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    • 3. 发明申请
    • “重新签名”标识转录模块
    • WO2002073498A1
    • 2002-09-19
    • PCT/IL2002/000211
    • 2002-03-14
    • YEDA RESEARCH AND DEVELOPMENT CO. LTDIHMELS, JanBERGMANN, SvenBARKAI, Naama
    • IHMELS, JanBERGMANN, SvenBARKAI, Naama
    • G06F19/00
    • G06F19/20G06F19/12
    • A method for analyzing and identifying functional linkages between biological processes which are regulated in a coordinate manner. An especially preferred example of a biological process to which the method of the present invention may be applied is the analysis of groups of coordinately regulated genes. More preferably, the present invention analyzes large set of genome-wide expression data or transcriptional data in order to discover coordinately regulated genes, which can be termed "transcriptional modules". Optionally and most preferably, the groups of genes are identified with their corresponding cis -regulatory elements. Thus, if the cis -regulatory elements for the transcriptional module are not known, they can optionally be identified with the method of the present invention, for example if functional linkages between genes are known and the associated cis-regulatory element is also available, this information can be used to identify the corresponding transcriptional module.
    • 用于分析和识别以协调方式调节的生物过程之间的功能性连接的方法。 可应用本发明方法的生物过程的特别优选实例是对协调调节基因组的分析。 更优选地,本发明分析大量全基因组表达数据或转录数据,以便发现可被称为“转录模块”的协调调节基因。 任选地,最优选地,用相应的顺式调节元件鉴定基因组。 因此,如果用于转录模块的顺式 - 调节元件是未知的,则它们可以任选地用本发明的方法鉴定,例如如果基因之间的功能性连接是已知的并且相关的顺式调节元件也可用,则 信息可用于识别相应的转录模块。