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    • 4. 发明申请
    • LARGE EFFECTIVE AREA FIBER
    • 大型有效区域纤维
    • WO2008136918A2
    • 2008-11-13
    • PCT/US2008005157
    • 2008-04-22
    • CORNING INCBICKHAM SCOTT RBOOKBINDER DANA CCHEN XINLI MING-JUNMISHRA SNIGDHARAJ KNOLAN DANIEL A
    • BICKHAM SCOTT RBOOKBINDER DANA CCHEN XINLI MING-JUNMISHRA SNIGDHARAJ KNOLAN DANIEL A
    • G02B6/036G02B6/032
    • G02B6/0365G02B6/02019
    • An optical fiber according to an embodiment of the present invention comprises: a glass core extending from a centerline to a radius R 1 wherein R 1 is greater than about 5 µm; a glass cladding surrounding and in contact with the core, the cladding comprising: (i) a first annular region extending from the radius R 1 to a radius R 2 the first annular region comprising a radial width, W 2 = R 2 - R 1 , (ii) a second annular region extending from the radius R 2 to a radius R 3 , and comprising a radial width, W 3 = R 3 - R 2 , and (iii) a third annular region surrounding the second annular region and extending from the radius R 3 to an outermost glass radius R 4 ; wherein the core comprises a maximum relative refractive index, ? 1max , relative to the third annular region, and wherein ? 1MAX is greater than about 0.1 % and less than about 0.3 %; the first annular region has a refractive index delta ? 2 (r) is less than about 0.025%; wherein the second annular region comprises a minimum relative refractive index, ? 3MIN , relative to the third annular region; wherein ? 1MAX > ? 2MAX > ? 3MIN , and ? 2MIN > ? 3MIN 2 and bend loss of ==0.5 dB/turn on a 20 mm diameter mandrel.
    • 根据本发明实施例的光纤包括:从中心线延伸到半径R 1 1的玻璃芯,其中R 1大于约5μm; 围绕并与芯接触的玻璃包层,所述包层包括:(i)从半径R 1> 1延伸到半径R 2的第一环形区域,所述第一环形 包括径向宽度的区域,(2)从半径R 2 到半径R 3 3,并且包括径向宽度,W 3 3 = R 3→R 2 和(iii)围绕第二环形区域并从半径R 3 3延伸到最外玻璃半径R 4的第三环形区域; 其中所述芯包括相对于所述第三环形区域的最大相对折射率α1 max,并且其中Δ1MAX1大于约0.1%且小于约0.3% ; 第一环形区域的折射率Δθ2(r)小于约0.025%; 其中所述第二环形区域相对于所述第三环形区域包括最小相对折射率β3ININ; 其中α1 M 1 M 2 M 2 M 3 M 3 M 1 M 2 N M N N N > <0; 并且其中所述芯和所述包层提供具有小于1500nm的电缆截止的光纤,并且在1550nm处的有效面积大于95μm2,并且对于20°的弯曲损耗为0.5dB / mm直径心轴。
    • 7. 发明申请
    • MODIFIED SUBSTRATES FOR PROTECTION OF PEPTIDE-IMMOBILIZED SURFACES FROM GAMMA RADIATION DEGRADATION
    • 用于保护γ-辐射降解的肽 - 固定化表面的修饰的基质
    • WO2011106222A3
    • 2011-11-24
    • PCT/US2011025138
    • 2011-02-17
    • CORNING INCBOOKBINDER DANA CMARTIN ARTHUR WPAL SANTONASHOGBON CHRISTOPHER BWEBER JENNIFERZHOU YUE
    • BOOKBINDER DANA CMARTIN ARTHUR WPAL SANTONASHOGBON CHRISTOPHER BWEBER JENNIFERZHOU YUE
    • C12N5/00
    • C12N5/0068C12N2533/20C12N2533/50
    • In the present specification and claims, three modified cell culture substrates are disclosed for protecting peptide mimetic surfaces used in cell culture technology. The methods are able to retain the functionality of the bioactive species conjugated to the surface. In particular, a vitronectin peptide fragment Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH2 was able to facilitate growth and proliferation of undifferentiated human embryonic stem cells after stabilization using 3 different modified cell culture substrates for of protection against gamma irradiation. The modified substrates disclosed in this invention are (i) covalent attachment of the antioxidant molecules (via blocking step); (ii) The use of coatings consisting of antioxidants and stabilizers comprising glycoprotiens, sugars, carbohydrates, poly(amino acids), peptides and hydrophilic polymers; and (iii) a third method wherein the same methionine contained in the bioactive sequence used to facilitate growth and proliferation of human embryonic stem cells was also used as a sacrificial coating to protect the same conjugated sequence against damage by gamma irradiation.
    • 在本说明书和权利要求书中,公开了三种修饰的细胞培养基质,用于保护细胞培养技术中使用的肽模拟物表面。 该方法能够保持与表面结合的生物活性物质的功能。 具体而言,玻连蛋白肽片段Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH 2能够促进未分化人的生长和增殖 胚胎干细胞稳定后使用3种不同的修饰细胞培养基质来防止γ辐射。 本发明公开的改性底物是(i)抗氧化剂分子的共价连接(通过封闭步骤); (ii)使用由抗氧化剂和稳定剂组成的包衣,所述稳定剂包含糖蛋白,糖,碳水化合物,聚(氨基酸),肽和亲水性聚合物; 和(iii)第三种方法,其中用于促进人类胚胎干细胞生长和增殖的生物活性序列中所含的相同甲硫氨酸也用作牺牲性涂层以保护相同的缀合序列免受伽玛辐射的损害。