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    • 4. 发明申请
    • SUSTAINED RELEASE FILM FORMULATION FOR HEALING WOUND COMPRISING EPIDERMAL GROWTH FACTOR
    • 持续发布电影制作用于包围人造生长因子的治疗
    • WO2007055481A1
    • 2007-05-18
    • PCT/KR2006/004401
    • 2006-10-27
    • DAEWOONG CO., LTD.KIM, Sun HeeLEE, Sang KilLEE, Min SukHONG, Joon Pio
    • KIM, Sun HeeLEE, Sang KilLEE, Min SukHONG, Joon Pio
    • A61L27/20
    • A61L26/0066A61L15/28A61L26/0023A61L26/0095C08L5/08
    • The present invention relates to a sustained release film formulation for healing wound comprising epidermal growth factor, chitosan, viscosity modifiers, plasticizers, and stabilizers. Specifically, the present invention relates to a sustained release film formulation for healing wound comprising epidermal growth factor as an effective ingredient and chitosan as a main base, and additionally comprising one or more antioxidants selected from the group consisting of EDTA and vitamin C; one or more viscosity modifiers selected from the group consisting of hydroxypropylmethylcellulose, gellan gum and pullulan; and one or more plasticizers selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone thereto. When the present film is attached to wound site, it absorbs exudation from wound site, and so is changed to hydrogel to keep wound site humid, which is good for wound-healing. And, the present film has superior attachment property to human body, and antifungal activity. Thus, the present film has more merits than simple ointment/cream formulation.
    • 本发明涉及用于治疗伤口的持续释放膜制剂,其包括表皮生长因子,壳聚糖,粘度调节剂,增塑剂和稳定剂。 具体地,本发明涉及一种用于治疗伤口的持续释放膜制剂,其包含表皮生长因子作为有效成分和壳聚糖作为主要基质,并且还包含一种或多种选自EDTA和维生素C的抗氧化剂; 选自羟丙基甲基纤维素,结冷胶和支链淀粉的一种或多种粘度调节剂; 和一种或多种选自甘油,丙二醇,聚乙二醇,聚乙烯醇和聚乙烯吡咯烷酮的增塑剂。 当本膜附着于伤口部位时,吸收伤口部位的渗出物,因此变为水凝胶,保持伤口部位湿润,有利于伤口愈合。 而且,本发明的膜具有优异的人体附着性和抗真菌活性。 因此,本发明的薄膜比简单的软膏/霜剂具有更多的优点。
    • 8. 发明申请
    • A SOLID DISPERSION COMPRISING SIBUTRAMINE AND SURFACTANTS, AND A PREPARATION METHOD THEREOF
    • 包含西布曲明和表面活性剂的固体分散体及其制备方法
    • WO2007040306A1
    • 2007-04-12
    • PCT/KR2006/003401
    • 2006-08-29
    • DAEWOONG PHARMACEUTICAL CO., LTD.CHANG, Hee ChulLEE, Min Suk
    • CHANG, Hee ChulLEE, Min Suk
    • A61K9/16A61K9/22A61K31/13
    • A61K9/146A61K9/145A61K31/13
    • A compatible optical pickup including an active compensation device to actively switch an angle of incidence of the light on the objective lens when either a third information storage medium that has a different format than that of the first and second information storage media, or the second information storage medium is adopted for use in a data recording/reproducing operation. The active compensation device includes a plurality of transparent substrates, and at least one material layer, interposed between the plurality of substrates, having a refractive index which is actively switched according to an applied voltage. A holographic pattern, formed adjacent to the material layer on a surface of at least one of the transparent substrates, changes a divergence angle of the light by diffracting or transmitting without diffraction the incident light according to change of the refractive index of the material layer. The voltage applied to the material layer is adjusted according to the applied information storage medium that is adopted for the use in the data recording/reproducing operation.
    • 一种兼容的光学拾取器,包括有源补偿装置,用于当具有与第一和第二信息存储介质的格式不同的格式的第三信息存储介质或第二信息时主动切换光在物镜上的入射角 采用存储介质用于数据记录/再现操作。 有源补偿装置包括多个透明基板,以及介于多个基板之间的至少一个材料层,具有根据施加的电压有效切换的折射率。 根据材料层的折射率的变化,与至少一个透明基板的表面上的材料层相邻形成的全息图案通过衍射或透射衍射或透射来改变入射光的衍射角。 根据在数据记录/再现操作中使用的应用信息存储介质来调整施加到材料层的电压。