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1. 发明申请

WO2021262844A1 METHODS FOR DETERMINING BLOOD OXYGENATION AND TISSUE PERFUSION LEVELS AND DEVICES THEREOF 审中-公开
公开(公告)号：WO2021262844A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/038674
申请日：2021-06-23
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , GOMER, Heather, E. , STEWART, Shona , SMITH, Aaron, G.
发明人： TREADO, Patrick, J. , GOMER, Heather, E. , STEWART, Shona , SMITH, Aaron, G.
IPC分类号： H04N5/33 , A61B5/00 , G01N33/483 , A61B5/1455 , A61B5/0261
摘要： Methods for improved tissue perfusion monitoring are disclosed. A method includes collecting hyperspectral image data from an image sensor positioned to collect interacted photons from a tissue region resulting from illumination of the tissue sample at a plurality of wavelengths in the visible, near infrared, or shortwave infrared regions. Hypercubes are generated based on the collected hyperspectral image data. The hypercubes are analyzed to identify one or more of the plurality of wavelengths resulting in contrast in the hyperspectral images. One or more regions in the tissue region with altered perfusion states are identified based on the contrast in the hyperspectral images. A tissue perfusion monitoring computing device and non-transitory medium are also disclosed.

2. 发明申请

WO2021236615A1 SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2021236615A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/032931
申请日：2021-05-18
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , SMITH, Aaron , TREADO, Patrick, J.
发明人： STEWART, Shona , SMITH, Aaron , TREADO, Patrick, J.
IPC分类号： A61B17/24
摘要： Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.

3. 发明申请

WO2007021485A2 RAMAN SPECTRAL ANALYSIS OF PATHOGENS 审中-公开
标题翻译：拉曼光谱分析病原体
公开(公告)号：WO2007021485A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029187
申请日：2006-07-27
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
发明人： STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.
摘要翻译：使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。

4. 发明申请

WO2006135628A2 CYTOLOGICAL METHODS FOR DETECTING A DISEASE CONDITION SUCH AS MALIGNANCY BY RAMAN SPECTROSCOPIC IMAGING 审中-公开
标题翻译：用于通过拉曼光谱成像检测疾病状态如恶性肿瘤的细胞学方法
公开(公告)号：WO2006135628A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022083
申请日：2006-06-06
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , STEWART, Shona , TREADO, Patrick, J.
发明人： MAIER, John, S. , STEWART, Shona , TREADO, Patrick, J.
IPC分类号： C12Q1/00 , C12Q1/70 , C12Q1/68 , G06F19/00 , G01J3/44
CPC分类号： G01N21/65 , G01N2021/656
摘要： Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.
摘要翻译：拉曼分子成像（RMI）用于检测特定表型的哺乳动物细胞。例如，本公开包括使用RMI来区分正常和患病细胞或组织，例如癌细胞，以及确定所述癌细胞的等级。在一个优选实施方案中，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾，乳腺和结肠以及非上皮组织，例如骨髓和脑。可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。此外，RMI技术可以与可视图像数据组合，并用其他检测方法验证，以确定RMI获得的事项。

5. 发明申请

WO2006007064A2 SYSTEM AND METHOD FOR SPECTROSCOPY AND IMAGING 审中-公开
标题翻译：用于光谱和成像的系统和方法
公开(公告)号：WO2006007064A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/016141
申请日：2005-05-06
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , NELSON, Matthew, P. , DEMUTH, Joseph, E. , TREADO, Patrick, J.
发明人： STEWART, Shona , NELSON, Matthew, P. , DEMUTH, Joseph, E. , TREADO, Patrick, J.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/0297 , G01N21/65
摘要： The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.
摘要翻译：本公开涉及用于通过光学成像光谱的拉曼的光谱表征的生物材料的改进的检测，分辨和成像的基底材料。衬底提供均匀的光学平坦的高反射表面，其可以被制成疏水性以防止样品的扩散并且便于其光学评估。此外，当暴露于所述照射光子时，衬底可以涂覆有不发射拉曼散射光子的材料。本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。

6. 发明申请

WO2007050602A2 AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA 审中-公开
标题翻译：自动采集光谱数据和图像数据
公开(公告)号：WO2007050602A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041471
申请日：2006-10-24
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , NELSON, Matthew , MCCLELLAND, Lindy , STEWART, Shona
发明人： MAIER, John, S. , TREADO, Patrick, J. , NELSON, Matthew , MCCLELLAND, Lindy , STEWART, Shona
IPC分类号： H04B10/08 , H04B17/00
CPC分类号： G01N21/65 , G01J3/28 , G01J3/2823 , G01J3/44 , G01N21/274 , G01N2021/656
摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.
摘要翻译：自动获取样品光谱的系统和方法。该方法涉及包括光漂白相和光谱采集阶段的两相过程。在漂白漂白阶段，收集样品的一系列光谱数据集。在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

7. 发明申请

WO2021247541A1 A METHOD FOR FUSING SENSOR DATA FOR CARDIAC MONITORING AND DEVICES THEREOF 审中-公开
公开(公告)号：WO2021247541A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035207
申请日：2021-06-01
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , SMITH, Aaron, G. , GOMER, Heather, E. , LANKER, Lewis, L.
发明人： TREADO, Patrick, J. , SMITH, Aaron, G. , GOMER, Heather, E. , LANKER, Lewis, L.
IPC分类号： G16H50/20 , G16H50/30 , A61B5/0205 , A61B5/14551 , A61B5/318 , A61B5/4878 , A61B5/7267 , A61B5/7275 , A61B5/7282 , G06K9/6289 , G06V20/52 , G16H20/00 , G16H30/20 , G16H30/40 , G16H40/63 , G16H40/67 , G16H50/70
摘要： A method for improved cardiac monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring edema in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to cardiac activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A cardiac condition for the patient is determined based on the fused data set. A cardiac monitoring computing device and non-transitory medium are also disclosed.

8. 发明申请

WO2006083716A2 METHOD AND APPARATUS FOR A MICROSCOPE IMAGE SELECTOR 审中-公开
标题翻译：一种显微镜图像选择器的方法和装置
公开(公告)号：WO2006083716A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002976
申请日：2006-01-30
申请人： CHEMIMAGE CORPORATION , WANG, Xinghua , VOIGHT, Thomas , TUSCHEL, David , WANG, Chenhui , TREADO, Patrick, J.
发明人： WANG, Xinghua , VOIGHT, Thomas , TUSCHEL, David , WANG, Chenhui , TREADO, Patrick, J.
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

9. 发明申请

WO2006005022A2 DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
标题翻译：生物细胞和其他物质的动态化学成像
公开(公告)号：WO2006005022A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023638
申请日：2005-06-30
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
发明人： MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像的方法，包括细胞成像的方法。该方法包括用基本上单色的光照射单元的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。拉曼位移光可以在每个离散时间的多个拉曼位移（RS）值处被评估，并且RS值可以被选择为在每个离散时间处的预选分量的特征。由此获得的图像的拉曼光谱特征的多变量分析可以产生组件在视场中的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见的显微图像）组合或覆盖。

10. 发明申请

WO2007101279A2 METHOD AND APPARATUS FOR COMPACT SPECTROMETER WITH FIBER ARRAY SPECTRAL TRANSLATOR 审中-公开
标题翻译：具有光纤阵列光谱转换器的紧凑光谱仪的方法和装置
公开(公告)号：WO2007101279A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/063348
申请日：2007-03-05
申请人： CHEMIMAGE CORPORATION , GARDNER, Charles, W. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , WANG, Chenhul , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H.
发明人： GARDNER, Charles, W. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , WANG, Chenhul , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H.
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

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