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1. 发明申请

WO2012077139A1 METHOD FOR THE DIAGNOSIS OF A CARCINOMA AND USES THEREOF 审中-公开
标题翻译：癌的诊断方法及其用途
公开(公告)号：WO2012077139A1
公开(公告)日：2012-06-14
申请号：PCT/IT2010000484
申请日：2010-12-06
申请人： THD SPA , BASTIA FILIPPO , ALTOMARE DONATO , DI LEO ALFREDO , ROTELLI MARIA TERESA , BARONE MICHELE
发明人： BASTIA FILIPPO , ALTOMARE DONATO , DI LEO ALFREDO , ROTELLI MARIA TERESA , BARONE MICHELE
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/5073 , G01N33/57419 , G01N33/57484 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to a method for diagnosing a carcinoma or a residual disease associated thereto, or for the prognosis of a carcinoma, or for monitoring the effectiveness of an anti-tumour therapy directed against a carcinoma, or for monitoring the follow-up of an individual affected by a carcinoma, in particular colorectal carcinoma, carcinoma of the stomach, mammary carcinoma, pulmonary carcinoma or carcinoma of the prostate, carcinoma of the liver, carcinoma of the ovary, carcinoma of the kidney, carcinoma of the thyroid, carcinoma of the bladder or carcinoma of the pancreas. The method of the invention consists in placing adult stem cells in contact with a sample of a haemo-derivative of the individual to be analysed and in verifying the expression of at least an epithelial marker in the stem cells by means of immunofluorescence, immunohistochemistry, ELISA or RT-PCR.
摘要翻译：本发明涉及用于诊断与其相关的癌症或残余疾病或用于癌症预后的方法，或用于监测针对癌症的抗肿瘤疗法的有效性或用于监测受癌症影响的个体，特别是结肠直肠癌，胃癌，乳腺癌，肺癌或前列腺癌，肝癌，卵巢癌，肾癌，甲状腺癌，癌膀胱或胰腺癌。本发明的方法在于将成体干细胞与待分析个体的血红素衍生物样品接触，并通过免疫荧光，免疫组织化学，ELISA法验证干细胞中至少上皮标志物的表达或RT-PCR。

2. 发明申请

WO2010041280A1 A DEVICE FOR SURGICAL OPERATIONS ON A PROLAPSE 审中-公开
标题翻译：一种手术手术的手段
公开(公告)号：WO2010041280A1
公开(公告)日：2010-04-15
申请号：PCT/IT2008/000633
申请日：2008-10-06
申请人： THD SPA , BASTIA, Filippo
发明人： BASTIA, Filippo
IPC分类号： A61B1/31 , A61B1/303
CPC分类号： A61B1/31 , A61B17/02
摘要： A device for surgical operations on a prolapse, comprising a hollow stretcher body (2) having a prevalent development direction along a longitudinal axis (A) and being insertable in an orifice, the stretcher body (2) exhibiting a through-window (7), defining an area of intervention and realising a communication between an internal cavity (3) of the stretcher body (2) and a portion of a prolapse, a mobile wall (8) defining the through-window (7) in combination with the stretcher body (2) and being slidably associated to the stretcher body (2) in order to open and/or close the through-window (7) between a configuration of minimum extension and a configuration of maximum extension of the through-window (7); characterised in that it comprises means for blocking (10) which act between the mobile wall (8) and the stretcher body (2) in order to maintain the through- window (7) stably in the configuration of minimum extension during insertion of the stretcher body (2).
摘要翻译：一种用于在脱垂时进行外科手术的装置，包括具有沿着纵向轴线（A）的普遍显影方向并且可插入到孔中的中空拉伸器主体（2），所述展开器主体（2）呈现通孔（7），限定一个介入区域，并实现了拉伸器本体（2）的内腔（3）与脱垂部分之间的连通，以及限定通孔（7）的移动壁（8）与拉伸器主体（2）并且可滑动地关联到担架主体（2），以便在通孔（7）的最小延伸部分和最大延伸部分的构造之间打开和/或关闭通过窗口（7） ; 其特征在于，其包括用于阻挡（10）在所述可移动壁（8）和所述担架体（2）之间作用的装置，以便在所述担架插入期间将所述通孔（7）稳定地保持在最小延伸的构型身体（2）。

3. 发明申请

WO2007094016A1 A PROCESS AND A DEVICE FOR SURGICAL TREATMENT OF RECTAL AND HAEMORRHOIDAL PROLAPSE 审中-公开
标题翻译：一种手术和手术治疗的手术和手术治疗手段
公开(公告)号：WO2007094016A1
公开(公告)日：2007-08-23
申请号：PCT/IT2006/000074
申请日：2006-02-14
申请人： METECH S.R.L. , BASTIA, Filippo , DAL MONTE, Pier, Paolo
发明人： BASTIA, Filippo , DAL MONTE, Pier, Paolo
IPC分类号： A61B1/31 , A61B17/00
CPC分类号： A61B17/0206 , A61B1/31 , A61B5/489 , A61B2017/3452
摘要： A process for surgical operations on a rectal/haemorrhoidal prolapse comprises stages of realising, in the anal canal, at least a first circular stitching at a first portion of a haemorrhoidal prolapse; realising at least a second circular stitching in a second portion of the haemorrhoidal prolapse, and nearing the first circular stitching and the second circular stitching in order to create a constriction of the haemorrhoidal prolapse. The invention also relates to a device, preferably for actuating the process, which comprises a hollow divaricator (17) having a prevalent development direction along a longitudinal axis (Z) and being insertable in a patient's anal orifice. The device further exhibits a window (29) defining an operational area and creating a communication between a cavity (17b) internal of the divaricator (17) and a portion of haemorrhoidal prolapse. The device further comprises means for opening and closing (31) the window (29).
摘要翻译：在直肠/痔疮脱垂的外科手术过程包括在肛管中实现在痔疮脱垂的第一部分处的至少第一圆形缝合的阶段; 在痔疮脱垂的第二部分中实现至少第二圆形缝合，并且靠近第一圆形缝合和第二圆形缝合以便产生痔疮脱垂的收缩。本发明还涉及一种优选用于致动该过程的装置，该装置包括具有沿着纵向轴线（Z）的普遍显影方向并且可插入到患者肛门口中的中空分裂器（17）。该装置还具有限定操作区域并且在分裂器（17）内部的空腔（17b）和痔疮脱垂部分之间形成连通的窗口（29）。该装置还包括用于打开和关闭（31）窗（29）的装置。

4. 发明申请

WO2012077139A8 METHOD FOR THE DIAGNOSIS OF A CARCINOMA AND USES THEREOF 审中-公开
公开(公告)号：WO2012077139A8
公开(公告)日：2012-06-14
申请号：PCT/IT2010/000484
申请日：2010-12-06
申请人： THD S.p.A. , BASTIA Filippo , ALTOMARE, Donato , DI LEO, Alfredo , ROTELLI, Maria Teresa , BARONE, Michele
发明人： BASTIA Filippo , ALTOMARE, Donato , DI LEO, Alfredo , ROTELLI, Maria Teresa , BARONE, Michele
IPC分类号： G01N33/50 , G01N33/574
摘要： The present invention relates to a method for diagnosing a carcinoma or a residual disease associated thereto, or for the prognosis of a carcinoma, or for monitoring the effectiveness of an anti-tumour therapy directed against a carcinoma, or for monitoring the follow-up of an individual affected by a carcinoma, in particular colorectal carcinoma, carcinoma of the stomach, mammary carcinoma, pulmonary carcinoma or carcinoma of the prostate, carcinoma of the liver, carcinoma of the ovary, carcinoma of the kidney, carcinoma of the thyroid, carcinoma of the bladder or carcinoma of the pancreas. The method of the invention consists in placing adult stem cells in contact with a sample of a haemo-derivative of the individual to be analysed and in verifying the expression of at least an epithelial marker in the stem cells by means of immunofluorescence, immunohistochemistry, ELISA or RT-PCR.

5. 发明申请

WO2008035384A1 A DEVICE FOR EXAMINIG AND SURGICALLY OPERATING ON BODY CAVITIES, IN PARTICULAR THE ANAL AND VAGINAL CAVITIES 审中-公开
标题翻译：用于检查和手术操作身体机构的装置，特别是大脑和阴道
公开(公告)号：WO2008035384A1
公开(公告)日：2008-03-27
申请号：PCT/IT2006/000674
申请日：2006-09-21
申请人： METECH SRL , BASTIA, Filippo , DAL MONTE, Pier Paolo
发明人： BASTIA, Filippo , DAL MONTE, Pier Paolo
IPC分类号： A61B1/32
CPC分类号： A61B17/0218 , A61B1/303 , A61B1/31 , A61B1/32
摘要： The device for examining and surgically operating on body cavities, in particular the anal and vaginal cavities, comprises an elongate hollow body (2) exhibiting an insertion portion (3) for at least a partial insertion of the device (1) internally of the cavity and an open portion (4), through which the doctor or surgeon can operate. The hollow body (2) exhibits a longitudinal window (5) through which the pathological site of interest on the cavity wall can be isolated. Tthe hollow body (2) exhibits, along the longitudinal window, a transversal section constituted by a curved sector, ends of which extend in a substantially parallel directions which diverge in such a way as to stretch the affected portion of cavity without invading the viewing space and/or the manoeuvring space defined by the hollow body (2).
摘要翻译：用于在体腔，特别是肛门和阴道腔上进行检查和手术操作的装置包括细长的中空体（2），该中空体（2）具有插入部分（3），用于在腔体内至少部分地插入装置和开放部分（4），医生或外科医生可以通过该部分操作。中空体（2）具有纵向窗口（5），空洞壁上的感兴趣的病理部位可通过该窗口隔离。中空体（2）沿着纵向窗口显示由弯曲的扇形部分构成的横截面，其弯曲部分的端部沿基本上平行的方向延伸，该方向以扩张空腔的受影响部分而不会侵入观察空间和/或由中空体（2）限定的操纵空间。

6. 发明申请

WO2013114410A1 A COMPOSITION AND USE THEREOF IN THE TREATMENT OF ANAL RHAGADES 审中-公开
标题翻译：组合物及其在治疗恶性肿瘤中的应用
公开(公告)号：WO2013114410A1
公开(公告)日：2013-08-08
申请号：PCT/IT2012/000027
申请日：2012-01-30
申请人： THD S.p.A. , BASTIA, Filippo , SACCOMANNO, Maurizio
发明人： BASTIA, Filippo , SACCOMANNO, Maurizio
IPC分类号： A61K31/716 , A61K36/185 , A61K9/00
CPC分类号： A61K38/168 , A61K9/0031 , A61K31/716 , A61K36/185 , A61K38/011 , A61K47/10 , A61K47/36 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one protein extract of hibiscus and/or at least one beta glucan or a salt thereof. Furthermore, the present invention relates to the use of said composition for the treatment of anal rhagades.
摘要翻译：本发明涉及包含至少一种芙蓉蛋白提取物和/或至少一种β-葡聚糖或其盐的组合物。此外，本发明涉及所述组合物用于治疗肛门痛的用途。

7. 发明申请

WO2010103434A1 A DEVICE FOR STRETCHING AN ELASTIC RING 审中-公开
标题翻译：一种用于拉伸弹性环的装置
公开(公告)号：WO2010103434A1
公开(公告)日：2010-09-16
申请号：PCT/IB2010/050932
申请日：2010-03-04
申请人： THD S.P.A. , BASTIA, Filippo
发明人： BASTIA, Filippo
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12009 , A61B2017/0053 , A61B2017/12018
摘要： A device for stretching a plastic ring which comprises pushing means (2) and a loading body (5) which are reciprocally slidable across a plurality of ribs (4) solidly constrained to the pushing means (2), and a plurality of grooves (6) afforded on the loading body (5). The loading body (5) exhibits a first substantially conical portion (7) exhibiting a base (7a), having an external diameter (D) and an apex (7b). The loading body (5) further comprises a second portion (8), contiguous to the first conical portion (7) and exhibiting a proximal end (8a) and a distal end (8b).
摘要翻译：一种用于拉伸塑料环的装置，包括推动装置（2）和装载体（5），所述推动装置（2）和装载体（5）能够穿过固定地限制在推动装置（2）上的多个肋（4）往复滑动;以及多个凹槽）提供在装载体（5）上。装载体（5）具有呈现出具有外径（D）和顶点（7b）的基部（7a）的第一基本圆锥形部分（7）。装载体（5）还包括与第一圆锥形部分（7）邻接且呈现近端（8a）和远端（8b）的第二部分（8）。

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