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1. 发明申请

WO02059148A8 A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A8
公开(公告)日：2003-01-16
申请号：PCT/EP0200546
申请日：2002-01-21
申请人： CISTEM BIOTECHNOLOGIES GMBH , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: - providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - screening said at least one expression library with said antibody preparation, - identifying antigens which bind in said screening to antibodies in said antibody preparation, - screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and - optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.
摘要翻译：描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗其特征在于以下步骤： - 提供来自所述给定类型动物的血浆池或来自人血浆池或个体血清的抗体制剂，其具有抗所述特定病原体，肿瘤，变应原或组织或宿主的抗体易于自身免疫， - 提供至少一种易于自身免疫的所述特异性病原体，肿瘤，变应原或组织或宿主的表达文库， - 用所述抗体制剂筛选所述至少一种表达文库， - 鉴定结合于对所述抗体制剂中的抗体进行筛选， - 从具有抗体的个体的个体血清中筛选鉴别的抗原针对所述特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主， - 鉴定所述鉴定的抗原的超免疫血清反应性抗原部分，以及哪些超免疫血清反应性抗原与所述单个抗体制剂的相关部分结合所述个体血清和 - 任选地分离所述超免疫血清反应性抗原并通过化学或重组方法产生所述超免疫血清反应性抗原。

2. 发明申请

WO02059148A9 A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A9
公开(公告)日：2002-10-31
申请号：PCT/EP0200546
申请日：2002-01-21
申请人： CISTEM BIOTECHNOLOGIES GMBH , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: - providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - screening said at least one expression library with said antibody preparation, - identifying antigens which bind in said screening to antibodies in said antibody preparation, - screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and - optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.
摘要翻译：描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗其特征在于以下步骤： - 提供来自所述给定类型动物的血浆池或来自人血浆池或个体血清的抗体制剂，其具有抗所述特定病原体，肿瘤，变应原或组织或宿主的抗体易于自身免疫， - 提供至少一种易于自身免疫的所述特异性病原体，肿瘤，变应原或组织或宿主的表达文库， - 用所述抗体制剂筛选所述至少一种表达文库， - 鉴定结合于对所述抗体制剂中的抗体进行筛选， - 从具有抗体的个体的个体血清中筛选鉴别的抗原针对所述特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主， - 鉴定所述鉴定的抗原的超免疫血清反应性抗原部分，以及哪些超免疫血清反应性抗原与所述单个抗体制剂的相关部分结合所述个体血清和 - 任选地分离所述超免疫血清反应性抗原并通过化学或重组方法产生所述超免疫血清反应性抗原。

3. 发明申请

WO02059148A3 A METHOD FOR IDENTIFICATION, ISOLATION AND PRODUCTION OF ANTIGENS TO A SPECIFIC PATHOGEN 审中-公开
标题翻译：用于鉴定，分离和产生抗特异性病原体的方法
公开(公告)号：WO02059148A3
公开(公告)日：2003-07-31
申请号：PCT/EP0200546
申请日：2002-01-21
申请人： INTERCELL AG , MEINKE ANDREAS , NAGY ESZTER , AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
发明人： MEINKE ANDREAS , NAGY ESZTER , VON AHSEN UWE , KLADE CHRISTOPH , HENICS TAMAS , ZAUNER WOLFGANG , MINH DUC BUI , VYTVYTSKA ORESTA , ETZ HILDEGARD , DRYLA AGNIESZKA , WEICHHART THOMAS , HAFNER MARTIN , TEMPELMAIER BRIGITTE , FRASER CLAIRE M , GILL STEVEN
IPC分类号： G01N33/50 , A61K39/00 , A61K39/39 , A61K39/395 , A61P31/10 , B64C9/02 , C07K14/195 , C07K14/31 , C07K16/12 , C12N15/02 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53
CPC分类号： C40B40/02 , A61K39/00 , C07K14/195 , C07K14/31 , C07K16/1271 , C12N15/1037 , C12N15/1041 , C12Q1/6806 , C12Q2527/125 , C12Q2521/537
摘要： Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans.
摘要翻译：描述了用于鉴定，分离和产生来自特异性病原体，肿瘤，变应原或易于自身免疫的组织或宿主的超免疫血清反应性抗原的方法，所述抗原适用于给定类型动物的疫苗或人类。

4. 发明申请

WO2004013166A3 S. AUREUS ANTIGENE 审中-公开
标题翻译： S.Aureus抗原
公开(公告)号：WO2004013166A3
公开(公告)日：2004-04-08
申请号：PCT/EP0307955
申请日：2003-07-22
申请人： INTERCELL AG , AHSEN UWE , SOELLNER JOHANNES , WEICHHART THOMAS , HAFNER MARTIN
发明人： VON AHSEN UWE , SOELLNER JOHANNES , WEICHHART THOMAS , HAFNER MARTIN
IPC分类号： A61K39/00 , C07K14/31 , A61K39/085 , C07K14/195
CPC分类号： C07K14/31 , A61K39/00
摘要： Described are novel antigens from S. aureus selected from the group consisting of Seq.ID.Nos. 7 to 12, as well as their use in a pharmaceutical preparation, especially in a vaccine.
摘要翻译：描述了来自金黄色葡萄球菌的新型抗原，其选自Seq.ID.Nos。 7至12，以及它们在药物制剂中的用途，特别是在疫苗中的用途。

5. 发明申请

WO2012146778A3 METHOD FOR INDICATING A RENAL DISEASE IN A PATIENT BY DETERMINING AT LEAST ONE PROTEIN IN ISOLATED HDL 审中-公开
标题翻译：通过确定分离的HDL中的至少一种蛋白质来指示患者的肾病的方法
公开(公告)号：WO2012146778A3
公开(公告)日：2012-12-20
申请号：PCT/EP2012057892
申请日：2012-04-30
申请人： UNIV WIEN MED , WEICHHART THOMAS , SAEEMANN MARCUS
发明人： WEICHHART THOMAS , SAEEMANN MARCUS
IPC分类号： G01N33/92 , G01N33/68
CPC分类号： G01N33/92 , G01N33/6893 , G01N2800/347
摘要： The invention discloses a method for indicating a renal disease in a patient comprising the following steps: - providing a blood, serum or plasma sample from said patient, - isolating high density lipoprotein (HDL) from said sample to obtain isolated HDL, - determining the protein content of at least one protein of the following group of proteins in said isolated HDL: Surfactant protein B (SP-B), ApoC-II, Serum amyloid A, AMBP, ApoH, Serpin A12, Serotransferrin, Pigment epithelium- derived factor (PEDF), ADAM30 and Complement factor D, preferably at least one of SP-B, ApoC-II, Serum amyloid A and AMBP, especially SP-B, wherein a renal disease is indicated in said patient if the determined protein content of said at least one protein is elevated in said isolated HDL compared with a healthy subject.
摘要翻译：本发明公开了一种用于指示患者的肾脏疾病的方法，包括以下步骤： - 从所述患者提供血液，血清或血浆样品， - 从所述样品中分离高密度脂蛋白（HDL）以获得分离的HDL， - 确定所述分离的HDL中的至少一种蛋白质的蛋白质含量：表面活性剂蛋白B（SP-B），ApoC-II，血清淀粉样蛋白A，AMBP，ApoH，Serpin A12，血清转铁蛋白，颜料上皮衍生因子 PEDF），ADAM30和补体因子D，优选SP-B，ApoC-II，血清淀粉样蛋白A和AMBP，特别是SP-B中的至少一种，其中如果所述患者的所述确定的蛋白质含量与健康受试者相比，所述分离的HDL中至少一种蛋白质升高。

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