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1. 发明申请

WO2011079343A2 SUBSTITUTED PYRIDINES AND PYRIMIDINES 审中-公开
标题翻译：取代的吡啶和吡啶
公开(公告)号：WO2011079343A2
公开(公告)日：2011-07-07
申请号：PCT/AT2010000495
申请日：2010-12-28
申请人： UNIV WIEN TECH , UNIV WIEN MED , MIHOVILOVIC MARKO , SCHNUERCH MICHAEL , KOLEY MOUMITA , HILBER KARLHEINZ , KOENIG XAVER
发明人： MIHOVILOVIC MARKO , SCHNUERCH MICHAEL , KOLEY MOUMITA , HILBER KARLHEINZ , KOENIG XAVER
IPC分类号： C07D213/74
CPC分类号： C07D239/48 , C07D213/74 , C12N5/0657 , C12N2500/40
摘要： A process for the production of cardiomocyte-like cells from mammalian cells, comprising cultering mammalian cells in the presence of a compound of formula (I) wherein the radicals have various meanings, compounds of formula (I), wherein the radicals have various meanings and the pharmaceutical use of compounds of formula (I) for the production of cardiomyocyte-like cells from omnipotent, pluripotent or lineage committed mammalian cells and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.
摘要翻译：一种用于从哺乳动物细胞产生心肌细胞样细胞的方法，包括在式（I）化合物存在下对哺乳动物细胞进行切割，其中基团具有各种含义，式（I）化合物，其中基团具有各种含义，由式（I）化合物制备用于从全能，多能或谱系确定的哺乳动物细胞产生心肌细胞样细胞的药物用途，以及使用由此产生的心肌细胞样细胞来治疗与心脏受损功能相关的疾病。

2. 发明申请

WO2010043561A3 REGENERATIVE THERAPY 审中-公开
标题翻译：再生疗法
公开(公告)号：WO2010043561A3
公开(公告)日：2010-07-08
申请号：PCT/EP2009063167
申请日：2009-10-09
申请人： UNIV WIEN MED , BAER ALEXANDRA , KOTTER MARK
发明人： BAER ALEXANDRA , KOTTER MARK
IPC分类号： A61K31/4015 , A61K31/407 , A61K31/4409 , A61K31/551 , A61K31/7076 , A61K31/7105 , A61K39/395 , A61P25/00 , A61P25/02 , A61P25/28
CPC分类号： A61K31/4015 , A61K31/407 , A61K31/4409 , A61K31/551 , A61K31/7076 , A61K31/7105 , C07K16/18 , C07K16/2866 , C07K2317/74 , C07K2317/76
摘要： The present invention relates to the use of an agent capable of enhancing the PKA-p38-CREB pathway, suppressing the Fyn-RhoA-Rock and/or PKC-alpha-MARCKS pathways or Ephrin-B3 for the manufacture of a pharmaceutical composition for the treatment of damaged myelin sheaths, characterized in that, the agent neutralizes the effect of inhibitors of the regeneration of damaged myelin sheaths by oligodendrocytes, and wherein the inhibitors are selected from myelin associated inhibitors, in particular Ephrin-B3, and inhibitors of the glial scar, in particular Sema3A, and kits suitable for the treatment of damaged myelin sheaths.
摘要翻译：本发明涉及能够增强PKA-p38-CREB途径，抑制Fyn-RhoA-Rock和/或PKC-α-MARCKS途径或Ephrin-B3的试剂在制备用于治疗损伤的髓鞘，其特征在于，所述药剂中和少突胶质细胞再生受损髓鞘的抑制剂的作用，并且其中所述抑制剂选自髓鞘相关抑制剂，特别是Ephrin-B3，和胶质瘢痕抑制剂，特别是Sema3A，以及适用于治疗受损髓鞘的药盒。

3. 发明申请

WO2009062225A3 METHOD AND DEVICE FOR CARRYING OUT A PERCRESTALE SINUS LIFT 审中-公开
标题翻译：方法和装置用于实施PERCRESTALEN窦提升
公开(公告)号：WO2009062225A3
公开(公告)日：2010-05-20
申请号：PCT/AT2008000414
申请日：2008-11-14
申请人： UNIV WIEN MED , WATZEK GEORG , UNGER EWALD
发明人： WATZEK GEORG , UNGER EWALD
IPC分类号： A61C3/02 , A61B17/34 , A61C8/00
CPC分类号： A61C3/02 , A61B17/24 , A61B17/3472 , A61B17/8802 , A61B2017/320044 , A61B2017/3419 , A61B2017/3486 , A61B2017/3488 , A61C8/0089 , A61C8/0092
摘要： The invention relates to a method for carrying out a percrestale sinus lift, wherein a bore channel is created with the aid of a boring, milling and/or hammering method, the Schneider membrane is lifted from the jaw bone using a flowable medium that is supplied via the opened bore channel, bone replacement material is introduced, a supply line is introduced into the bore channel prior to introducing the flowable liquid and is sealingly fixed in a detachable manner to the bore channel or onto the edge thereof and the flowable medium in introduced through the supply line. The invention also relates to a surgical instrument (1) for introducing a flowable medium for lifting the Schneider membrane from the jaw bone whilst carrying out a percrestale sinus lift. Said instrument comprises a supply line that can be introduced into the bore channel and that has at least one sealing element for sealing and detachably fixing the supply line to the bore channel or to the edge thereof, a displaceable sleeve (4) on the supply line is guided in the axial direction in relation to the supply line and the sealing element (7) is arranged between a front surface of the sleeve (4) and a surface, preferably a ring surface (6), protruding in the radial direction from the supply line, and can be deformed by axially pressing the sleeve (4) in the radial direction and can be pressed counter to the inner wall of the bore channel (3).
摘要翻译：在用于执行percrestalen窦提升，其中设置有钻孔，铣削和/或冲击的方法的HiIfe钻孔和施奈德膜从使用通过插入可流动介质和骨移植物材料的开孔通道供给，是颌骨提升的方法供给可流动介质，供给管线到所述钻孔通道和密封在钻孔或在其边缘可释放地固定，该可流动的介质通过供应管线引入之前引入。当用于将可流动介质从在一percrestalen窦提升的实施颌骨，其中，所述器具是插入到具有至少一个密封元件的钻孔通道供应管线用于密封地和可释放地固定供应管在钻孔或提升施奈德膜的外科器械（1）有其周缘，相对于供给管套在轴向上的滑动（4）被引导在供给线和所述密封元件（7）的套管（4）的端面，并在从供给表面沿径向方向突出，特别是环形表面之间（6 ），以及通过轴向推压在抵靠钻孔通道（3）的内壁上的径向方向上和可变形的套筒（4）形成的按压布置。

4. 发明申请

WO2009004443A3 COMPOSITIONS FOR THE DETECTION OF GENE EXPRESSION IN DIABETIC MICROANGIOPATHY 审中-公开
标题翻译：用于检测糖尿病微血管病变中基因表达的组合物
公开(公告)号：WO2009004443A3
公开(公告)日：2009-03-12
申请号：PCT/IB2008001680
申请日：2008-06-27
申请人： UNIV WIEN MED , KERJASCHKI DONTSCHO , WICK NIKOLAUS , THURNER STEFAN
发明人： KERJASCHKI DONTSCHO , WICK NIKOLAUS , THURNER STEFAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridisable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition. The present invention further relates to a composition comprising a plurality of polynucleotide probes for use in research and diagnostic applications, in particular for the diagnosis of diabetic microangiopathy. The present invention also relates to novel bio-markers and sets thereof that are useful in the diagnosis and treatment of diabetic microangiopathy.
摘要翻译：本发明涉及包含多个多核苷酸探针的组合物。组合物可以用作微阵列中的可混合阵列元件。本发明还涉及用于选择该组合物的多核苷酸探针的方法。本发明还涉及包含用于研究和诊断应用的多个多核苷酸探针的组合物，特别是用于糖尿病性微血管病变的诊断。本发明还涉及可用于诊断和治疗糖尿病性微血管病变的新型生物标志物及其组合。

5. 发明申请

WO2013063629A8 DEVICE AND METHOD FOR TRIMMING THE TOP OF AN UPPER-JAW MODEL 审中-公开
标题翻译：装置和方法用于调整模型上颌TOP
公开(公告)号：WO2013063629A8
公开(公告)日：2013-07-11
申请号：PCT/AT2012000276
申请日：2012-10-31
申请人： UNIV WIEN MED
发明人： PITTSCHIELER ELISABETH , UNGER EWALD
IPC分类号： A61C13/00
CPC分类号： A61C13/0027
摘要： The invention relates to a device (1) and a method for trimming the top (3) of an upper-jaw model (2), with a mechanism (4) which consists of at least two elements (6) and is used to position the upper-jaw model (2) on the reference points of the HIP (hamulus-incisive papilla) plane, and with a mechanism (5) for fixing the upper-jaw model (2) in position in this HIP plane. To permit trimming of the top (3) of the upper-jaw model (2) parallel to the HIP plane, the at least two elements (6) of the positioning mechanism (4) and the fixing mechanism (5) are arranged in a retainer (7), such that the top (3) of the upper-jaw model (2) to be trimmed protrudes from the retainer (7) in the position in the HIP plane, and, furthermore, a guide platform (9) is provided which is oriented perpendicularly with respect to a grinding mechanism (8), and along which guide platform (9) the retainer (7) with the fixed upper-jaw model (2) is movable, in a manner secure against rotation, with respect to the grinding mechanism (8).
摘要翻译：本发明涉及一种装置（1）和用于调整上颌模型（2）的顶部（3）的方法，具有至少两个元件中的一个（6）现有装置（4），用于定位上颌模型（2）连接到HIP的基准点（钩-切牙乳突）面，以及装置（5）用于固定上颚模型（2）在此HIP-水平位置。为了允许微调顶部（3）的上颌模型的（2），所述至少两个元件（6）的定位装置（4）和所述固定装置（5）的保持器（7）平行于HIP平面，从而使至修整的上侧（3）的上颌模型（2）在HIP-水平位置从（七）延伸，并且还具有一个垂直于研磨装置（8）提供定向的引导平台（9）支撑，沿该导引平台（9）的保持器（7）到固定上颚模型（2）不能转动到研磨装置（8）是可移动的。

6. 发明申请

WO2012142286A8 METHODS FOR SUPPRESSING ALLERGIC REACTIONS 审中-公开
标题翻译：抑制过敏反应的方法
公开(公告)号：WO2012142286A8
公开(公告)日：2012-12-13
申请号：PCT/US2012033319
申请日：2012-04-12
申请人： UNIV CINCINNATI , U S DEPT OF VETERAN AFFAIRS , CINCINNATI CHILDREN S HOSPITAL MEDICAL CT , UNIV WIEN MED , FINKELMAN FRED D , KHODOUN MARAT V , KUCUK ZEYNEP YESIM , KRISHNMURTHY DURGA , STRAIT RICHARD T
发明人： FINKELMAN FRED D , KHODOUN MARAT V , KUCUK ZEYNEP YESIM , KRISHNMURTHY DURGA , STRAIT RICHARD T
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： C07K16/283 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/4291
摘要： Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid desensitization. Specific embodiments are herein provided for suppressing allergic reactions in a subject, including specific methods of providing a monoclonal antibody selected from the group consisting of anti-FcaRIa and anti-Fc?RIIb / RIII; administering the antibody to a subject at a dose that is lower than the level required to induce shock; and administering sequentially escalating doses of the monoclonal antibody so as to induce rapid desensitization to an allergen, thereby suppressing allergic reaction in the subject.
摘要翻译：提供了通过单克隆抗体应用抑制IgE和IgG介导的过敏反应的方法。更具体地，本文提供了用于快速脱敏的安全诱导的方法。本文提供了用于抑制受试者中的过敏反应的具体实施方案，包括提供选自抗FcaRIa和抗FcγRIIb/ RIII的单克隆抗体的特异性方法; 以低于诱导休克所需水平的剂量对受试者施用抗体; 并施用顺序递增剂量的单克隆抗体，以引起对变应原的快速脱敏，从而抑制受试者的过敏反应。

7. 发明申请

WO2007002973A3 USE OF STILBENE DERIVATIVES FOR THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF SOLID TUMOURS 审中-公开
标题翻译：芪的药品生产用于实体瘤的治疗
公开(公告)号：WO2007002973A3
公开(公告)日：2007-08-02
申请号：PCT/AT2006000283
申请日：2006-07-03
申请人： UNIV WIEN MED , WACHECK VOLKER , SZEKERES THOMAS
发明人： WACHECK VOLKER , SZEKERES THOMAS
IPC分类号： A61K31/05 , A61K31/085 , A61K31/09 , A61K31/4164 , A61P35/00
CPC分类号： A61K31/09 , A61K31/05 , A61K31/085 , A61K31/655 , A61K2300/00
摘要： The invention relates to the use of stilbene derivatives of general formula (I), for the production of medicaments for the treatment of solid tumours, such as melanomas, or stomach cancers. In addition to the anti-tumour activity of the single substance, furthermore, acceptable results can be achieved by means of the combination dosing of a DNA-intercalating substance such as dacarbazine with stilbene derivatives of formula (I).
摘要翻译：本发明涉及使用用于制备药物的固体肿瘤，如黑色素瘤或胃癌的治疗中，通式（I）的二苯乙烯衍生物。除了抗肿瘤活性作为当通式（I）的二苯乙烯衍生物结合有DNA的嵌入物给药，特别是达卡巴嗪进一步令人满意的结果是可以实现的单一剂。

8. 发明申请

WO2013186153A3 AMIDOPHENOXYPROPANOLAMINES 审中-公开
公开(公告)号：WO2013186153A3
公开(公告)日：2014-02-27
申请号：PCT/EP2013061880
申请日：2013-06-10
申请人： UNIV WIEN MED
发明人： GSTACH HUBERT , CHIBA PETER , MASTALIR MATTHIAS
IPC分类号： C07D211/14 , A61K31/166 , A61K31/396 , A61K31/445 , C07C235/46 , C07C235/60 , C07D229/02 , C07D295/088
CPC分类号： C07D295/088 , C07C235/60 , C07C235/64 , C07C235/66 , C07C237/28 , C07C2601/02 , C07C2601/18 , C07C2601/20 , C07C2603/74 , C07D211/14 , C07D211/18 , C07D229/02
摘要： The use of compounds of formula wherein R2, R3, R4, R5, R6 and R7 have several meanings, for the treatment of disorders mediated by protozoan organisms, novel compounds of the above formula and intermediates for the preparation of such compounds, pharmaceutical compositions comprising such novel compounds, a method of treating disorders mediated by protozoan organisms comprising administering such compounds, optionally together with a second drug substance, to a subject in need thereof and the use of such compounds, whenever comprising a photoaffinity label, for the identification of the molecular target(s) of arylamino alcohol antimalarials.
摘要翻译：使用其中R 2，R 3，R 4，R 5，R 6和R 7具有几个含义的化合物用于治疗由原生动物生物介导的病症，上式的新化合物和用于制备这些化合物的中间体，药物组合物包含这样的新化合物，一种治疗由原生动物生物介导的病症的方法，其包括向有需要的受试者施用任选与第二药物物质的这类化合物，以及每当包含光亲和标签时，使用这些化合物来鉴定芳基氨基醇抗疟药的分子靶标。

9. 发明申请

WO2013093045A3 CYCLOTIDES AS IMMUNOSUPPRESSIVE AGENTS 审中-公开
标题翻译： CYCLOTIDES作为免疫抑制剂
公开(公告)号：WO2013093045A3
公开(公告)日：2013-08-22
申请号：PCT/EP2012076739
申请日：2012-12-21
申请人： UNIV WIEN MED , UNIVERSITAETSKLINIKUM FREIBURG
发明人： GRUBER CHRISTIAN WERNER , GRUENDEMANN CARSTEN
IPC分类号： A61K38/12 , A61K38/16 , A61K38/56 , C07K14/415
CPC分类号： A61K38/168 , A61K38/12 , A61K38/16 , A61K45/06 , A61K51/08 , C07K14/00 , C07K14/415 , G01N33/5023
摘要： The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder; (ii) a hypersensitivity disorder; and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosupressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及包含用于免疫抑制的环核苷酸的药物组合物以及用于免疫抑制的方法，所述方法包括向有需要的受试者施用有效量的包含所述环核苷酸的药物组合物的步骤。本发明还涉及包含环肽的药物组合物，其用于治疗或预防选自以下的疾病：（i）自身免疫性疾病; （ii）过敏性疾病; 和（iii）淋巴细胞介导的炎症。同样地，本发明还涉及治疗或预防选自以下的病症的方法：（i）自身免疫病症; （ii）过敏性疾病; 和（iii）淋巴细胞介导的炎症。本发明进一步涉及筛选和/或选择导致具有诱导或增强的免疫抑制活性的突变环肽的免疫抑制性环核苷酸或突变的方法。本发明进一步涉及生产免疫抑制性环肽或免疫抑制药物组合物的方法。本发明进一步涉及具有免疫抑制活性的突变环肽和包含其的药物组合物。

10. 发明申请

WO2011050379A1 USE OF GSTP1 审中-公开
标题翻译：使用GSTP1
公开(公告)号：WO2011050379A1
公开(公告)日：2011-05-05
申请号：PCT/AT2010000408
申请日：2010-10-28
申请人： UNIV WIEN MED , AHARINEJAD SEYEDHOSSEIN
发明人： AHARINEJAD SEYEDHOSSEIN
IPC分类号： A61K38/45 , A61P9/04 , C12Q1/68 , G01N33/50
CPC分类号： A61K38/45 , C12Q1/6883 , C12Q2600/158 , G01N2333/91177 , G01N2800/325
摘要： The invention discloses the use of glutathione S-transferase P1 (GSTP1) for the prevention or treatment of cardiomyopathies or ischemic heart diseases and for the diagnosis thereof.
摘要翻译：本发明公开了谷胱甘肽S-转移酶P1（GSTP1）用于预防或治疗心肌病或缺血性心脏病及其诊断的用途。

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