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1. 发明申请

WO2008070797A2 SYSTEM AND METHOD FOR TRANSAPICAL DELIVERY OF AN ANNULUS ANCHORED SELF-EXPANDING VALVE 审中-公开
标题翻译：系统和方法递送递送的环形锚定自扩张阀
公开(公告)号：WO2008070797A2
公开(公告)日：2008-06-12
申请号：PCT/US2007086685
申请日：2007-12-06
申请人： COREVALVE INC , NGUYEN THAN , SEGUIN JACQUES , KOMATSU STAN , NGUYEN HUNG , BOERTLEIN GEORG
发明人： NGUYEN THAN , SEGUIN JACQUES , KOMATSU STAN , NGUYEN HUNG , BOERTLEIN GEORG
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/915 , A61F2/93 , A61F2/95 , A61F2002/91591 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0003 , A61F2250/0069
摘要： A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve (820) supported on an expandable prosthesis frame. The valve (820) may be delivered transluminally or transmyocardially using a thorascopic or other limited access approach using a delivery catheter (920). Preferably, the initial partial expansion of the valve (820) is performed against the native valve annulus (916) to provide adequate anchoring and positioning of the valve (820) as the remaining portions of the valve (820) expand. The valve (820) may be be delivered using a retrograde or antegrade approach. When delivered using a retrograde approach, a delivery catheter (920) with a pull-back sheath (922) may be used, while antegrade delivery is preferably performed with a delivery catheter (920) with a push- forward sheath (922) that releases the proximal end of the valve (820) first.
摘要翻译：用于置换缺陷天然瓣膜的假体瓣膜组件包括支撑在可膨胀假体框架上的置换瓣膜（820）。使用递送导管（920），使用胸腔镜或其他有限的进入方法，可以经腔或穿心肌输送瓣膜（820）。优选地，抵抗天然瓣膜环（916）执行瓣膜（820）的初始部分扩张，以在瓣膜（820）的其余部分扩张时提供瓣膜（820）的适当锚定和定位。阀（820）可以使用逆行或顺行方式递送。当使用逆行方法递送时，可以使用具有回拉护套（922）的递送导管（920），而顺行递送优选地用递送导管（920）执行，递送导管（920）具有向前推进护套（922）首先是阀（820）的近端。

2. 发明申请

WO2008070797A9 SYSTEM AND METHOD FOR TRANSAPICAL DELIVERY OF AN ANNULUS ANCHORED SELF-EXPANDING VALVE 审中-公开
公开(公告)号：WO2008070797A9
公开(公告)日：2008-10-02
申请号：PCT/US2007086685
申请日：2007-12-06
申请人： COREVALVE INC , NGUYEN THAN , SEGUIN JACQUES , KOMATSU STAN , NGUYEN HUNG , BOERTLEIN GEORG
发明人： NGUYEN THAN , SEGUIN JACQUES , KOMATSU STAN , NGUYEN HUNG , BOERTLEIN GEORG
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/915 , A61F2/93 , A61F2/95 , A61F2002/91591 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0003 , A61F2250/0069
摘要： A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve (820) supported on an expandable prosthesis frame. The valve (820) may be delivered transluminally or transmyocardially using a thorascopic or other limited access approach using a delivery catheter (920). Preferably, the initial partial expansion of the valve (820) is performed against the native valve annulus (916) to provide adequate anchoring and positioning of the valve (820) as the remaining portions of the valve (820) expand. The valve (820) may be be delivered using a retrograde or antegrade approach. When delivered using a retrograde approach, a delivery catheter (920) with a pull-back sheath (922) may be used, while antegrade delivery is preferably performed with a delivery catheter (920) with a push- forward sheath (922) that releases the proximal end of the valve (820) first.

3. 发明申请

WO2006124649A2 HEART VALVE PROTHESIS AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：心脏阀门的制造及其制造和使用方法
公开(公告)号：WO2006124649A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018514
申请日：2006-05-12
申请人： COREVALVE INC , NGUYEN THAN , NGUYEN HUNG , NGUYEN MYKIM , KOMATSU STANLEY , MICHIELS ROBRECHT
发明人： NGUYEN THAN , NGUYEN HUNG , NGUYEN MYKIM , KOMATSU STANLEY , MICHIELS ROBRECHT
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2415 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2230/008 , A61F2250/0039 , Y10S623/90
摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.
摘要翻译：提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。或者，阀体可以用作可手术植入的置换瓣膜假体。

4. 发明申请

WO2011163275A3 REPLACEMENT HEART VALVE 审中-公开
标题翻译：更换心瓣膜
公开(公告)号：WO2011163275A3
公开(公告)日：2012-04-19
申请号：PCT/US2011041306
申请日：2011-06-21
申请人： CARDIAQ VALVE TECHNOLOGIES INC , QUADRI ARSHAD , RATZ BRENT J , LIAO YEN , KOMATSU STAN , THYGARAJAN KALATHI , MICHIELS ROBRECHT , NGUYEN HUNG , NGUYEN MYKIM
发明人： QUADRI ARSHAD , RATZ BRENT J , LIAO YEN , KOMATSU STAN , THYGARAJAN KALATHI , MICHIELS ROBRECHT , NGUYEN HUNG , NGUYEN MYKIM
IPC分类号： A61F2/24 , A61M29/02
CPC分类号： A61F2/2418 , A61F2/2415 , A61F2220/0008 , A61F2230/0054 , A61F2230/0067 , A61F2230/008 , A61F2250/0029 , A61F2250/0039
摘要： A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.
摘要翻译：替换心脏瓣膜可以具有被构造为接合天然瓣膜环的可扩张框架。阀体可以安装在可膨胀框架上，以提供类似于自然阀的功能。阀体具有上游端和下游端，下游端的直径大于上游端的直径。

5. 发明申请

WO2004098405A8 PATIENT MONITER 审中-公开
标题翻译：患者监护仪
公开(公告)号：WO2004098405A8
公开(公告)日：2004-12-23
申请号：PCT/AU2004000599
申请日：2004-05-07
申请人： AIMEDICS PTY LTD , GHEVONDIAN NEJHDEH , NGUYEN HUNG , WILLSHIRE RICHARD JOHN
发明人： GHEVONDIAN NEJHDEH , NGUYEN HUNG , WILLSHIRE RICHARD JOHN
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0402 , A61B5/053
CPC分类号： A61B5/6831 , A61B5/0002 , A61B5/0205 , A61B5/0402 , A61B5/0531 , A61B5/4806 , G06F19/34
摘要： A monitoring device for monitoring the physiological condition of a patient (1) on a continuous basis, which includes a transmitter unit (2) adapted to attach to a patient so as to be in contact with the skin of a patient, a corresponding receiver unit (5). The transmitter unit includes a strap or belt (3) adapted to attach to or around a body part of a patient. A plurality of sensors (E) are mounted to the belt for monitoring a plurality of patient physiological parameters, including at least the patient's skin impedance, heart rate and aspects of the heart beat. The sensors are connected to a microcontroller (8) which processes the signals and which is linked to a wireless transmitter (9). A portable receiver unit is adapted to receive and process the signal from the transmitter. The receiver unit includes a display (14) for data relating to the patient and preferably an alarm (15).
摘要翻译：一种用于连续地监视患者（1）的生理状况的监测装置，该监测装置包括适于附着到患者以便与患者的皮肤接触的发射器单元（2），相应的接收器单元（5）。发射器单元包括适于附接到患者的身体部位或其周围的带或带（3）。多个传感器（E）安装到皮带上用于监测多个患者生理参数，包括至少患者的皮肤阻抗，心率和心跳的各个方面。传感器连接到处理信号并连接到无线发射器（9）的微控制器（8）。便携式接收机单元适用于接收和处理来自发射机的信号。接收器单元包括用于与患者相关的数据的显示器（14），并且优选地包括警报器（15）。

6. 发明申请

WO2007019103A3 METHOD AND APPARATUS FOR SORTING PARTICLES WITH A MEMS DEVICE 审中-公开
标题翻译：用于与MEMS器件分离颗粒的方法和装置
公开(公告)号：WO2007019103A3
公开(公告)日：2007-07-05
申请号：PCT/US2006029661
申请日：2006-07-31
申请人： INNOVATIVE MICRO TECHNOLOGY , FOSTER JOHN S , HARLEY JOHN C , HOVEY STEVEN H , MARTIN RICHARD T , NGUYEN HUNG , RUBEL PAUL J
发明人： FOSTER JOHN S , HARLEY JOHN C , HOVEY STEVEN H , MARTIN RICHARD T , NGUYEN HUNG , RUBEL PAUL J
IPC分类号： G01N1/10 , A61M1/36 , B01L3/00 , C12M1/34 , C12Q1/00 , G01N15/02 , G01N21/05 , G01N21/64 , H01L21/00
CPC分类号： C12M47/04 , A61M1/36 , A61M1/3633 , A61M1/3678 , A61M2202/0437 , B01L3/5027 , G01N21/6428 , G01N2015/0288 , G01N2015/149 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A micromechanical particle sorting chip (300) uses laser light (305) directed through at least one of a reflective (360) and refractive (310) surface to come to a focus (320) in an optically transparent layer. The laser light (305) impinges on a particle of interest, causing it to fluoresce. Upon detecting the fluorescence, a micromechanical actuator (400) is activated, which directs the particle of interest into one of a plurality of possible exit paths.
摘要翻译：微机械粒子分选芯片（300）使用穿过反射（360）和折射（310）表面中的至少一个的激光（305）到达光学透明层中的聚焦（320）。激光（305）撞击感兴趣的颗粒，使其发荧光。在检测到荧光时，微机械致动器（400）被激活，其将感兴趣的颗粒引导到多个可能的出口路径中的一个。

7. 发明申请

WO2007053281A3 MEMS ACTUATOR AND METHOD OF MANUFACTURE FOR MEMS PARTICLE SORTING DEVICE 审中-公开
标题翻译： MEMS致动器及其制造方法用于MEMS颗粒分选器件
公开(公告)号：WO2007053281A3
公开(公告)日：2007-06-28
申请号：PCT/US2006040015
申请日：2006-10-12
申请人： INNOVATIVE MICRO TECHNOLOGY , FOSTER JOHN S , HARLEY JOHN C , MARTIN RICHARD T , NGUYEN HUNG , RUBEL PAUL J
发明人： FOSTER JOHN S , HARLEY JOHN C , MARTIN RICHARD T , NGUYEN HUNG , RUBEL PAUL J
IPC分类号： G01N1/10 , A61M1/36 , B01L3/00 , C12M1/34 , C12Q1/00 , G01N15/02 , G01N21/05 , G01N21/64 , H01L21/00
CPC分类号： B01L3/502707 , A61M1/3633 , A61M1/3678 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0484 , C12M47/04 , G01N21/6428 , G01N2015/0288 , G01N2015/149 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A micromechanical particle sorting chip uses an actuator divided into two parts to direct a component of interest into one of a plurality of possible exit paths, based on detection of a fluorescent signal emanating from the component of interest. The two-part actuator may include a force-generating portion (350) and a microactuator portion (330). The microactuator portion (330) may be disposable, whereas the force-generating portion (350) may be reuseable. By bringing the force-generating portion (350) into proximity to the microactuator portion (330), the microactuator (300) is induced to move, thereby separating the component of interest from the rest of the fluid stream. The force-generating portion (350) and the microactuator portion (330) may be optimized and fabricated separately, thereby leading to faster, more reliable and less expensive particle sorting.
摘要翻译：微机械粒子分选芯片基于从感兴趣的部件发出的荧光信号的检测，使用被分成两部分的致动器将感兴趣的部件引导到多个可能的出口路径中的一个。两部分致动器可以包括力产生部分（350）和微致动器部分（330）。微致动器部分（330）可以是一次性的，而力产生部分（350）可以是可再利用的。通过使力产生部分（350）接近微致动器部分（330），微致动器（300）被诱导移动，从而将感兴趣的部件与其余的流体流分离。力产生部分（350）和微致动器部分（330）可以被分开地优化和制造，从而导致更快，更可靠和更便宜的颗粒分选。

8. 发明申请

WO2010108154A3 SELECTIVE AND POTENT PEPTIDE INHIBITORS OF KV1.3 审中-公开
标题翻译： KV1.3的选择和磷酸肽抑制剂
公开(公告)号：WO2010108154A3
公开(公告)日：2011-03-03
申请号：PCT/US2010028061
申请日：2010-03-19
申请人： AMGEN INC , SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
发明人： SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
IPC分类号： A61K38/00
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed are compositions of matter having an amino acid sequence of SEQ ID NO:4, or a pharmaceutically acceptable salt thereof, including embodiments comprising a toxin peptide analog related to ShK, HmK, and AETX-K and pharmaceutical compositions or medicaments containing them along with a pharmaceutically acceptable carrier. Some embodiments include a half-life extending moiety. Also disclosed are a method of preventing or mitigating a relapse of a symptom of multiple sclerosis and a method of treating an autoimmune disorder using the compositions.
摘要翻译：公开了具有SEQ ID NO：4的氨基酸序列或其药学上可接受的盐的物质组合物，包括包含与ShK，HmK和AETX-K相关的毒素肽类似物的实施方案，以及含有它们的药物组合物或药物以及药学上可接受的载体。一些实施方案包括半衰期延长部分。还公开了预防或减轻多发性硬化症状的复发的方法以及使用该组合物治疗自身免疫病症的方法。

9. 发明申请

WO0184383A8 METHOD AND APPARATUS SUPPORTING DYNAMICALLY ADAPTIVE USER INTERACTIONS IN A MULTIMODAL COMMUNICATION SYSTEM 审中-公开
标题翻译：在多模通信系统中支持动态自适应用户交互的方法和装置
公开(公告)号：WO0184383A8
公开(公告)日：2002-01-31
申请号：PCT/CA0100576
申请日：2001-04-26
申请人： APTILON INC , BENTHIN MARK LOUIS , NGUYEN HUNG , MUSTILLO PARDO , CHI LEUNG TAM HENRY , CAI SHAN , CONTRERAS YAJAIRA , MARTINEAU DENIS
发明人： BENTHIN MARK LOUIS , NGUYEN HUNG , MUSTILLO PARDO , CHI LEUNG TAM HENRY , CAI SHAN , CONTRERAS YAJAIRA , MARTINEAU DENIS
IPC分类号： G06Q30/02 , G06Q30/06 , G06F17/60
CPC分类号： G06Q30/02 , G06Q30/0212 , G06Q30/0277 , G06Q30/0601

10. 发明申请

WO2009053772A2 METHODS AND SYSTEMS FOR TRANSFERRING MULTIMEDIA CONTENT USING AN EXISTING DIGITAL SOUND TRANSFER PROTOCOL 审中-公开
标题翻译：使用现有的数字音频传输协议传输多媒体内容的方法和系统
公开(公告)号：WO2009053772A2
公开(公告)日：2009-04-30
申请号：PCT/IB2007004607
申请日：2007-10-26
申请人： CHOURAQUI JEAN , NGUYEN HUNG
发明人： CHOURAQUI JEAN , NGUYEN HUNG
IPC分类号： G06Q50/10 , H04L12/16 , H04M11/06 , H04W4/18
CPC分类号： H04N21/439 , G10L19/00 , H04N1/00281 , H04N1/00307 , H04N1/00312 , H04N21/233 , H04N21/2368 , H04N21/41407 , H04N21/4341 , H04N21/643 , H04N2201/0025 , H04N2201/0084
摘要： There are provided methods and systems for transferring multimedia content using an existing digital sound transfer protocol. A system for processing multimedia content for transfer over one or more networks includes a transformation device (211 ) and a reconstruction device (251 ). The transformation device (211 ) is for transforming a multimedia file into a sound file for subsequent transfer over the one or more networks using an existing digital sound transfer protocol. The multimedia file represents the multimedia content. The reconstruction device (251 ) is for reconstructing the multimedia content from the sound file, after the sound file has been transferred.
摘要翻译：提供了使用现有数字声音传输协议传送多媒体内容的方法和系统。用于处理通过一个或多个网络传送的多媒体内容的系统包括变换设备（211）和重建设备（251）。变换装置（211）用于将多媒体文件变换成声音文件，以便使用现有的数字声音传送协议通过一个或多个网络进行后续传送。多媒体文件表示多媒体内容。重建装置（251）用于在传送声音文件之后从声音文件重建多媒体内容。

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