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1. 发明申请

WO2007068747A1 IMMUNOSTIMULATORY NUCLEIC ACID PACKAGED PARTICLES FOR THE TREATMENT OF HYPERSENSITIVITY 审中-公开
标题翻译：免疫增强核酸包装颗粒治疗高血压
公开(公告)号：WO2007068747A1
公开(公告)日：2007-06-21
申请号：PCT/EP2006/069734
申请日：2006-12-14
申请人： CYTOS BIOTECHNOLOGY AG , Ludwig Maximilians Universität München , RENNER, Wolfgang , BACHMANN, Martin , CIELENS, Indulis , COESTER, Conrad , DIETMEIER, Klaus , FUCHS, Sebastian , MANOLOVA, Vania , MAURER, Patrik , PUMPENS, Paul , RENHOFA, Regina , TISSOT, Alain , ZOU, Yu
发明人： RENNER, Wolfgang , BACHMANN, Martin , CIELENS, Indulis , COESTER, Conrad , DIETMEIER, Klaus , FUCHS, Sebastian , MANOLOVA, Vania , MAURER, Patrik , PUMPENS, Paul , RENHOFA, Regina , TISSOT, Alain , ZOU, Yu
IPC分类号： A61P37/00 , A61K39/39 , A61K47/48
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译：本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。

2. 发明申请

WO2006032674A1 VIRUS-LIKE PARTICLES COMPRISING A FUSION PROTEIN OF THE COAT PROTEIN OF AP205 AND AN ANTIGENIC POLYPEPTIDE 审中-公开
标题翻译：含有AP205和抗原多肽的蛋白质融合蛋白的病毒颗粒
公开(公告)号：WO2006032674A1
公开(公告)日：2006-03-30
申请号：PCT/EP2005/054721
申请日：2005-09-21
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , TISSOT, Alain , JENNINGS, Gary , RENHOFA, Regina , PUMPENS, Paul , CIELENS, Indulis
发明人： BACHMANN, Martin , TISSOT, Alain , JENNINGS, Gary , RENHOFA, Regina , PUMPENS, Paul , CIELENS, Indulis
IPC分类号： C07K19/00 , A61K39/00 , A61P37/00 , A61P43/00
CPC分类号： C12N7/00 , A61K2039/5258 , A61K2039/6075 , C12N2795/18123
摘要： The present invention is in the fields of medicine, immunology, virology and molecular biology. The present invention provides a composition comprising a modified virus-like (VLP) particle derived from RNA bacteriophage AP205. The invention also provides a process for producing the aforementioned VLP. The modified VLP disclosed in the present invention is useful in the production of compositions for inducing immune responses for the prevention or treatment of diseases, disorders including infectious diseases, allergies, cancers and drug addiction. Moreover, the modified VLP disclosed in the present invention is, in particular, useful to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及医学，免疫学，病毒学和分子生物学领域。本发明提供包含衍生自RNA噬菌体AP205的经修饰的病毒样（VLP）颗粒的组合物。本发明还提供了制备上述VLP的方法。本发明公开的经修饰的VLP可用于生产用于预防或治疗疾病，包括感染性疾病，过敏症，癌症和药物成瘾的疾病的免疫应答的组合物。此外，本发明公开的修饰的VLP尤其可有效地诱导自身特异性免疫应答，特别是抗体应答。

3. 发明申请

WO2006063974A3 IL-15 ANTIGEN ARRAYS AND USES THEREOF 审中-公开
公开(公告)号：WO2006063974A3
公开(公告)日：2006-06-22
申请号：PCT/EP2005/056680
申请日：2005-12-12
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , ZOU, Yu , TISSOT, Alain , MAURER, Patrik
发明人： BACHMANN, Martin , ZOU, Yu , TISSOT, Alain , MAURER, Patrik
IPC分类号： A61K39/00 , A61K39/385 , A61P11/06 , A61P19/02 , A61P9/10
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

4. 发明申请

WO2006045849A1 T-CADHERIN ANTIGEN ARRAYS AND USES THEREOF 审中-公开
标题翻译： T-CADHERIN抗原阵列及其用途
公开(公告)号：WO2006045849A1
公开(公告)日：2006-05-04
申请号：PCT/EP2005/055668
申请日：2005-10-31
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SAUDAN, Philippe , TISSOT, Alain , DIETMEIER, Klaus
发明人： BACHMANN, Martin , SAUDAN, Philippe , TISSOT, Alain , DIETMEIER, Klaus
IPC分类号： A61K39/00 , A61K39/385 , C07K14/705 , C07K16/28
CPC分类号： A61K39/385 , A61K47/6901 , A61K2039/6075 , A61K2039/627
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a T- cadherin domain protein, a combination of any T-cadherin domain proteins, a T-cadherin domain fragment or a combination of any T-cadherin domain fragments, linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of T-cadherin related disease, and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是T-钙粘蛋白结构域蛋白，任何T-cadherin结构域蛋白，T-钙粘蛋白结构域片段或与VLP分别连接的任何T-cadherin结构域片段的组合。本发明还提供了一种制备上述组合物的方法。本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗T-钙粘蛋白相关疾病，特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫应答。

5. 发明申请

WO2006134125A1 ANTIGEN CONJUGATES AND USES THEREOF 审中-公开
标题翻译：抗原结合及其用途
公开(公告)号：WO2006134125A1
公开(公告)日：2006-12-21
申请号：PCT/EP2006/063198
申请日：2006-06-14
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , TISSOT, Alain , JEGERLEHNER, Andrea , SAUDAN, Philippe , ZOU, Yu , SCHMITZ, Nicole , HUBER, Adrian , MARTIN, Stephen , HINTON, Heather
发明人： BACHMANN, Martin , TISSOT, Alain , JEGERLEHNER, Andrea , SAUDAN, Philippe , ZOU, Yu , SCHMITZ, Nicole , HUBER, Adrian , MARTIN, Stephen , HINTON, Heather
IPC分类号： A61K39/12 , C12N15/12 , C12N15/48 , C12N15/52
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/622 , A61K2039/627 , A61K2039/64 , C07K2319/70 , C12N2740/16211 , C12N2740/16234 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含连接至本发明的至少一种抗原的病毒样颗粒（VLP）的组合物，其中本发明的所述抗原是本发明的CCR5，本发明的胃泌素，本发明的CXCR4，本发明的CETP或 C5a。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于疫苗的生产，特别是用于治疗其中本发明的抗原介导或有助于该疾病的疾病，特别是用于治疗AIDS，胃肠癌，冠心病或炎性疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

6. 发明申请

WO2008129020A1 VACCINATION REGIMEN FOR B-CELL VACCINES 审中-公开
标题翻译： B细胞疫苗的疫苗接种
公开(公告)号：WO2008129020A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054775
申请日：2008-04-18
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , MAURER, Patrik , MÜLLER, Philipp , PFISTER, Thomas , RENNER, Wolfgang
发明人： BACHMANN, Martin , MAURER, Patrik , MÜLLER, Philipp , PFISTER, Thomas , RENNER, Wolfgang
IPC分类号： A61K39/385 , A61K47/48 , A61P25/30
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/55505
摘要： This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibodyresponses in a vaccinated subject. The invention further provides a method forprevention or treatment of a disease by inducing hapten-specific antibodiesin asubject comprising administering into said subject acomposition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.
摘要翻译：本发明涉及疫苗接种和治疗或预防疾病领域。特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。本发明进一步提供了一种预防或治疗疾病的方法，通过诱导半抗原特异性抗体作为对象，包括向所述受试者的复合物施用，其包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原。

7. 发明申请

WO2006097530A3 CAT ALLERGEN FUSION PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2006097530A3
公开(公告)日：2006-09-21
申请号：PCT/EP2006/060845
申请日：2006-03-17
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , BAUER, Monika , DIETMEIER, Klaus , SCHMITZ, Nicole , UTZINGER, Stephan
发明人： BACHMANN, Martin , BAUER, Monika , DIETMEIER, Klaus , SCHMITZ, Nicole , UTZINGER, Stephan
IPC分类号： A61K39/35 , A61P37/08
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

8. 发明申请

WO2008074895A1 CIRCULAR CCR5 PEPTIDE CONJUGATES AND USES THEREOF 审中-公开
标题翻译：通用CCR5肽结合物及其用途
公开(公告)号：WO2008074895A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064522
申请日：2007-12-21
申请人： CYTOS BIOTECHNOLOGY AG , PEPSCAN SYSTEM BV , HUBER, Adrian , BACHMANN, Martin , JENNINGS, Gary , TISSOT, Alain , LANGEDIJK, Johannes , TIMMERMAN, Peter , SLOOTSTRA, Jelle , BOSHUIZEN, Ronald
发明人： HUBER, Adrian , BACHMANN, Martin , JENNINGS, Gary , TISSOT, Alain , LANGEDIJK, Johannes , TIMMERMAN, Peter , SLOOTSTRA, Jelle , BOSHUIZEN, Ronald
IPC分类号： A61K39/00 , A61K39/21 , A61P31/18
CPC分类号： A61K39/0005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/60 , A61K2039/6075 , A61K2039/62 , A61K2039/64 , C12N2740/16011 , C12N2740/16034 , C12N2795/18123 , C12N2795/18142
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biologyand virology. The invention provides composition comprising a virus-like particle (VLP) linked to atleast one antigen, wherein said antigen is CCR5 PNt domain comprising one looped peptidic structure. The invention also provides a process for producing the composition. The compositions ofthis invention are useful in the production of vaccines, in particular, for the prevention and treatment of HIV infection. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供了包含与至少一种抗原连接的病毒样颗粒（VLP）的组合物，其中所述抗原是包含一个环状肽结构的CCR5 PNt结构域。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于疫苗的生产，特别是用于预防和治疗HIV感染。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。

9. 发明申请

WO2003039225A2 ANTIGEN ARRAYS FOR TREATMENT OF BONE DISEASE 审中-公开
标题翻译：用于治疗骨质疏松症的抗原阵列
公开(公告)号：WO2003039225A2
公开(公告)日：2003-05-15
申请号：PCT/EP2002/012449
申请日：2002-11-07
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
发明人： BACHMANN, Martin , MAURER, Patrik , SPOHN, Gunther
IPC分类号： A61K39/12 , A61K38/11 , A61K38/19 , A61K39/00 , A61K39/02 , A61K39/165 , A61K39/21 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P1/02 , A61P19/00 , A61P19/08 , A61P25/28 , A61P35/00 , C07K14/02 , C07K14/08 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N7/01
CPC分类号： A61K39/35 , A61K38/00 , A61K39/0007 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2710/20022 , C12N2730/10122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

10. 发明申请

WO2011029870A1 USE OF INTERLEUKIN-1 BETA MUTEIN CONJUGATES IN THE TREATMENT OF DIABETES 审中-公开
标题翻译：在治疗糖尿病中使用白细胞介素-1β蛋白偶联物
公开(公告)号：WO2011029870A1
公开(公告)日：2011-03-17
申请号：PCT/EP2010/063237
申请日：2010-09-09
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SPOHN, Gunther , MAURER, Patrik
发明人： BACHMANN, Martin , SPOHN, Gunther , MAURER, Patrik
IPC分类号： A61K47/48 , A61K38/20 , A61K39/385 , C07K14/545 , A61P3/10
CPC分类号： A61K39/385 , A61K39/0005 , A61K47/646 , A61K47/6901 , A61K2039/5258 , C07K14/545
摘要： The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and / or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β.
摘要翻译：本发明提供用于治疗，改善和/或预防II型糖尿病的组合物，药物组合物和疫苗。本发明的组合物，药物组合物和疫苗包含RNA噬菌体和抗原的病毒样颗粒，其中所述抗原包含白细胞介素-1β（IL-1β）突变蛋白。当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选所述抗体应答针对IL-1β。因此，本发明提供了通过对IL-1β的主动免疫来治疗，改善或预防II型糖尿病的方法。

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