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1. 发明申请

WO2012154268A1 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012154268A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/026225
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , ZHENG, Ying , XU, Yuan , GE, Junhao , FRANCIS, Charles, A. , SUN, Yuan , LIU, Yuwen , CHEN, Charlie , HONG, Ye , QIU, Hongjin , YAO, Li , BACK, Arthur
发明人： ZHENG, Ying , XU, Yuan , GE, Junhao , FRANCIS, Charles, A. , SUN, Yuan , LIU, Yuwen , CHEN, Charlie , HONG, Ye , QIU, Hongjin , YAO, Li , BACK, Arthur
IPC分类号： C08F290/06
CPC分类号： B29D11/00125 , B29D11/0025 , C08F290/068 , G02B1/043 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ethercontaining monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weighs are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当在聚合性组合物中存在至少一种含亲水性乙烯基醚单体时，以1〜20个单位重量的量存在。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

2. 发明申请

WO2012118683A1 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012118683A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/026226
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , GE, Junhao , LIU, Yuwen , CHEN, Charlie , XU, Yuan , HONG, Ye , QIU, Hongjin
发明人： GE, Junhao , LIU, Yuwen , CHEN, Charlie , XU, Yuan , HONG, Ye , QIU, Hongjin
IPC分类号： G02C7/04
CPC分类号： G02C7/049 , G02B1/043 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one hydrophilic vinyl amide-containing monomer, at least one acrylate-containing siloxane monomer, and at least one hydrophilic vinyl ether-containing monomer. The contact lenses have ophthalmically-acceptable surface wettability and can be manufactured without the use of volatile organic solvents.
摘要翻译：硅氧水凝胶隐形眼镜由包含至少一种含亲水性乙烯基酰胺的单体，至少一种含丙烯酸酯的硅氧烷单体和至少一种含亲水性乙烯基醚的单体的可聚合组合物的反应产物形成。隐形眼镜具有眼科可接受的表面润湿性，并且可以在不使用挥发性有机溶剂的情况下制造。

3. 发明申请

WO2012118684A2 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012118684A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/026228
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , LIU, Yuwen , HONG, Ye , GE, Junhao , XU, Yuan , CHEN, Charlie , FRANCIS, Charles, A. , YAO, Li , BACK, Arthur
发明人： LIU, Yuwen , HONG, Ye , GE, Junhao , XU, Yuan , CHEN, Charlie , FRANCIS, Charles, A. , YAO, Li , BACK, Arthur
IPC分类号： G02C7/04 , C08L51/08
CPC分类号： G02B1/043 , C08F226/00 , C08F236/20 , C08F283/065 , C08F283/126 , C08J11/02 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.
摘要翻译：衍生自包含由式（3）表示的第一硅氧烷单体的聚合性组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。和至少一种含乙烯基醚的交联剂。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

4. 发明申请

WO2012118686A3 SILICONE HYDROGEL CONTACT LENSES 审中-公开
公开(公告)号：WO2012118686A3
公开(公告)日：2012-09-07
申请号：PCT/US2012/026231
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , CHEN, Charlie , LIU, Yuwen , XU, Yuan , ZHENG, Ying , GE, Junhao , YAO, Li , BACK, Arthur
发明人： CHEN, Charlie , LIU, Yuwen , XU, Yuan , ZHENG, Ying , GE, Junhao , YAO, Li , BACK, Arthur
IPC分类号： C08G77/04 , G02C7/04
摘要： Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

5. 发明申请

WO2012118680A1 SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：硅胶水镜接触镜
公开(公告)号：WO2012118680A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/026220
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , LIU, Yuwen , GE, Junhao , CHEN, Charlie , XU, Yuan , YAO, Li , BACK, Arthur , FRANCIS, Charles, A.
发明人： LIU, Yuwen , GE, Junhao , CHEN, Charlie , XU, Yuan , YAO, Li , BACK, Arthur , FRANCIS, Charles, A.
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , B29D11/00125 , C08L83/12 , G02C7/04 , G02C7/049 , C08L101/14 , C08L83/04
摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent. The contact lenses have ophthalmically-acceptable ionoflux values and surface wettability, and can be manufactured without the use of volatile organic solvents.
摘要翻译：硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成。隐形眼镜具有眼睛可接受的离子通量值和表面润湿性，并且可以在不使用挥发性有机溶剂的情况下制造。

6. 发明申请

WO2012118675A2 WETTABLE SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：可湿式水胶接触镜
公开(公告)号：WO2012118675A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/026215
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , LIU, Yuwen , CHEN, Charlie , FRANCIS, Charles, A. , GE, Junhao , XU, Yuan , YAO, Li , BACK, Arthur , ZHENG, Ying
发明人： LIU, Yuwen , CHEN, Charlie , FRANCIS, Charles, A. , GE, Junhao , XU, Yuan , YAO, Li , BACK, Arthur , ZHENG, Ying
IPC分类号： C08F230/08
CPC分类号： G02C7/04 , B65B5/04 , G02B1/043 , C08L83/12 , C08L33/08 , C08L33/10
摘要： Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了眼科可接受的可湿性硅氧水凝胶隐形眼镜。透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是具有1至4个碳原子的烷基，式（1）的每个R 2独立地为氢原子或甲基，第一硅氧烷单体的数均分子量为400道尔顿至700道尔顿和数均分子量大于7,000道尔顿的第二硅氧烷单体; 其中存在于聚合性组合物中的硅氧烷单体的总量为30单位份〜50单位份; 透镜还包括衍生自至少一种具有一个N-乙烯基的亲水性酰胺单体的单元，该单体存在于可聚合组合物中的量为30至60单位份。当完全水合时，镜片具有眼科可接受的可润湿透镜表面。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

7. 发明申请

WO2012118674A3 SILICONE HYDROGEL CONTACT LENSES 审中-公开
公开(公告)号：WO2012118674A3
公开(公告)日：2012-09-07
申请号：PCT/US2012/026214
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , YAO, Li , HONG, Ye , LIU, Yuwen , CHEN, Charlie , FRANCIS, Charles, A. , BACK, Arthur
发明人： YAO, Li , HONG, Ye , LIU, Yuwen , CHEN, Charlie , FRANCIS, Charles, A. , BACK, Arthur
IPC分类号： C08G77/04 , G02C7/04
摘要： Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono- functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate- containing siloxane monomer of at least 30:1, respectively.

8. 发明申请

WO2012118678A1 WETTABLE SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：可湿式水胶接触镜
公开(公告)号：WO2012118678A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/026218
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , HONG, Ye , YAO, Li , LIU, Yuwen , CHEN, Charlie , BACK, Arthur
发明人： HONG, Ye , YAO, Li , LIU, Yuwen , CHEN, Charlie , BACK, Arthur
IPC分类号： G02C7/04
CPC分类号： G02C7/049 , C08L83/12 , G02B1/043 , C08L101/14 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively. The silicone hydrogel contact lenses have good manufacturing processability, can be manufactured without the use of alcohol solvents, and have excellent surface wettability.
摘要翻译：硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成，其中可聚合组合物具有亲水性含乙烯基单体的总量与含丙烯酸酯的硅氧烷单体的总量的摩尔比分别为5:1至30:1。硅酮水凝胶隐形眼镜具有良好的制造加工性，可以在不使用醇溶剂的情况下制造，并且具有优异的表面润湿性。

9. 发明申请

WO2012118670A2 SILICONE HYDROGEL CONTACT LENSES AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译：硅胶水凝胶接触镜及相关组合物及方法
公开(公告)号：WO2012118670A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/026210
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , LIU, Yuwen , CHEN, Charlie , HONG, Ye , FRANCIS, Charles, A. , YAO, Li , BACK, Arthur
发明人： LIU, Yuwen , CHEN, Charlie , HONG, Ye , FRANCIS, Charles, A. , YAO, Li , BACK, Arthur
IPC分类号： B65B55/02 , G02C7/04
CPC分类号： G02B1/043 , B65B55/02 , C08L101/14 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.
摘要翻译：制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

10. 发明申请

WO2012118682A2 SILICONE HYDROGEL CONTACT LENSES WITH HIGH FREEZABLE WATER CONTENT 审中-公开
标题翻译： SILICONE HYDROGEL联系眼镜具有高可冻结水含量
公开(公告)号：WO2012118682A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/026223
申请日：2012-02-23
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , LEE, Paul, Hungchaung , LIU, Ronghua , SHI, Xinfeng , LIU, Yuwen , HONG, Ye , CHEN, Charlie , YAO, Li , BACK, Arthur , FRANCIS, Charles, A.
发明人： LEE, Paul, Hungchaung , LIU, Ronghua , SHI, Xinfeng , LIU, Yuwen , HONG, Ye , CHEN, Charlie , YAO, Li , BACK, Arthur , FRANCIS, Charles, A.
IPC分类号： B65B63/00 , C08L43/04
CPC分类号： B29D11/00038 , G02B1/043 , C08L101/14 , C08L83/04 , C08L33/10
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophilic monomer are described. These silicone hydrogel contact lenses have, when fully hydrated, has an equilibrium freezable water content of at least 25% wt/wt as determined by differential scanning calorimetry (DSC). Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了衍生自包含至少一种硅氧烷单体和至少一种亲水单体的可聚合组合物的硅氧烷水凝胶隐形眼镜。当通过差示扫描量热法（DSC）测定时，这些硅氧水凝胶隐形眼镜在完全水合时具有至少25％wt / wt的平衡可冷冻水含量。还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

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