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1. 发明申请

WO2012003003A2 COMPOSITIONS AND METHODS FOR PREPARING NANOFORMULATIONS AND SYSTEMS FOR NANO-DELIVERY USING FOCUSED ACOUSTICS 审中-公开
标题翻译：使用焦点声学处理纳米交付纳米生成和系统的组合物和方法
公开(公告)号：WO2012003003A2
公开(公告)日：2012-01-05
申请号：PCT/US2011001171
申请日：2011-07-01
申请人： COVARIS INC , BECKETT CARL , LAUGHARN JAMES A JR , KAKUMANU SRIKANTH
发明人： BECKETT CARL , LAUGHARN JAMES A JR , KAKUMANU SRIKANTH
IPC分类号： B01F11/02 , B01J2/18 , B01J19/10
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents. A formulation may also include a suspension of micron or submicron sized particles dispersed within a solvent. Or, a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent (e.g., liposome/micelle containing a pharmaceutical, polynucleotide, etc.). In some cases, the polydispersity index of the particle size distribution in a formulation is less than 0.1. Formulations may be suitably prepared using focused acoustic energy that results in a reduction of the average particle size of a mixture. Alternatively, suitable formulations may be prepared using focused acoustics in a manner that does not reduce the average particle size of the mixture.
摘要翻译：聚焦超音波处理用于制备约10nm至约50微米（例如，1微米至20微米）之间或约10nm约400nm（例如，10nm至100nm）之间的制剂颗粒。制剂（例如，纳米制剂）可以包括悬浮液（例如纳米悬浮液），乳剂（例如纳米乳剂）或另一小颗粒系统。制剂可用作治疗剂的递送系统。制剂还可以包括分散在溶剂中的微米或亚微米级颗粒的悬浮液。或者，制剂可以包括生物活性剂和载体化合物，例如包封生物活性剂的表面活性剂（例如含有药物，多核苷酸等的脂质体/胶束）。在一些情况下，制剂中粒度分布的多分散指数小于0.1。可以使用导致混合物的平均粒度的降低的聚焦声能适当地制备制剂。或者，可以以不降低混合物的平均粒度的方式使用聚焦声学制备合适的制剂。

2. 发明申请

WO0170381A2 METHOD AND APPARATUS FOR ACOUSTICALLY CONTROLLING LIQUID SOLUTIONS IN MICROFLUIDIC DEVICES 审中-公开
标题翻译：用于在微流体装置中控制液体溶液的方法和装置
公开(公告)号：WO0170381A2
公开(公告)日：2001-09-27
申请号：PCT/US0109163
申请日：2001-03-21
申请人： COVARIS INC , LAUGHARN JAMES A JR , GARRISON BREVARD S
发明人： LAUGHARN JAMES A JR , GARRISON BREVARD S
IPC分类号： B01F3/08 , B01F11/02 , B01F13/00 , B01F13/02 , B01F15/00 , B01F15/02 , B81B1/00 , C40B60/14 , B01F3/00
CPC分类号： B01F15/0201 , B01F3/08 , B01F11/02 , B01F13/0001 , B01F13/0059 , B01F13/02 , B01F15/00123 , B01F15/00285 , B01F2215/0037 , B01F2215/0073 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0477 , B01J2219/00317 , B01J2219/00486 , B01J2219/00659 , B01L2400/0433 , C40B60/14
摘要： Acoustic energy is used to control motion in a fluid. According to one embodiment, the invention directs acoustic energy at selected naturally occurring nucleation features to control motion in the fluid. In another embodiment, the invention provides focussed or unfocussed acoustic energy to selectively placed nucleation features to control fluid motion. According to one embodiment, the invention includes an acoustic source, a controller for controlling operation of the acoustic source, and one or more nucleation features located proximate to or in the fluid to be controlled.
摘要翻译：声能用于控制流体中的运动。根据一个实施例，本发明将选定的天然存在的成核特征的声能引导以控制流体中的运动。在另一个实施例中，本发明提供聚焦或未聚焦的声能以选择性地放置成核特征以控制流体运动。根据一个实施例，本发明包括声源，用于控制声源的操作的控制器和位于要被控制的流体附近或之中的一个或多个成核特征。

3. 发明申请

WO0025125A9 APPARATUS AND METHODS FOR CONTROLLING SONIC TREATMENT 审中-公开
标题翻译：用于控制SONIC处理的装置和方法
公开(公告)号：WO0025125A9
公开(公告)日：2002-08-29
申请号：PCT/US9925274
申请日：1999-10-28
申请人： COVARIS INC , LAUGHARN JAMES A JR , GARRISON BREVARD S
发明人： LAUGHARN JAMES A JR , GARRISON BREVARD S
IPC分类号： B01F11/02 , B01F13/00 , B01F13/02 , C40B60/14 , G01N29/02
CPC分类号： B01F13/0277 , B01F11/02 , B01F11/0283 , B01F13/0059 , B01F13/0222 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J2219/00317 , B01J2219/00486 , B01J2219/00659 , C12M35/04 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
摘要： Apparatus and methods are disclosed for treating a sample by selectively controlling sonic energy and/or selectively controlling the location of the sample relative to the sonic energy.
摘要翻译：公开了用于通过选择性地控制声能和/或选择性地控制样品相对于声能的位置来处理样品的装置和方法。

4. 发明申请

WO2012040571A3 METHOD AND APPARATUS FOR FRAGMENTING NUCLEIC ACIDS 审中-公开
标题翻译：用于制备核酸的方法和装置
公开(公告)号：WO2012040571A3
公开(公告)日：2012-05-31
申请号：PCT/US2011052959
申请日：2011-09-23
申请人： COVARIS INC , DURIN GUILLAUME , LAUGHARN JAMES A JR
发明人： DURIN GUILLAUME , LAUGHARN JAMES A JR
IPC分类号： C12M1/00 , C12N1/24 , C12N15/10 , C12Q1/68
CPC分类号： B01L3/50215 , B01L3/5021 , B01L3/50255 , B01L2200/0631 , B01L2200/0663 , B01L2200/141 , B01L2300/042 , B01L2300/0681 , B01L2300/0838 , B01L2300/0841 , B01L2300/0854 , B01L2400/0409 , B01L2400/0463 , B01L2400/086 , C12N15/10 , C12Q1/6806 , G01N1/28 , Y10T436/25
摘要： Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again.
摘要翻译：系统和方法包括用于分解核酸以平均约5kbp至约20kbp的核酸大小的加工装置。处理装置可以包括入口部分和从剪切区域上游的通道，其布置成使得在剪切区域的入口处建立和维持相对恒定的压力（例如，变化小于约40％的压力）大部分样品流过剪切区域。在一些实施方案中，在将样品强制通过剪切区域一次之后，处理装置可以从离心机中取出，倒置并放回到离心机中，使得样品再次被迫穿过剪切区域。

5. 发明申请

WO2007016605A3 AN APPARATUS AND A METHOD FOR PROCESSING A SAMPLE USING ACOUSTIC ENERGY 审中-公开
标题翻译：一种使用声学能量处理样品的装置和方法
公开(公告)号：WO2007016605A3
公开(公告)日：2007-05-24
申请号：PCT/US2006030019
申请日：2006-08-01
申请人： COVARIS INC , LAUGHARN JAMES A JR , GARRISON BREVARD S , YATES DOUGLAS A
发明人： LAUGHARN JAMES A JR , GARRISON BREVARD S , YATES DOUGLAS A
IPC分类号： G01N1/44 , B01J19/10 , G01N35/02
CPC分类号： B01F11/0283 , G01N1/44 , G01N29/02 , G01N35/028 , G01N35/109 , G01N2001/4094 , G01N2035/00554 , G01N2291/02408 , G01N2291/02872 , G01N2291/02881
摘要： The apparatus includes an acoustic energy source for emitting acoustic energy substantially converging in a focal zone proximate to the sample, a liquid, semi- solid or solid medium for coupling the converged acoustic energy to the sample, a sensor for sensing a physical parameter of the sample, and a controller for controlling delivery of the acoustic energy to the sample base on a signal sensed by the sensor. In the method, a processing sequence appropriate to the sensed parameters of the sample is executed in order to deliver acoustic energy to the sample, periodically or continuously interrogating the at least one sample to detect the presence or absence of a desired condition of the at last one sample, and adjusting or terminating the processing sequence when the desired condition is detected.
摘要翻译：该装置包括用于发射声能的声能源，所述声能基本上聚集在靠近样本的聚焦区域中，液体，半固体或固体介质，用于将会聚的声能耦合到样品，用于感测所述样品的物理参数的传感器样品和控制器，用于根据由传感器感测到的信号控制向样品基底传递声能。在该方法中，执行适合于所检测到的样本参数的处理顺序，以便将声能递送到样本，周期性地或连续地询问至少一个样本以检测是否存在最终的期望条件一个样本，并且当检测到期望条件时调整或终止处理序列。

6. 发明申请

WO2016061098A8 ACOUSTIC ENERGY MEDIATION OF GENETIC FRAGMENTATION 审中-公开
标题翻译：声学能量介导遗传碎片
公开(公告)号：WO2016061098A8
公开(公告)日：2016-06-23
申请号：PCT/US2015055319
申请日：2015-10-13
申请人： COVARIS INC
发明人： LAUGHARN JAMES A JR , KHOJA HAMID
IPC分类号： B01F11/02 , G01N1/28 , G01N35/00
CPC分类号： C12P19/34 , B01F11/0283 , B01F13/0052 , B01L3/5082 , C12Q1/6806 , G01N1/286 , C12Q2523/301 , C12Q2525/301 , C12Q2535/122
摘要： Method and apparatus for controlling acoustic treatment of a sample to mediate a tagmentation process used on double stranded DNA.
摘要翻译：用于控制样品的声学处理以介导在双链DNA上使用的标签化过程的方法和设备。

7. 发明申请

WO2013078194A2 SAMPLE HOLDER AND METHOD FOR FRAGMENTING SAMPLE MATERIAL 审中-公开
标题翻译：样品容器和碎片化样品材料的方法
公开(公告)号：WO2013078194A2
公开(公告)日：2013-05-30
申请号：PCT/US2012066043
申请日：2012-11-20
申请人： COVARIS INC
发明人： LAUGHARN JAMES A JR , TSINTERIS ION A
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , G01N1/286 , G01N1/42 , G01N2001/2866
摘要： Method and apparatus for holding and/or treating a sample material. A sample may be positioned in a vessel and a crushing force may be applied to the sample material while in the vessel, e.g., by a plunger that is part of a cap to pulverize the sample at cryogenic temperatures. The sample holder may include an acoustic window arranged to admit acoustic energy into the vessel for acoustic treatment of the sample. A flexible film may be used at a portion of the vessel, e.g., at the acoustic window, to cooperate with a plunger for crushing a sample.
摘要翻译：用于保存和/或处理样本材料的方法和设备。样品可以放置在容器中，并且可以在容器中施加压碎力，例如通过作为盖的一部分的柱塞在低温下粉碎样品。样品架可以包括声学窗口，该声学窗口布置成将声能引入容器中以对样品进行声学处理。可在容器的一部分处（例如在声窗处）使用柔性膜以与柱塞配合以压碎样品。

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