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1. 发明申请

WO2006107506A3 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导传感器执行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A3
公开(公告)日：2006-11-16
申请号：PCT/US2006008582
申请日：2006-03-10
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , YUEN PO KI , LAHIRI JOYDEEP
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器实时监测活细胞内激动剂诱导的GPCR信号事件的系统和方法。特别地，本发明包括使用光学LID生物传感器基于由于激动剂诱导的GPCR活化导致的质量再分布来筛选活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自参考光学LID生物传感器以消除对环境温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在又一个扩展的实施方案中，本发明公开了在单一培养基溶液中的多种类型的细胞中单种类型细胞或多种GPCR筛选多种GPCR的不同方式。在又一个延伸的实施方案中，本发明公开了确定化合物对活细胞内特异性GPCR的生理或药理作用的不同方式。

2. 发明申请

WO2006108183A2 LABEL FREE BIOSENSORS AND CELLS 审中-公开
标题翻译：标签免费生物传感器和细胞
公开(公告)号：WO2006108183A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/013539
申请日：2006-04-05
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H , LAHIRI, Joydeep , YUEN, Po Ki
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H , LAHIRI, Joydeep , YUEN, Po Ki
IPC分类号： C12Q1/02
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

3. 发明申请

WO2006107506A2 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导光栅传感器进行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/008582
申请日：2006-03-10
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器来实时监测活细胞内激动剂诱导的GPCR信号传导事件的系统和方法。具体而言，本发明包括使用光学LID生物传感器基于由激动剂诱导的GPCR激活引起的质量重新分布来筛选针对活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自引用光学LID生物传感器以消除对周围温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在另一个扩展的实施方案中，本发明公开了用于在单一介质溶液内的多种类型的细胞中筛选单一类型的细胞中的多种GPCR或多种GPCR的不同方式。在另一个扩展的实施方案中，本发明公开了确认化合物针对活细胞内特定GPCR的生理学或药理学作用的不同方法。

4. 发明申请

WO2006108183A3 LABEL FREE BIOSENSORS AND CELLS 审中-公开
标题翻译：标签免费生物传感器和细胞
公开(公告)号：WO2006108183A3
公开(公告)日：2009-04-16
申请号：PCT/US2006013539
申请日：2006-04-05
申请人： CORNING INC , FANG YE , FERRIE ANN M , FONTAINE NORMAN H , LAHIRI JOYDEEP , YUEN PO KI
发明人： FANG YE , FERRIE ANN M , FONTAINE NORMAN H , LAHIRI JOYDEEP , YUEN PO KI
IPC分类号： A61B5/05 , A61N1/30 , G01N33/552
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

5. 发明申请

WO2011066097A9 VARIABLE PENETRATION DEPTH BIOSENSOR AND METHODS 审中-公开
标题翻译：可变渗透深度生物传感器和方法
公开(公告)号：WO2011066097A9
公开(公告)日：2011-08-04
申请号：PCT/US2010055950
申请日：2010-11-09
申请人： CORNING INC , COUILLARD JAMES G , FONTAINE NORMAN H , LAHIRI JOYDEEP , LI GUANGSHAN , LIU ANPING , PENG JINLIN , WALTON DONNELL T
发明人： COUILLARD JAMES G , FONTAINE NORMAN H , LAHIRI JOYDEEP , LI GUANGSHAN , LIU ANPING , PENG JINLIN , WALTON DONNELL T
IPC分类号： G02B6/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射数倍大几倍。本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

6. 发明申请

WO2011066097A1 VARIABLE PENETRATION DEPTH BIOSENSOR AND METHODS 审中-公开
标题翻译：可变穿透深度生物传感器和方法
公开(公告)号：WO2011066097A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/055950
申请日：2010-11-09
申请人： CORNING INCORPORATED , COUILLARD, James G , FONTAINE, Norman H , LAHIRI, Joydeep , LI, Guangshan , LIU, Anping , PENG, Jinlin , WALTON, Donnell T
发明人： COUILLARD, James G , FONTAINE, Norman H , LAHIRI, Joydeep , LI, Guangshan , LIU, Anping , PENG, Jinlin , WALTON, Donnell T
IPC分类号： G02B6/00
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.
摘要翻译：表面等离子体共振传感器系统包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电探测器，数据采集单元和如本文所定义的。传感器芯片可以包括例如在透明基板的一个面上的硅和金的薄层以及与透明基板的相对面相邻的棱镜。这样的布置提供了可变的穿透深度达约1.5微米，并具有用于感测样本中的折射率变化的动态范围，其比传统的SPR传感器的折射率的数倍大。本公开提供了使用表面等离子体共振传感器系统进行细胞测定或化学测定相关应用的方法。

7. 发明申请

WO2006107967A1 OPTICAL INTERROGATION SYSTEM AND METHOD FOR 2-D SENSOR ARRAYS 审中-公开
标题翻译：用于二维传感器阵列的光学互连系统和方法
公开(公告)号：WO2006107967A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/012504
申请日：2006-04-04
申请人： CORNING INCORPORATED , FONTAINE, Norman, H , MOZDY, Eric, J. , YUEN, Po, Ki
发明人： FONTAINE, Norman, H , MOZDY, Eric, J. , YUEN, Po, Ki
IPC分类号： G01N21/55 , G01N21/77
CPC分类号： G01N21/6452 , G01N21/253 , G01N21/553 , G01N21/6456 , G01N21/7743
摘要： An optical interrogation system and method are described herein that can interrogate a two-dimensional (2D) array of optical sensors (114) e.g., grating coupled waveguide sensors, located in a 2D specimen plate (116) , e.g., microplate. In one embodiment, the optical interrogation system has a launch system (101) which directs an array of light beams (110) towards the array of sensors in the two-dimensional specimen plate. The optical interrogation system also has a receive system (103) that includes a Keplerian beam expander (126) (used in reverse as a beam condenser) which receives an array of light beams (120) output from the array of sensors and directs each received light beam to a unique region on the detection plane (130) of a small area detector (132) e.g., CCD camera. In addition, the optical interrogation system has a processor that analyzes changes in the position or shape of each detected light beam to determine if a binding event (bio-chemical interaction) or a mass transport (cell-based assay) occurred, or to determine the rate of binding (kinetics) that occurred on each sensor.
摘要翻译：本文描述了一种光询问系统和方法，其可以询问光学传感器（114）的二维（2D）阵列，例如位于2D样本板（116），例如微板中的光栅耦合波导传感器。在一个实施例中，光学询问系统具有发射系统（101），其将光束阵列（110）引导到二维样本板中的传感器阵列。光询问系统还具有接收系统（103），该接收系统（103）包括开普勒光束扩展器（126）（反向用作光束聚光器），其接收从传感器阵列输出的光束阵列（120）光束到小区域检测器（132）的检测平面（130）上的唯一区域，例如CCD照相机。此外，光学询问系统具有处理器，其分析每个检测到的光束的位置或形状的变化，以确定是否发生结合事件（生物化学相互作用）或质量传输（基于细胞的测定），或者确定在每个传感器上发生的结合速率（动力学）。

8. 发明申请

WO2006055401A1 SYSTEM AND METHOD FOR SELF-REFERENCING A SENSOR IN A MICRON-SIZED DEEP FLOW CHAMBER 审中-公开
标题翻译：自动深孔深度传感器自动调节系统及方法
公开(公告)号：WO2006055401A1
公开(公告)日：2006-05-26
申请号：PCT/US2005/040845
申请日：2005-11-09
申请人： CORNING INCORPORATED , MOZDY, Eric J , YUEN, Po Ki , FONTAINE, Norman H , MAZUMDER, Prantik , QUESADA, Mark A
发明人： MOZDY, Eric J , YUEN, Po Ki , FONTAINE, Norman H , MAZUMDER, Prantik , QUESADA, Mark A
IPC分类号： G01N21/55 , G01N21/05 , G01N21/27 , G01N21/77
CPC分类号： G01N21/7743 , G01N21/05 , G01N21/276 , G01N21/553 , G01N2021/0346 , G01N2021/058 , G01N2201/108 , G01N2201/1211 , G01N2201/1217 , G01N2201/127 , G01N2201/12723 , G01N2201/128 , Y10T436/117497 , Y10T436/2575
摘要： A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
摘要翻译：本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

9. 发明申请

WO2005006055A1 OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 审中-公开
标题翻译：光学互连系统及其使用方法
公开(公告)号：WO2005006055A1
公开(公告)日：2005-01-20
申请号：PCT/US2004/015726
申请日：2004-05-19
申请人： CORNING INCORPORATED , CARRACCI, Stephen, J. , FONTAINE, Norman, H.
发明人： CARRACCI, Stephen, J. , FONTAINE, Norman, H.
IPC分类号： G02B27/10
CPC分类号： G01N21/253 , G01N2201/04 , G01N2201/10 , G02B27/1086
摘要： An optical interrogation system and method are described herein that are capable of generating light beams that have desired optical properties which are directed towards a specimen array. In one embodiment, the optical interrogation system includes a light source, a diffractive element and a collimating optic (e.g., simple lens(es), f-θ lens(es), segmented mirror, fiber array). The light source emits a light beam to the diffractive optic which receives the light beam and outputs an array of light beams to the collimating optic. The collimating optic receives and conditions the light beams emitted from the diffractive optic and then outputs the conditioned light beams which have desired optical properties towards a specimen array. Several other embodiments of the optical interrogation system are also described herein.
摘要翻译：本文描述的光学询问系统和方法能够产生具有指向样本阵列的所需光学特性的光束。在一个实施例中，光学询问系统包括光源，衍射元件和准直光学元件（例如简单透镜，f-θ透镜，分割镜，光纤阵列）。光源向衍射光学器件发射光束，该衍射光学器件接收光束并将光束阵列输出到准直光学元件。准直光学器件接收并调节从衍射光学器件发出的光束，然后将具有期望的光学特性的经调节的光束输出到样本阵列。光学询问系统的其他几个实施例在这里也被描述。

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