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1. 发明申请

WO2012135834A3 DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 审中-公开
公开(公告)号：WO2012135834A3
公开(公告)日：2012-10-04
申请号：PCT/US2012/031864
申请日：2012-04-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , YUNG, Chong, Wing , DOMANSKY, Karel , TERRY, Richard , KALISH, David , SCHULTE, Alexa , KANG, Joo, Hun , INGBER, Donald, E. , SUPER, Mike , COOPER, Ryan, M.
发明人： YUNG, Chong, Wing , DOMANSKY, Karel , TERRY, Richard , KALISH, David , SCHULTE, Alexa , KANG, Joo, Hun , INGBER, Donald, E. , SUPER, Mike , COOPER, Ryan, M.
IPC分类号： G01N33/569 , G01N35/10 , G01N35/08 , B81B1/00
摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

2. 发明申请

WO2010009307A2 ORGAN MIMIC DEVICE WITH MICROCHANNELS AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
标题翻译：具有微通道的有机MIMIC器件及其使用及制造方法
公开(公告)号：WO2010009307A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050830
申请日：2009-07-16
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , HUH, Dongeun
发明人： INGBER, Donald, E. , HUH, Dongeun
IPC分类号： C12M3/06 , B01L3/00
CPC分类号： C12M23/16 , B01L3/5027 , B01L3/50273 , B01L2200/0663 , B01L2300/0854 , B01L2300/0877 , B01L2300/0887 , B01L2300/163 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , C12M21/08 , C12M23/58 , C12M25/02 , C12M29/10 , C12N5/0606 , C12N5/061 , C12N5/0623 , C12N5/0647 , C12N5/0654 , C12N5/0662 , C12N5/0671 , C12N5/0688 , C12N5/0696 , C12N5/0697 , G01N33/5005 , G01N33/5088 , G01N33/5091
摘要： System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers.
摘要翻译：系统和方法包括具有由一个或多个多孔膜分离的中心微通道的主体。膜构造成将中心微通道分成两个或更多个平行的中央微通道，其中一个或多个第一流体通过第一中心微通道施加，并且一个或多个第二流体通过第二或更多个中心微通道施加。每个多孔膜的表面可以涂覆有细胞粘附分子以支持细胞的附着并促进它们组织在膜的上表面和下表面上的组织中。毛孔可能足够大，仅允许气体和小化学物质的交换，或允许大蛋白质和整个活细胞的迁移和经通道通过。流体压力，流动和通道几何形状也可以变化，以将所需的机械力施加到一个或两个组织层。

3. 发明申请

WO2006039675A2 APPARATUS AND METHOD FOR NANOMANIPULATION OF BIOMOLECULES AND LIVING CELLS 审中-公开
标题翻译：生物分子和生物细胞纳米生物的装置和方法
公开(公告)号：WO2006039675A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/035551
申请日：2005-10-03
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , MATTHEWS, Benjamin, D. , LAVAN, David, A. , OVERBY, Darryl
发明人： INGBER, Donald, E. , MATTHEWS, Benjamin, D. , LAVAN, David, A. , OVERBY, Darryl
CPC分类号： A61B18/08 , A61M2037/0046 , A61N2/002
摘要： The present invention relates to an electromagnetic needle for magnetically manipulating microscopic particles and a method of making the same, and more particularly, to a method for nanomanipulating biomolecules and/or living cells using the electromagnetic needle of the present invention. The temperature-controlled electromagnetic microneedle includes an electromagnetic core having a magnetic probe tip. A wire coil is wound around at least a portion of the core and electrically isolated from the core. A thermo-regulating water jacket having a first and second end and enveloping the electromagnetic core and wire coil allows the probe tip to extend from the first end. The present invention also relates to a method for localized in vivo treatment of disease. Magnetically responsive particles upon which a biologically active substance is absorbed are administered to a subject. A catheter having a magnet attached thereto is inserted into the body of the subject. The magnet guides the particles to a site to be treated with the biologically active substance and causes retention of the particles at the site.
摘要翻译：本发明涉及一种用于磁微操作微粒的电磁针及其制造方法，更具体地说，涉及使用本发明的电磁针对生物分子和/或活细胞进行纳米操作的方法。温度控制电磁微针包括具有磁性探头尖端的电磁铁心。线圈缠绕在芯的至少一部分上并与芯电隔离。具有第一端和第二端并包封电磁铁芯和线圈线圈的热调节水套允许探针尖端从第一端延伸。本发明还涉及一种局部体内治疗疾病的方法。对受试者施用吸收了生物活性物质的磁性响应性颗粒。具有附着于其上的磁体的导管插入到受试者的身体中。磁体将颗粒引导到要用生物活性物质处理的位点，并使颗粒保留在现场。

4. 发明申请

WO2013058812A1 TARGETED DELIVERY TO PANCREATIC ISLET ENDOTHELIAL CELLS 审中-公开
标题翻译：针对胰岛细胞内皮细胞的定向递送
公开(公告)号：WO2013058812A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/023619
申请日：2012-02-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , GHOSH, Kaustabh , KANAPATHIPILLAI, Mathumai
发明人： INGBER, Donald, E. , GHOSH, Kaustabh , KANAPATHIPILLAI, Mathumai
IPC分类号： A61K47/48 , A61K9/16 , A61K9/14 , A61K39/395 , A61P29/00
CPC分类号： A61K38/13 , A61K9/5146 , A61K31/202 , A61K31/352 , A61K31/366 , A61K31/395 , A61K31/573 , A61K31/606 , A61K47/62 , A61K47/6935 , A61K47/6937
摘要： The present invention provides, in part, compositions and methods of targeted delivery of an agent or cells to islet endothelial cells in the pancreas using a novel islet-targeting molecule. Accordingly, one aspect of the present invention provides a composition comprising a carrier particle attached to an islet targeting molecule, wherein an agent is associated with the carrier particle, and is therefore targeted to islet cells by the islet targeting molecule. In some embodiments, the islet targeting molecule is an islet-targeting peptide. In some embodiments, such a carrier particle is a nanoparticle or similar.
摘要翻译：本发明部分地提供使用新颖的胰岛靶向分子将试剂或细胞靶向递送到胰腺中的胰岛内皮细胞的组合物和方法。因此，本发明的一个方面提供一种组合物，其包含与胰岛靶向分子连接的载体颗粒，其中药剂与载体颗粒结合，因此被胰岛靶向分子靶向胰岛细胞。在一些实施方案中，胰岛靶向分子是胰岛靶向肽。在一些实施方案中，这种载体颗粒是纳米颗粒或类似物。

5. 发明申请

WO2008130618A1 METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 审中-公开
标题翻译：分离颗粒，细胞，分子和颗粒的方法和装置
公开(公告)号：WO2008130618A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/005002
申请日：2008-04-18
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , CHILDREN'S MEDICAL CENTER CORPORATION , VARGHESE, Mathew , FIERING, Jason, O. , INGBER, Donald, E. , XIA, Shannon , MESCHER, Mark, J. , BORENSTEIN, Jeffrey, T. , YUNG, Chong
发明人： VARGHESE, Mathew , FIERING, Jason, O. , INGBER, Donald, E. , XIA, Shannon , MESCHER, Mark, J. , BORENSTEIN, Jeffrey, T. , YUNG, Chong
IPC分类号： B03C1/033
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译：用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废流体的磁场梯度，以及在流过磁场梯度之后收集每个流体流。

6. 发明申请

WO2002086452A2 SELECTIVE DEPOSITION OF MATERIALS ON CONTOURED SURFACES 审中-公开
标题翻译：选择性沉积在表面上的材料
公开(公告)号：WO2002086452A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/009149
申请日：2002-03-25
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
发明人： OSTUNI, Emanuele , CHEN, Christopher, S. , INGBER, Donald, E. , WHITESIDES, George, M.
IPC分类号： G01N
CPC分类号： B01L3/5085 , B01J2219/00317 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00743 , B01L3/5088 , C12N11/08 , Y10S530/812 , Y10S530/815
摘要： The present invention is directed to a method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on the surface and to a cell containment device that may be constructed by this method. In one embodiment, the present invention is directed to a method of selectively depositing a material on a substrate including a contoured surface including a protrusion and a recess. The method includes applying a first fluid to the contoured surface of the substrate and allowing the first fluid to distribute across a portion of the contoured surface such that the first fluid contacts the protrusion and not the recess. The method also includes allowing a first material to deposit on the substrate where the substrate is in contact with the first fluid. Optionally, this method may further include applying a second fluid to the contoured surface of the substrate, allowing the second fluid to distribute across a portion of the contoured surface such that the second fluid contacts the recess, and allowing a second material to deposit on the substrate where the substrate is in contact with the second fluid. Optionally, the method may still further include applying a third fluid to the contoured surface of the substrate, allowing the third fluid to distribute across a portion of the contoured surface, and allowing a third material with an affinity for one of the first material and the second material to deposit on the substrate only where the one of the first material and the second material is deposited. In one embodiment, of this method the first material is a cytophobic material, the second material is a cytophilic material and the third material is a cell. In another embodiment, the present invention is directed to a cell containment device, including a substrate having a contoured surface, a recess in the surface of the substrate, cytophobic material connected to the surface of the substrate outside the recess and a cytophilic material connected to the recess.
摘要翻译：本发明涉及通过将材料沉积在表面上的突起上以及可以通过该方法构建的细胞容纳装置，在轮廓表面上图案化材料（例如蛋白质）的方法。在一个实施例中，本发明涉及一种选择性地将材料沉积在包括突起和凹陷的轮廓表面的基底上的方法。该方法包括将第一流体施加到基底的轮廓表面，并允许第一流体分布在轮廓表面的一部分上，使得第一流体接触突出体而不是凹部。该方法还包括允许第一材料沉积在衬底上，其中衬底与第一流体接触。可选地，该方法还可以包括将第二流体施加到基底的轮廓表面，允许第二流体跨过轮廓表面的一部分分布，使得第二流体接触凹部，并允许第二材料沉积在衬底，其中衬底与第二流体接触。可选地，该方法还可以进一步包括将第三流体施加到基底的轮廓表面，允许第三流体跨越轮廓表面的一部分分布，并允许具有与第一材料和第二材料仅沉积在第一材料和第二材料之一上沉积在基底上。在一个实施方案中，该方法的第一种材料是细胞免疫材料，第二种材料是嗜细胞性材料，第三种材料是细胞。在另一个实施方案中，本发明涉及一种细胞容纳装置，包括具有轮廓表面的基底，基底表面中的凹槽，连接到凹部外部的基底表面的细胞免疫材料和连接到凹槽

7. 发明申请

WO2010123545A3 ANGIOGENESIS INHIBITORS 审中-公开
公开(公告)号：WO2010123545A3
公开(公告)日：2010-10-28
申请号：PCT/US2010/001121
申请日：2010-04-16
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , COREY, Elias, James , CZAKÓ, Barbara , KÜRTI, László , MAMMOTO, Akiko , INGBER, Donald, E.
发明人： COREY, Elias, James , CZAKÓ, Barbara , KÜRTI, László , MAMMOTO, Akiko , INGBER, Donald, E.
IPC分类号： C07J41/00 , C07J43/00 , A61K31/56 , A61P35/00
摘要： Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:

8. 发明申请

WO2009149239A1 METHODS OF MODULATING ANGIOGENESIS VIA TRPV4 审中-公开
标题翻译：通过TRPV4调节血管生成的方法
公开(公告)号：WO2009149239A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046219
申请日：2009-06-04
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , THODETI, Charles, K.
发明人： INGBER, Donald, E. , THODETI, Charles, K.
IPC分类号： A61K38/00 , A61K31/70
CPC分类号： C12N15/1138 , A61K31/70 , A61K31/713 , A61K45/06 , C07K16/2842 , C12N2310/14 , G01N33/5064
摘要： The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating angiogenesis-related diseases and disorders, particularly when the diseases or disorders are directly related aberrant angiogenesis. Inhibition is achieved by inhibiting TRPV4 activity, such as the levels of TRPV4 expression, calcium influx through TRPV4, and/or the intracellular signaling from TRPV4 via β1 integrin activation.
摘要翻译：本发明涉及抑制毛细血管内皮细胞迁移，CE网络形成和血管生成的方法及其用于治疗血管生成相关疾病和病症的用途，特别是当疾病或病症直接相关异常血管生成。通过抑制TRPV4活性，例如TRPV4表达的水平，通过TRPV4的钙流入和/或通过β1整联蛋白激活来自TRPV4的细胞内信号传导来实现抑制。

9. 发明申请

WO2008127295A3 GUIDED SELF-ASSEMBLY OF MATRICES WITH ORDERD NANO-SCALE STRUCTURE FOR TISSUE ENGINEERING 审中-公开
公开(公告)号：WO2008127295A3
公开(公告)日：2008-10-23
申请号：PCT/US2007/022397
申请日：2007-10-22
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E.
发明人： INGBER, Donald, E.
IPC分类号： A61F13/00
摘要： Described herein are methods for producing structures useful, for example, for tissue engineering. In their most general form, the methods described herein involve an enzyme activity immobilized on a surface, which is placed in contact with a solution comprising polypeptide monomers. The activity of the enzyme modifies the polypeptide monomers to promote polymerization of the monomers to form polymer structures associated with the surface. Thus, the methods described herein provide a guided self-assembly of polypeptide structures. In preferred embodiments, the self assembly is guided to form regular lattices or other specific structures by specifying the arrangement of the surfaces to which the enzyme, optionally with one or more co-factors, is attached.

10. 发明申请

WO2004081729A2 A METHOD AND APPARATUS FOR DISPLAYING INFORMATION 审中-公开
标题翻译：一种用于显示信息的方法和装置
公开(公告)号：WO2004081729A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/006901
申请日：2004-03-05
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , HUANG, Sui , EICHLER, Gabriel
发明人： INGBER, Donald, E. , HUANG, Sui , EICHLER, Gabriel
IPC分类号： G06F
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference elements; assigning a respective value to each respective tile of the spatial layout of the representative elements; and displaying an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成各自对应于代表参考元素的瓦片的空间布局; 将观察到的元素映射到代表参考元素的瓦片的空间布局上; 将相应的值分配给代表元素的空间布局的每个相应瓦片; 并显示代表性元素的瓦片的空间布局的图像。每个瓦片包括代表性元素的原子属性。本发明还涉及一种显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器，每个对应于代表参考元件; 将观察到的元素映射到代表参考元素的瓦片的所述空间布局上的比较器; 分配器，将代表参考元素的所述空间布局的相应值分配给相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器。

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