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1. 发明申请

WO2012170331A4 CATHETER ASSEMBLY 审中-公开
标题翻译：导管总成
公开(公告)号：WO2012170331A4
公开(公告)日：2013-02-21
申请号：PCT/US2012040684
申请日：2012-06-04
申请人： CLEVELAND CLINIC FOUNDATION , PARKER HANNIFIN CORP , VOGELBAUM MICHAEL A , CHEN JI-FENG , GAO SHENGQIANG , COLLINSON MICHAEL , GUTHRIE ROBERT B
发明人： VOGELBAUM MICHAEL A , CHEN JI-FENG , GAO SHENGQIANG , COLLINSON MICHAEL , GUTHRIE ROBERT B
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/0102 , A61M25/003 , A61M25/0054 , A61M25/0082 , A61M25/1002 , A61M2025/0024 , A61M2025/0039 , A61M2025/0057 , A61M2025/0096 , A61M2025/0175 , A61M2025/105 , A61M2025/1086 , A61M2025/1093 , A61M2210/0693
摘要： A catheter assembly comprises a first catheter including, a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter. A first portion of the wall of the first catheter is made of a relatively low durometer elastomeric material and is relatively extensible. A second portion of the wall is formed of a relatively high durometer elastomeric material, and is relatively inextensible.
摘要翻译：导管组件包括第一导管，其包括具有至少部分限定内腔的内表面的壁。第二导管连接到第一导管的壁并设置在壁的内表面的外侧。第二导管至少部分被第一导管的鞘部覆盖。第一导管的壁的第一部分由较低硬度的弹性体材料制成并且是相对可延伸的。壁的第二部分由相对高的硬度弹性体材料形成，并且是相对不可延展的。

2. 发明申请

WO2013009614A3 SYSTEM FOR WOUND HEALING 审中-公开
标题翻译：创伤治疗系统
公开(公告)号：WO2013009614A3
公开(公告)日：2014-01-09
申请号：PCT/US2012045743
申请日：2012-07-06
申请人： CLEVELAND CLINIC FOUNDATION , PAPAY FRANCIS A , CHEN JI-FENG , GAO SHENGQIANG
发明人： PAPAY FRANCIS A , CHEN JI-FENG , GAO SHENGQIANG
IPC分类号： A61N1/04 , A61M1/00 , A61M35/00 , A61N1/30 , A61N1/32
CPC分类号： A61N1/0468 , A61F13/00068 , A61F13/0216 , A61M1/0084 , A61M1/0088 , A61M35/00 , A61M2202/0208 , A61M2205/054 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/303 , A61N1/32 , A61N1/325
摘要： A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.
摘要翻译：提供一种用于治愈伤口的系统。该系统包括柔性体，治疗剂递送机构，抽吸机构和电源。柔性体包括具有相对设置的限定隔室的第一和第二表面的覆盖膜。隔室包括第一多孔材料，第二多孔材料和设置在其中的至少一个电极。第二多孔材料设置在第一多孔材料和至少一个电极之间。治疗剂输送机构和吸引机构流体地连接到隔室。电源与至少一个电极电连通。

3. 发明申请

WO2011031733A3 APPARATUS AND METHOD FOR DELIVERING AN IMPLANTABLE MEDICAL DEVICE TO A DISEASED CARDIAC VALVE 审中-公开
标题翻译：将可植入医疗器械输送到疾病心脏瓣膜的装置和方法
公开(公告)号：WO2011031733A3
公开(公告)日：2011-06-23
申请号：PCT/US2010048094
申请日：2010-09-08
申请人： CLEVELAND CLINIC FOUNDATION , NAVIA JOSE L , CHEN JI-FENG , GAO SHENGQIANG , DAVIS BRIAN L , HORVATH DAVID J
发明人： NAVIA JOSE L , CHEN JI-FENG , GAO SHENGQIANG , DAVIS BRIAN L , HORVATH DAVID J
IPC分类号： A61M37/00 , A61B17/34 , A61F2/24 , A61M25/01
CPC分类号： A61F2/2466 , A61F2/2427 , A61F2/2445
摘要： An apparatus is provided for delivering an implantable medical device to a diseased cardiac valve includes an elongated shank, a brace member, and a locking mechanism. The shank has a first end portion, a second end portion, and a first longitudinal axis extending between the end portions. The first end portion includes a rotatable annular lower support and a fixing member. The lower support includes an annular ring having oppositely disposed upper and lower surfaces and a plane extending radially between the upper and lower surfaces. The brace member includes a barrel portion operably connected to a drive system. The barrel portion includes a first end portion, a second end portion, and a second longitudinal axis extending between the end portions. The drive system includes a housing operably connected to an actuating handle. The locking mechanism is operably connected to the housing and the elongated shank.
摘要翻译：提供了一种用于将可植入医疗装置递送到患病心脏瓣膜的装置，包括细长柄，支撑构件和锁定机构。柄具有第一端部，第二端部和在端部之间延伸的第一纵向轴线。第一端部包括可旋转的环形下支撑件和固定构件。下支撑件包括具有相对设置的上表面和下表面的环形环和在上表面和下表面之间径向延伸的平面。支撑构件包括可操作地连接到驱动系统的筒部。筒部包括第一端部，第二端部和在端部之间延伸的第二纵向轴线。驱动系统包括可操作地连接到致动手柄的壳体。锁定机构可操作地连接到壳体和细长柄部。

4. 发明申请

WO0012164A8 RIGID CLAMPABLE CANNULA 审中-公开
标题翻译：刚性钳夹
公开(公告)号：WO0012164A8
公开(公告)日：2001-02-22
申请号：PCT/US9919474
申请日：1999-08-26
申请人： CLEVELAND CLINIC FOUNDATION , CHEN JI FENG
发明人： CHEN JI-FENG
IPC分类号： A61B17/34 , A61M1/12 , A61M1/36 , A61M25/00 , A61M25/06
CPC分类号： A61M25/0662 , A61B17/3462 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/367 , A61M25/0045
摘要： A clamping cannula (10) comprises a generally rigid layer (12) having a first end (14), and a generally flexible tube (18) generally coaxial with the rigid layer. The flexible tube extends axially in a first direction beyond the first end. The cannula also has a generally rigid sleeve (22) movable between a cover position (Fig. 1), wherein the sleeve covers a first part of the flexible tube, and an uncovered position (Fig. 2), wherein the sleeve does not cover the first part of a flexible tube to enable clamping of the cannula.
摘要翻译：夹紧套管（10）包括具有第一端（14）的大体上刚性的层（12）和大体上与刚性层同轴的柔性管（18）。柔性管在第一方向上轴向延伸超过第一端。插管还具有可在盖位置（图1）之间移动的大致刚性的套筒（22），其中套筒覆盖柔性管的第一部分和未覆盖位置（图2），其中套筒不覆盖柔性管的第一部分，以能够夹持插管。

5. 发明申请

WO2004026124B1 APPARATUS FOR USE WITH AN INFLOW CANNULA 审中-公开
标题翻译：设备使用一个无袖的指南
公开(公告)号：WO2004026124B1
公开(公告)日：2004-08-19
申请号：PCT/US0331012
申请日：2003-09-23
申请人： CLEVELAND CLINIC FOUNDATION
发明人： MCCARTHY PATRICK M , CHEN JI-FENG
IPC分类号： A61M1/10 , A61M1/12 , A61M1/36 , A61M39/08 , A61N1/362
CPC分类号： A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M39/08
摘要： An apparatus (10) for use with an inflow cannula (12) of a ventricular assist device (VAD) (14). The cannula (12) has a first part (30) for connecting with a ventricle (22) of a heart (24) and a second part (32) for connecting with the VAD (14). The apparatus (10) comprises a flexible conduit (60) having oppositely disposed first and second ends (70 and 72) and a main body portion (68) intermediate the ends. The main body portion (68) is movable between a radially collapsed closed condition in which blood flow through the conduit (60) is blocked and a radially expanded open condition in which blood flow through the conduit is unrestricted. A first connector (64) connects the first end (70) of the conduit (60) to the first part (30) of the inflow cannula (12). A second connector (62 and 66) connects the second end (72) of the conduit (60) to the second part (32) of the inflow cannula (12). Several designs are disclosed for securing the connectors (64, 62, and 66) together to prevent relative movement of the ends (70, 72) away from each other.
摘要翻译：一种用于心室辅助装置（VAD）（14）的流入套管（12）的装置（10）。套管（12）具有用于与心脏（24）的心室（22）连接的第一部分（30）和用于与VAD（14）连接的第二部分（32）。装置（10）包括具有相对设置的第一和第二端部（70和72）的柔性导管（60）以及位于端部之间的主体部分（68）。主体部分（68）可在通过导管（60）的血液流动被阻断的径向折叠关闭状态与通过导管的血流不受限制的径向扩张打开状态之间移动。第一连接器（64）将导管（60）的第一端（70）连接到流入套管（12）的第一部分（30）。第二连接器（62和66）将导管（60）的第二端（72）连接到流入套管（12）的第二部分（32）。公开了用于将连接器（64,62和66）固定在一起以防止端部（70,72）彼此远离的相对移动的若干设计。

6. 发明申请

WO2011002996A3 APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE 审中-公开
标题翻译：装置和方法替代一种疾病的心脏瓣膜
公开(公告)号：WO2011002996A3
公开(公告)日：2011-06-30
申请号：PCT/US2010040786
申请日：2010-07-01
申请人： CLEVELAND CLINIC FOUNDATION
发明人： NAVIA JOSE L , CHEN JI-FENG , GAO SHENGQIANG , DAVIS BRIAN L , STUCKE SAMANTHA
IPC分类号： A61F2/24 , A61M29/00 , A61M29/02
CPC分类号： A61F2/243 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005
摘要： An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the main body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.
摘要翻译：用于更换患病心脏瓣膜的装置可从径向收缩的构型移动到径向扩张的构型。该装置包括可扩张的支撑构件和固定在其中的假体阀。主体部分在第一和第二端部之间延伸并且包括外圆周表面，围绕圆周表面延伸的周向轴线以及通过可扩张区域彼此间隔开的多个翼构件。每个翼构件包括第一和第二端部以及在端部之间延伸的柔性中间部分。第二端部与主体部一体形成。第一端部部分与周向轴线相邻并且在径向折叠构型中基本上与外圆周表面齐平。第一端部部分在径向膨胀的构造中基本上径向延伸到外周表面。

7. 发明申请

WO2010127041A4 APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE 审中-公开
标题翻译：装置和方法替代一种疾病的心脏瓣膜
公开(公告)号：WO2010127041A4
公开(公告)日：2011-02-17
申请号：PCT/US2010032844
申请日：2010-04-28
申请人： CLEVELAND CLINIC FOUNDATION
发明人： NAVIA JOSE LUIS , CHEN JI-FENG , ZHOU QUN
IPC分类号： A61F2/24 , A61B17/00 , A61B17/34
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/005 , A61F2220/0066 , A61F2230/0054 , A61F2230/0078 , A61F2250/006
摘要： An apparatus is provided for replacing a native cardiac valve. The native cardiac valve has at least one leaflet and is surrounded by a native cardiac valve annulus having superior and inferior aspects. The apparatus comprises a barbell -shaped, expandable anchoring member (42) including first (44), second (46), and main body (48) portions extending between the end portions. The main body portion includes a channel (50) defined by inner and outer surfaces. Each of the first and second end portions has a diameter greater than the diameter of the main body portion. The first and second end portions are sized to respectively contact the superior and inferior aspects of the native cardiac valve annulus when the expandable anchoring member is in an expanded configuration. The apparatus also includes an expandable support member (56) operably disposed within the main body portion of the expandable anchoring member, and a prosthetic cardiac valve secured within the expandable support member.
摘要翻译：提供一种用于替换原生心脏瓣膜的装置。天然心脏瓣膜具有至少一个小叶并被具有上下方面的天然心脏瓣膜环包围。该装置包括杠铃形的可膨胀锚定构件（42），其包括在端部之间延伸的第一（44），第二（46）和主体（48）部分。主体部分包括由内表面和外表面限定的通道（50）。第一和第二端部中的每一个具有大于主体部分的直径的直径。当可膨胀锚固构件处于膨胀构型时，第一和第二端部的尺寸分别接触天然心脏瓣膜环的上下方面。该装置还包括可操作地设置在可膨胀锚定构件的主体部分内的可膨胀支撑构件（56）和固定在可扩张支撑构件内的假体心脏瓣膜。

8. 发明申请

WO2004026124A3 APPARATUS FOR USE WITH AN INFLOW CANNULA 审中-公开
标题翻译：用于流鼻涕的装置
公开(公告)号：WO2004026124A3
公开(公告)日：2004-06-24
申请号：PCT/US0331012
申请日：2003-09-23
申请人： CLEVELAND CLINIC FOUNDATION
发明人： MCCARTHY PATRICK M , CHEN JI-FENG
IPC分类号： A61M1/10 , A61M1/12 , A61M1/36 , A61M39/08 , A61N1/362
CPC分类号： A61M1/10 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M39/08
摘要： An apparatus (10) for use with an inflow cannula (12) of a ventricular assist device (VAD) (14). The cannula (12) has a first part (30) for connecting with a ventricle (22) of a heart (24) and a second part (32) for connecting with the VAD (14). The apparatus (10) comprises a flexible conduit (60) having oppositely disposed first and second ends (70 and 72) and a main body portion (68) intermediate the ends. The main body portion (68) is movable between a radially collapsed closed condition in which blood flow through the conduit (60) is blocked and a radially expanded open condition in which blood flow through the conduit is unrestricted. A first connector (64) connects the first end (70) of the conduit (60) to the first part (30) of the inflow cannula (12). A second connector (62 and 66) connects the second end (72) of the conduit (60) to the second part (32) of the inflow cannula (12). Several designs are disclosed for securing the connectors (64, 62, and 66) together to prevent relative movement of the ends (70, 72) away from each other.
摘要翻译：一种与心室辅助装置（VAD）（14）的流入套管（12）一起使用的装置（10）。插管（12）具有用于与心脏（24）的心室（22）连接的第一部分（30）和用于与VAD（14）连接的第二部分（32）。装置（10）包括具有相对设置的第一和第二端（70和72）以及在端部之间的主体部分（68）的柔性导管（60）。主体部分（68）可在其中阻塞血管通过导管（60）的血液流动的径向收缩闭合状态和径向膨胀的打开状态之间移动，其中通过导管的血液流动是不受限制的。第一连接器（64）将导管（60）的第一端（70）连接到流入插管（12）的第一部分（30）。第二连接器（62和66）将导管（60）的第二端（72）连接到流入插管（12）的第二部分（32）。公开了若干设计用于将连接器（64,62和66）固定在一起以防止端部（70,72）彼此远离的相对运动。

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