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1. 发明申请

WO2009103788A1 COMPOSITIONS COMPRISING PHYTOESTROGENS SELECTIVE FOR ESTROGEN BETA RECEPTOR AND DIETARY FIBRES 审中-公开
标题翻译：包含雌激素受体和食物纤维选择性植物诱导物的组合物
公开(公告)号：WO2009103788A1
公开(公告)日：2009-08-27
申请号：PCT/EP2009/052038
申请日：2009-02-20
申请人： CM & D PHARMA LIMITED , DI LEO, Alfredo , BARONE, Michele
发明人： DI LEO, Alfredo , BARONE, Michele
IPC分类号： A61K31/357 , A61K31/352 , A61K31/05 , A61K31/716 , A61K45/06 , A61P1/00 , A61P35/00
CPC分类号： A61K47/42 , A61K31/05 , A61K31/352 , A61K31/357 , A61K31/716 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： Oral compositions comprising an association of one or of a mixture of phytoestrogens, selective for the estrogen receptor-β, with dietary fibres are described. The compositions thereof can be profitably used for the prophylactic and therapeutic treatment in mammals, including humans, of health conditions characterised by a high risk of onset and recurrence of intestinal adenomas (adenopolyposis coli), and of adenoma's progression to colorectal carcinoma. In presence of pre-cancerous lesions in the colon, characterised by mutations of the APC tumor suppressor and defined as polyps or adenomas, the oral compositions disclosed can be in fact profitably used to reduce the number and volume of polyps, and to prevent their progression to neoplastic transformation, reducing their degree of dysplasia.
摘要翻译：描述了包含与雌激素受体-β选择性的植物雌激素的一种或一种混合物与膳食纤维的缔合的口腔组合物。其组合物可以有利地用于哺乳动物（包括人）在由肠道腺瘤（腺病毒大肠杆菌）发病和复发的高风险以及腺瘤进展为结肠直肠癌的特征的健康状况中的预防和治疗性治疗。在结肠癌前病变的存在下，其特征在于APC肿瘤抑制因子的突变并被定义为息肉或腺瘤，所公开的口腔组合物实际上可以有利地用于减少息肉的数量和体积并防止其进展进行肿瘤转化，减少其发育不良程度。

2. 发明申请

WO2012077139A8 METHOD FOR THE DIAGNOSIS OF A CARCINOMA AND USES THEREOF 审中-公开
公开(公告)号：WO2012077139A8
公开(公告)日：2012-06-14
申请号：PCT/IT2010/000484
申请日：2010-12-06
申请人： THD S.p.A. , BASTIA Filippo , ALTOMARE, Donato , DI LEO, Alfredo , ROTELLI, Maria Teresa , BARONE, Michele
发明人： BASTIA Filippo , ALTOMARE, Donato , DI LEO, Alfredo , ROTELLI, Maria Teresa , BARONE, Michele
IPC分类号： G01N33/50 , G01N33/574
摘要： The present invention relates to a method for diagnosing a carcinoma or a residual disease associated thereto, or for the prognosis of a carcinoma, or for monitoring the effectiveness of an anti-tumour therapy directed against a carcinoma, or for monitoring the follow-up of an individual affected by a carcinoma, in particular colorectal carcinoma, carcinoma of the stomach, mammary carcinoma, pulmonary carcinoma or carcinoma of the prostate, carcinoma of the liver, carcinoma of the ovary, carcinoma of the kidney, carcinoma of the thyroid, carcinoma of the bladder or carcinoma of the pancreas. The method of the invention consists in placing adult stem cells in contact with a sample of a haemo-derivative of the individual to be analysed and in verifying the expression of at least an epithelial marker in the stem cells by means of immunofluorescence, immunohistochemistry, ELISA or RT-PCR.

3. 发明申请

WO2009065952A1 PANEL SECURING CLIP 审中-公开
标题翻译：面板安全夹
公开(公告)号：WO2009065952A1
公开(公告)日：2009-05-28
申请号：PCT/EP2008/066041
申请日：2008-11-21
申请人： PILKINGTON ITALIA S.p.A. , PILKINGTON AUTOMOTIVE DEUTSCHLAND GmbH , SENGE, Christoph , BARONE, Michele
发明人： SENGE, Christoph , BARONE, Michele
IPC分类号： B60J1/00 , B62D65/06 , F16B5/06 , B62D27/00
CPC分类号： F16B5/065 , B60J1/006 , F16B2/10
摘要： A panel (24) intended for mounting within a vehicle having a panel securing clip (21) mounted thereon is disclosed. The panel mounted clip is intended to secure the panel to a frame (27). Preferably the panel (24) is a vehicle glazing, and the frame surrounds an aperture in a vehicle into which the glazing will be secured. The panel securing clip (21) comprises a base portion (22); a securing portion (28), joined to the base portion and adapted to be inserted into a hole (29) in a frame, and locking means (37) for holding the securing portion (28) in fixed relation to the base portion (22). The securing portion (28) is moveable between a first position, in which the panel securing clip (21) may be inserted into a frame, and a second position, where the securing portion is held in fixed relation to the base portion, and the panel securing clip-secures the panel to the frame. A method of inserting a panel into a frame is also disclosed.
摘要翻译：公开了一种用于安装在具有安装在其上的面板固定夹（21）的车辆中的面板（24）。面板安装的夹子旨在将面板固定到框架（27）上。优选地，面板（24）是车辆玻璃窗，并且框架围绕车辆中的窗口，玻璃窗将被固定到该孔中。面板固定夹（21）包括基部（22）; 固定部分（28），其连接到所述基部并且适于插入框架中的孔（29）中;以及锁定装置（37），用于将所述固定部分（28）固定在所述基部（22）上）。固定部分（28）能够在面板固定夹（21）可插入框架中的第一位置和第二位置之间移动，其中固定部分固定在基座部分上，面板固定夹将面板固定在框架上。还公开了将面板插入框架中的方法。

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