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1. 发明申请

WO2008110456A3 METHOD OF TREATING CELLULOSIC MATERIALS WITH HYDROPHOBINS 审中-公开
公开(公告)号：WO2008110456A3
公开(公告)日：2008-09-18
申请号：PCT/EP2008/052333
申请日：2008-02-27
申请人： CIBA HOLDING INC. , GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
发明人： GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
IPC分类号： D21C5/00 , D21H17/22 , D06M15/15 , B27K3/34
摘要： By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.

2. 发明申请

WO2010060811A2 SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：表面活性蛋白作为固体药物制剂的优点
公开(公告)号：WO2010060811A2
公开(公告)日：2010-06-03
申请号：PCT/EP2009/065100
申请日：2009-11-13
申请人： BASF SE , BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , GABOR, Esther , MEURER, Guido , ECK, Jürgen , BRADLEY, Gordon
发明人： BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , GABOR, Esther , MEURER, Guido , ECK, Jürgen , BRADLEY, Gordon
IPC分类号： A61K9/20 , A61K9/28 , C07K14/37 , A61K9/00
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e. g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
摘要翻译：本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， G。作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。用于本发明目的的表面活性蛋白质可以从其各自的天然来源分离或通过重组技术制备并在合适的宿主中表达。

3. 发明申请

WO2011101457A1 CHIMERIC SURFACE ACTIVE PROTEINS 审中-公开
标题翻译： CHIMERIC表面活性蛋白
公开(公告)号：WO2011101457A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052470
申请日：2011-02-18
申请人： B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG , MEURER, Guido , GABOR, Esther , BACHERT, Anke , ECK, Jürgen
发明人： MEURER, Guido , GABOR, Esther , BACHERT, Anke , ECK, Jürgen
IPC分类号： C07K14/37 , A61K47/42 , C09D189/00
CPC分类号： C07K14/37 , A61K9/286 , A61K9/2873 , C09D189/00 , C12N15/62
摘要： The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invention furthermore relates to a method of coating and/or impregnating a material, comprising contacting the material with the chimeric protein or the composition of the invention.
摘要翻译：本发明涉及编码具有表面活性蛋白的生化活性的嵌合蛋白的核酸分子，其中所述嵌合蛋白包含：（a）第一表面活性蛋白的N末端部分，其中所述N末端部分没有成熟的第一表面活性蛋白的最多N末端氨基酸的0和10之间; 并且其C末端，（b）第二表面活性蛋白质的C末端部分，其中所述C末端部分缺少所述成熟第二表面活性蛋白质的最C末端氨基酸的0至10个。本发明还涉及载体，非人宿主和生产具有表面活性蛋白的生化活性的嵌合蛋白的方法。此外，本发明涉及由本发明的核酸分子编码的嵌合蛋白质和包含该嵌合蛋白质的组合物。嵌合蛋白质只能由上述（a）和（b）的核心组成，但也可以由核心的另外的组分，即（a）或（b）或另外一个完整的核心）（a）和（b）。本发明还涉及一种涂覆和/或浸渍材料的方法，包括使材料与本发明的嵌合蛋白或组合物接触。

4. 发明申请

WO2012172050A1 NEW MEANS AND METHODS FOR PRODUCING PROPANEDIOL 审中-公开
标题翻译：用于生产丙二醇的新手段和方法
公开(公告)号：WO2012172050A1
公开(公告)日：2012-12-20
申请号：PCT/EP2012/061449
申请日：2012-06-15
申请人： B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG , KOCH, Daniel , MEURER, Guido , ECK, Jürgen
发明人： KOCH, Daniel , MEURER, Guido , ECK, Jürgen
IPC分类号： C12P7/18 , C12P7/24 , C12N9/00 , C12N9/02 , C12N9/10 , C12N15/52 , C12N1/21
CPC分类号： C12P7/24 , C12N9/0006 , C12N9/0008 , C12N9/13 , C12P7/18 , C12Y101/01077 , C12Y102/01 , C12Y208/03001 , Y02P20/52
摘要： The present invention relates to a host cell having an elevated expression or activity of an enzyme as compared with the parent cell from which it has been derived, said enzyme having lactoyl-CoA reductase activity. Furthermore, provided is a method of producing lactaldehyde and/or 1,2-propanediol, said method comprising culturing said host cell and/or utilizing said enzyme to produce said compound.
摘要翻译：本发明涉及一种具有升高的酶表达或活性的宿主细胞，与其衍生的亲本细胞相比，所述酶具有乳酰基-CoA还原酶活性。此外，提供了生产乳醛和/或1,2-丙二醇的方法，所述方法包括培养所述宿主细胞和/或利用所述酶产生所述化合物。

5. 发明申请

WO2010012604A1 PRODUCTION METHOD 审中-公开
标题翻译：生产方法
公开(公告)号：WO2010012604A1
公开(公告)日：2010-02-04
申请号：PCT/EP2009/059132
申请日：2009-07-16
申请人： CLARIANT INTERNATIONAL LTD , MAMPEL, Jörg , MEURER, Guido , ECK, Jürgen
发明人： MAMPEL, Jörg , MEURER, Guido , ECK, Jürgen
IPC分类号： C12N1/20
CPC分类号： C12P7/18
摘要： The invention relates to the development of microorganisms that produce 1,2- propanediol (1,2-PD) from glycerol, whereas glycerol is simultaneously the substrate carbon source for 1,2-PD- and biomass production. The invention demonstrates that any type of glycerol serves as carbon substrate for 1,2-PD biosynthesis. The microorganism is a recombinant organism, preferentially an E. coli K12 strain or a derivative thereof, particularly a strain, which is inactivated in competing pathways that lower 1,2-PD production.
摘要翻译：本发明涉及从甘油生产1,2-丙二醇（1,2-PD）的微生物的开发，而甘油同时是用于1,2-PD和生物质生产的底物碳源。本发明证明任何类型的甘油都用作用于1,2-PD生物合成的碳底物。微生物是重组生物，优选大肠杆菌K12菌株或其衍生物，特别是在降低1,2-PD产生的竞争途径中灭活的菌株。

6. 发明申请

WO2003054544A2 VERFAHREN ZUR BESTIMMUNG DER RESPONSIVITÄT EINES INDIVIDUUMS FÜR MISTELLEKTIN 审中-公开
标题翻译：方法用于确定个体的响应到槲寄生凝集素
公开(公告)号：WO2003054544A2
公开(公告)日：2003-07-03
申请号：PCT/EP2002/014682
申请日：2002-12-20
申请人： VISCUM AG , MÜTHING, Johannes , PETER-KATALINIC, Jasna , LANGER, Martin , MÖCKEL, Babette , ECK, Jürgen
发明人： MÜTHING, Johannes , PETER-KATALINIC, Jasna , LANGER, Martin , MÖCKEL, Babette , ECK, Jürgen
IPC分类号： G01N33/566
CPC分类号： C12Q1/48 , C07K16/18 , G01N33/566 , G01N33/66 , G01N2333/42 , G01N2400/00 , G01N2800/52
摘要： Beschrieben wird ein Verfahren zur Bestimmung der Responsivität eines Individuums auf Mistellektin oder für (eine) Mistellektin-Einzellkette(n), wobei die Expression eines membranständigen Rezeptors für Mistellektin charakteristisch für eine entsprechende Responsivität ist.
摘要翻译：公开的是用于确定槲寄生凝集素或的（a）外源凝集素槲寄生Einzellkette（n），其中对于槲寄生凝集素膜结合受体的表达是一个相应的响应性的特性的个体的响应性的方法。

7. 发明申请

WO2003054177A2 NEUE GLYKOSYLHYDROLASEN 审中-公开
标题翻译：新糖
公开(公告)号：WO2003054177A2
公开(公告)日：2003-07-03
申请号：PCT/EP2002/014210
申请日：2002-12-13
申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN , BREVES, Roland , MAURER, Karl-Heinz , ECK, Jürgen , LORENZ, Patrick , ZINKE, Holger
发明人： BREVES, Roland , MAURER, Karl-Heinz , ECK, Jürgen , LORENZ, Patrick , ZINKE, Holger
IPC分类号： C12N9/00
CPC分类号： C12N9/2414 , C07K2319/00 , C11D3/386 , Y02E50/17
摘要： Die vorliegende Erfindung betrifft neue Glykosylhydrolasen mit amylolytischer Aktivität und die für diese Glykosylhydrolasen codierenden Nukleinsäuren, ein PCR-basiertes Verfahren zur Identifizierung und Gewinnung neuer Glykosylhydrolasen aus Metagenom-DNA sowie diverse technische Anwendungsmöglichkeiten für derartige Glykosylhydrolasen mit amylolytischer Aktivität. Hierunter sind Wasch- und Reinigungsmittel mit solchen Enzymen sowie entsprechende Verfahren und Verwendungsmöglichkeiten von besonderem Interesse.
摘要翻译：本发明涉及具有淀粉分解活性的新的糖基水解酶和编码这些糖基水解酶，用于鉴定和获得来自宏基因组DNA，以及用于与淀粉分解活性，例如糖基水解酶的各种技术应用的新糖基水解酶基于PCR的方法中的核酸。其中，洗涤剂和清洁产品，例如酶和相应的方法和特别感兴趣的用途。

8. 发明申请

WO2010099955A1 PROTEASE FOR WOUND CONDITIONING AND SKIN CARE 审中-公开
标题翻译：蛋白酶对伤口调理和皮肤护理
公开(公告)号：WO2010099955A1
公开(公告)日：2010-09-10
申请号：PCT/EP2010/001328
申请日：2010-03-03
申请人： B.R.I.A.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG , NIEHAUS, Frank , ECK, Jürgen , SCHULZE, Renate
发明人： NIEHAUS, Frank , ECK, Jürgen , SCHULZE, Renate
IPC分类号： C12N9/64 , C07K16/40 , A61K38/43 , C12N15/62 , C12N5/10
CPC分类号： C12N9/6408
摘要： We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80 % identical to the amino acid sequence of (a), preferably at least 85 % identical, more preferably at least 90 % identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80 % identical to the nucleotide sequence of (b), preferably at least 85 % identical, more preferably at least 90 % identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.
摘要翻译：我们已经通过分子克隆鉴定了来源于丝光绿蝇幼虫的蛋白酶，并且由于其活性可用于伤口清创，因此被称为清创酶。描述了编码丝氨酸蛋白酶的核酸分子，所述丝氨酸蛋白酶具有切割纤维蛋白和酪蛋白的能力，所述纤维蛋白和酪蛋白是（a）编码包含SEQ ID NO：4的氨基酸序列或由SEQ ID NO：4的氨基酸序列组成的丝氨酸蛋白酶的核酸分子，编码所述丝氨酸蛋白酶的前体或片段的酸分子; （b）包含SEQ ID NO：3的核苷酸序列或由其组成的核酸分子; （c）编码丝氨酸蛋白酶的核酸分子，其氨基酸序列与（a）的氨基酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，且大多数优选的95％相同; （d）包含与（b）的核苷酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，并且最优选95％相同的核苷酸序列或由其组成的核酸分子，相同; （e）相对于（b）或（d）的核酸分子简并的核酸分子; 或（f）对应于（a）至（d）中任一项的核酸分子的核酸分子，其中T被U取代。

9. 发明申请

WO2005090595A2 NITRILE HYDRATASES FROM METAGENOME LIBRARIES 审中-公开
标题翻译：来自METAGENOME图书馆的NITRILE HYDRATASES
公开(公告)号：WO2005090595A2
公开(公告)日：2005-09-29
申请号：PCT/EP2005/002556
申请日：2005-03-10
申请人： DEGUSSA AG , VERSECK, Stefan , LIEBETON, Klaus , ECK, Jürgen
发明人： VERSECK, Stefan , LIEBETON, Klaus , ECK, Jürgen
IPC分类号： C12Q1/68
CPC分类号： C12N9/88 , C12Y402/01084
摘要： The present invention is concerned with the preparation of novel nitrile hydratases. These latter are preferably obtained from nonculturable organisms by means of a PCR-based screening, in metagenome DNA libraries, using special degenerate primers.
摘要翻译：本发明涉及新型腈水合酶的制备。这些后者优选通过基于PCR的筛选从使用特殊简并引物的宏基因组DNA文库中获得来自非可培养生物体。

10. 发明申请

WO2005090577A1 EXPRESSION OF NITRILLE HYDRATASES IN A TWO-VECTOR EXPRESSION SYSTEM 审中-公开
标题翻译：在两个向量表达系统中表达NITRILLE HYDRATASES
公开(公告)号：WO2005090577A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/001688
申请日：2005-02-18
申请人： DEGUSSA AG , VERSECK, Stefan , OSSWALD, Steffen , PHONG, Wai-Yee , LIEBETON, Klaus , ECK, Jürgen
发明人： VERSECK, Stefan , OSSWALD, Steffen , PHONG, Wai-Yee , LIEBETON, Klaus , ECK, Jürgen
IPC分类号： C12N15/52
CPC分类号： C12N15/70 , C12N9/88
摘要： The present invention relates to a novel system for expressing nitrile hydratase. In this system, the nitrile hydratases, which are composed of subunits, are formed such that the respective subunits are located on different plasmids and are expressed simultaneously in E. coli.
摘要翻译：本发明涉及一种表达腈水合酶的新型体系。在该系统中，形成由亚基组成的腈水合酶，使得各个亚基位于不同的质粒上并在大肠杆菌中同时表达。

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