharmaceutically active ingredient, at least one compound selected from the group consisting of magnesium aluminometasilicate and calcium silicate, and a pharmacologically acceptable carrier, and a method of preparing the pharmaceutical composition. The oral pharmaceutical composition may be prepared without using a costly special manufacturing system or additive, have an off-taste masking effect on active ingredients, and exhibit an appropriate drug dissolution behavior in the body for manifestation of pharmaceutical effect. Also, the oral pharmaceutical composition is compatible with both a water-soluble active ingredient and a poorly water-soluble active ingredient, with high industrial applicability due to simple manufacturing processes and high economical efficiency and productivity. The oral pharmaceutical composition may be formulated in any of a variety of solid dosage forms with improved pharmaceutical characteristics.
摘要翻译：一种用于口服给药的药物组合物，其中掩蔽了药物活性成分的味道，其通过湿法制粒药物活性成分，至少一种选自硅酸铝镁和硅酸钙的化合物的混合物和药理学上可接受的制剂载体和制备药物组合物的方法。可以在不使用昂贵的特殊制造系统或添加剂的情况下制备口服药物组合物，对活性成分具有异味掩蔽作用，并且在体内表现出药物作用的表现出适当的药物溶解行为。此外，口服药物组合物与水溶性活性成分和水难溶性活性成分相适应，由于制造工艺简单，经济性和生产率高，因此具有高的工业实用性。口服药物组合物可配制成具有改进的药物特性的多种固体剂型中的任一种。

3. 发明申请

WO2013122413A1 ORAL FORMULATION COMPRISING LANSOPRAZOLE AND THE PREPARATION METHOD THEREOF 审中-公开
标题翻译：包含兰索唑的口服制剂及其制备方法
公开(公告)号：WO2013122413A1
公开(公告)日：2013-08-22
申请号：PCT/KR2013/001189
申请日：2013-02-15
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： CHANG, Hee Chul , KANG, Bok Ki , KIM, Jung Soo
IPC分类号： A61K9/16 , A61K9/14 , A61K31/4439
CPC分类号： A61K9/5073 , A61K9/5026 , A61K31/4439
摘要： An acid-unstable, insoluble lansoprazole-containing oral formulation, and a method of preparing the same are provided. The lansoprazole-containing oral formulation is resistant to activity loss caused by gastric juice, has improved dissolution characteristics, and thus ensures effective delivery of lansoprazole into the body through oral administration.
摘要翻译：提供了一种酸不稳定的不溶性兰索拉唑口服制剂及其制备方法。含有兰索拉唑的口服制剂对胃液引起的活性损失具有抗性，具有改善的溶出特性，从而通过口服给药确保了兰索拉唑有效地输送到体内。

4. 发明申请

WO2004112746A1 CONTROLLED RELEASE-DRUG DELIVERY SYSTEM FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的控制释放药物递送系统
公开(公告)号：WO2004112746A1
公开(公告)日：2004-12-29
申请号：PCT/KR2004/001437
申请日：2004-06-16
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , LEE, Hai Bang , CHO, Sun Hang , KHANG, Gilson , JEONG, Sang Young , KANG, Bok Ki , SEO, Kwang Su , KIM, Moon Suk , CHON, Se Kang
发明人： LEE, Hai Bang , CHO, Sun Hang , KHANG, Gilson , JEONG, Sang Young , KANG, Bok Ki , SEO, Kwang Su , KIM, Moon Suk , CHON, Se Kang
IPC分类号： A61K9/00
CPC分类号： A61K9/5042 , A61K9/5026 , A61K9/5047 , A61K9/5078
摘要： The present invention relates to a controlled-release drug delivery system for oral administration and a composition for forming a controlled-release porous membrane employed in the system. The controlled-release drug delivery system for oral administration of the present invention comprises a core containing a pharmaceutically active ingredient; and a controlled-release porous membrane coated on the outer surface of the core comprising at least one film formation material selected from the group consisting of a cellulose based compound, polymethacrylate, an acetate based compound, polyamide, polyurethane and sulfonated polystyrene. The controlled-release drug delivery system for oral administration according to the present invention can provide an effective and consistent drug release in gastrointestinal tracts because the release rate of the drugs can be controlled. Also, the timing of drug release can be controlled by varying the thickness of the porous membrane, composition of the membrane material, amount of the plasticizer and amount of the vehicles. And, preparation of the controlled-release formulation becomes simple and cost-effective because a small amount of the porous membrane is coated on a conventional tablet or granule. In addition, since the membrane is highly stable, a controlled-release formulation for oral administration not affected by temperature or humidity can be produced in large quantities.
摘要翻译：本发明涉及用于口服给药的控释药物递送系统和用于形成用于该系统的控释多孔膜的组合物。用于口服本发明的控释药物递送系统包含含有药物活性成分的核心; 以及涂布在所述芯的外表面上的控释多孔膜，其包含选自纤维素基化合物，聚甲基丙烯酸酯，乙酸酯基化合物，聚酰胺，聚氨酯和磺化聚苯乙烯的至少一种成膜材料。根据本发明的用于口服给药的控释药物递送系统可以在胃肠道中提供有效且一致的药物释放，因为可以控制药物的释放速率。此外，可以通过改变多孔膜的厚度，膜材料的组成，增塑剂的量和车辆的量来控制药物释放的时间。并且，由于少量的多孔膜被涂覆在常规的片剂或颗粒上，所以控制释放制剂的制备变得简单且成本有效。此外，由于膜是高度稳定的，因此可以大量生产不受温度或湿度影响的用于口服的控释制剂。

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