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1. 发明申请

WO2008019368A3 ALBUMIN-INSULIN FUSION PROTEINS 审中-公开
标题翻译：铝白蛋白融合蛋白
公开(公告)号：WO2008019368A3
公开(公告)日：2008-12-24
申请号：PCT/US2007075361
申请日：2007-08-07
申请人： COGENESYS INC , BELL ADAM C , ROSEN CRAIG A , SANYAL INDRAJIT , ZHAO QINGHAI
发明人： BELL ADAM C , ROSEN CRAIG A , SANYAL INDRAJIT , ZHAO QINGHAI
IPC分类号： C07K14/62 , A61K38/28 , A61K38/38 , A61P3/10 , C07K14/765 , C12N5/10 , C12N15/17
CPC分类号： C07K14/62 , A61K38/28 , C07K14/765 , C07K2319/35 , C12N15/62
摘要： Disclosed are fusion proteins that include albumin fused to a polypeptide that has insulin activity. The fusion proteins may include albumin fused to insulin or an insulin analog. In particular, the fusions proteins may include albumin fused to a single chain insulin analog. The fusion proteins may exhibit extended insulin activity in vivo or in vitro relative to insulin that is not fused to albumin. The fusion proteins may be formulated as aerosol compositions.
摘要翻译：公开了融合蛋白，其包括与具有胰岛素活性的多肽融合的白蛋白。融合蛋白可包括与胰岛素或胰岛素类似物融合的白蛋白。特别地，融合蛋白可以包括与单链胰岛素类似物融合的白蛋白。融合蛋白可以在体内或体外相对于不与白蛋白融合的胰岛素表现出延长的胰岛素活性。融合蛋白可以配制成气溶胶组合物。

2. 发明申请

WO2008052043A3 OPIOID RECEPTOR AGONIST FUSION PROTEINS 审中-公开
标题翻译：阿片受体激动剂融合蛋白
公开(公告)号：WO2008052043A3
公开(公告)日：2009-01-08
申请号：PCT/US2007082363
申请日：2007-10-24
申请人： COGENESYS INC , ROSEN CRAIG A , BELL ADAM C , SANYAL INDRAJIT , LAFLEUR DAVID
发明人： ROSEN CRAIG A , BELL ADAM C , SANYAL INDRAJIT , LAFLEUR DAVID
IPC分类号： C07K14/665 , A61K38/22 , C07K14/575 , C12N15/62
CPC分类号： C07K14/665 , C07K14/4715 , C07K2319/00
摘要： Disclosed are fusion proteins that include an opioid receptor agonist protein, or a fragment, variant, or an analog thereof fused to a serum protein. Suitable serum proteins for the fusion proteins in albumin, alpha- fetoprotein (AFP) and albumin- AFP hybrid proteins. The fusion proteins have opioid receptor agonist activity. Typically, the fusion proteins may exhibit extended or stabilized opioid receptor agonist activity in vivo or in vitro relative to an opioid receptor agonist that is not fused to the serum protein.
摘要翻译：公开了融合蛋白，其包含与血清蛋白融合的阿片受体激动剂蛋白或其片段，变体或类似物。用于白蛋白，甲胎蛋白（AFP）和白蛋白AFP杂交蛋白中的融合蛋白的合适的血清蛋白。融合蛋白具有阿片受体激动剂活性。通常，融合蛋白可以相对于不与血清蛋白融合的阿片样物质受体激动剂在体内或体外表现出延长的或稳定的阿片受体激动剂活性。

3. 发明申请

WO2008052043A9 OPIOID RECEPTOR AGONIST FUSION PROTEINS 审中-公开
标题翻译：阿片类药物受体激动剂融合蛋白
公开(公告)号：WO2008052043A9
公开(公告)日：2008-07-31
申请号：PCT/US2007082363
申请日：2007-10-24
申请人： COGENESYS INC , ROSEN CRAIG A , BELL ADAM C , SANYAL INDRAJIT , LAFLEUR DAVID
发明人： ROSEN CRAIG A , BELL ADAM C , SANYAL INDRAJIT , LAFLEUR DAVID
IPC分类号： C07K14/435
CPC分类号： C07K14/665 , C07K14/4715 , C07K2319/00
摘要： Disclosed are fusion proteins that include an opioid receptor agonist protein, or a fragment, variant, or an analog thereof fused to a serum protein. Suitable serum proteins for the fusion proteins in albumin, alpha- fetoprotein (AFP) and albumin- AFP hybrid proteins. The fusion proteins have opioid receptor agonist activity. Typically, the fusion proteins may exhibit extended or stabilized opioid receptor agonist activity in vivo or in vitro relative to an opioid receptor agonist that is not fused to the serum protein.
摘要翻译：公开了融合蛋白，其包含与血清蛋白融合的阿片受体激动蛋白或其片段，变体或类似物。白蛋白，甲胎蛋白（AFP）和白蛋白-AFP杂合蛋白中融合蛋白的合适血清蛋白。融合蛋白具有阿片受体激动剂活性。典型地，融合蛋白相对于未与血清蛋白融合的阿片受体激动剂，可在体内或体外表现出延长的或稳定的阿片受体激动剂活性。

4. 发明申请

WO02098448A9 METHODS AND COMPOSITIONS FOR MODULATING ACE-2 ACTIVITY 审中-公开
标题翻译：调节ACE-2活性的方法和组合物
公开(公告)号：WO02098448A9
公开(公告)日：2003-04-10
申请号：PCT/US0217199
申请日：2002-06-03
申请人： HUMAN GENOME SCIENCES INC , PARRY TOM J , ROSEN CRAIG A , ALBERT VIVIAN R , SANYAL INDRAJIT , HUANG LILI , WESCOTT CHARLES R , SEKUT LES
发明人： PARRY TOM J , ROSEN CRAIG A , ALBERT VIVIAN R , SANYAL INDRAJIT , HUANG LILI , WESCOTT CHARLES R , SEKUT LES
IPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/12 , A61K38/16
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： Binding polypeptides comprising specific amino acid sequences are disclosed that specifically bind ACE-2 protein or ACE-2 -like polypeptides. The binding polypeptides can be used in methods of the invention for detecting, isolating, or purifying ACE-2 protein or ACE-2 -like polypeptides in solutions or mixtures, or biological samples. The invention also relates to nucleic acid molecules encoding these ACE-2 binding polypeptides, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding polypeptides or fragments or variants thereof, that specifically bind to ACE-2.
摘要翻译：公开了包含特异性氨基酸序列的结合多肽，其特异性结合ACE-2蛋白或ACE-2样多肽。结合多肽可用于本发明的方法中用于在溶液或混合物或生物样品中检测，分离或纯化ACE-2蛋白或ACE-2样多肽。本发明还涉及编码这些ACE-2结合多肽的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明还涉及用于检测，诊断，预后，预防，治疗或改善与异常ACE-2或ACE-2受体表达或ACE-2或ACE-2受体的不适当功能相关的疾病或病症的方法和组合物，包括使用特异性结合ACE-2的ACE-2结合多肽或其片段或变体。

5. 发明申请

WO2007146038A3 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO2007146038A3
公开(公告)日：2008-10-09
申请号：PCT/US2007013383
申请日：2007-06-07
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
发明人： ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
IPC分类号： A61K38/26 , C07K14/605 , C07K14/76
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

6. 发明申请

WO2004042000A3 157 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 157人类分泌蛋白
公开(公告)号：WO2004042000A3
公开(公告)日：2005-10-06
申请号：PCT/US0315439
申请日：2003-05-16
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M , OLSEN HENRIK , BAKER KEVIN P , FISCELLA MICHELE , WEI PING , BIRSE CHARLES E , KOMATSOULIS GEORGE , CHOI GIL H , MOORE PAUL A , GUPTA RAM , SHI YANGGU
发明人： ROSEN CRAIG A , RUBEN STEVEN M , OLSEN HENRIK , BAKER KEVIN P , FISCELLA MICHELE , WEI PING , BIRSE CHARLES E , KOMATSOULIS GEORGE , CHOI GIL H , MOORE PAUL A , GUPTA RAM , SHI YANGGU
IPC分类号： C07K14/47 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

7. 发明申请

WO2005003296A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2005003296A3
公开(公告)日：2005-04-21
申请号：PCT/US2004001369
申请日：2004-01-20
申请人： HUMAN GENOME SCIENCES INC , HASELTINE WILLIAM A , ROSEN CRAIG A
发明人： HASELTINE WILLIAM A , ROSEN CRAIG A
IPC分类号： A61K38/00 , A61K38/38 , A61K47/48 , C07H21/04 , C07K14/765 , C12N20060101 , C12P21/02 , C12P21/04
CPC分类号： A61K38/38 , A61K47/643 , C07K14/765 , C07K2319/31
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括清蛋白融合蛋白。编码本发明的清蛋白融合蛋白的核酸分子也包括在本发明中，含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的清蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。此外，本发明涵盖包含清蛋白融合蛋白的药物组合物以及使用本发明的清蛋白融合蛋白治疗，预防或改善疾病，失调或病症的方法。

8. 发明申请

WO2004003144A3 ANTIBODIES THAT SPECIFICALLY BIND TO REG IV 审中-公开
标题翻译： IV特异性结合的抗体
公开(公告)号：WO2004003144A3
公开(公告)日：2004-06-10
申请号：PCT/US0319908
申请日：2003-06-26
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A
发明人： ROSEN CRAIG A
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.
摘要翻译：本发明涉及特异性结合Reg IV的抗体和相关分子。这些抗体例如用于预防和治疗胃肠道癌症，炎症性肠病和糖尿病。本发明还涉及编码抗Reg III抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是胃肠道癌症，炎症性肠病和糖尿病的方法和组合物，所述方法和组合物包含给予动物，优选人类有效量的一种或更多的与Reg IV特异性结合的抗体或其片段或变体或相关分子。

9. 发明申请

WO03004623A2 HUMAN SECRETED PROTEINS 审中-公开
标题翻译：人体分泌蛋白
公开(公告)号：WO03004623A2
公开(公告)日：2003-01-16
申请号：PCT/US0209922
申请日：2002-03-26
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M
发明人： ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： A61K38/00 , C07K14/47 , G01N33/53 , C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞和用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

10. 发明申请

WO03004622A2 HUMAN SECRETED PROTEINS 审中-公开
标题翻译：人体分泌蛋白
公开(公告)号：WO03004622A2
公开(公告)日：2003-01-16
申请号：PCT/US0208124
申请日：2002-03-19
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M
发明人： ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： A61K35/76 , A61K38/00 , C07K14/47 , C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diabetes mellitus and/or conditions related to diabetes. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of, polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the jpolypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与糖尿病相关的糖尿病和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明的多肽的生产和功能的方法和组合物。

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