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1. 发明申请

WO2012167388A1 ENHANCED ENZYMATIC CO2 CAPTURE TECHNIQUES ACCORDING TO SOLUTION PKA, TEMPERATURE AND/OR ENZYME CHARACTER 审中-公开
标题翻译：根据解决方案PKA，温度和/或酶特性提高ENZYMATIC CO2捕获技术
公开(公告)号：WO2012167388A1
公开(公告)日：2012-12-13
申请号：PCT/CA2012/050393
申请日：2012-06-11
申请人： CO2 SOLUTIONS INC. , PENDERS, Nathalie J.M.C. , DERKS, Peter W.J. , VERSTEEG, Geert F. , MADORE, Eric , SHELDON, Roger , VOYER, Normand , FRADETTE, Sylvie , CARLEY, Jonathan , KELLY, Glenn R.
发明人： PENDERS, Nathalie J.M.C. , DERKS, Peter W.J. , VERSTEEG, Geert F. , MADORE, Eric , SHELDON, Roger , VOYER, Normand , FRADETTE, Sylvie , CARLEY, Jonathan , KELLY, Glenn R.
IPC分类号： B01D53/62 , B01D53/14 , B01D53/84
CPC分类号： B01D53/62 , B01D53/1475 , B01D53/1493 , B01D2252/20431 , B01D2252/20484 , B01D2252/20489 , B01D2252/602 , B01D2256/24 , B01D2258/025 , B01D2258/0283 , Y02A50/2342 , Y02C10/02 , Y02C10/04 , Y02C10/06
摘要： Techniques related to enhancement of CO 2 absorption use selection of an enzyme coordinated with selection of an absorption solution having a pKa to enhance or maximize the CO 2 capture rate. The techniques may use various relationships between process variables such as temperature, concentration, and so on, in order to provide efficient CO 2 capture.
摘要翻译：与增强CO2吸收有关的技术使用选择与选择具有pKa的吸收溶液相配合的酶以增强或最大化CO 2捕获率。这些技术可以使用诸如温度，浓度等的过程变量之间的各种关系，以便提供有效的CO 2捕获。

2. 发明申请

WO2014012181A1 METHOD FOR PREPARING SURFACE MODIFIED CARBONIC ANHYDRASE WITH ENHANCED ACTIVITY AND/OR STABILITY 审中-公开
标题翻译：用增强活性和/或稳定性制备表面改性碳纳米管的方法
公开(公告)号：WO2014012181A1
公开(公告)日：2014-01-23
申请号：PCT/CA2013/050552
申请日：2013-07-16
申请人： CO2 SOLUTIONS INC.
发明人： GINGRAS, Julie , MADORE, Eric , SIMARD, Mathieu , VOYER, Normand , KELLY, Glenn R.
IPC分类号： C12N9/96 , B01D53/62 , C12N9/88 , C12P3/00 , C12Q1/527
CPC分类号： B01D53/62 , B01D53/86 , B01D2255/804 , B01D2257/504 , C12N9/88 , C12N9/96 , C12P7/40 , C12Q1/527 , C12Y402/01001 , Y02C10/04 , Y02P20/152 , Y02P20/59
摘要： A method for obtaining surface modified carbonic anhydrases having improved activity and/or stability is provided. The method comprises modifying surface functional groups of a carbonic anhydrase having an initial surface charge by reaction with a reagent while varying a predetermined reaction parameter, whereby the reaction allows obtaining a set of modified carbonic anhydrases with respective surface charges different than the initial surface charge; testing the stability and/or activity of the modified carbonic anhydrases; and identifying modified carbonic anhydrases having improved stability and/or activity. The method may also 10 comprise surface modifying a plurality of different carbonic anhydrases in the presence of at least one reagent; testing the stability and/or activity of resulting modified carbonic anhydrases; and identifying the modified carbonic anhydrases having improved stability and/or activity. A surface modified carbonic anhydrase having improved stability and/or activity is also provided. The modified carbonic anhydrase is useful biocatalyst for CO 2 hydration or desorption.
摘要翻译：提供了获得具有改善的活性和/或稳定性的表面改性碳酸酐酶的方法。该方法包括通过与试剂反应来改变具有初始表面电荷的碳酸酐酶的表面官能团，同时改变预定的反应参数，由此反应允许获得一组具有不同于初始表面电荷的表面电荷的改性碳酸酐酶; 测试改性碳酸酐酶的稳定性和/或活性; 并鉴定具有改善的稳定性和/或活性的改性碳酸酐酶。该方法还可以包含在至少一种试剂存在下表面修饰多种不同的碳酸酐酶; 测试所得改性碳酸酐酶的稳定性和/或活性; 并鉴定具有改善的稳定性和/或活性的改性碳酸酐酶。还提供了具有改善的稳定性和/或活性的表面改性的碳酸酐酶。改性碳酸酐酶是用于CO 2水合或解吸的生物催化剂。

3. 发明申请

WO2013106932A1 INTEGRATED PROCESS FOR DUAL BIOCATALYTIC CONVERSION OF CO2 GAS INTO BIO-PRODUCTS BY ENZYME ENHANCED HYDRATION AND BIOLOGICAL CULTURE 审中-公开
标题翻译：通过酶增强水化和生物文化将二氧化碳气体转化为生物产物的双重生物转化的综合方法
公开(公告)号：WO2013106932A1
公开(公告)日：2013-07-25
申请号：PCT/CA2013/050029
申请日：2013-01-17
申请人： CO2 SOLUTIONS INC.
发明人： FRADETTE, Sylvie , GUIMOND, Chantal , MADORE, Eric , KELLY, Glenn R. , CARLEY, Jonathan A. , VERSTEEG, Geert F.
IPC分类号： C12P1/00 , B01D53/62 , B01D53/86 , C12M1/00 , C12M1/04 , C12N1/12 , C12P3/00 , C12P7/46
CPC分类号： C12P3/00 , B01D53/62 , B01D53/73 , B01D2257/504 , B01D2258/0283 , C10L1/02 , C12M21/02 , C12M23/58 , C12M29/26 , C12M43/04 , C12N1/12 , C12N9/88 , C12P7/02 , C12P7/06 , C12P7/6463 , C12P7/649 , C12Y402/01001 , Y02C10/04 , Y02E50/13 , Y02E50/17 , Y02P20/125 , Y02P20/152 , Y02P20/59
摘要： A method, process, apparatus, use and formulation for dual biocatalytic conversion of CO 2 containing gas into carbon containing bio-products by enzymatic hydration of CO 2 into bicarbonate ions in the presence of carbonic anhydrase and metabolic conversion of the bicarbonate ions into carbon containing bio-products in a biological culture. The dual biocatalytic conversion may be relatively constant with controlling a feeding of the bicarbonate ions to the biological culture in accordance with demands of the biological culture by retaining over-production of bicarbonate ions and feeding part of the over-production to the biological culture in accordance with nutrient demands of the biological culture. Bicarbonate ions may also be reconverted to generate a pure CO 2 gas stream. The CO 2 containing gas may be derived from operations of a power plant which receives a carbon-containing fuel for combustion, and the biological culture may be an algae culture.
摘要翻译：通过在碳酸酐酶存在下将CO 2水解成碳酸氢根离子并将碳酸氢根离子代谢转化成含碳生物产物的方法，方法，装置，用途和配方用于将含CO 2的气体双重生物催化转化为含碳生物产物，产品在生物文化中。双重生物催化转化可以相对恒定，通过根据生物培养物的需要控制碳酸氢根离子进入生物培养物，通过保留过量生产碳酸氢根离子并将部分过量生产加入到生物培养物中具有生物培养的营养需求。碳酸氢根离子也可以被再转化以产生纯的CO 2气流。含二氧化碳的气体可以来自接收用于燃烧的含碳燃料的发电厂的操作，并且生物培养物可以是藻类培养物。

4. 发明申请

WO2009062309A1 METHODS FOR THE REGULATION OF THE PROSTAGLANDIN F SYNTHASE (PGFS) ACTIVITY OF AKR1B1 AND USES THEREOF 审中-公开
标题翻译： AKR1B1的前列腺素F合成酶（PGFS）活性的调控方法及其用途
公开(公告)号：WO2009062309A1
公开(公告)日：2009-05-22
申请号：PCT/CA2008/002012
申请日：2008-11-14
申请人： UNIVERSITE LAVAL , FORTIER, Michel , CHAPDELAINE, Pierre , BRESSON, Eva , MADORE, Eric
发明人： FORTIER, Michel , CHAPDELAINE, Pierre , BRESSON, Eva , MADORE, Eric
IPC分类号： C12N5/10 , A61K31/713 , A61K39/395 , A61K48/00 , C12N5/08 , C12Q1/02 , C12Q1/32 , G01N33/573 , C12N9/02 , C12N9/99
CPC分类号： A61K31/517 , A61K31/197 , A61K31/4188 , A61K31/426 , A61K31/501 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2503/02 , C12Q1/26 , C12Y101/01188 , G01N33/88 , G01N2333/902 , G01N2500/10 , G01N2800/52
摘要： AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH 2 into PGF 2α . AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF 2α are also provided.
摘要翻译： AKR1B1（EC 1.1.1.21）是一种主要与多元醇途径相关的醛糖还原酶，最近是脂质脱氧化。我们已经发现，该酶的主要活性是PGFS活性，催化PGH2转化成PGF2a。提供AKR1B1作为治疗靶标，以及调节其表达和活性的方法。还提供了调节PGF2a表达和活性的方法。

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