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1. 发明申请

WO2022016156A1 SYSTEMS AND METHODS OF CONFORMAL SPECTRAL LIBRARY TRAINING 审中-公开
公开(公告)号：WO2022016156A1
公开(公告)日：2022-01-20
申请号：PCT/US2021/042232
申请日：2021-07-19
申请人： CHEMIMAGE CORPORATION
发明人： TREADO, Patrick, J. , NELSON, Matthew, P. , TAZIK, Shawna , SCHWEITZER, Robert, C.
IPC分类号： G01J3/28 , G01J3/30 , G01J3/36 , G01N21/25 , G01N21/31 , G02F1/347 , G01J2003/2826 , G01J2003/2833 , G01J2003/2836 , G01J3/2823
摘要： The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation. Methods, optical devices, and software are disclosed.

2. 发明申请

WO2020159682A2 SYSTEMS AND METHODS OF COVERT IDENTIFICATION 审中-公开
公开(公告)号：WO2020159682A2
公开(公告)日：2020-08-06
申请号：PCT/US2020/012769
申请日：2020-01-08
申请人： CHEMIMAGE CORPORATION
发明人： TREADO, Patrick, J. , CAUDLE, David, W. , NELSON, Matthew, P. , TAZIK, Shawna
IPC分类号： G01N21/27
摘要： In order to avoid friendly fire incidents in the combat theater, novel covert identification systems and methods of identifying friendly forces are provided. The systems include at least a spectroscopic imaging device and a marker that interact with each other by using a synchronized, predetermined filter tuning sequence. The filter tuning sequence enables interacted photons to wavelength hop according to the predetermined tuning sequence. As a result, the covert identification system allows friendly forces to clearly identify each while avoiding detection by enemy forces that employ conventional broadband and night vision sensors.

3. 发明申请

WO2006083716A2 METHOD AND APPARATUS FOR A MICROSCOPE IMAGE SELECTOR 审中-公开
标题翻译：一种显微镜图像选择器的方法和装置
公开(公告)号：WO2006083716A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002976
申请日：2006-01-30
申请人： CHEMIMAGE CORPORATION , WANG, Xinghua , VOIGHT, Thomas , TUSCHEL, David , WANG, Chenhui , TREADO, Patrick, J.
发明人： WANG, Xinghua , VOIGHT, Thomas , TUSCHEL, David , WANG, Chenhui , TREADO, Patrick, J.
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

4. 发明申请

WO2006005022A2 DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
标题翻译：生物细胞和其他物质的动态化学成像
公开(公告)号：WO2006005022A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023638
申请日：2005-06-30
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
发明人： MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像的方法，包括细胞成像的方法。该方法包括用基本上单色的光照射单元的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。拉曼位移光可以在每个离散时间的多个拉曼位移（RS）值处被评估，并且RS值可以被选择为在每个离散时间处的预选分量的特征。由此获得的图像的拉曼光谱特征的多变量分析可以产生组件在视场中的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见的显微图像）组合或覆盖。

5. 发明申请

WO2020163338A1 QUANTIFICATION OF HEART FAILURE USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2020163338A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/016589
申请日：2020-02-04
申请人： CHEMIMAGE CORPORATION
发明人： COHEN, Jeffrey, K. , POST, J. Christopher , STEWART, Shona , TREADO, Patrick, J. , GOMER, Heather , SMITH, Aaron
IPC分类号： A61B5/1455 , G01N21/17 , G02F1/1335 , A61B5/05 , A61B5/00 , G01J3/28
摘要： Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

6. 发明申请

WO2007101279A2 METHOD AND APPARATUS FOR COMPACT SPECTROMETER WITH FIBER ARRAY SPECTRAL TRANSLATOR 审中-公开
标题翻译：具有光纤阵列光谱转换器的紧凑光谱仪的方法和装置
公开(公告)号：WO2007101279A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/063348
申请日：2007-03-05
申请人： CHEMIMAGE CORPORATION , GARDNER, Charles, W. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , WANG, Chenhul , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H.
发明人： GARDNER, Charles, W. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , WANG, Chenhul , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H.
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

7. 发明申请

WO2007092010A2 SYSTEM AND METHOD FOR ELECTROSTATIC DETECTION AND IDENTIFICATION OF THREAT AGENTS 审中-公开
标题翻译：用于静电检测和识别故障代理的系统和方法
公开(公告)号：WO2007092010A2
公开(公告)日：2007-08-16
申请号：PCT/US2006/004566
申请日：2006-02-09
申请人： CHEMIMAGE CORPORATION , SARNOFF CORPORATION , TREADO, Patrick, J. , GARDNER, Charles, W., Jr. , MAIER, John, S. , KELLER, David
发明人： TREADO, Patrick, J. , GARDNER, Charles, W., Jr. , MAIER, John, S. , KELLER, David
CPC分类号： G01J3/44 , G01N21/65
摘要： A system and method for detecting aerosol threats comprising electrostatic collection and deposition of a threat agent onto a substrate. The threat agent deposited on the substrate is illuminated with a plurality of photons to thereby produce Raman scattered photons. The Raman scattered photons are analyzed in order to identify the threat agent.
摘要翻译：一种用于检测气溶胶威胁的系统和方法，包括将威胁剂静电收集和沉积到基底上。沉积在基板上的威胁剂被多个光子照射，由此产生拉曼散射的光子。分析拉曼散射光子以识别威胁剂。

8. 发明申请

WO2007055981A2 INVASIVE AND NON-INVASIVE CHEMOMETRY 审中-公开
标题翻译：入侵和非入侵化学
公开(公告)号：WO2007055981A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/042538
申请日：2006-11-01
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , MAIER, John, S. , COHEN, Jeffrey, K. , DEMUTH, Joseph, E.
发明人： TREADO, Patrick, J. , MAIER, John, S. , COHEN, Jeffrey, K. , DEMUTH, Joseph, E.
IPC分类号： A61B5/00
CPC分类号： G06F19/10 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/415 , A61B5/418 , A61B5/4519
摘要： The invention relates to methods and devices for assessing one or more components of blood or a selected tissue in an animal. The present invention permits non-invasive assessment of blood or tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the blood or the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood or tissue component for one or more regions that exhibit the optical characteristic of the blood or the tissue of interest.
摘要翻译：本发明涉及用于评估动物中血液或选定组织的一种或多种组分的方法和装置。本发明通过评估动物身体的多个区域以获得血液或感兴趣的组织的光学特征，并且分别评估一种或多种光学（例如，血液或组织）的身体结构中的血液或组织成分的非侵入性评估。，拉曼或NIR）特征，其表现出血液或感兴趣的组织的光学特征的一个或多个区域。

9. 发明申请

WO2007044594A2 MOTION INVARIANT GENERALIZED HYPERSPECTRAL TARGETING AND IDENTIFICATION METHODOLOGY AND APPARATUS THEREFOR 审中-公开
标题翻译：运动无差异化的高效指标和识别方法及其设备
公开(公告)号：WO2007044594A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/039271
申请日：2006-10-10
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , NEISS, Jason, H.
发明人： TREADO, Patrick, J. , NEISS, Jason, H.
IPC分类号： C12N9/10
CPC分类号： G01N21/6456 , G01J3/2823 , G01N21/359 , G01N21/65 , G01N33/0004 , G01N2021/1793 , G01N2021/3531 , G01N2021/6423
摘要： The present disclosure relates to a method and system for enhancing the ability of nuclear, chemical, and biological ("NBC") sensors, specifically mobile sensors, to detect, analyze, and identify NBC agents on a surface, in an aerosol, in a vapor cloud, or other similar environment. Embodiments include the use of a two-stage approach including targeting and identification of a contaminant. Spectral imaging sensors may be used for both wide-field detection (e.g., for scene classification) and narrow-field identification.
摘要翻译：本公开内容涉及一种用于增强核，化学和生物（“NBC”）传感器，特别是移动传感器在表面上，气溶胶中检测，分析和鉴定NBC试剂的能力的方法和系统，蒸汽云或其他类似环境。实施方案包括使用包括靶向和鉴定污染物的两阶段方法。光谱成像传感器可用于宽场检测（例如，用于场景分类）和窄场识别。

10. 发明申请

WO2007021485A2 RAMAN SPECTRAL ANALYSIS OF PATHOGENS 审中-公开
标题翻译：拉曼光谱分析病原体
公开(公告)号：WO2007021485A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029187
申请日：2006-07-27
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
发明人： STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.
摘要翻译：使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。

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