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1. 发明申请

WO1991013973A1 MEGAKARYOCYTIC IN VITRO CELL LINE 审中-公开
标题翻译：体细胞细胞系中的巨噬细胞
公开(公告)号：WO1991013973A1
公开(公告)日：1991-09-19
申请号：PCT/US1991001301
申请日：1991-02-28
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , UNIVERSITY OF CINCINNATI
发明人： CHILDREN'S HOSPITAL MEDICAL CENTER , UNIVERSITY OF CINCINNATI , LIEBERMAN, Michael, A. , FUGMAN, Douglas, A.
IPC分类号： C12N05/08
CPC分类号： C07K14/495 , C07K14/503 , C12N5/0644 , C12N2502/1394
摘要： Human monophenotypic cloned cell lines of megakaryocytic lineage are established in vitro through use of adherent stromal cells in long term human bone marrow culture. One cloned in vitro cell line, CHRF-288-11, exhibits a karyotype and markers characteristic of megakaryocytes and platelets. CHRF-288-11 cells express platelet peroxidase, platelet factor IV, platelet CA -ATPase, gpIIbIIIa, factor VIII, and MY7, MY9 and HLA-Dr antigens. CHRF-288-11 cell lines do not express erythroid markers glycophorin A and hemoglobin, myeloid marker myeloperoxidase, nor markers specific for T- and B-cells. CHRF-288-11 cells also express basic FGF and TGF-beta properties. CHRF-288-11 cells exhibit a constant karyotype (50, XY) and displays a doubling time of approximately 33 hours in either 25 % horse or calf serum. Treatment of CHRF-288-11 cells with phorbol 12-myristate 13-acetate (PMA) induces multi-nucleation and hyperploidy with about 35 % of the cells exhibiting two or more nuclei per cell, and greater than 80 % of the cells enlarging in size. CHRF-288-11 cell line is deposited under the Budapest Treaty with American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852, under accession no. CRL 10107.
摘要翻译：通过在长期人类骨髓培养物中使用贴壁基质细胞体外建立巨核细胞谱系的人类单克隆克隆细胞系。一个克隆的体外细胞系CHRF-288-11表现出核型和巨核细胞和血小板特征的标记。 CHRF-288-11细胞表达血小板过氧化物酶，血小板因子IV，血小板CA ++，ATP酶，gpIIbIIIa，因子VIII和MY7，MY9和HLA-Dr抗原。 CHRF-288-11细胞系不表达红细胞标志物血型糖蛋白A和血红蛋白，骨髓标志物髓过氧化物酶，也不表示特异于T细胞和B细胞的标志物。 CHRF-288-11细胞也表达基本的FGF和TGF-β特性。 CHRF-288-11细胞表现出恒定的核型（50，XY），在25％的马或小牛血清中显示约33小时的倍增时间。用佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA）处理CHRF-288-11细胞诱导多核和超倍性，约35％的细胞每个细胞呈现两个或更多个细胞核，大于80％的细胞扩大尺寸。 CHRF-288-11细胞系根据布达佩斯条约与美国典型培养物保藏中心共享，12301 Parklawn Drive，Rockville，Maryland 20852，登录号： CRL 10107。

2. 发明申请

WO1996006803A1 PROCESS FOR PRODUCING CERAMIC POWDERS, ESPECIALLY TITANIUM DIOXIDE USEFUL AS A PHOTOCATALYST 审中-公开
标题翻译：用于生产陶瓷粉末的方法，特别是作为光催化剂有用的二氧化钛
公开(公告)号：WO1996006803A1
公开(公告)日：1996-03-07
申请号：PCT/US1995010841
申请日：1995-08-25
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , PRATSINIS, Sotiris, Emmanuel , VEMURY, Srinivas , FOTOU, George, P. , GUTSCH, Andreas
IPC分类号： C01G23/07
CPC分类号： C01B21/06 , C01B13/28 , C01B33/183 , C01G19/02 , C01G23/07 , C01P2002/54 , C01P2004/82 , C01P2006/12
摘要： A gas phase process for the production of titanium dioxide powders having well-controlled crystalline and surface area characteristics is disclosed. In this process, which is preferably carried out in a laminar diffusion flame reactor, vapor phase TiCl4 and oxygen are mixed in a reaction area which is heated externally. The titanium dioxide powder formed is then collected. It is preferred that the heat source used be a hydrocarbon fueled (e.g., methane) flame. Optionally, a vapor phase dopant (such as SiCl4) may be added to the reaction mixture to desirably affect the physical properties of the titanium dioxide produced. In a particularly preferred embodiment, a corona electric field is positioned across the area where the combustion reaction takes place (i.e., the reaction area). High anatase, high surface area titanium dioxide powders made by this process are excellent photocatalysts. The products of this process and the use of those products as photocatalysts are also disclosed. This process is also useful for producing other ceramic powders (such as silicon dioxide and tin oxide), as well as pure metallic or alloy powders.
摘要翻译：公开了一种用于生产具有良好控制的结晶和表面积特性的二氧化钛粉末的气相方法。在该方法中，其优选在层状扩散火焰反应器中进行，气相TiCl 4和氧气在外部加热的反应区域中混合。然后收集形成的二氧化钛粉末。优选地，所使用的热源是烃燃料（例如甲烷）火焰。任选地，可将气相掺杂剂（例如SiCl 4）加入到反应混合物中以期望影响所生产的二氧化钛的物理性能。在特别优选的实施例中，电晕电场位于燃烧反应发生的区域（即反应区域）上。高锐钛型，通过该方法制备的高表面积二氧化钛粉末是优异的光催化剂。还公开了该方法的产物和这些产物作为光催化剂的用途。该方法对于生产其它陶瓷粉末（例如二氧化硅和氧化锡）以及纯金属或合金粉末也是有用的。

3. 发明申请

WO1994017012A1 POROUS CERAMIC AND POROUS CERAMIC COMPOSITE STRUCTURE 审中-公开
标题翻译：多孔陶瓷和多孔陶瓷复合结构
公开(公告)号：WO1994017012A1
公开(公告)日：1994-08-04
申请号：PCT/US1993000735
申请日：1993-01-27
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , SEKHAR, Jainagesh, A. , BHADURI, Sarit, B.
IPC分类号： C04B35/64
CPC分类号： B01D39/2051 , B01D39/2093 , B22C9/086 , C04B35/651 , C04B38/0022 , C04B2111/00793 , C04B2111/0087 , C22C1/058 , C04B38/061
摘要： A process for producing a porous ceramic, ceramic composite or metal-ceramic composite structure by combustion synthesis wherein a foamed polymer shape is impregnated with a slurry of ceramic precursors and ignited to initiate combustion synthesis, thereby obtaining a ceramic, ceramic composite or metal-ceramic composite article having interconnected porosity. Ceramic composite filters having improved strength, toughness and thermal shock resistance are provided, with the ceramic composite being an oxide and a nonoxide.
摘要翻译：通过燃烧合成制造多孔陶瓷，陶瓷复合材料或金属 - 陶瓷复合结构的方法，其中用陶瓷前体的浆料浸渍发泡聚合物形状并点燃以引发燃烧合成，由此获得陶瓷，陶瓷复合材料或金属陶瓷复合制品具有互连孔隙。提供了具有改善的强度，韧性和耐热冲击性的陶瓷复合过滤器，陶瓷复合材料是氧化物和非氧化物。

4. 发明申请

WO1994002851A1 CLINICAL TEST FOR DETECTION OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于检测阿尔茨海默病的临床试验
公开(公告)号：WO1994002851A1
公开(公告)日：1994-02-03
申请号：PCT/US1993006900
申请日：1993-07-23
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , ZEMLAN, Frank, Paul , DEAN, Gary, E.
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821 , Y10S436/811
摘要： A clinical method for the detection of Alzheimer's disease in living patients tests cerebrospinal fluid obtained from the patient. The cerebrospinal fluid is tested using a Western blot analysis to determine reactivity with a polyclonal or a monoclonal antibody. The antibody is one which reacts with a broad band of immunoreactivity obtained upon separation of Alzheimer's specific, material derived from filaments obtained from brains of deceased individuals having Alzheimer's disease. The test is particularly selective and enables one to identify patients with Alzheimer's disease and distinguishes these from patient's with other neurological disorders with similar symptoms such as Parkinson's disease and Pick's disease.
摘要翻译：在患者中检测阿尔茨海默病的临床方法测试患者获得的脑脊液。使用蛋白质印迹分析测试脑脊液，以确定与多克隆或单克隆抗体的反应性。抗体是与分离阿尔茨海默氏特异性获得的宽带免疫反应性的抗体反应的，该衍生自从具有阿尔茨海默氏病的死亡个体的大脑获得的细丝。该测试是特别选择性的，并且能够识别患有阿尔茨海默病的患者，并将其与具有类似症状的其他神经障碍患者与帕金森氏病和皮克病区分开来。

5. 发明申请

WO1992009710A1 DIELESS MICRO-PYRETIC MANUFACTURING TECHNIQUE FOR FABRICATING BEARING MATERIALS AND THE BEARING MATERIALS PRODUCED THEREBY 审中-公开
标题翻译：用于生产轴承材料的无心微型制造技术和生产的轴承材料
公开(公告)号：WO1992009710A1
公开(公告)日：1992-06-11
申请号：PCT/US1991008967
申请日：1991-12-02
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , SEHKAR, Jainagesh, A. , BHATTACHARYA, A., K. , LI, Hung, P.
IPC分类号： C22C01/05
CPC分类号： F16C33/14 , C22C1/058 , C22C29/14 , C22C32/0089 , F16C33/043 , F16C2220/20 , F16C2223/42 , F16C2223/44 , Y10T428/12056
摘要： The present invention relates to a method of fabricating various types of bearing materials and the bearing materials produced thereby. The processes of the invention may be used to produce porous self-lubricating bearings, laminated composite bearings (babbitt bearings) and bearings for high temperature application. The processes of the invention involve the use of micro-pyretic synthesis to achieve bearing materials with improved bearing properties, including higher bearing capacity and toughness.
摘要翻译：本发明涉及一种制造各种类型的轴承材料的方法和由此生产的轴承材料。本发明的方法可用于生产多孔自润滑轴承，层压复合轴承（巴氏合金轴承）和用于高温应用的轴承。本发明的方法涉及使用微裂解合成来实现具有改进的轴承性能的轴承材料，包括较高的承载能力和韧性。

6. 发明申请

WO1991004827A1 A MAGNETIC PLASMA PRODUCING DEVICE WITH ADJUSTABLE RESONANCE PLANE 审中-公开
标题翻译：具有可调谐共振平面的磁性等离子体生产装置
公开(公告)号：WO1991004827A1
公开(公告)日：1991-04-18
申请号：PCT/US1990005592
申请日：1990-10-01
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , MANTEI, Thomas, D.
IPC分类号： B23K09/00
CPC分类号： H01J37/32192 , H01J37/32678
摘要： An apparatus (11) is provided for the production of plasma. An evacuable chamber (12) is operatively connected to a microwave waveguide (15), down which microwave energy at approximately 2.45 GHz is transported. The microwave energy enters the evacuable chamber (12) through an opening (23) in the upper wall (17) of the chamber covered by microwave transparent material. Centrally located above the opening in the upper wall of the chamber and outside the waveguide, a permanent magnet (14) is provided. The strong downward magnetic field of the magnet enters the chamber in the same direction as the propagation path (30) of the microwaves. The downward magnetic field component is at a right angle to the electric field associated with the microwaves. When a working gas is present a plasma of ions, electrons and atoms is created which etches workpiece (28).

7. 发明申请

WO1996029990A1 FIBRINOGEN-COATED LIPOSOMES 审中-公开
标题翻译：纤维蛋白涂层脂质体
公开(公告)号：WO1996029990A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004323
申请日：1996-03-29
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , RETZINGER, Gregory, Scott , DEANGLIS, Ashley, P.
IPC分类号： A61K09/127
CPC分类号： A61K9/1271
摘要： A method for preparing fibrinogen-coated liposomes is disclosed. In this process, fibrinogen and an acylating agent are reacted in the presence of a dispersion of liposomes under specifically defined reaction conditions. The liposomes formed using this process, pharmaceutical compositions containing those liposomes, and the methods of clotting blood and delivering pharmaceutically-active agents and/or other chemicals utilizing those pharmaceutical compositions are also disclosed.
摘要翻译：公开了一种制备纤维蛋白原包被的脂质体的方法。在此过程中，纤维蛋白原和酰化剂在脂质体分散体存在下在特定的反应条件下反应。还公开了使用该方法形成的脂质体，含有这些脂质体的药物组合物，以及使用这些药物组合物凝结血液和递送药物活性剂和/或其它化学物质的方法。

8. 发明申请

WO1996020205A1 1,4-DIHYDRODIOXINS AND RELATED COMPOUNDS AS DNA CLEAVING REAGENTS 审中-公开
标题翻译： 1,4-二氢吲哚和相关化合物作为DNA清除试剂
公开(公告)号：WO1996020205A1
公开(公告)日：1996-07-04
申请号：PCT/US1995016434
申请日：1995-12-21
申请人： UNIVERSITY OF CINCINNATI , WILSON, Robert, Marshall , SCHNAPP, Karlyn, A. , HARSCH, Andreas , KELLER, Stephen, J. , SCHLEMM, Donna, J.
发明人： UNIVERSITY OF CINCINNATI
IPC分类号： C07H21/00
CPC分类号： C07D319/14
摘要： The present invention relates to a class of 1,4-dihydrodioxin masked quinone compounds which are useful as DNA or RNA cleaving reagents. These compounds may additionally include moieties which target the compounds to specific base sequences on the DNA or RNA molecule to permit site-specific cleavage. The process for using these compounds in a UV or short wavelength visible light-activated reaction for cleaving DNA, as well as pharmaceutical compositions containing these compounds, are also disclosed.
摘要翻译：本发明涉及可用作DNA或RNA切割试剂的一类1,4-二氢二恶英掩蔽的醌化合物。这些化合物还可以包括将化合物靶向DNA或RNA分子上的特定碱基序列以允许位点特异性切割的部分。还公开了在UV或短波长可见光激活反应中使用这些化合物以切割DNA的方法，以及含有这些化合物的药物组合物。

9. 发明申请

WO1996001786A1 PROCESS FOR NITRIDE POWDER PRODUCTION 审中-公开
标题翻译：硝酸粉生产工艺
公开(公告)号：WO1996001786A1
公开(公告)日：1996-01-25
申请号：PCT/US1995008680
申请日：1995-07-11
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , PRATSINIS, Sotiris, E. , AKHTAR, M., Kamal , WANG, Guizhi , PANDA, Siddhartha
IPC分类号： C01B21/072
CPC分类号： B82Y30/00 , C01B21/06 , C01B21/072 , C01P2002/60 , C01P2002/80 , C01P2004/03 , C01P2004/50 , C01P2004/51 , C01P2004/52 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2006/12
摘要： Processes for the direct manufacture of nitride powders suitable for low temperature sintering are provided. An elemental vapor is contacted with a nitriding gas at temperatures between 1400 and 1973 K and atmospheric pressure to produce nitride powder.
摘要翻译：提供了用于直接制造适用于低温烧结的氮化物粉末的方法。元素蒸汽在1400和1973K之间的温度和大气压下与氮化气体接触以产生氮化物粉末。

10. 发明申请

WO1995030164A1 OPTICAL SYNCHRONOUS CLOCK DISTRIBUTION NETWORK AND HIGH-SPEED SIGNAL DISTRIBUTION NETWORK 审中-公开
标题翻译：光同步时钟分配网络和高速信号分配网络
公开(公告)号：WO1995030164A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005365
申请日：1995-04-25
申请人： UNIVERSITY OF CINCINNATI
发明人： UNIVERSITY OF CINCINNATI , KOH, Seungug , CARTER, Harold, W. , BOYD, Joseph, T.
IPC分类号： G02B06/43
CPC分类号： G02B6/12007 , G02B6/29323 , G02B6/2938 , G02B6/4215 , G02B6/43 , G06F1/105
摘要： An optical waveguide H-tree design is provided for global clock distribution of multichip modules (MCM) which has nearly zero clock skew and is useful for a distributed computer system environment. The optical waveguide H-tree design utilizes channel waveguides (24), curved sections and directional couplers (34) formed using silica glass and silicon oxynitride (SiON) channel waveguide technologies. A hybrid combination of both SiON and silica glass is disclosed which has the advantages of each. The achievable clock speed is limited by the laser diode source and photodiode receiver at each chip module, and not by the optical waveguide distribution network. The high-speed optical waveguide can be configured to transmit clock signals, or for use a multi-wavelength communication network that communicates signals to various integrated circuits (ICs) mounted on the multichip module. This is achieved using multiple laser diodes (121) having different output wavelengths and directing their outputs into an optical multiplexer. At the receiving points on the ICs, optical demultiplexers filter the optical signals into individual output signals. In addition, multiple "stacked" optical waveguides can be constructed on the MCM to transmit multiple optical signals, and such optical signals can be either of single wavelength or multiple wavelength type.
摘要翻译：提供了一种光波导H树设计，用于具有几乎零时钟偏移的多芯片模块（MCM）的全局时钟分配，并且对于分布式计算机系统环境是有用的。光波导H树设计利用了使用石英玻璃和氮氧化硅（SiON）通道波导技术形成的通道波导（24），弯曲部分和定向耦合器（34）。公开了SiON和石英玻璃的混合组合，其具有各自的优点。可实现的时钟速度受到每个芯片模块处的激光二极管源和光电二极管接收器的限制，而不受光波导分配网络的限制。高速光波导可以被配置为传输时钟信号，或者用于使用将信号传送到安装在多芯片模块上的各种集成电路（IC）的多波长通信网络。这是使用具有不同输出波长的多个激光二极管（121）并将其输出引导到光复用器中来实现的。在IC上的接收点，光解复用器将光信号滤波为各个输出信号。此外，可以在MCM上构造多个“堆叠”光波导以传输多个光信号，并且这样的光信号可以是单波长或多波长类型。

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