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1. 发明申请

WO2013058496A1 TASTE-MASKED PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：用于口服给药的香味化学药物组合物及其制备方法
公开(公告)号：WO2013058496A1
公开(公告)日：2013-04-25
申请号：PCT/KR2012/008230
申请日：2012-10-11
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： CHANG, Hee Chul , PARK, Sang Han , KANG, Bok Ki
IPC分类号： A61K9/20 , A61K9/48 , A61K47/02
CPC分类号： A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077
摘要： A pharmaceutical composition for oral administration, wherein taste of the pharmaceutically active ingredient is masked, prepared by wet granulation of a mixture of a pharmaceutically active ingredient, at least one compound selected from the group consisting of magnesium aluminometasilicate and calcium silicate, and a pharmacologically acceptable carrier, and a method of preparing the pharmaceutical composition. The oral pharmaceutical composition may be prepared without using a costly special manufacturing system or additive, have an off-taste masking effect on active ingredients, and exhibit an appropriate drug dissolution behavior in the body for manifestation of pharmaceutical effect. Also, the oral pharmaceutical composition is compatible with both a water-soluble active ingredient and a poorly water-soluble active ingredient, with high industrial applicability due to simple manufacturing processes and high economical efficiency and productivity. The oral pharmaceutical composition may be formulated in any of a variety of solid dosage forms with improved pharmaceutical characteristics.
摘要翻译：一种用于口服给药的药物组合物，其中掩蔽了药物活性成分的味道，其通过湿法制粒药物活性成分，至少一种选自硅酸铝镁和硅酸钙的化合物的混合物和药理学上可接受的制剂载体和制备药物组合物的方法。可以在不使用昂贵的特殊制造系统或添加剂的情况下制备口服药物组合物，对活性成分具有异味掩蔽作用，并且在体内表现出药物作用的表现出适当的药物溶解行为。此外，口服药物组合物与水溶性活性成分和水难溶性活性成分相适应，由于制造工艺简单，经济性和生产率高，因此具有高的工业实用性。口服药物组合物可配制成具有改进的药物特性的多种固体剂型中的任一种。

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