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1. 发明申请

WO2004065644A3 METHOD FOR CONTROLLING BIOOXIDATION REACTIONS 审中-公开
标题翻译：控制生物反应的方法
公开(公告)号：WO2004065644A3
公开(公告)日：2005-04-28
申请号：PCT/US2004000907
申请日：2004-01-14
申请人： COGNIS CORP , ANDERSON KEVIN W , WENZEL J DOUGLAS
发明人： ANDERSON KEVIN W , WENZEL J DOUGLAS
IPC分类号： C12P7/44 , C12P7/46 , C12P7/64 , C22B20060101
CPC分类号： C12P7/6409 , C12P7/44 , C12P7/46
摘要： Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate and carbon dioxide evolution rate from the reaction mixture; (3) determining the instantaneous rates of substrate and cosubstrate consumption by solving simultaneous equations relating carbon dioxide evolution rate and oxygen consumption rate to the substrate oxidation stoichiometry, the cosubstrate combustion stoichiometry, and optionally the biomass formation stoichiometry; (4) simultaneously adjusting the substrate and cosubstrate addition rates to the rates of substrate oxidation and cosubstrate consumption in order to maximize the rate of product formation while simultaneously minimizing the rate of cosubstrate usage. The method provides a rapid means of controlling fed-batch biooxidation reactions which can employ in-line techniques and is broadly applicable for diverse oxidation reactions.
摘要翻译：生物氧化反应可以通过一种方法来控制，该方法包括以下步骤：（1）以包含生物催化剂的生物氧化反应混合物以预定速率独立地加入底物和共底物; （2）从反应混合物中测量氧气消耗速率和二氧化碳释放速率; （3）通过求解将二氧化碳进化速率和氧耗率相关联的联立方程与底物氧化化学计量，同位素燃烧化学计量学和任选的生物质形成化学计量来确定底物和辅助消耗的瞬时速率; （4）同时调整衬底并将衬底加入速率与底物氧化和辅助消耗的速率进行调和，以最大限度地提高产物形成速率，同时最大限度地降低衬底使用率。该方法提供了控制补料分批生物氧化反应的快速方法，其可以使用在线技术并且广泛适用于多种氧化反应。

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