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1. 发明申请

WO2011123779A1 CELL THERAPY TO IMPROVE WOUND HEALING AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译：细胞疗法改善伤口愈合及相关成分及方法
公开(公告)号：WO2011123779A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030939
申请日：2011-04-01
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G. , GARCIA-MORALES, Rolando, O.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G. , GARCIA-MORALES, Rolando, O.
IPC分类号： C12N5/071
CPC分类号： A61K35/48 , A61K35/14 , C12N5/0682
摘要： Therapeutic compositions for improving wound healing and related methods of formulation and use are provided. The therapeutic compositions comprise a dosage of MSCs seeded to any one of a biodegradable matrix, a gel, or a solution suitable for subcutaneous injection. The dosage of MSCs may range from about 1X10 6 MSCs to about 1X10 10 per administration. The administration regime may be daily, weekly, or monthly. The dosage and treatment intervals may be adjusted depending upon a patient's response to treatment. The therapeutic compositions may be co-administered, such as for example, topical application of a seeded matrix or gel combined with simultaneous or other recurring subcutaneous injection of MSCs.
摘要翻译：提供了用于改善伤口愈合的治疗组合物和相关的制剂和用途方法。治疗组合物包含接种到生物可降解基质，凝胶或适于皮下注射的溶液中的任何一种的MSCs的剂量。 MSC的剂量可以在每次施用约1×10 6个MSC至约1×10 10个范围内。管理制度可以是每天，每周或每月。可以根据患者对治疗的反应来调整剂量和治疗间隔。治疗组合物可以共同施用，例如局部施用接种的基质或凝胶，以及同时或其他重复的皮下注射MSC。

2. 发明申请

WO2011109717A1 METHODS AND PROCESSES FOR COLLECTING, PRESERVING, AND CULTURING ADULT STEM CELLS OBTAINED FROM LOCHIA AND RELATED COMPOSITIONS OF MATTER 审中-公开
标题翻译：用于收集，保存和培养从LOCHIA获得的成熟干细胞的方法和方法及相关成分
公开(公告)号：WO2011109717A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027205
申请日：2011-03-04
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G.
IPC分类号： A61K35/14 , A01N63/00
CPC分类号： A01N1/0278 , A61K35/12
摘要： A method is provided for collecting and isolating stem-like cells from lochia. The method includes cryopreserving, thawing, and culturing isolated cells. The isolated lochia cells may be combined with a pharmaceutically-acceptable excipient, a cosmeceutical agent, a therapeutic agent, or a media.
摘要翻译：提供了一种用于收集和分离来自lochia的干细胞的方法。该方法包括冷冻保存，解冻和培养分离的细胞。分离的lochia细胞可以与药学上可接受的赋形剂，药用化妆品，治疗剂或培养基组合。

3. 发明申请

WO2008109063A3 PROCUREMENT, ISOLATION AND CRYOPRESERVATION OF ENDOMETRIAL/MENSTRUAL CELLS 审中-公开
公开(公告)号：WO2008109063A3
公开(公告)日：2008-09-12
申请号：PCT/US2008/002838
申请日：2008-03-03
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G.
IPC分类号： C12N5/00
摘要： Compositions comprising menstrual stem cells (MSCs) and methods, processes, and system therefor are provided by the invention. MSCs are processed from menstrual flow collected during menses. MSCs may be cryopreserved, processed through various culturing and selection steps in preparation for cryopreservation, or processed for therapeutic or cosmeceutical use. Cryopreserved MSCs may be thawed in preparation for therapeutic and cosmeceutical use. MSCs express CD9, CDlO, CD13, CD29, CD44, CD49e, CD49f, CD59, CD81, CD105, CD166, and HLA class I, and have low or no expression of CD3 and HLA class II.

4. 发明申请

WO2013025189A1 METHODS FOR CO-CULTURING CORD BLOOD CELLS OR CORD TISSUE CELLS WITH MENSTRUAL MULTIPOTENT CELLS 审中-公开
标题翻译：用于同时培养具有多种细胞的细胞的骨髓细胞或脊髓组织细胞的方法
公开(公告)号：WO2013025189A1
公开(公告)日：2013-02-21
申请号：PCT/US2011/047631
申请日：2011-08-12
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G.
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N5/0665 , C12N2502/1388
摘要： Methods are provided for obtaining expanded human cord blood cells or cord tissue cells expressing CD34. The methods involve seeding a sufficient amount of human cord blood cells or cord tissue cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord cells, and co-culturing the cord cells with the menstrual cells under culture conditions that support at least two or more population doublings of the cord cells. Methods are also provided for growing expanded human cord cells to give rise to any one of colony forming units, colony forming unit granulocyte macrophages (CFU-GM), burst forming unit erythroids (BFU-E), and colony forming unit granulocyte erythrocyte macrophage megakaryocyte (CFU-GEMM) blood lineage precursor cells. The expanded cells may express CD34, SSEA-4, and HLA-II. Compositions of the expanded cells are also provided.
摘要翻译：提供了用于获得扩增的人脐带血细胞或表达CD34的脐带组织细胞的方法。所述方法包括在适合促进脐带细胞扩增的共培养条件下，用足量的月经细胞接种足量的人脐带血细胞或脐带组织细胞，并在培养物下与月经细胞共培养脐带细胞支持至少两个或更多个绳索细胞群体倍增的条件。还提供了用于生长扩大的人类绳状细胞以产生集落形成单位，集落形成单位粒细胞巨噬细胞（CFU-GM），爆发形成单位红细胞（BFU-E）和集落形成单位粒细胞红细胞巨噬细胞巨核细胞（CFU-GEMM）血谱系前体细胞。扩增的细胞可以表达CD34，SSEA-4和HLA-II。还提供了扩展的细胞的组合物。

5. 发明申请

WO2009035706A1 INFECTIOUS DISEASE TESTING OF MENSTRUAL FLUID, ENDOMETRIAL /MENSTRUAL CELLS, AMNIOTIC FLUID, UMBILICAL CORD BLOOD OR OTHER SAMPLES 审中-公开
标题翻译：淋巴细胞，子宫内膜/淋巴细胞，生物流体，脐带血或其他样本的感染性疾病测试
公开(公告)号：WO2009035706A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/010751
申请日：2008-09-15
申请人： CRYO-CELL INTERNATIONAL, INC. , WALTON, Mercedes, A. , ALLICKSON, Julie, G.
发明人： WALTON, Mercedes, A. , ALLICKSON, Julie, G.
IPC分类号： A61K35/12 , C12Q1/02
CPC分类号： G01N33/56983 , G01N33/56905 , G01N33/56911 , G01N33/571 , G01N33/6854 , G01N2800/26 , Y02A50/54
摘要： Methods are provided for obtaining and testing or analyzing a non-venous and non-arterial puncture human fluid or cell sample or human body fluid or cell sample to detect the presence of at least one infectious disease. The sample may be menstrual fluid, endometrial menstrual cells, umbilical cord blood, or amniotic fluid. Confirmatory testing of a corresponding arterial or venous blood sample for comparison to the test results for the non-venous and non-arterial human fluid or cell sample may be performed. The testing may comprise a screening test or a confirmatory test.
摘要翻译：提供了用于获得和测试或分析非静脉和非动脉穿刺人流体或细胞样品或人体液或细胞样品以检测至少一种感染性疾病的存在的方法。样本可能是月经液，子宫内膜月经细胞，脐带血或羊水。可以对相应的动脉或静脉血样进行验证测试，以便与非静脉和非动脉的人类流体或细胞样品的测试结果进行比较。测试可以包括筛选测试或验证性测试。

6. 发明申请

WO2009058365A1 METHODS FOR CO-CULTURING CORD BLOOD DERIVED CELLS WITH MENSTRUAL STEM CELLS 审中-公开
标题翻译：方法用于共培养具有淋巴细胞的骨髓细胞衍生细胞
公开(公告)号：WO2009058365A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012376
申请日：2008-10-31
申请人： CRYO-CELL INTERNATIONAL, INC. , ALLICKSON, Julie, G. , WALTON, Mercedes, A.
发明人： ALLICKSON, Julie, G. , WALTON, Mercedes, A.
IPC分类号： C12N5/08
CPC分类号： C12N5/0647 , C12N2502/137 , C12N2502/1388 , C12N2502/243
摘要： Methods are provided for obtaining expanded human cord blood cells expressing CD34. The methods involve seeding a sufficient amount of cord blood cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord blood cells, and co-culturing the cord blood cells with the menstrual cells under culture conditions that support at least two or more population doublings of the cord blood cells. Methods are also provided for growing expanded human cord blood cells to give rise to any one of colony forming units, colony forming unit granulocyte macrophages (CFU-GM), burst forming unit erythroids (BFU-E), and colony forming unit granulocyte erythrocyte macrophage megakaryocyte (CFU- GEMM) blood lineage precursor cells. The expanded cells may express CD34, SSEA-4, and HLA-II. Compositions of the expanded cells are also provided.
摘要翻译：提供用于获得表达CD34的扩增的人脐带血细胞的方法。所述方法包括在适于促进脐带血细胞扩张的共培养条件下，用足够数量的月经细胞接种足量的脐带血细胞，并在支持的培养条件下与月经细胞共培养脐带血细胞至少两个或多个脐带血细胞群体倍增。还提供了用于生长扩大的人脐带血细胞以产生集落形成单位，集落形成单位粒细胞巨噬细胞（CFU-GM），爆发形成单位红细胞（BFU-E）和集落形成单位粒细胞红细胞巨噬细胞巨核细胞（CFU-GEMM）血谱系前体细胞。扩增的细胞可以表达CD34，SSEA-4和HLA-II。还提供了扩展的细胞的组合物。

7. 发明申请

WO2007146106A2 PROCUREMENT, ISOLATION AND CRYOPRESERVATION OF MATERNAL PLACENTAL CELLS 审中-公开
标题翻译：采购，分离和重组的细胞体细胞
公开(公告)号：WO2007146106A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013482
申请日：2007-06-05
申请人： CRYO- CELL INTERNATIONAL, INC. , ALLICKSON, Julie, G.
发明人： ALLICKSON, Julie, G.
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , A01N1/02
摘要： Methods, processes and systems for procuring, isolating and cryopreserving at least one viable, multipotent maternal placental stem cell is provided. Viable maternal placental stem cells are also provided. The maternal placental stem cell of the invention expresses the cell surface marker CDl 17 and at least one of the cell surface markers selected from the group consisting of CD29, CD44, CD73, CD90, CD105, CD166, SSEA-3 and SSEA-4 and has low or no expression of at least one of the cell surface markers selected from the group consisting of CD34, CD45, CD133, TRA-1-60 and TRA-1-81. The methods and process comprise generally obtaining a piece of placental tissue from a whole placenta, disaggregating the placental tissue with mechanical separation or enzymatic digestion, collecting and concentrating placental cells comprising maternal placental cells with centrifugation and optionally cryopreserving the placental cells. Additional steps for selecting and culturing the maternal placental stem cells is provided.
摘要翻译：提供了用于采购，分离和冷冻保存至少一种可行的，多能的母体胎盘干细胞的方法，过程和系统。还提供了可行的母体胎盘干细胞。本发明的母体胎盘干细胞表达细胞表面标志物CD17和选自CD29，CD44，CD73，CD90，CD105，CD166，SSEA-3和SSEA-4的细胞表面标志物中的至少一种，以及具有选自CD34，CD45，CD133，TRA-1-60和TRA-1-81中的至少一种细胞表面标志物的低表达或没有表达。方法和方法包括通常从整个胎盘获得一片胎盘组织，用机械分离或酶消化分解胎盘组织，通过离心收集和浓缩包含母体胎盘细胞的胎盘细胞，并任选冷冻保存胎盘细胞。提供了选择和培养母体胎盘干细胞的附加步骤。

8. 发明申请

WO2007146105A2 PROCUREMENT, ISOLATION AND CRYOPRESERVATION OF FETAL PLACENTAL CELLS 审中-公开
标题翻译：采购，隔离和胎儿细胞的CRYOPRESVATION
公开(公告)号：WO2007146105A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013481
申请日：2007-06-05
申请人： CRYO-CELL INTERNATIONAL, INC. , ALLICKSON, Julie, G.
发明人： ALLICKSON, Julie, G.
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , A01N1/02
摘要： Methods, processes and systems for procuring, isolating and cryopreserving fetal placental cells are provided. A population of fetal placental cells is also provided.
摘要翻译：提供了采购，分离和冷冻保存胎儿胎盘细胞的方法，过程和系统。还提供了胎盘胎盘细胞群。

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