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1. 发明申请

WO2012024046A2 PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：重组微生物的戊糖发酵
公开(公告)号：WO2012024046A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/044441
申请日：2011-07-19
申请人： CODEXIS, INC. , SUBBIAN, Ezhilkani , ZHANG, Xiyun
发明人： SUBBIAN, Ezhilkani , ZHANG, Xiyun
IPC分类号： C12P7/04
CPC分类号： C12Y503/01005 , C12N9/92 , C12P7/10 , Y02E50/16
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
摘要翻译：本发明提供了包含木糖异构酶多核苷酸的重组核酸构建体，包含重组木糖异构酶多核苷酸的重组真菌宿主细胞以及相关方法。

2. 发明申请

WO2012135110A1 PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：重组微生物的发酵发酵
公开(公告)号：WO2012135110A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/030549
申请日：2012-03-26
申请人： CODEXIS, INC. , ZHANG, Xiyun , FONG, Ryan, C. , SUBBIAN, Ezhilkani
发明人： ZHANG, Xiyun , FONG, Ryan, C. , SUBBIAN, Ezhilkani
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12Y101/01307
摘要： The present invention provides methods and compositions suitable for use in the conversion of xylose to xylitol and xylulose, including nucleic acid constructs, recombinant fungal host cells, and related materials.
摘要翻译：本发明提供适用于将木糖转化为木糖醇和木酮糖的方法和组合物，包括核酸构建体，重组真菌宿主细胞和相关材料。

3. 发明申请

WO2012009272A2 PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：重组微生物的发酵发酵
公开(公告)号：WO2012009272A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/043548
申请日：2011-07-11
申请人： CODEXIS, INC. , SUBBIAN, Ezhilkani , ZHANG, Xiyun
发明人： SUBBIAN, Ezhilkani , ZHANG, Xiyun
IPC分类号： C12P7/06
CPC分类号： C12N9/92 , C12P7/10 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
摘要翻译：本发明提供包含木糖异构酶多核苷酸，包含重组木糖异构酶多核苷酸的重组真菌宿主细胞和相关方法的重组核酸构建体。

4. 发明申请

WO2011150313A1 PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：重组微生物的发酵发酵
公开(公告)号：WO2011150313A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038300
申请日：2011-05-27
申请人： CODEXIS, INC. , SUBBIAN, Ezhilkani , ZHANG, Xiyun , MIJTS, Benjamin , CHO, Catherine, M.
发明人： SUBBIAN, Ezhilkani , ZHANG, Xiyun , MIJTS, Benjamin , CHO, Catherine, M.
IPC分类号： C12P19/02 , C07H21/04
CPC分类号： C12P19/24 , C12N9/90 , C12N9/92 , C12N15/81 , C12P7/04 , C12P7/10 , C12P19/02 , C12P2203/00 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
摘要翻译：本发明提供包含木糖异构酶多核苷酸的重组核酸构建体，包含重组木糖异构酶多核苷酸的重组真菌宿主细胞和相关方法。

5. 发明申请

WO2013003219A1 PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM 审中-公开
标题翻译：重组微生物的发酵发酵
公开(公告)号：WO2013003219A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/043689
申请日：2012-06-22
申请人： CODEXIS, INC. , SUBBIAN, Ezhilkani , GRATE, John, H. , CHO, Catherine, M. , MIJTS, Benjamin , BENOIT, Jeanne, Bonomo
发明人： SUBBIAN, Ezhilkani , GRATE, John, H. , CHO, Catherine, M. , MIJTS, Benjamin , BENOIT, Jeanne, Bonomo
IPC分类号： C12N15/53 , C07K14/195 , C07K14/33 , C07K19/00 , C12N1/15 , C12N1/19 , C12N9/04 , C12P7/26
CPC分类号： C12N9/90 , C12N9/92 , C12P7/06 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
摘要翻译：本发明提供包含木糖异构酶多核苷酸的重组核酸构建体，包含重组木糖异构酶多核苷酸的重组真菌宿主细胞和相关方法。

6. 发明申请

WO2008143704A3 ENGINEERED MICROORGANISMS FOR PRODUCING N-BUTANOL AND RELATED METHODS 审中-公开
公开(公告)号：WO2008143704A3
公开(公告)日：2008-11-27
申请号：PCT/US2007/086311
申请日：2007-12-03
申请人： GEVO, INC. , BUELTER, Thomas , HAWKINS, Andrew , KERSH, Kalib , MEINHOLD, Peter , PETERS, Matthew , SUBBIAN, Ezhilkani
发明人： BUELTER, Thomas , HAWKINS, Andrew , KERSH, Kalib , MEINHOLD, Peter , PETERS, Matthew , SUBBIAN, Ezhilkani
IPC分类号： C12N1/21 , C12N15/09
摘要： A recombinant microorganism expressing at least a heterologous enzyme of an NADH-dependent pathway for conversion of a carbon source to n-butanol, metabolic intermediate and/or a derivative thereof and capable of producing n-butanol, a metabolic intermediate and/or a derivative thereof at a high yield and related methods. The recombinant microorganism engineered to inactivate a native enzyme of one or more pathways that compete with NADH-dependent heterologous pathway, and/or to balance the NADH-dependent heterologous pathway with respect to NADH production and consumption.

7. 发明申请

WO2004078773A1 STABILIZING PROTEINS FOR USE IN PERSONAL CARE, COSMETIC, AND PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：稳定蛋白质用于个人护理，化妆品和药物产品
公开(公告)号：WO2004078773A1
公开(公告)日：2004-09-16
申请号：PCT/US2004/006521
申请日：2004-03-03
申请人： OREGON HEALTH AND SCIENCE UNIVERSITY , SHINDE, Ujwal, P. , SUBBIAN, Ezhilkani , YABUTA, Yukihiro
发明人： SHINDE, Ujwal, P. , SUBBIAN, Ezhilkani , YABUTA, Yukihiro
IPC分类号： C07H21/04
CPC分类号： C07H21/04 , A61K8/66 , A61K38/482 , A61K2800/52 , A61Q11/02 , A61Q17/04 , C11D3/0078 , C11D3/386 , C12N9/54 , A61K2300/00
摘要： Several secreted proteases (Figure 5) are produced with dedicated single-turnover intramolecular chaperones (IMC) or propeptides. Protease maturation necessitates IMCs to switch from a chaperone to a protease inhibitor and subsequently into a proteolytic substrate. The present invention provides compositions and methods using environmental signals to modulate the stochastic behavior associated with the inhibitor-substrate switch between infinitely probabilistic and precisely deterministic temporal events. This provides a unique biological switch that enable proteases to function as biochemical regulators through modulation of conformational entropy of their cognate IMCs. The present invention provides compositions comprising proteases that are stabilized as inactive proteases, but that can yet be rapidly activated by external signals (Figure 4).
摘要翻译：用专用的单周转分子伴侣（IMC）或前肽产生几种分泌的蛋白酶（图5）。蛋白酶成熟需要IMC从分子伴侣转变为蛋白酶抑制剂，随后进入蛋白水解底物。本发明提供使用环境信号在无限概率和精确确定性时间事件之间调制与抑制剂 - 底物转换相关联的随机行为的组合物和方法。这提供了一种独特的生物开关，通过调节其同源IMC的构象熵，使蛋白酶能够用作生物化学调节剂。本发明提供了包含作为无活性蛋白酶稳定但可被外部信号快速激活的蛋白酶的组合物（图4）。

8. 发明申请

WO2008131286A1 ENGINEERED MICROORGANISMS FOR PRODUCING ISOPROPANOL 审中-公开
标题翻译：用于生产异丙酚的工程微生物
公开(公告)号：WO2008131286A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060911
申请日：2008-04-18
申请人： GEVO, INC. , SUBBIAN, Ezhilkani , MEINHOLD, Peter , BUELTER, Thomas , HAWKINS, Andrew C.
发明人： SUBBIAN, Ezhilkani , MEINHOLD, Peter , BUELTER, Thomas , HAWKINS, Andrew C.
IPC分类号： C12P7/66 , C12N1/20
CPC分类号： C12P7/04
摘要： In an embodiment, there is disclosed a recombinant microbial host cell having each of the DNA molecules encoding a polypeptide or group of polypeptides that catalyze the conversion: (i) Acetyl-CoA to Acetate and CoA (conversion 1) (ii) Acetyl-CoA to Acetoacetyl-CoA and CoA (conversion 2) (iii) Acetoacetyl-CoA and Acetate to Acetoacetate and Acetyl-CoA (conversion 3.1) (iv) Acetoacetate to Acetone and CO2 (conversion 4) (v) Acetone and NAD(P)H and H+ to Isopropanol and NAD(P)+ (conversion 5) wherein the at least one DNA molecule is heterologous to the microbial host cell and wherein the microbial host cell produces isopropanol. In another embodiment, a method is disclosed for the production of isopropanol including providing a recombinant microbial host cell, the host cell of (i) with a fermentable carbon substrate in a fermentation medium under conditions whereby isopropanol is produced, and recovering the isopropanol.
摘要翻译：在一个实施方案中，公开了一种重组微生物宿主细胞，其具有编码催化转化的多肽或多肽组的每个DNA分子：（i）乙酰辅酶A至乙酸酯和CoA（转化1）（ii）乙酰辅酶A 乙酰乙酰辅酶A和CoA（转化2）（iii）乙酰乙酰辅酶A和乙酸酯与乙酰乙酸酯和乙酰辅酶A（转化3.1）（iv）乙酰乙酸酯向丙酮和CO 2（转化4）（v）丙酮和NAD（P）H 和H +与异丙醇和NAD（P）+（转化5），其中至少一个DNA分子与微生物宿主细胞是异源的，并且其中微生物宿主细胞产生异丙醇。在另一个实施方案中，公开了用于生产异丙醇的方法，包括提供重组微生物宿主细胞，宿主细胞（i）在发酵培养基中的可发酵碳底物，其中产生异丙醇的条件下，并回收异丙醇。

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