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1. 发明申请

WO2005051313A3 METHODS AND REAGENTS FOR TREATING, PREVENTING AND DIAGNOSING BUNYAVIRUS INFECTION 审中-公开
公开(公告)号：WO2005051313A3
公开(公告)日：2005-06-09
申请号：PCT/US2004/039333
申请日：2004-11-19
申请人： CHIRON CORPORATION , CHOO, Qui-Lim , HOUGHTON, Michael , SCOTT, Elizabeth , WEINER, Amy
发明人： CHOO, Qui-Lim , HOUGHTON, Michael , SCOTT, Elizabeth , WEINER, Amy
IPC分类号： A61K39/12 , C12Q1/70 , C07H19/00
摘要： Immunogenic compositions for use in treating, preventing and diagnosing infection caused by the California (CAL) serotype of the genus Bunyavirus, such as La Crosse virus (LACV), are disclosed. Also described are reagents for use in diagnostic assays.

2. 发明申请

WO2004112694A3 IMMUNOGENIC REAGENTS FROM WEST NILE VIRUS 审中-公开
公开(公告)号：WO2004112694A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/015976
申请日：2004-05-21
申请人： CHIRON CORPORATION , ANDREWS, William , CHIEN, David Y. , CHOO, Qui-Lim , COATES, Stephen R. , COIT, Doris , HARRINGTON, Charles , HILT, Susan , HOUGHTON, Michael , MEDINA-SELBY, Angelica , PICHUANTES, Sergio
发明人： ANDREWS, William , CHIEN, David Y. , CHOO, Qui-Lim , COATES, Stephen R. , COIT, Doris , HARRINGTON, Charles , HILT, Susan , HOUGHTON, Michael , MEDINA-SELBY, Angelica , PICHUANTES, Sergio
IPC分类号： A61K39/145 , C12Q1/70
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.

3. 发明申请

WO2004112694A2 IMMUNOGENIC REAGENTS FROM WEST NILE VIRUS 审中-公开
标题翻译：来自西尼病毒的免疫原性试剂
公开(公告)号：WO2004112694A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/015976
申请日：2004-05-21
申请人： CHIRON CORPORATION , ANDREWS, William , CHIEN, David Y. , CHOO, Qui-Lim , COATES, Stephen R. , COIT, Doris , HARRINGTON, Charles , HILT, Susan , HOUGHTON, Michael , MEDINA-SELBY, Angelica , PICHUANTES, Sergio
发明人： ANDREWS, William , CHIEN, David Y. , CHOO, Qui-Lim , COATES, Stephen R. , COIT, Doris , HARRINGTON, Charles , HILT, Susan , HOUGHTON, Michael , MEDINA-SELBY, Angelica , PICHUANTES, Sergio
IPC分类号： A61K
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

4. 发明申请

WO2004092360A2 THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 审中-公开
标题翻译：严重急性呼吸道综合症冠状病毒
公开(公告)号：WO2004092360A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011710
申请日：2004-04-09
申请人： CHIRON CORPORATION , RAPPUOLI, Rino , MASIGNANI, Vega , STADLER, Konrad , GREGERSEN, Jens-Peter , CHIEN, David , HAN, Jang , POLO, John , WEINER, Amy , HOUGHTON, Michael , SONG, Hyun, Chul , SEO, Mi, Young , DONNELLY, John, J. , KLENK, Hans, Dieter , VALIANTE, Nicholas
发明人： RAPPUOLI, Rino , MASIGNANI, Vega , STADLER, Konrad , GREGERSEN, Jens-Peter , CHIEN, David , HAN, Jang , POLO, John , WEINER, Amy , HOUGHTON, Michael , SONG, Hyun, Chul , SEO, Mi, Young , DONNELLY, John, J. , KLENK, Hans, Dieter , VALIANTE, Nicholas
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , C07K16/10 , C07K2317/34 , C07K2317/76 , C07K2319/21 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034 , C12N2770/20043 , C12N2770/20051 , C12N2770/20063 , C12Q1/701 , G01N2333/165 , G01N2469/20
摘要： An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.
摘要翻译：在2003年，中国香港和世界各地越来越多的国家确定了现在称为严重急性呼吸综合征（SARS）的毒性呼吸道病毒的爆发。本发明涉及SARS冠状病毒的核酸和蛋白质。这些核酸和蛋白质可用于制备和制造疫苗制剂，诊断试剂，试剂盒等。本发明还提供了通过施用小分子抗病毒化合物治疗SARS的方法，以及鉴定用于治疗SARS的有效小分子的方法治疗SARS。

5. 发明申请

WO2008024413A2 TISSUE CULTURE SYSTEM FOR PRODUCTION OF HEPATITIS C VIRUS 审中-公开
标题翻译：生产丙型肝炎病毒的组织培养系统
公开(公告)号：WO2008024413A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018591
申请日：2007-08-22
申请人： NOVARTIS AG , CHOO, Qui-Lim , HAN, Jang , HOUGHTON, Michael , KWON, Taewoo , SONG, Hyun Chul , ZHU, Yifei
发明人： CHOO, Qui-Lim , HAN, Jang , HOUGHTON, Michael , KWON, Taewoo , SONG, Hyun Chul , ZHU, Yifei
IPC分类号： C12N15/861
CPC分类号： C12N7/00 , A61K2039/525 , C07K14/005 , C07K2319/61 , C12N2760/16022 , C12N2770/24243 , G01N2333/186 , G01N2500/10
摘要： A tissue culture system for production of infectious hepatitis C virus is described. In particular, the invention provides recombinant monocistronic and bicistronic genomic constructs for production of virus, including constructs for production of wild-type HCV type 2a strain JFH1 and constructs for production of chimeric viruses comprising HCV proteins from strain JFH1 and a second HCV isolate (e.g., type 1a H77, type 1b Con1, or type 3a NZ1 or 452). Constructs of the invention also include a reporter gene to facilitate measurement of RNA replication and viral infectivity in cultures. The cell culture system may also include various factors that improve viral replication or infectivity, such as an RNA silencing suppressor (e.g., an influenza virus NS1 polypeptide) to inhibit host defense pathways or CD81 to facilitate viral entry into host cells. In addition, a neutralization assay using HCV grown in cell culture is described and neutralization titers measured by this assay have been found to correlate well with actual protection from HCV infection in vaccinated animals.
摘要翻译：描述了用于产生传染性丙型肝炎病毒的组织培养系统。具体而言，本发明提供了用于产生病毒的重组单顺反子和双顺反子基因组构建体，包括用于生产野生型HCV 2a型菌株JFH1的构建体和用于产生包含来自菌株JFH1和第二HCV分离株（例如，，类型1a H77，类型1b Con1或类型3a NZ1或452）。本发明的构建体还包括报道基因以促进测量培养物中的RNA复制和病毒感染性。细胞培养系统还可以包括改善病毒复制或感染性的各种因子，例如抑制宿主防御途径的RNA沉默抑制子（例如流感病毒NS1多肽）或促进病毒进入宿主细胞的CD81。另外，描述了使用在细胞培养物中生长的HCV的中和测定法，并且发现通过该测定法测量的中和滴度与在接种疫苗的动物中实际保护免受HCV感染相关联。

6. 发明申请

WO2006039656A2 MODIFIED SMALL INTERFERING RNA MOLECULES AND METHODS OF USE 审中-公开
标题翻译：修饰的小分子干扰RNA分子及其使用方法
公开(公告)号：WO2006039656A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/035493
申请日：2005-09-30
申请人： CHIRON CORPORATION , HAN, Jang , HOUGHTON, Michael
发明人： HAN, Jang , HOUGHTON, Michael
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , A61K38/00 , C12N2310/14 , C12N2310/322 , C12N2310/334 , C12N2310/335 , C12N2310/3515 , Y02A50/463
摘要： The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA (dsRNA) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer. The invention provides modified RNA molecules that are modified to include a dsRNA or siRNA wherein one or more of the pyrimidines in the RNA molecule are modified to include 2'-Fluorine. The invention also provides dsRNA or siRNA in which all pyrimidines are modified to include a 2'-Fluorine. The invention provides that the 2'-Fluorine dsRNA or siRNA molecule is further modified to include a two base deoxynucleotide "TT" sequence at the 3' end of the molecule.
摘要翻译：本发明提供了在靶细胞，优选肝细胞中介导RNA干扰的双链RNA分子。本发明还提供经修饰以抵抗核酸酶降解的双链RNA（dsRNA）分子，其使病毒失活，并且更具体地使丙型肝炎病毒（HCV）失活。本发明还提供了使用这些修饰的RNA分子使哺乳动物细胞中的病毒失活的方法以及使用人类切丁酶制备修饰的小干扰RNA（siRNA）的方法。本发明提供了修饰的RNA分子，其被修饰以包括dsRNA或siRNA，其中RNA分子中的一个或多个嘧啶被修饰以包括2'-氟。本发明还提供了其中所有嘧啶被修饰为包含2'-氟的dsRNA或siRNA。本发明提供了将2'-氟dsRNA或siRNA分子进一步修饰以包括双碱基脱氧核苷酸“TT” 序列在分子的3'末端。

7. 发明申请

WO2004005473A2 HCV FUSION PROTEINS WITH MODIFIED NS3 DOMAINS 审中-公开
标题翻译： HCV融合蛋白与修饰的NS3结构域
公开(公告)号：WO2004005473A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/020996
申请日：2003-07-02
申请人： CHIRON CORPORATION , HOUGHTON, Michael
发明人： HOUGHTON, Michael
IPC分类号： C12N
CPC分类号： C07K14/005 , C07K2319/00 , C12N9/506 , C12N2770/24222
摘要： The invention provides HCV fusion proteins that include a mutated NS3 protease domain, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating a cellular immune response to HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4 + and CD8 + T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.
摘要翻译：本发明提供HCV融合蛋白，其包括突变的NS3蛋白酶结构域，其与至少一种源自HCV多蛋白的另一区域的其它HCV表位融合。融合物可以用于刺激对HCV的细胞免疫应答的方法，例如激活丙型肝炎病毒（HCV）特异性T细胞，包括CD4 +和CD8 + T细胞。该方法可以在模型系统中用于开发HCV特异性免疫原性组合物，以及免疫哺乳动物抗HCV。

8. 发明申请

WO2003002065A3 HCV E1E2 VACCINE COMPOSITIONS 审中-公开
公开(公告)号：WO2003002065A3
公开(公告)日：2003-01-09
申请号：PCT/US2002/020676
申请日：2002-06-28
申请人： CHIRON CORPORATION , HOUGHTON, Michael , COATES, Stephen, R. , O'HAGAN, Derek
发明人： HOUGHTON, Michael , COATES, Stephen, R. , O'HAGAN, Derek
IPC分类号： C07K14/18
摘要： HCV E1E2 compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or immunostimulatory nucleic acid sequences are described. The compositions can be used in methods of stimulating an immune response in a vertebrate subject.

9. 发明申请

WO2004039950A2 ACTIVATION OF HCV-SPECIFIC CELLS 审中-公开
标题翻译： HCV特异性细胞的活化
公开(公告)号：WO2004039950A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/033610
申请日：2003-10-24
申请人： CHIRON CORPORATION , HOUGHTON, Michael , COATES, Steve , SELBY, Mark , PALIARD, Xavier
发明人： HOUGHTON, Michael , COATES, Steve , SELBY, Mark , PALIARD, Xavier
IPC分类号： C12N
CPC分类号： C07K14/005 , A61K2039/53 , A61K2039/57 , C07K2319/00 , C12N2770/24222
摘要： The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4 + and CD8 + T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.
摘要翻译：本发明提供一种激活丙型肝炎病毒（HCV）特异性T细胞，包括CD4 +和CD8 + T细胞的方法。使用包含HCV NS3，NS4，NS5a和NS5b多肽的融合蛋白，编码这种融合蛋白的多核苷酸或含有这些融合物的各个成分的多肽或多核苷酸组合物来激活HCV特异性T细胞。该方法可以在模型系统中用于开发HCV特异性免疫原性组合物，以及免疫哺乳动物抗HCV。

10. 发明申请

WO2004096136A2 COMPOSITIONS COMPRISING CATIONIC MICROPARTICLES AND HCV E1E2 DNA AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含阳离子MICROPARTICLESES和HCV E1E2 DNA的组合物及其使用方法
公开(公告)号：WO2004096136A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012510
申请日：2004-04-23
申请人： CHIRON CORPORATION , O'HAGAN, Derek , HOUGHTON, Michael , SINGH, Manmohan
发明人： O'HAGAN, Derek , HOUGHTON, Michael , SINGH, Manmohan
IPC分类号： A61K
CPC分类号： A61K31/7088 , A61K9/0019 , A61K9/1617 , A61K9/1647 , A61K39/12 , A61K39/29 , A61K39/39 , A61K47/6927 , A61K48/00 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
摘要： Immunogenic HCV ElE2 809 DNA compositions and methods of using the same are described. The compositions comprise HCV EIE2 809 DNA adsorbed to cationic microparticles, such as poly(lactide-co-glycolide) (PLG) microparticles.
摘要翻译：描述了免疫原性HCV ElE2809 DNA组合物及其使用方法。组合物包含吸附在阳离子微粒上的HCV EIE2809 DNA，如聚（丙交酯 - 共 - 乙交酯）（PLG）微粒。

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