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1. 发明申请

WO2006091470A2 IMPROVED HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES 审中-公开
标题翻译：改进的氢化物脱氢酶和相关多核苷酸
公开(公告)号：WO2006091470A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/005487
申请日：2006-02-15
申请人： CODEXIS, INC. , GAVRILOVIC, Vesna , DAVIS, S., Christopher , FOX, Richard, John , HUISMAN, Gjalt, W. , MUNDORFF, Emily, C. , NEWMAN, Lisa, M. , FOX, Richard
发明人： DAVIS, S., Christopher , FOX, Richard, John , HUISMAN, Gjalt, W. , MUNDORFF, Emily, C. , NEWMAN, Lisa, M. , FOX, Richard
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/04 , C12N1/21 , C12N15/74
CPC分类号： C12N9/14 , C12N9/88
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译：本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。本发明还提供相关载体，宿主细胞和方法。

2. 发明申请

WO2009008908A2 STRUCTURE-ACTIVITY RELATIONSHIPS 审中-公开
标题翻译：结构 - 活动关系
公开(公告)号：WO2009008908A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/001907
申请日：2008-02-12
申请人： CODEXIS, INC. , MUNDORFF, Emily , DAVIS, Simon, Christopher , FOX, Richard , GAVRILOVIC, Vesna , HUISMAN, Gjalt , KREBBER, Anke , SAVILE, Christopher , SEGRAVES, Erika , GRATE, John
发明人： MUNDORFF, Emily , DAVIS, Simon, Christopher , FOX, Richard , GAVRILOVIC, Vesna , HUISMAN, Gjalt , KREBBER, Anke , SAVILE, Christopher , SEGRAVES, Erika , GRATE, John
IPC分类号： C07K14/00 , C12N9/00 , G01N33/53
CPC分类号： C12Q1/25 , C12N9/00 , C12N15/1093 , C12Q1/00 , C12Q1/26 , C40B10/00 , C40B30/04 , C40B40/02 , C40B40/10 , G01N33/6803 , G01N33/6845 , G06F19/18
摘要： The present disclosure relates to compositions and methods for screening a plurality of polypeptide variants.
摘要翻译：本公开涉及用于筛选多种多肽变体的组合物和方法。

3. 发明申请

WO2009102901A1 METHOD OF GENERATING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS 审中-公开
标题翻译：生成优化的多样化人口变化的方法
公开(公告)号：WO2009102901A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/033971
申请日：2009-02-12
申请人： CODEXIS, INC. , FOX, Richard
发明人： FOX, Richard
IPC分类号： G06F19/00 , G06N3/12
CPC分类号： C12N15/1089 , C12N15/1058 , C40B50/02 , G06F19/24 , G06F19/707 , G06N3/126
摘要： The disclosure relates to a method of generating a diverse set of variants to screen improved and novel properties within the variant population, a system for creating the diverse set of variants, and the variant peptides.
摘要翻译：本公开涉及一种产生不同组的变体以筛选变体群体内的改进和新颖性质的方法，用于产生不同变体组的系统和变体肽。

4. 发明申请

WO2009102899A1 METHOD OF GENERATING AN OPTIMIZED DIVERSE POPULATION OF VARIANTS 审中-公开
标题翻译：生成优化人口多样性变化的方法
公开(公告)号：WO2009102899A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/033969
申请日：2009-02-12
申请人： CODEXIS, INC. , FOX, Richard
发明人： FOX, Richard
IPC分类号： G06F19/00 , G06N3/12
CPC分类号： C40B50/02 , G06F19/24 , G06N3/126
摘要： The present disclosure relates to methods of rapidly and efficiently searching biologically-related data space to identify a population set maximally diverse and optimized for sets of desired properties. More specifically, the disclosure provides methods of identifying a diverse, evolutionary separated bio-molecules with desired properties from complex bio-molecule libraries. The disclosure additionally provides digital systems and software for performing these methods.
摘要翻译：本公开涉及快速有效地搜索生物相关数据空间的方法，以识别针对所需属性的集合最大程度地多样化和优化的群体集合。更具体地，本公开提供了鉴定来自复杂生物分子文库的具有所需性质的多种，进化分离的生物分子的方法。本公开另外提供用于执行这些方法的数字系统和软件。

5. 发明申请

WO2011035105A1 REDUCED CODON MUTAGENESIS 审中-公开
标题翻译：减少CODON MUTAGENESIS
公开(公告)号：WO2011035105A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049251
申请日：2010-09-17
申请人： CODEXIS, INC. , FOX, Richard , GIVER, Lorraine J. , HELD, Daniel , HATTENDORF, Douglas , CHOUDHARY, Trish
发明人： FOX, Richard , GIVER, Lorraine J. , HELD, Daniel , HATTENDORF, Douglas , CHOUDHARY, Trish
IPC分类号： C40B50/06 , C40B40/06 , C12P19/34
CPC分类号： C12N15/102 , C12N15/1027 , C40B40/06 , C40B50/06
摘要： Methods and compositions that reduce complexity of libraries of variant biological molecules, that reduce oversampling of these libraries during screening and that improve screening efficiency are provided. Sets of efficient degenerate codon sets are provided that efficiently encode all, or nearly all canonical amino acids. Degenerate oligonucleotides comprising these codons are provided, as are polynucleotide variants. Variant pooling strategies are used during library construction. Logical filtering is applied to select codon sites for mutagenesis, or to select amino acid sets to be incorporated at such sites. Methods for reducing non-optimal oversampling during screening are provided.
摘要翻译：提供了减少变体生物分子的文库的复杂性的方法和组合物，可以减少筛选过程中这些文库的过采样并提高筛选效率。提供了有效地编码所有或几乎所有规范氨基酸的有效简并密码子集的集合。提供了包含这些密码子的简并寡核苷酸，以及多核苷酸变体。图书馆建设期间采用变式汇总策略。应用逻辑过滤来选择用于诱变的密码子位点，或选择要在这些位点掺入的氨基酸组。提供了在筛选期间减少非最佳过采样的方法。

6. 发明申请

WO2005016386A1 IMPROVED THERAPEUTIC PROTOCOLS 审中-公开
标题翻译：改进的治疗方案
公开(公告)号：WO2005016386A1
公开(公告)日：2005-02-24
申请号：PCT/AU2004/001108
申请日：2004-08-19
申请人： MEDITECH RESEARCH LIMITED , BROWN, Tracey , BROWNLEE, Gary , FOX, Richard
发明人： BROWN, Tracey , BROWNLEE, Gary , FOX, Richard
IPC分类号： A61K47/36
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0019 , A61K31/00
摘要： The present invention relates generally to therapeutic protocols to ameliorate infection by pathogenic agents. More particularly, the present invention relates to the use of hyaluronan (HA) or any of its chemical derivatives in conjunction with an anti-pathogenic agent to reduce its toxic effects and/or to target the anti-pathogenic agent to an infected cell which expresses HA-binding proteins including HA receptors. Even more particularly, HA is administered in conjunction with an anti-pathogenic agent to facilitate the prolonged administration of the agent, while reducing its toxic side affects and/or to facilitate targeted delivery of the anti-pathogenic agent. Owing to the protective effects of HA, the dose of anti-pathogenic agent may be substantially higher than a generally accepted effective dose, which would other wise cause unacceptable side effects in the subject.
摘要翻译：本发明一般涉及改善病原体感染的治疗方案。更具体地说，本发明涉及透明质酸（HA）或其任何化学衍生物与抗病原体结合使用以降低其毒性作用和/或将抗病原体靶向感染细胞，其表达 HA结合蛋白包括HA受体。甚至更具体地，HA与抗病原剂联合施用以促进药剂的延长施用，同时减少其毒副作用和/或促进抗病原体的靶向递送。由于HA的保护作用，抗病原剂的剂量可能显着高于普遍接受的有效剂量，否则这将有助于造成受试者的不可接受的副作用。

7. 发明申请

WO2011084277A3 MACHINABLE THERMALLY INSULATING STYRENE - ACRYLONITRILE COPOLYMER FOAM 审中-公开
公开(公告)号：WO2011084277A3
公开(公告)日：2011-07-14
申请号：PCT/US2010/058630
申请日：2010-12-02
申请人： DOW GLOBAL TECHNOLOGIES LLC , FOX, Richard , FRANKOWSKI, David , SMITH, Roy , LEE, Simon
发明人： FOX, Richard , FRANKOWSKI, David , SMITH, Roy , LEE, Simon
IPC分类号： C08J9/14
摘要： Provide a foamable polymer composition containing: (i) a thermoplastic polymer matrix and a blowing agent, (a) the thermoplastic polymer matrix containing a styrene-acrylonitrile copolymer having a weight-averaged molecular weight in a range of 90,000 to 150,000 and polymerized acrylonitrile concentration in a range of five to twenty weight-percent relative to total polymer matrix weight; and (ii) a blowing agent containing water, 1,1,1,2-tetrafluouroethane and at least one of difluoromethane and 1,1-difluoroethane; (b) cooling the foamable polymer composition to a foaming temperature; and (c) extruding the foamable polymer composition and allowing the blowing agent to expand the foamable polymer composition into a polymeric foam having an average vertical cell size in a range of 0.5 millimeters to 1.8 millimeters and a density in a range of 24 to 40 kilograms per cubic meter and a Normalized Roughness Quotient of 3.5 or less in a Milled Surface Test.

8. 发明申请

WO2010062889A2 MOLD SYSTEM FOR PRODUCING OPHTHALMIC DEVICES 审中-公开
标题翻译：用于生产眼科装置的模具系统
公开(公告)号：WO2010062889A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/065688
申请日：2009-11-24
申请人： JOHNSON & JOHNSON VISION CARE, INC. , ANSELL, Scott , BARRE, Vincent , FOX, Richard , ANSEMS, Marc , VAES, Marnik
发明人： ANSELL, Scott , BARRE, Vincent , FOX, Richard , ANSEMS, Marc , VAES, Marnik
IPC分类号： B29D11/00
CPC分类号： B29D11/00009 , B29D11/0048
摘要： A molding system for forming ophthalmic devices includes at least one mold half having a base wherein the at least one mold half is configured to be engaged by an injection molding machine, at least one insert retainer, the at least one insert retainer being configured to receive a plurality of inserts wherein each of the inserts is configured to receive thermoplastic material for forming at least one lens curve wherein the at least one mold half is configured to receive the at least one insert retainer, and means for attaching the at least one insert retainer to the at least one mold half.
摘要翻译：用于形成眼科装置的模制系统包括至少一个具有底座的半模，其中所述至少一个半模配置成由注射成型机啮合，至少一个插入物保持器，所述at 至少一个插入物保持器被配置成接收多个插入物，其中每个插入物被配置为接收热塑性材料以形成至少一个透镜曲线，其中至少一个半模被配置为接收至少一个插入物保持器，用于将所述至少一个插入物保持器附接到所述至少一个半模。

9. 发明申请

WO2007146365A2 DECREASED LENS DELAMINATION DURING OPHTHALMIC LENS MANUFACTURE 审中-公开
标题翻译：在眼镜镜片制造期间减少镜片分类
公开(公告)号：WO2007146365A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013937
申请日：2007-06-14
申请人： JOHNSON & JOHNSON VISION CARE, INC. , ANSELL, Scott F. , FOX, Richard , STRONG, Michael J. , TOKARSKI, Jason , WALKER, Craig W. , YIN, Changhong , BERCKMILLER, Gregory
发明人： ANSELL, Scott F. , FOX, Richard , STRONG, Michael J. , TOKARSKI, Jason , WALKER, Craig W. , YIN, Changhong , BERCKMILLER, Gregory
CPC分类号： B29D11/00192
摘要： The present invention includes molds for forming ophtalmic lenses, such as contact lens. In particluar, the present invention relates to apparatus, molds and methods for fashioning an ophthalmic lens with a mold assembly that includes a two or more mold parts and an adhesion differential between a surface of each mold part in the lens forming area as the surface relates to the ophthalmic lens.
摘要翻译：本发明包括用于形成眼底透镜的模具，例如隐形眼镜。具体地说，本发明涉及一种具有模具组件来形成眼镜片的装置，模具和方法，所述模具组件包括两个或多个模具部件以及在所述透镜形成区域中的每个模具部件的表面之间的粘合差异到眼科镜片。

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