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1. 发明申请

WO2009148195A1 5-(4-HYDROXYBENZYL)THIAZOLIDINE-2,4-DIONE AS INTERMEDIATE FOR SYNTHESIS OF THIAZOLIDINEDIONE BASED COMPOUNDS AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译： 5-（4-羟基苄基）噻唑烷-2,4-二酮作为合成基于噻唑烷二酮的化合物的中间体及其制备方法
公开(公告)号：WO2009148195A1
公开(公告)日：2009-12-10
申请号：PCT/KR2008/003102
申请日：2008-06-03
申请人： DAEBONG LS, LTD. , PARK, Jin Oh , KIM, Yong Gil , SON, Han Il , LEE, Yun Jeong , KIM, Eun Mi
发明人： PARK, Jin Oh , KIM, Yong Gil , SON, Han Il , LEE, Yun Jeong , KIM, Eun Mi
IPC分类号： C07D283/02 , C07D283/00 , A61P3/10
CPC分类号： C07D277/34 , C07D417/12
摘要： The present invention relates to 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by the following Chemical Formula [1], which is useful as an intermediate for synthesis of thiazolidinedione based compounds, a method for preparing the compound, and a method for preparing pioglitazone or pioglitazone hydrochloride, which is a thiazolidinedione based drug and useful in treating and preventing diabetes, using the 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by Chemical Formula [1] as an intermediate:
摘要翻译：本发明涉及由以下化学式[1]表示的5-（4-羟基苄基）噻唑烷-2,4-二酮，其可用作合成噻唑烷二酮类化合物的中间体，该化合物的制备方法和使用由化学式[1]表示的5-（4-羟基苄基）噻唑烷-2,4-二酮作为中间体制备作为噻唑烷二酮类药物的吡格列酮或吡格列酮盐酸盐的方法，其用于治疗和预防糖尿病。

2. 发明申请

WO2008130082A1 TGFP-CAP PEPTIDE AND ITS USES 审中-公开
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：WO2008130082A1
公开(公告)日：2008-10-30
申请号：PCT/KR2007/004405
申请日：2007-09-12
申请人： CAREGEN CO., LTD , CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K19/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列和细胞粘附序列的GFP-CAP肽，其中衍生自TGF-β1的氨基酸序列由 SEQ ID NO：1，TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素生成，从而具有皮肤美白效果。本发明的肽显示比天然存在的TGF-β1更高的稳定性和对皮肤的渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

3. 发明申请

WO2007102686A1 PEPTIDES HAVING ACTIVITIES OF INSULIN LIKE GROWTH FACTOR-1 AND THEIR USES 审中-公开
标题翻译：胰岛素样生长因子-1及其用途的活性肽
公开(公告)号：WO2007102686A1
公开(公告)日：2007-09-13
申请号：PCT/KR2007/001086
申请日：2007-03-06
申请人： CAREGEN CO., LTD , CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-I) and derived from IGF-I, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-I mimicking peptides of this invention have identical functions or actions to natural- occurring IGF-I and much better stability and skin permeation than natural-occurring IGF-I. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-I activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有胰岛素样生长因子-1（IGF-I）的活性并衍生自IGF-1的肽，用于改善皮肤病症或治疗包含该肽的牙周病的组合物。与天然存在的IGF-I相比，本发明的IGF-I模拟肽与天然存在的IGF-I具有相同的功能或作用，并且具有更好的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要IGF-1活性的疾病或病症方面表现出优异的功效。此外，本发明的肽可以有利地应用于药物组合物，准药物和化妆品。

4. 发明申请

WO2008044846A1 PEPTIDES HAVING ACTIVITIES OF EPIDERMAL GROWTH FACTOR AND ITS USES 审中-公开
标题翻译：具有活性生长因子活性及其用途的肽
公开(公告)号：WO2008044846A1
公开(公告)日：2008-04-17
申请号：PCT/KR2007/004895
申请日：2007-10-08
申请人： CAREGEN CO., LTD , CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
发明人： CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
IPC分类号： C07K14/485 , A61K38/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural- occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi- drugs and cosmetics.
摘要翻译：本发明涉及包含由下式1表示的氨基酸序列并具有表皮生长因子活性及其用途的肽：Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp（1）本发明的EGF模拟肽对天然存在的人类EGF具有相同的功能或活性，并且能促进细胞中自分泌EGF的产生。此外，本发明的肽比天然发生的EGF具有更高的稳定性和皮肤穿透效力。因此，含有肽的组合物对于要求EGF活性的疾病或病症表现出优异的治疗和预防功效，并且可以有利地应用于药物组合物，准药物和化妆品。

5. 发明申请

WO2007032634A1 A METHOD FOR PRODUCTION OF MATURE NATURAL KILLER CELL 审中-公开
标题翻译：一种生产成熟自然杀伤细胞的方法
公开(公告)号：WO2007032634A1
公开(公告)日：2007-03-22
申请号：PCT/KR2006/003627
申请日：2006-09-12
申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY , GOOD CELL LIFE, INC. , KANG, Hyung Sik , KIM, Sang Hyun , KIM, Eun Mi , LEE, Eun Hee , YUN, Hee Jung , KO, Chang Bo , HEO, Young Jin , SHIM, Woo Young , HEO, Seong Beom , YOON, Ji Yeon
发明人： KANG, Hyung Sik , KIM, Sang Hyun , KIM, Eun Mi , LEE, Eun Hee , YUN, Hee Jung , KO, Chang Bo , HEO, Young Jin , SHIM, Woo Young , HEO, Seong Beom , YOON, Ji Yeon
IPC分类号： C07K2/00
CPC分类号： C12N5/0646 , A61K35/17 , C07K14/745 , C07K16/28 , C07K2317/73 , C07K2317/74
摘要： The present invention relates to a ligand of AxI receptor tyrosine kinase used to induce the differentiation from precursor natural killer cell to mature natural killer-cell. In addition, it relates to a process for producing mature natural killer cell comprising treating hematopoietic stem cell with interleukin-7, stem cell factor and Flt3L to differentiate into precursor natural killer cell, and treating the resulting precursor natural killer cell with ligand of AxI receptor tyrosine kinase to produce mature natural killer cell.
摘要翻译：本发明涉及用于诱导从前体天然杀伤细胞分化为成熟天然杀伤细胞的AxI受体酪氨酸激酶的配体。此外，本发明涉及一种生产成熟天然杀伤细胞的方法，包括用白细胞介素-7，干细胞因子和Flt3L处理造血干细胞以分化为前体天然杀伤细胞，并用AxI受体配体处理所得的前体天然杀伤细胞酪氨酸激酶产生成熟的天然杀伤细胞。

6. 发明申请

WO2007029953A1 MULTI HEATING SYSTEM USING INTERNAL COMBUSTION ENGINE AND HEAT EXCHANGER APPLIED THERETO 审中-公开
标题翻译：内燃机多用加热系统及应用于热交换器
公开(公告)号：WO2007029953A1
公开(公告)日：2007-03-15
申请号：PCT/KR2006/003512
申请日：2006-09-05
申请人： KIM, Eun Mi
发明人： KIM, Eun Mi
IPC分类号： B60H1/18
CPC分类号： B60H1/032 , B60H1/00885 , B60H1/2209 , B60H2001/225 , B60H2001/2265
摘要： The present invention provides a multi heating system using an internal combustion engine and a heat exchanger applied thereto. The heating system of the present invention includes an indoor warm water heater 11 to heat an indoor space using heat of the engine 10, a first check valve 16, which is provided on a cooling water pipe 12 connected between the engine 10 and the indoor warm water heater 11, a plurality of subsidiary water pipes 22, which are branched from the cooling water pipe 12 at positions adjacent to respective front and rear ends of the first check valve 16 to form a bypass circuit, a heat exchanger 100, which is coupled to the subsidiary water pipes 22 and heated by a burner 21, and a water pump 35 and a second check valve 36 which are provided on one subsidiary water pipe 22 in series.
摘要翻译：本发明提供一种使用内燃机和应用于其的热交换器的多重加热系统。本发明的加热系统包括使用发动机10的热量来加热室内空间的室内热水器11，设置在连接在发动机10与室内暖气之间的冷却水管12上的第一止回阀16 热水器11，多个辅助水管22，它们在与第一止回阀16的相应前端和后端相邻的位置处从冷却水管12分支以形成旁路回路;热交换器100，到辅助水管22并由燃烧器21加热，以及设置在一个辅助水管22上的水泵35和第二止回阀36。

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