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1. 发明申请

WO2005090987A1 PROCEDURE FOR MANUFACTURE OF STRIPS FOR LATERAL FLOW IMMUNOCHROMATOGRAPHIC DEVICES 审中-公开
标题翻译：用于制造横向流动免疫荧光装置的步骤
公开(公告)号：WO2005090987A1
公开(公告)日：2005-09-29
申请号：PCT/GB2005/050037
申请日：2005-03-17
申请人： COZART BIOSCIENCE LIMITED , JEHANLI, Ahmed, Mohammed, Taki , BALDWIN, Dene
发明人： JEHANLI, Ahmed, Mohammed, Taki , BALDWIN, Dene
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： The present invention relates to preparing a test strip or sheet, e.g. of nitrocellulose card, for use in a lateral flow analytical device for detecting one or more analytes in a liquid sample. According to the invention, errors in the provision of such test strips are prevented by use of soluble colourants in the spraying stage of the manufacturing process for provision of immobilized specific binding reagents in detection zones.
摘要翻译：本发明涉及制备测试条或片，例如，的硝化纤维素卡，用于检测液体样品中的一种或多种分析物的侧流分析装置。根据本发明，通过在用于在检测区域中提供固定化的特异性结合试剂的制造方法的喷涂阶段中使用可溶性着色剂来防止提供这种试纸的错误。

2. 发明申请

WO2008155579A1 MONITORING AN IMMUNOASSAY 审中-公开
标题翻译：监测免疫
公开(公告)号：WO2008155579A1
公开(公告)日：2008-12-24
申请号：PCT/GB2008/050466
申请日：2008-06-19
申请人： COZART BIOSCIENCE LIMITED , ABBOTT, Timothy John , BROOKES, David Patrick Edward
发明人： ABBOTT, Timothy John , BROOKES, David Patrick Edward
IPC分类号： G01N33/557 , G01N33/543 , C12M1/40
CPC分类号： G01N11/02 , G01N33/54306 , G01N33/558
摘要： A method of monitoring an immunoassay comprises determining the position of the flow edge of fluid across an immunoassay region. This allows, for example, early detection of possible errors in the test. For example the speed of the movement of the fluid flow edge may be determined from measurements of the position of the fluid flow edge at times throughout the test, and the determined speed may be compared with one or more thresholds to determine whether the test is proceeding correctly. A further method of monitoring an immunoassay comprising monitoring the variation with time of a reference zone of an immunoassay region. This can provide the user with early information as to whether the test is proceeding correctly. The above methods may also be used to provide methods to improve the run conditions of a test during its development. The method may be applied to a competitive assay.
摘要翻译：监测免疫测定的方法包括确定流体在流动免疫测定区域的位置。这允许例如早期检测测试中的可能错误。例如，流体流动边缘的移动速度可以通过在整个测试期间的流体流动边缘的位置的测量来确定，并且所确定的速度可以与一个或多个阈值进行比较，以确定测试是否正在进行正确。一种监测免疫测定的方法，包括监测免疫测定区域的参考区域随时间的变化。这可以向用户提供关于测试是否正确进行的早期信息。上述方法也可用于提供在其开发期间改进测试的运行条件的方法。该方法可以应用于竞争性测定。

3. 发明申请

WO2005121793A2 DETECTION OF METHAMPHETAMINE GROUP DRUGS 审中-公开
标题翻译：甲喹胺组药物检测
公开(公告)号：WO2005121793A2
公开(公告)日：2005-12-22
申请号：PCT/GB2005/050087
申请日：2005-06-10
申请人： COZART BIOSCIENCE LIMITED , JEHANLI, Ahmed, Mohammed, Taki
发明人： JEHANLI, Ahmed, Mohammed, Taki
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , G01N33/946 , Y10S436/808 , Y10S436/81 , Y10S436/815 , Y10S436/816
摘要： The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.
摘要翻译：本发明提供了对甲基苯丙胺和其他滥用甲基苯丙胺类药物的生物样品中的检测具有高度特异性的免疫测定，例如摇头丸和其它类似摇头丸的药物。更具体地，提供竞争性测定法，其包括：（a）使所述样品与（i）伪麻黄碱/载体缀合物接触，其中伪麻黄碱通过其羟基与载体连接，和（ii）抗体，其能够结合两者之一或更多的甲基苯丙胺类药物和所述缀合物; 和（b）确定所述抗体与所述缀合物的结合是否通过所述样品的存在而降低，结合的降低指示样品含有甲基苯丙胺类药物。

4. 发明申请

WO2010106061A1 ORAL FLUID COLLECTION DEVICE 审中-公开
标题翻译：口腔液体收集装置
公开(公告)号：WO2010106061A1
公开(公告)日：2010-09-23
申请号：PCT/EP2010/053378
申请日：2010-03-16
申请人： COZART BIOSCIENCE LIMITED , JOWETT, Gorden , WOODHEAD, Andrew
发明人： JOWETT, Gorden , WOODHEAD, Andrew
IPC分类号： A61B10/00
CPC分类号： A61B10/0051 , Y10T29/49826
摘要： According to a first aspect of the present invention there is provided an oral fluid collection device (1). The oral fluid collection device (1) comprises a handle (2), a swab holder (4), and a swab (3). The swab (3) is in the form of a hollow tube of absorbent material coaxially located about the swab holder (4), such that the swab (3) is supported by the swab holder (4) along the entire length of the swab (3).
摘要翻译：根据本发明的第一方面，提供了一种口腔液体收集装置（1）。口腔液体收集装置（1）包括手柄（2），拭子保持器（4）和拭子（3）。拭子（3）为吸收材料的中空管的形式，其同轴地位于拭子保持器（4）周围，使得拭子（3）沿着拭子的整个长度由拭子保持器（4）支撑（ 3）。

5. 发明申请

WO2009144660A1 DEVICE AND METHODS FOR DETECTING ANALYTES IN SALIVA 审中-公开
标题翻译：用于检测SALIVA中分析物的装置和方法
公开(公告)号：WO2009144660A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052196
申请日：2009-05-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COZART BIOSCIENCE LIMITED , NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
发明人： NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
IPC分类号： G01N33/543
CPC分类号： G01N33/9486 , B01L3/502753 , G01N27/745 , G01N33/54326 , G01N33/54393 , G01N33/946
摘要： The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the preence of on e or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one ormore analytes and/or analyte analogues.
摘要翻译：本发明提供了一种用于检测唾液中的药物或其他化合物的装置。因此，本发明提供了一种用于检测唾液样品中e或更多分析物的优先性的装置，其包括：（a）用于特异性或非特异性地去除唾液部分的至少一部分的一个或多个预处理区域样品干扰一种或多种分析物的检测; 和（b）包含生物传感器表面的检测区域，所述表面包括：能够特异性结合所述一种或多种分析物的分子; 或一种或多种分析物和/或分析物类似物。

6. 发明申请

WO2006064285A1 ANALYTE COLLECTION APPARATUS AND METHOD 审中-公开
标题翻译：分析仪收集装置和方法
公开(公告)号：WO2006064285A1
公开(公告)日：2006-06-22
申请号：PCT/GB2005/050241
申请日：2005-12-13
申请人： COZART BIOSCIENCE LIMITED , JEHANLI, Ahmed , BALDWIN, Dene
发明人： JEHANLI, Ahmed , BALDWIN, Dene
IPC分类号： A61B10/00
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/0064
摘要： An analyte collection apparatus (1) is provided, comprising a gripper (3); and a compressible analyte collecting portion (5) releasably gripped (3) by the gripper (3), wherein the gripper exerts a force to grip and compress the analyte collecting portion (5). The analyte collecting portion (5) can be immersed in a buffer solution whilst in the partially compressed state, and allowed to expand therein, reducing the time required for non-specific binding of analytes to the analyte collecting portion. The analyte collection device (1) facilitates indirect handling of the collected analyte, preventing cross-contamination, and also allows for quick on-site testing.
摘要翻译：提供了一种分析物收集装置（1），包括夹持器（3）; 以及通过所述夹持器（3）可释放地夹持（3）的可压缩分析物收集部分（5），其中所述夹持器施加力以夹持并压缩所述分析物收集部分（5）。分析物收集部分（5）可以在部分压缩状态下浸入缓冲溶液中，并允许其在其中膨胀，减少分析物非特异性结合分析物收集部分所需的时间。分析物收集装置（1）有助于收集的分析物的间接处理，防止交叉污染，并且还允许快速现场测试。

7. 发明申请

WO2006003472A1 DELTA-9-TETRAHYDROCANNABINOL DETECTION METHOD 审中-公开
标题翻译： DELTA-9-TRETRAHYDROCANNABINOL检测方法
公开(公告)号：WO2006003472A1
公开(公告)日：2006-01-12
申请号：PCT/GB2005/050099
申请日：2005-07-01
申请人： COZART BIOSCIENCE LIMITED , JEHANLI, Ahmed, Mohammed, Taki , HAND, Christopher, William
发明人： JEHANLI, Ahmed, Mohammed, Taki , HAND, Christopher, William
IPC分类号： G01N33/53 , G01N33/94
CPC分类号： G01N33/5008 , G01N33/50 , G01N33/5038 , G01N33/526 , G01N33/94 , G01N33/948
摘要： The invention provides competitive immunoassay techniques for high sensitivity detection of delta-9-tetrahydrocannabinol (cannabis; THC) employing a carrier conjugate of an intermediate in the biosynthesis of cannabis, more particularly 5-pentylresorcinol conjugated to a macromolecular carrier via its hydroxyl groups. By employing such a conjugate with anti-THC antibody in a lateral flow immunochromtography test device convenient on-site testing for low levels of cannabis in liquid samples may be achieved. Such testing is particularly favoured for roadside testing for cannabis in oral fluid samples.
摘要翻译：本发明提供了竞争性免疫测定技术，用于在大麻生物合成中使用中间体的载体缀合物，更特别是通过其羟基与大分子载体缀合的5-戊基间苯二酚，高灵敏度检测δ-9-四氢大麻酚（大麻; THC）。通过在侧流免疫色谱测定装置中使用与抗-THC抗体的这种缀合物，可以实现便利的液体样品中低水平大麻的现场测试。这种测试特别适用于口腔液样品中大麻的路边测试。

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