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    • 2. 发明申请
    • DETECTION OF METHAMPHETAMINE GROUP DRUGS
    • 甲喹胺组药物检测
    • WO2005121793A2
    • 2005-12-22
    • PCT/GB2005/050087
    • 2005-06-10
    • COZART BIOSCIENCE LIMITEDJEHANLI, Ahmed, Mohammed, Taki
    • JEHANLI, Ahmed, Mohammed, Taki
    • G01N33/543
    • G01N33/558G01N33/946Y10S436/808Y10S436/81Y10S436/815Y10S436/816
    • The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.
    • 本发明提供了对甲基苯丙胺和其他滥用甲基苯丙胺类药物的生物样品中的检测具有高度特异性的免疫测定,例如摇头丸和其它类似摇头丸的药物。 更具体地,提供竞争性测定法,其包括:(a)使所述样品与(i)伪麻黄碱/载体缀合物接触,其中伪麻黄碱通过其羟基与载体连接,和(ii)抗体,其能够结合两者之一或 更多的甲基苯丙胺类药物和所述缀合物; 和(b)确定所述抗体与所述缀合物的结合是否通过所述样品的存在而降低,结合的降低指示样品含有甲基苯丙胺类药物。