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1. 发明申请

WO2004085412A3 SYMMETRICAL TRIAZINE DERIVATIVES 审中-公开
标题翻译：对称TRIAZINE衍生物
公开(公告)号：WO2004085412A3
公开(公告)日：2005-02-10
申请号：PCT/EP2004050331
申请日：2004-03-19
申请人： CIBA SC HOLDING AG , EHLIS THOMAS , MUELLER STEFAN , HAYOZ PASCAL
发明人： EHLIS THOMAS , MUELLER STEFAN , HAYOZ PASCAL
IPC分类号： A61K8/49 , A61Q17/04 , C07D251/24 , A61K7/42
CPC分类号： C07D251/24 , A61K8/4966 , A61Q17/04
摘要： Disclosed is the use of the compounds of formula wherein A is a radical of formula (1a) or (1b) R, R1 and R5 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R2, R3 and R4 independently from each other are hydrogen; or a radical of formula wherein at least one of the radicals R2, R3 and R4are a radical of formula (1c); R6, R7, R8, R9 and R10 independently from each other are hydrogen; hydroxy; C1-C18alkyl; C1-C18alkoxy;C6-C12aryl; C6-C12aryloxy; C1-C18alkylthio; carboxy; -COOM; C1-C18alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The compounds of formula (1) are high effective UV absorbers for cosmetic formulations aund can - depending on their physical properties - be used in micronized or soluble form.
摘要翻译：公开了下式化合物的用途其中A是式（1a）或（1b）的基团，R，R 1和R 5彼此独立地是氢; C1-C18烷基; 或C6-C12芳基; R2，R3和R4彼此独立地是氢; 或下式的基团，其中基团R 2，R 3和R 4中的至少一个为式（1c）的基团; R 6，R 7，R 8，R 9和R 10彼此独立地为氢; 羟基; C1-C18烷基; C1-C18烷氧基; C 6 -C 12芳基; C6-C12aryloxy; C1-C18alkylthio; 羧基; -COOM; C1-C18alkylcarboxyl; 羰基; 或单或二C1-C18烷基氨基; M是碱金属离子; x为1或2; y为2〜10的数; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。式（1）的化合物是用于化妆品制剂的高效紫外线吸收剂，可根据其物理性质 - 以微粉化或可溶形式使用。

2. 发明申请

WO2007137958A2 SELF TANNING COMPOSITION 审中-公开
标题翻译：自拍组合
公开(公告)号：WO2007137958A2
公开(公告)日：2007-12-06
申请号：PCT/EP2007054864
申请日：2007-05-21
申请人： CIBA SC HOLDING AG , EHLIS THOMAS , MUELLER STEFAN , MONGIAT SEBASTIEN
发明人： EHLIS THOMAS , MUELLER STEFAN , MONGIAT SEBASTIEN
IPC分类号： A61K8/04 , A61K8/19 , A61K8/49 , A61K8/60 , A61Q19/04
CPC分类号： A61Q19/04 , A61K8/044 , A61K8/4973 , A61K8/498 , A61K8/60 , A61K2800/31 , A61K2800/412 , A61K2800/413 , A61Q5/10 , A61Q17/04 , B82Y5/00
摘要： Disclosed is a method for the colouration of skin or a keratinic fibre, characterized in that the skin or keratinic fibre is contacted with a formulation containing a dispersion of solid particles of a tanning substance selected from a compound of the formula (I) wherein i is 0 or 1 and each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 independently of each other is selected from group consisting of hydrogen, OH, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl and C 2 -C 6 al- kenyl; in an organic liquid of low polarity or non-polar organic liquid.
摘要翻译：公开了一种使皮肤或角质纤维着色的方法，其特征在于使皮肤或角质纤维与含有鞣制物质的固体颗粒分散体的制剂接触，所述鞣制物质的分散体选自式（I）的化合物，其中i是 0或1，R 1，R 2，R 3，R 4，R 3， R 5，R 6，R 7，R 8彼此独立地选自氢，OH，C C 1 -C 6烷基，C 1 -C 6羟烷基和C 2 -C 6烷基，C 1 -C 6 - -C 6亚烯基; 在低极性的有机液体或非极性有机液体中。

3. 发明申请

WO2004052837A3 AMINO SUBSTITUTED HYDROXYPHENYL BENZOPHENONE DERIVATIVES 审中-公开
标题翻译：氨基取代的羟苯基苯并噻吩酮衍生物
公开(公告)号：WO2004052837A3
公开(公告)日：2004-09-10
申请号：PCT/EP0350937
申请日：2003-12-03
申请人： CIBA SC HOLDING AG , HAASE JUERG , EHLIS THOMAS , BORSOS ELEK , MUELLER STEFAN
发明人： HAASE JUERG , EHLIS THOMAS , BORSOS ELEK , MUELLER STEFAN
IPC分类号： A61K8/42 , A61K8/44 , A61K8/49 , A61Q17/04 , C07C229/52 , C07C237/32 , C07C237/34 , C07C237/40 , C07C237/42 , C07D277/46 , C07D277/66 , C07D295/18 , C07D295/192 , C07D313/12 , A61K7/44
CPC分类号： C07D295/192 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/4973 , A61Q17/04 , C07C229/52 , C07C237/32 , C07C237/34 , C07C237/40 , C07C237/42 , C07D277/46 , C07D277/66 , C07D313/12
摘要： Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1,-C20alkyl; C2-C20alkenyl; C3-C10,cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1,-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; wenn n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; wenn n1 is 4, R3 is an alkanetetrayl radical; A is -O-; or -N(R5)-; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.
摘要翻译：描述了式（I）的氨基取代的羟基苯基二苯甲酮衍生物，其中R1和R2彼此独立地为; C1，-C20alkyl; C2-C20alkenyl; C3-C10，环烷基; C3-C10cycloalkenyl; 或者R1和R2与连接氮原子一起形成5-或6-元杂环; n1是从1到4的数字; 当n1 = 1时，R3是饱和或不饱和的杂环基; 羟基C1-C5烷基; 任选被一个或多个C1-C5烷基取代的环己基; 任选被杂环基，氨基羰基或C 1 -C 5烷基羧基取代的苯基; n1是2，R3是任选被羰基或羧基取代的亚烷基 - ，亚环烷基 - 或亚烯基; R3与A一起形成式（Ia）的二价基团，其中n2是1至3的数; 当n1是3时，R3是链烷三基; 文n1为4，R3为链烷四基; A是-O-; 或-N（R 5） - ; 并且R5是氢; C1-C5烷基; 或羟基-C 1 -C 5烷基。该化合物在防晒应用中用作UV过滤剂。

4. 发明申请

WO2007128744A2 TRIAZINE DERIVATIVES 审中-公开
标题翻译： TRIAZINE衍生物
公开(公告)号：WO2007128744A2
公开(公告)日：2007-11-15
申请号：PCT/EP2007054239
申请日：2007-05-02
申请人： CIBA SC HOLDING AG , EHLIS THOMAS , BORSOS ELEK
发明人： EHLIS THOMAS , BORSOS ELEK
IPC分类号： C07D251/52 , A61Q17/04 , C07D251/70
CPC分类号： C07D251/52 , C07D251/70
摘要： Disclosed are triazine derivatives of formula (1), wherein X 1 is a bivalent radical of formula (1a) -NR 9 -A-NR 9 -; (1b); or (1c) *-O-A-O-* A and A' independently from each other are unsubstituted or substituted, straight-chain or branched C 1 -C 12 alkylene, which is optionally interrupted by C 5 -C 12 cycloalkylene, N, O or S; C 5 -C 12 cycloalkylene; biphenylene; C 6 -C 10 arylene; or C 5 -C 10 arylene-(C 1 -C 12 alkylene); R 1 is a radical of formula (1d); (1e); (1f); (1g); or (1h); R 2 and R 3 independently from each other are hydrogen; C 1 -C 12 alkyl; OR 7 ; NR 7 R 8 ; C 6 -C 10 aryl; X 2 is O, or NH; W 1 is C 1 -C 20 alkyl; or a group Sp-Sil; Sp is a straight-chain or branched saturated or single or multiple unsaturated C 3 -C 12 hydrocarbon; Sil is a silane; an oligosiloxane; or a polysiloxane moiety; and R 4 , R 5 R 6 , R 7 , R 8 and R 9 independently from each other are hydrogen; C 1 -C 12 alkyl; or C 3 -C 12 cycloalkyl.
摘要翻译：公开了式（1）的三嗪衍生物，其中X 1是式（1a）的二价基团-NR 9 -A-NR 9 - ; （1B）; 或（1c）* -OAO- * A和A'彼此独立地是未取代或取代的直链或支链C 1 -C 12亚烷基，其是任选被C 5 -C 12亚环烷基，N，O或S中断; ç_{5 -C _{12 亚环烷基; 联苯; ç_{6 -C _{10 亚芳基; 或C 5 -C 10亚芳基 - （C 1 -C 12 - 亚烷基）; R 1是式（1d）的基团; （1E）; （1F）; （1G）; 或（1h）; R 2和R 3彼此独立地是氢; ç_{1 -C _{12 烷基; OR _{7 ; NR _{7 - [R _{8 ; ç_{6 -C _{10 芳基; X 2是O或NH; W 1是C 1 -C 20烷基; 或一组Sp-Sil; Sp是直链或支链饱和或单或多不饱和C 3 -C 12烃; 硅是硅烷; 低聚硅氧烷; 或聚硅氧烷部分; 和R 4，R 5 R 6，R 7，R 8和R 8，和 R 9彼此独立地是氢; ç_{1 -C _{12 烷基; 或C 3 -C 12环烷基。}}}}}}}}}}}}}

5. 发明申请

WO2006003094A3 MEROCYANINE DERIVATIVES 审中-公开
标题翻译：月桂酰胺衍生物
公开(公告)号：WO2006003094A3
公开(公告)日：2006-07-13
申请号：PCT/EP2005052850
申请日：2005-06-20
申请人： CIBA SC HOLDING AG , WAGNER BARBARA , BIENEWALD FRANK , WOLLEB HEINZ , WALLQUIST OLOF , HERZOG BERND , EHLIS THOMAS , HAASE JUERG
发明人： WAGNER BARBARA , BIENEWALD FRANK , WOLLEB HEINZ , WALLQUIST OLOF , HERZOG BERND , EHLIS THOMAS , HAASE JUERG
IPC分类号： A61K8/41 , A61K8/49 , A61K8/81 , A61Q17/04
CPC分类号： A61K8/498 , A61K8/4913 , A61K8/494 , A61Q17/04
摘要： Disclosed is the use of merocyanine derivatives of formula (I) for protecting of human hair and skin against the damaging effect of UV radiation.
摘要翻译：公开了式（I）的部花青衍生物用于保护人的头发和皮肤免受紫外线辐射的破坏作用。

6. 发明申请

WO03086341A2 AMINOPHENYLBENZOTHIAZOLE COMPOUNDS 审中-公开
标题翻译：氨基苯基苯并噻唑化合物
公开(公告)号：WO03086341A2
公开(公告)日：2003-10-23
申请号：PCT/EP0303870
申请日：2003-04-14
申请人： CIBA SC HOLDING AG , WAGNER BARBARA , EHLIS THOMAS , MONGIAT SEBASTIEN , EICHIN KAI
发明人： WAGNER BARBARA , EHLIS THOMAS , MONGIAT SEBASTIEN , EICHIN KAI
IPC分类号： A61K8/00 , A61K8/49 , A61K8/893 , A61K8/894 , A61K8/898 , A61K8/92 , A61K31/428 , A61P17/16 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/02 , A61Q17/04 , A61Q19/00 , C07D277/66 , A61K7/42
CPC分类号： A61K8/49 , A61K8/893 , A61K8/894 , A61Q17/04 , C07D277/66
摘要： The Use, as a UV filter, of a compound of formula (I), wherein R1 and R2 are each independently of the other hydrogen; unsubstituted or halo-, amino-, mono- or di-C1-C5alkylamino-, cyano- or C1-C5alkoxy-substituted C1-C22alkyl, C5-C10cycloalkyl, carboxy-C1-C22alkyl, carboxy-C6-C10aryl, C6-C10aryl, C6-C10aryl-C1-C5alkyl; carbamoyl; or sulfamoyl; or R1 and R2, together with the nitrogen atom linking them, form a 5- to 7-membered heterocyclic radical; and R3 is hydrogen; or C1-C22alkyl; and R4 is hydrogen; hydroxy; C1-C22alkyl; or C1-C22alkoxy; is described. The compounds of formula (I) are suitable especially as UV filters in cosmetic preparations.
摘要翻译：用作UV过滤器的式（I）化合物，其中R 1和R 2各自独立于另一个氢; 未取代或卤代，氨基 - ，单 - 或二-C 1 -C 5烷基氨基 - ，氰基 - 或C 1 -C 5烷氧基取代的C 1 -C 22烷基，C 5 -C 10环烷基，羧基-C 1 -C 22烷基，羧基-C 6 -C 10芳基，C 6 -C 10芳基， C6-C10芳基，C1-C5烷基; 氨基甲酰基; 或氨磺酰; 或R 1和R 2与连接它们的氮原子一起形成5-至7-元杂环基; 并且R 3是氢; 或C 1 -C 22烷基; R4为氢; 羟基; C1-C22烷基; 或C 1 -C 22烷氧基; 被描述。式（I）的化合物特别适用于化妆品制剂中的UV过滤器。

7. 发明申请

WO2008090066A3 STABILIZATION OF UV-SENSITIVE ACTIVE INGREDIENTS 审中-公开
标题翻译：稳定紫外敏感活性成分
公开(公告)号：WO2008090066A3
公开(公告)日：2008-09-12
申请号：PCT/EP2008050440
申请日：2008-01-16
申请人： CIBA HOLDING INC , WAGNER BARBARA , HERZOG BERND , MUELLER STEFAN , EHLIS THOMAS
发明人： WAGNER BARBARA , HERZOG BERND , MUELLER STEFAN , EHLIS THOMAS
IPC分类号： A61K8/41 , A61K8/44 , A61K8/49 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/44 , A61K2800/52 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/004 , A61Q19/04
摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.
摘要翻译：公开了式（1）的部花青衍生物用于稳定UV敏感的活性成分如二苯甲酰基甲烷衍生物的用途。

8. 发明申请

WO2007071584A3 USE OF TRANSMISSION DYES FOR PROTECTING HUMAN SKIN FROM BROWNING AND AGEING 审中-公开
标题翻译：用于保护人类皮肤免受衰老和衰老的传染性染料
公开(公告)号：WO2007071584A3
公开(公告)日：2008-07-03
申请号：PCT/EP2006069519
申请日：2006-12-11
申请人： CIBA HOLDING INC , MUELLER STEFAN , HAASE JUERG , EHLIS THOMAS , KREYER GILBERT , GIESINGER JOCHEN , VOGT MARTIN
发明人： MUELLER STEFAN , HAASE JUERG , EHLIS THOMAS , KREYER GILBERT , GIESINGER JOCHEN , VOGT MARTIN
IPC分类号： A61Q17/04 , A61K8/35 , A61K8/37 , A61K8/42
CPC分类号： C07D295/192 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/494 , A61K2800/43 , A61Q17/04
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic compound which has a UV-Vis spectrum with a maximum from 380 to 420 nm; and (b) an anionic dispersing agent for protecting the human skin from browning and skin aging.
摘要翻译：公开了包含（a）微波化的微溶有机化合物的水分散体的使用，其具有最大值为380至420nm的UV-Vis光谱; 和（b）用于保护人体皮肤免于褐变和皮肤老化的阴离子分散剂。

9. 发明申请

WO2008135421A3 CRYSTAL MODIFICATIONS OF TRANSMISSION DYES 审中-公开
标题翻译：传染性染色体的晶体修饰
公开(公告)号：WO2008135421A3
公开(公告)日：2009-03-05
申请号：PCT/EP2008055139
申请日：2008-04-28
申请人： CIBA HOLDING INC , VOGT MARTIN , MUELLER STEFAN , GRUMELARD JULIE , DESHAYES CYRILLE , PAUL HOLGER , HAASE JUERG , EHLIS THOMAS
发明人： VOGT MARTIN , MUELLER STEFAN , GRUMELARD JULIE , DESHAYES CYRILLE , PAUL HOLGER , HAASE JUERG , EHLIS THOMAS
IPC分类号： A61K8/49 , A61Q17/04 , A61Q19/08
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70 Å; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06 Å; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25°C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

10. 发明申请

WO2009112403A3 DIMERIC BENZYLIDENE MALONATES 审中-公开
标题翻译：二甲苯胆碱
公开(公告)号：WO2009112403A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009052531
申请日：2009-03-04
申请人： BASF SE , HANSCH MARKUS , EHLIS THOMAS , WAGNER BARBARA
发明人： HANSCH MARKUS , EHLIS THOMAS , WAGNER BARBARA
IPC分类号： A61K8/37 , A61Q17/04 , C07C67/347 , C07C69/618
CPC分类号： A61Q17/04 , A61K8/37 , A61K8/585 , C07C67/03 , C07C67/31 , C07C67/343 , C07C69/734 , C07C2601/14 , C07F7/0889 , C07C69/732
摘要： Disclosed is the use of benzylidene malonates of formula (1), wherein R1 and R2, independently from each other are hydrogen; OH; C1-C12alkyl; C1-C12alkoxy; C1-C12alkylamino; C1-C12dialkylamino; water-solubilizing groups, selected from carboxylate, sulfonates or ammonium radicals; R3 is COOR5; COR5; CONR5R6; CN; or SO2R7, R4 is COOR8; COR9; CONR8R9; CN; or SO2R10; R5, R6, R7, R8, R9 and R10 independently from each other are C1-C18alkyl; unsubstituted or by one or more than one C1-C4alkyl substituted C3-C12-cycloalkyl; unsubstituted or C1-C6alkyl-substituted C6-C20aryl; organosilanyl, or organosiloxanyl; A is -C1-C20alkylene-, -CH2CH(OH)CH2-, -C5-C20cycloalkylene, --C2-C20alkenylene-, -C5- C10arylene-, or -C5-C10arylene-(C1-C10alkylene)- which are unsubstituted or substituted, straight-chain or branched, optionally interrupted by one or more than one heteroatoms selected from -O, -S- or -NH-; for the protection of human and animal hair and skin against UV radiation.
摘要翻译：公开了式（1）的亚苄基丙二酸酯的用途，其中R 1和R 2彼此独立地为氢; 哦; C1-C12烷基; C1-C12烷氧基; C1-C12alkylamino; C1-C12dialkylamino; 选自羧酸盐，磺酸盐或铵基的水溶性基团; R3为COOR5; COR5; CONR5R6; CN; 或SO 2 R 7，R 4为COOR 8; COR 9; CONR8R9; CN; 或SO2R10; R 5，R 6，R 7，R 8，R 9和R 10彼此独立地为C 1 -C 18烷基; 未取代或被一个或多个C 1 -C 4烷基取代的C 3 -C 12 - 环烷基取代; 未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; 有机硅烷基或有机硅氧烷基; A是未取代的-C 1 -C 20亚烷基 - ， - CH 2 CH（OH）CH 2 - ， - C 5 -C 20亚环烷基，-C 2 -C 20亚烯基，-C 5 -C 10亚芳基或-C 5 -C 10亚芳基 - （C 1 -C 10亚烷基）任选被一个或多于一个选自-O，-S-或-NH-的杂原子间隔的取代的，直链或支链的; 用于保护人和动物的头发和皮肤免受紫外线辐射。

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