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1. 发明申请

WO2015023672A1 OXIMETRY SIGNAL, PULSE-PRESSURE CORRELATOR 审中-公开
标题翻译： OXIMETRY信号，脉冲压力调节器
公开(公告)号：WO2015023672A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/050730
申请日：2014-08-12
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61B5/0205 , A61B5/021
CPC分类号： A61B5/7246 , A61B5/02116 , A61B5/02208 , A61B5/02416 , A61B5/0261 , A61B5/14552 , A61B5/1495 , A61B5/7278 , A61B5/746 , A61B2560/0223 , A61B2560/0238
摘要： A system and method are provided for using an oximeter to take blood pressure readings for an extended period of time. Calibration of the oximeter for this purpose requires use of a sphygmomanometer to determine a sequence of blood pressure readings taken for a patient over a sphygmomanometer duty cycle. During the duty cycle, readings for both blood pressure (sphygmomanometer) and blood flow amplitude (oximeter) are taken simultaneously at predetermined time intervals (e.g. patient pulse rate). These readings then determine an operational ratio between the two that can be used to translate pulse magnitude readings of the oximeter for presentation as blood pressure readings. Operationally, variations from the patient's systolic pressure can then be continuously monitored in real time.
摘要翻译：提供了一种用于使用血氧计在长时间内进行血压读数的系统和方法。用于此目的的血氧计的校准需要使用血压计来确定在血压计工作周期上为患者获取的血压读数的顺序。在占空比期间，以预定的时间间隔（例如患者脉搏率）同时获取血压（血压计）和血流量幅度（血氧计）的读数。然后，这些读数确定两者之间的运行比，可用于将血氧计的脉搏幅度读数转换成血压读数。在实际操作中，可以实时连续监测来自患者收缩压的变化。

2. 发明申请

WO2016171790A1 METHOD FOR STIMULATING HEART MUSCLE ACTIVITY DURING THE REFRACTORY PERIOD 审中-公开
标题翻译：刺激期间激发心肌活动的方法
公开(公告)号：WO2016171790A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/018867
申请日：2016-02-22
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0587 , A61N1/36507
摘要： A system and method for improving heart contractions during a heart function cycle (heartbeat) of a patient requires detecting a local electrical event (depolarization) during the cycle. This local electrical event is then used to trigger a stimulation interval Δt at a time t?0#191. Importantly, the stimulation interval Δt is set to end at a time t?1#191 during the absolute refractory period of the heart function cycle. At the time t?1#191, a stimulator is triggered to stimulate a local sympathetic nerve on the epicardial surface of the heart. With this stimulation the sympathetic nerve secretes norepinephrine to improve a subsequent contraction of the heart.
摘要翻译：在患者的心脏功能周期（心跳）期间改善心脏收缩的系统和方法需要在该周期期间检测局部电气事件（去极化）。然后，该局部电气事件用于触发在时间t 0＃191的刺激间隔Δt。重要的是，在心脏功能周期的绝对不应期内，刺激间隔Δt被设定为在时间t 1＃191处结束。在时间t 1＃191，刺激器被触发以刺激心脏的心外膜表面上的局部交感神经。通过这种刺激，交感神经分泌去甲肾上腺素来改善随后的心脏收缩。

3. 发明申请

WO2012170258A1 SYSTEM AND METHOD FOR TRANSVASCULAR ACTIVATION OF CARDIAC NERVES WITH AUTOMATIC RESTART 审中-公开
标题翻译：具有自动重启功能的心脏神经系统和方法
公开(公告)号：WO2012170258A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/040039
申请日：2012-05-30
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3615 , A61N1/36178 , A61N1/3627
摘要： A system and method for electrically stimulating the heart muscle to improve heart function requires identifying a site in the venous system adjacent a sympathetic nerve. An electrode is then positioned at the site to electrically stimulate the nerve. In turn, this stimulation releases norepinephrine from the nerve to improve heart muscle contraction.
摘要翻译：用于电刺激心脏肌肉以改善心脏功能的系统和方法需要识别邻近交感神经的静脉系统中的部位。然后将电极定位在位置以电刺激神经。反过来，这种刺激从神经中释放去甲肾上腺素以改善心肌收缩。

4. 发明申请

WO2017058513A1 PERFUSION SYSTEM FOR TREATING CARDIAC RHYTHM DISTURBANCES 审中-公开
标题翻译：用于治疗心脏血液循环障碍的灌注系统
公开(公告)号：WO2017058513A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/051543
申请日：2016-09-13
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61M25/00
CPC分类号： A61M25/1011 , A61M25/1002 , A61M25/10181 , A61M2025/1015 , A61M2025/1052 , A61M2025/1097
摘要： A system and method for perfusing a liquid medicament into tissue of a patient requires a catheter having a distal barrier and a proximal barrier mounted on the catheter. A perfusion section is formed into the catheter between these barriers. By way of example of a typical operation, the catheter is advanced through the vasculature of a patient and into the coronary sinus. Advancement continues until the barriers of the catheter are positioned to straddle the ostium of the left atrial vein. As so positioned, a perfusion chamber is established in the coronary sinus between the barriers. Also, the perfusion chamber is positioned for fluid communication with the left atrial vein. Liquid medicament can then be transferred from a source into the perfusion chamber for perfusion of the medicament into tissue of the atrial vein.
摘要翻译：用于将液体药物灌注到患者组织的系统和方法需要具有安装在导管上的远侧屏障和近侧屏障的导管。在这些障碍物之间的导管中形成灌注部分。作为典型操作的示例，导管通过患者的脉管系统进入冠状窦。继续进行直到导管的屏障定位成跨越左心房静脉的口。如此定位，在障碍之间的冠状窦中建立灌注室。此外，灌注室定位成与左心房静脉流体连通。然后可以将液体药物从源转移到灌注室中，以将药物灌注到心房静脉的组织中。

5. 发明申请

WO2015175097A1 CATHETER SYSTEM FOR VENOUS INFUSIONS 审中-公开
标题翻译：导管系统用于静脉输注
公开(公告)号：WO2015175097A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/022656
申请日：2015-03-26
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61M29/00
CPC分类号： A61M25/1002 , A61M5/16813 , A61M25/1011 , A61M25/104 , A61M2025/1013 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2025/1095
摘要： A system for anchoring a distal end of a catheter at a treatment site includes an elongated catheter shaft that is formed with a lumen and a cone shaped balloon membrane. For the system, the proximal and distal ends of the balloon membrane are affixed to an outer surface of the shaft to establish a balloon having an inflation chamber between the membrane and the shaft. A first membrane portion extends from the distal membrane end to a balloon membrane midsection and a second membrane portion extends from the midsection to the proximal membrane end. To establish the proper shape for the inflated balloon, the second membrane portion is configured to establish a cone angle, α, (relative to a proximally directed portion of the longitudinal axis) that is less than or equal to ninety degrees (α ≤ 90 degrees). A second embodiment includes two cone shaped balloons.
摘要翻译：用于将导管的远端锚定在治疗部位的系统包括形成有内腔和锥形球囊膜的细长导管轴。对于该系统，球囊膜的近端和远端固定到轴的外表面，以建立在膜和轴之间具有充气室的气囊。第一膜部分从远端膜端延伸到球囊膜中段，第二膜部分从中部延伸到近端膜端。为了建立充气球囊的适当形状，第二膜部分被配置成建立小于或等于九十度（α≤90度）的锥角α（相对于纵向轴线的近端指向部分））。第二实施例包括两个锥形气球。

6. 发明申请

WO2017180229A1 SYSTEM AND METHOD FOR IMPROVING A HEART MUSCLE RESPONSE 审中-公开
标题翻译：用于改善心脏肌肉反应的系统和方法
公开(公告)号：WO2017180229A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/016954
申请日：2017-02-08
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61M1/10 , A61B5/02 , A61B5/021 , A61B5/0215 , A61M25/10
摘要： A system for improving heart muscle response during a pre-ejection phase in the heart muscle pumping cycle requires a catheter having a pressure transducer and a fluid device mounted at its distal end. Also included is a pump connected to the proximal end of the catheter in fluid communication with the fluid device. A computer will activate the pump in response to a predetermined signal from the pressure transducer to inject and maintain an increased fluid volume in the pumping chamber of the heart for a predetermined time interval Δt during the pre-ejection phase. This supplements the isometric pressure in the heart's pumping chamber in preparation for a subsequent ejection of blood from the pumping chamber.
摘要翻译：用于改善心脏肌肉泵送周期的预弹射阶段期间的心肌响应的系统需要具有压力变换器和安装在其远端的流体装置的导管。还包括连接到与流体装置流体连通的导管近端的泵。响应于来自压力传感器的预定信号，计算机将启动泵以在预喷射阶段期间在心脏的增压室中注射并保持增加的流体体积达预定时间间隔Δt。这补充了心脏泵腔中的等压压力，以便随后从泵腔中排出血液。

7. 发明申请

WO2017023382A1 SYSTEM AND METHOD FOR ELECTRODE PLACEMENT IN THE PERICARDIAL SAC OF A PATIENT 审中-公开
标题翻译：系统和方法用于患者的周围SAC中的电极放置
公开(公告)号：WO2017023382A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/030902
申请日：2016-05-05
申请人： CURTIS, Guy P.
发明人： CURTIS, Guy P.
IPC分类号： A61B18/14 , A61N1/05
CPC分类号： A61N1/059
摘要： A device for stabilizing an electrode adjacent to a sympathetic nerve of a patient includes an elongated placement catheter having an electrode mounted at its distal end. The placement catheter is dimensioned for advancement through the potential space between the myocardium and the pericardial sac around the heart muscle of the patient, to position the electrode adjacent the sympathetic nerve. When activated, an engagement mechanism on the placement catheter inserts an anchor into the myocardium to stabilize and maintain the location of the electrode relative to the sympathetic nerve.
摘要翻译：用于稳定与患者的交感神经邻近的电极的装置包括具有安装在其远端处的电极的细长放置导管。放置导管的尺寸设计为通过心肌和患者心脏心脏周围的心包之间的潜在空间进行定位，以将电极定位在交感神经附近。当被激活时，放置导管上的接合机构将锚固件插入心肌中以稳定并保持电极相对于交感神经的位置。

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