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1. 发明申请

WO2014078646A1 LABEL FREE METHOD FOR ASSESSING CHEMICAL CARDIOTOXICITY 审中-公开
标题翻译：用于评估化学致病毒的无标记方法
公开(公告)号：WO2014078646A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/070281
申请日：2013-11-15
申请人： CORNING INCORPORATED , DEICHMANN, Oberon Denaci , FANG, Ye , FERRIE, Ann MeeJin , HU, Haibei , WU, Qi
发明人： DEICHMANN, Oberon Denaci , FANG, Ye , FERRIE, Ann MeeJin , HU, Haibei , WU, Qi
IPC分类号： G01N33/50 , G06F19/00
CPC分类号： G01N33/5014 , G01N21/255 , G01N21/272 , G01N21/47 , G01N33/5061 , G01N33/54373
摘要： A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.
摘要翻译：一种无标记的谐振波导光栅生物传感器成像系统，用于在不存在和存在药物分子的情况下测量培养的心肌细胞的搏动模式和动态质量再分配（DMR）信号。本公开还提供了一种使用成像仪系统分析心肌细胞的搏动模式和DMR信号以评估药物诱导的心脏毒性的方法。

2. 发明申请

WO2016065218A1 POLYMER-ENCAPSULATED MAGNETIC NANOPARTICLES 审中-公开
标题翻译：聚合物包覆磁性纳米粒子
公开(公告)号：WO2016065218A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057036
申请日：2015-10-23
申请人： CORNING INCORPORATED
发明人： FERRIE, Ann MeeJin , JIN, Yan , WANG, Lingyan , ZHOU, Yue
IPC分类号： H01F1/00 , A61K33/26
CPC分类号： H01F1/12 , C12N15/1013 , H01F1/0054 , H01F1/20 , H01F1/344 , H01F1/36
摘要： Magnetic particles (100) have a particle size (134) of 500 nm or less and include a core (110) and a polymer coating (120) that surrounds and encapsulates the core (110). The core (110) includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Yb, Dy, Gd or Er and Nb. The magnetic core (100) is a polycrystalline particle and is a superspin glass magnetic material, having a coercivity greater than zero and a magnetic remenance greater than zero at room temperature. Above room temperature and at low field, the magnetic moment of these superspin glass magnetic materials increases with temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles (100).
摘要翻译：磁性颗粒（100）具有500nm或更小的粒度（134），并且包括芯（110）和围绕并包封芯（110）的聚合物涂层（120）。芯（110）包括至少一种金属如B，Mg，Al，Mn，Co，Ni，Cu，Fe Sm，Yb，Dy，Gd或Er和Nb的金属，金属合金或金属氧化物。磁芯（100）是多晶颗粒，并且是在室温下具有大于零的矫顽力和大于零的磁性剩磁的超标玻璃磁性材料。超过室温和低场时，这些超级玻璃磁性材料的磁矩随温度升高。使用来自前体金属盐的原位水解/沉淀法形成聚合物包封的磁性颗粒（100）。

3. 发明申请

WO2021067211A1 KIT AND METHOD FOR PREPARATION OF DIGESTIBLE SPHEROID STABILIZING HYDROGELS 审中-公开
公开(公告)号：WO2021067211A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053181
申请日：2020-09-29
申请人： CORNING INCORPORATED
发明人： FERRIE, Ann MeeJin , GORAL, Vasiliy Nikolaevich
IPC分类号： C12M1/32 , C12M1/12 , C12N5/00
摘要： Kits for making a spheroid-stabilizing hydrogel in a calcium-free or calcium-chelated cell culture media include (a) a gelation agent including a polygalacturonic acid (PGA) compound or an alginic acid compound, wherein the PGA compound includes at least one of: (i) pectic acid or salts thereof, or (ii) partially esterified pectic acid having a degree of esterification from about 1 to about 40 mol % or salts thereof; (b) a crosslinking agent, wherein the crosslinking agent includes a salt of a divalent ion; and (c) a proton donor, wherein the proton donor includes lactones, esters, or other compounds that hydrolyze in aqueous solutions to form acids over a period of from 10 minutes to 1 hour. Resultant spheroid-stabilizing hydrogels and methods of preparing the same.

4. 发明申请

WO2016069892A1 DEVICES AND METHODS FOR GENERATION AND CULTURE OF 3D CELL AGGREGATES 审中-公开
标题翻译： 3D细胞聚集体的产生和培养的装置和方法
公开(公告)号：WO2016069892A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/058048
申请日：2015-10-29
申请人： CORNING INCORPORATED
发明人： FANG, Ye , FERRIE, Ann MeeJin , GORAL, Vasiliy Nikolaevich , MARTIN, Gregory Roger , MATIAS, Kaitlyn Mary , SCHAEFER, Michael Kurt , TANNER, Allison Jean
IPC分类号： C12M1/32 , C12M1/00
CPC分类号： C12M23/12 , C12M29/20
摘要： The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.
摘要翻译：本公开涉及用于培养细胞的装置，系统和方法。特别地，提供了用于3d细胞聚集体的产生和培养的装置和方法。

5. 发明申请

WO2016069930A1 MICROWELL DESIGN AND FABRICATION FOR GENERATION OF CELL CULTURE AGGREGATES 审中-公开
标题翻译：用于生成细胞培养物的MICROWELL设计和制造
公开(公告)号：WO2016069930A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/058123
申请日：2015-10-29
申请人： CORNING INCORPORATED
发明人： FANG, Ye , FERRIE, Ann MeeJin , GORAL, Vasiliy Nikolaevich , TANNER, Allison J , WU, Qi
IPC分类号： C12M1/32 , C12M1/34
CPC分类号： C12M23/12 , C12M41/36
摘要： A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
摘要翻译：细胞培养装置可以包括限定孔的衬底。井可以限定内表面，外表面，上孔和最低点。衬底可以限定内表面和外表面之间的厚度，其具有接近最低点的厚度，该厚度大于或等于靠近上孔的厚度。

6. 发明申请

WO2016044528A1 METHOD FOR FORMING A SCRATCH RESISTANT CRYSTALLIZED LAYER ON A SUBSTRATE AND ARTICLE FORMED THEREFROM 审中-公开
标题翻译：在基板上形成耐蚀刻结晶层的方法及其形成的制品
公开(公告)号：WO2016044528A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050587
申请日：2015-09-17
申请人： CORNING INCORPORATED
发明人： COOK, Glen Bennett , FERRIE, Ann MeeJin , O'MALLEY, Shawn Michael , SCHNEIDER, Vitor Marino
IPC分类号： C03C17/23 , C23C18/12 , C23C30/00
CPC分类号： C30B13/00 , C03C17/25 , C03C2217/214 , C03C2218/113 , C03C2218/116 , C03C2218/32 , C23C18/1216 , C23C18/1241 , C23C18/1245 , C23C18/1254 , C23C18/1295 , C30B29/20
摘要： A crystallized layer can be formed on a substrate from a precursor layer deposited on a surface of the substrate. The precursor layer can be an oxide, a nitride, a carbide, or an oxynitride. The process for forming the crystallized layer includes melting the precursor layer formed on the surface of the substrate by localized topical heating of the precursor layer and then cooling the melted precursor layer so that it crystallized to form a scratch resistant crystallized layer. The scratch resistant crystallized layer can have a hardness of 15 GPa or greater.
摘要翻译：结晶层可以从沉积在基板的表面上的前体层形成在基板上。前体层可以是氧化物，氮化物，碳化物或氧氮化物。形成结晶层的方法包括通过局部局部加热前体层熔化形成在基材表面上的前体层，然后冷却熔融的前体层，使其结晶形成耐划伤的结晶层。耐刮擦结晶层的硬度可以为15GPa以上。

7. 发明申请

WO2021091683A1 FIXED BED BIOREACTOR AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2021091683A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/056240
申请日：2020-10-19
申请人： CORNING INCORPORATED
发明人： FERRIE, Ann MeeJin , GORAL, Vasiliy Nikolaevich
IPC分类号： C12M1/12
摘要： A fixed-bed bioreactor system is provided that includes a vessel with a media inlet, a media outlet, and an interior cavity disposed between and in fluid communication with the media inlet and media outlet. The vessel further includes a cell culture substrate disposed in the interior cavity between the media inlet and the media outlet in a packed-bed configuration, the cell culture substrate including a plurality of porous disks in a stacked arrangement. The interior cavity includes a cell culture section and a spacer section, the cell culture substrate defining the cell culture section and the spacer section being disposed between the cell culture section and the media outlet, and each of the plurality of porous disks has a surface configured to culture cells thereon.

8. 发明申请

WO2020163329A1 WOVEN CELL CULTURE SUBSTRATES 审中-公开
公开(公告)号：WO2020163329A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/016576
申请日：2020-02-04
申请人： CORNING INCORPORATED
发明人： FERRIE, Ann MeeJin , GORAL, Vasiliy Nikolaevich , ROMEO, Lori E.
IPC分类号： C12M1/12 , C12N5/00
摘要： A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.

9. 发明申请

WO2015148742A1 COMPOSITION AND METHOD FOR CELL CULTURE SUSTAINED RELEASE 审中-公开
标题翻译：用于细胞培养的组合物和方法保持释放
公开(公告)号：WO2015148742A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022614
申请日：2015-03-26
申请人： CORNING INCORPORATED
发明人： FARIS, Ronald Allen , FERRIE, Ann MeeJin , GORAL, Vasiliy Nikolaevich , LIU, Jin , MARTIN, Gregory Roger
IPC分类号： A61K9/28 , C12N5/00
CPC分类号： A61K9/2866
摘要： An ex vivo cell culture sustained release composition, including: a mixture comprising: a sustenant; and a non-biodegradable binder; and a non-biodegradable and water insoluble encapsulant coat that encapsulates the mixture, as defined herein. Also disclosed is a method for sustainably providing a sustenant to a cell culture in aqueous media, including contacting a cell culture with the sustained release composition.
摘要翻译：一种离体细胞培养持续释放组合物，包括：包含：维生素的混合物; 和不可生物降解的粘合剂; 以及包封如本文所定义的混合物的不可生物降解的水不溶性包封剂涂层。还公开了一种用于将水分介质中的细胞培养物可持续地提供给细胞培养物的方法，包括使细胞培养物与持续释放组合物接触。

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