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1. 发明申请

WO2007149514A2 METHODS, DEVICES, AND KITS FOR MICROJET DRUG DELIVERY 审中-公开
标题翻译：用于MICROJET DRUG DELIVERY的方法，装置和工具
公开(公告)号：WO2007149514A2
公开(公告)日：2007-12-27
申请号：PCT/US2007014429
申请日：2007-06-19
申请人： CORIUM INT INC , SRINIVASAN RAVI , URSO RICHARD C , PISTOR CHRISTOPH , YOGI TAKASHI , KANTAK AMEYA
发明人： SRINIVASAN RAVI , URSO RICHARD C , PISTOR CHRISTOPH , YOGI TAKASHI , KANTAK AMEYA
IPC分类号： A61M35/00
CPC分类号： A61M5/30 , A61M5/2053 , A61M2005/3022
摘要： Described here are methods, devices, and kits for microjet drug delivery. The devices described here may be modular or non-modular. The modular devices typically include a first module having a drug reservoir and a nozzle in fluid communication with the drug reservoir and a second module having an actuator and a power supply. The power supply provides power to the actuator and when the first and second modules are coupled, the actuator is capable of acting on a dispensing member causing it to dispense a drug in liquid form from the drug reservoir via the nozzle at a velocity sufficient to penetrate skin. Other devices described include a nozzle, a reservoir in fluid communication with the nozzle, a dispensing member, and an actuator. In these devices, the nozzle has at least one feature that enhances nozzle contact with the skin in order to reduce lateral drug leakage about the nozzle.
摘要翻译：这里描述的是用于微喷射药物递送的方法，装置和试剂盒。这里描述的设备可以是模块化的或非模块化的。模块化装置通常包括具有药物储存器和与药物储存器流体连通的喷嘴的第一模块和具有致动器和电源的第二模块。电源为致动器提供动力，并且当第一和第二模块联接时，致动器能够作用在分配构件上，使得其以足以渗透的速度经由喷嘴从药物储存器中分配液体形式的药物皮肤。所描述的其它装置包括喷嘴，与喷嘴流体连通的储存器，分配构件和致动器。在这些装置中，喷嘴具有增强与皮肤的喷嘴接触的至少一个特征，以减少喷嘴周围的药物泄漏。

2. 发明申请

WO2007149514A9 METHODS, DEVICES, AND KITS FOR MICROJET DRUG DELIVERY 审中-公开
标题翻译：用于MICROJET DRUG DELIVERY的方法，装置和工具
公开(公告)号：WO2007149514A9
公开(公告)日：2008-02-07
申请号：PCT/US2007014429
申请日：2007-06-19
申请人： CORIUM INT INC , SRINIVASAN RAVI , URSO RICHARD C , PISTOR CHRISTOPH , YOGI TAKASHI , KANTAK AMEYA
发明人： SRINIVASAN RAVI , URSO RICHARD C , PISTOR CHRISTOPH , YOGI TAKASHI , KANTAK AMEYA
IPC分类号： A61M35/00
CPC分类号： A61M5/30 , A61M5/2053 , A61M2005/3022
摘要： Described here are methods, devices, and kits for microjet drug delivery. The devices described here may be modular or non-modular. The modular devices typically include a first module having a drug reservoir and a nozzle in fluid communication with the drug reservoir and a second module having an actuator and a power supply. The power supply provides power to the actuator and when the first and second modules are coupled, the actuator is capable of acting on a dispensing member causing it to dispense a drug in liquid form from the drug reservoir via the nozzle at a velocity sufficient to penetrate skin. Other devices described include a nozzle, a reservoir in fluid communication with the nozzle, a dispensing member, and an actuator. In these devices, the nozzle has at least one feature that enhances nozzle contact with the skin in order to reduce lateral drug leakage about the nozzle.
摘要翻译：这里描述的是用于微喷射药物递送的方法，装置和试剂盒。这里描述的设备可以是模块化的或非模块化的。模块化装置通常包括具有药物储存器和与药物储存器流体连通的喷嘴的第一模块和具有致动器和电源的第二模块。电源为致动器提供电力，并且当第一和第二模块被联接时，致动器能够作用在分配构件上，使得其以足以穿透的速度从药物储存器经由喷嘴分配液体形式的药物皮肤。所描述的其它装置包括喷嘴，与喷嘴流体连通的储存器，分配构件和致动器。在这些装置中，喷嘴具有增强与皮肤的喷嘴接触的至少一个特征，以减少喷嘴周围的药物泄漏。

3. 发明申请

WO2006110489A3 RAPID PROTOTYPING OF MICROSTRUCTURES USING A CUTTING PLOTTER 审中-公开
标题翻译：使用切割机快速实现微结构
公开(公告)号：WO2006110489A3
公开(公告)日：2007-01-04
申请号：PCT/US2006012899
申请日：2006-04-07
申请人： UNIV UTAH RES FOUND , BARTHOLOMEUSZ DANIEL A , KANTAK AMEYA , LEE SUNG , SRINIVAS MERUGU , SANT HIMANSHU , BOUTTE RONALD W , GALE BRUCE , THOMAS CHARLES
发明人： BARTHOLOMEUSZ DANIEL A , KANTAK AMEYA , LEE SUNG , SRINIVAS MERUGU , SANT HIMANSHU , BOUTTE RONALD W , GALE BRUCE , THOMAS CHARLES
IPC分类号： B32B37/00
CPC分类号： B32B38/10 , B26D7/10 , B26D7/2628 , B26F1/24 , B26F1/3806 , B26F2001/3893 , B29C64/141 , B81B2201/058 , B81C99/009 , B81C2201/019 , Y10T83/293 , Y10T83/303
摘要： A method for making a microstructure includes: providing a film (100) on a release liner (110); feeding the film through a cutting plotter (10); cutting the film with a knife blade (34) of the cutting plotter to form a microstructure pattern; peeling the microstructure pattern from the release liner; and transferring the microstructure pattern to a substrate (170). The cutting plotter for making microstructures includes a knife head with a knife blade disposed adjacent a feed mechanism (20), a motor (42) and control system coupled to the knife head for selectively moving the knife head in relation to the film, and the control system and the knife head having an addressable positioning resolution less than approximately 10 µm.
摘要翻译：制造微结构的方法包括：在剥离衬垫（110）上提供膜（100）; 通过切割机（10）将胶片进给; 用切割机的刀片（34）切割薄膜以形成微结构图案; 从分离衬片剥离微结构图案; 并将微结构图案转移到基板（170）。用于制造微结构的切割机包括具有邻近进给机构（20）设置的刀片的刀头，马达（42）和耦合到刀头的控制系统，用于相对于薄膜选择性地移动刀头，控制系统和刀头具有小于约10μm的可寻址定位分辨率。

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