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1. 发明申请

WO2009061374A2 DEUTERATED FINGOLIMOD 审中-公开
标题翻译：检测FINGOLIMOD
公开(公告)号：WO2009061374A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/012390
申请日：2008-10-31
申请人： CONCERT PHARMACEUTICALS, INC. , LIU, Julie, F. , PERSICHETTI, Rose, A.
发明人： LIU, Julie, F. , PERSICHETTI, Rose, A.
IPC分类号： C07C215/28 , C07F9/40
CPC分类号： C07F9/094 , C07B2200/05 , C07C215/28
摘要： This invention relates to novel compounds that are deuterated derivatives of fingolimod and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a lysophospholipid edgl (SlPl) receptor agonist, such as fingolimod.
摘要翻译：本发明涉及作为芬戈莫德的氘化衍生物及其药学上可接受的盐的新化合物。本发明还提供包含一种或多种本发明化合物和载体的组合物，以及所公开的化合物和组合物在治疗通过施用溶血磷脂edgl（S1P1）受体激动剂如芬戈莫德有益治疗的疾病和病症的方法中的用途。

2. 发明申请

WO2009128947A1 PIPERAZINE DERIVATIVES 审中-公开
标题翻译：哌嗪衍生物
公开(公告)号：WO2009128947A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/002424
申请日：2009-04-17
申请人： CONCERT PHARMACEUTICALS, INC. , LIU, Julie, F. , PERSICHETTI, Rose, A.
发明人： LIU, Julie, F. , PERSICHETTI, Rose, A.
IPC分类号： C07D401/14 , A61K31/506 , A61P31/18
CPC分类号： C07D401/14
摘要： This invention relates to novel compounds that are piperazine derivatives, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel piperazine compounds that are derivatives of the chemokine CCR5 receptor antagonist, vicriviroc. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering chemokine CCR5 receptor antagonists, such as vicriviroc. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving vicriviroc.
摘要翻译：本发明涉及作为哌嗪衍生物的新化合物及其药学上可接受的盐。更具体地，本发明涉及作为趋化因子CCR5受体拮抗剂vicriviroc的衍生物的新型哌嗪化合物。本发明还提供了不含热原的组合物，其包含一种或多种本发明化合物和载体，以及所公开的化合物和组合物在治疗通过施用趋化因子CCR5受体拮抗剂例如维利维罗治疗的疾病和病症的方法中的用途。本发明还涉及一种或多种所公开的化合物在涉及vicriviroc的分析研究中作为试剂的用途。

3. 发明申请

WO2008133949A1 ANALOGUES OF CILOSTAZOL 审中-公开
标题翻译： CILOSTAZOL的模拟
公开(公告)号：WO2008133949A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/005301
申请日：2008-04-24
申请人： CONCERT PHARMACEUTICALS, INC. , LIU, Julie, F. , PERSICHETTI, Rose, A.
发明人： LIU, Julie, F. , PERSICHETTI, Rose, A.
IPC分类号： C07D401/12 , A61K31/41 , A61P7/00 , A61P9/00
CPC分类号： C07D401/12
摘要： This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen- free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of an phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
摘要翻译：本发明涉及作为磷酸二酯酶抑制剂西洛他唑及其药学上可接受的盐的衍生物的新化合物。本发明还提供了包含一种或多种本发明化合物的无热原组合物，以及所公开的化合物和组合物在治疗通过施用磷酸二酯酶抑制剂如西洛他唑治疗的疾病和病症的方法中的用途。本发明还涉及所公开的化合物和组合物在涉及西洛他唑的分析研究中作为试剂的用途。

4. 发明申请

WO2010005520A2 2-ALKYL-3-ACYLPYRAZOLO[1,5-A]PYRIDINE DERIVATIVES 审中-公开
标题翻译： 2-烷基-3-氨基吡唑并[1,5-a]吡啶衍生物
公开(公告)号：WO2010005520A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/003888
申请日：2009-06-30
申请人： CONCERT PHARMACEUTICALS, INC. , LIU, Julie, F. , PERSICHETTI, Rose, A.
发明人： LIU, Julie, F. , PERSICHETTI, Rose, A.
IPC分类号： C07D471/04 , A61K31/437 , A61P11/06
CPC分类号： C07D471/04
摘要： This invention relates to novel compounds that are 2-alkyl-3-acylpyrazolo[l,5- a]pyridines, their derivatives, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to 2-alkyl-3-acylpyrazolo[l,5-a]pyridine compounds that are derivatives of ibudilast. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a phosphodiesterase (PDE) inhibitor, a leukotriene CysLTl (LTD4) antagonist, an inhibitor of nitric oxide synthase, and/or a glial cell activation suppressant, such as ibudilast.
摘要翻译：本发明涉及2-烷基-3-酰基吡唑并[1,5-a]吡啶，其衍生物及其药学上可接受的盐的新化合物。更具体地，本发明涉及作为异丁司特衍生物的2-烷基-3-酰基吡唑并[1,5-a]吡啶化合物。本发明还提供包含本发明化合物和这些组合物在治疗通过施用磷酸二酯酶（PDE）抑制剂，白三烯CysLT1（LTD4）拮抗剂，一氧化氮抑制剂）有益治疗的疾病和病症的方法中的用途合成酶和/或神经胶质细胞活化抑制剂，例如异丁司特。

5. 发明申请

WO2009117144A1 BENZAZEPINE COMPOUNDS 审中-公开
标题翻译：苯并噻吩化合物
公开(公告)号：WO2009117144A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/001767
申请日：2009-03-20
申请人： CONCERT PHARMACEUTICALS, INC. , LIU, Julie, F. , PERSICHETTI, Rose, A.
发明人： LIU, Julie, F. , PERSICHETTI, Rose, A.
IPC分类号： C07D487/04 , A61K31/55 , A61P7/00
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds that are benzazepines derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel benzazepines derivatives that are derivatives of conivaptan. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a dual antagonist of arginine vasopressin (AVP) Vi A and V2 receptors, such a conivaptan.
摘要翻译：本发明涉及苯并吖庚因衍生物及其药学上可接受的盐的新化合物。更具体地，本发明涉及作为conivaptan衍生物的新的苯并氮杂衍生物。本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所公开的化合物和组合物在治疗疾病和病症的方法中的用途，所述方法通过施用精氨酸加压素（AVP）ViA的双重拮抗剂和 V2受体，如conivaptan。

6. 发明申请

WO2009129181A1 PROPANEDIOL-DICARBAMATE DERIVATIVES 审中-公开
标题翻译：丙二醇二甲酯衍生物
公开(公告)号：WO2009129181A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040369
申请日：2009-04-13
申请人： CONCERT PHARMACEUTICALS INC. , MASSE, Craig, E. , PERSICHETTI, Rose, A.
发明人： MASSE, Craig, E. , PERSICHETTI, Rose, A.
IPC分类号： C07C271/12 , C07C271/14 , A61K31/27 , A61P25/08
CPC分类号： C07C271/12 , C07B59/001 , C07B2200/05
摘要： This disclosure relates to novel propanediol-dicarbamates, their derivatives, pharmaceutically acceptable salts thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a dual N -methyl D -aspartic acid (NMDA) receptor antagonist and sodium channel blocker.
摘要翻译：本公开涉及新型丙二醇 - 二氨基甲酸酯，其衍生物，其药学上可接受的盐。本公开还提供了包含本公开的化合物和这种组合物在治疗通过施用双N-甲基D-天冬氨酸（NMDA）受体拮抗剂和钠通道阻断剂有益治疗的疾病和病症的方法中的用途的组合物。

7. 发明申请

WO2008131259A1 DEUTERATED MORPHOLINYL COMPOUNDS 审中-公开
标题翻译：去离子的吗啉化合物
公开(公告)号：WO2008131259A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060877
申请日：2008-04-18
申请人： CONCERT PHARMACEUTICALS INC. , PERSICHETTI, Rose, A. , HARBESON, Scott, L.
发明人： PERSICHETTI, Rose, A. , HARBESON, Scott, L.
IPC分类号： C07D265/30 , A61P3/10 , A61P1/00 , A61K31/5375
CPC分类号： C07D265/30
摘要： This disclosure relates to novel deuterated morpholinyl compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a 5HT4 serotonin receptor agonist.
摘要翻译：本公开涉及新颖的氘代吗啉基化合物及其衍生物，其药学上可接受的盐，溶剂化物和水合物。本公开还提供了包含本公开的化合物和这种组合物在治疗通过施用5HT4血清素受体激动剂有益治疗的疾病和病症的方法中的用途的组合物。

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