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1. 发明申请

WO2011157803A1 PURIFICATION OF AMPHOTERIC PRODUCTS 审中-公开
标题翻译：净化产品
公开(公告)号：WO2011157803A1
公开(公告)日：2011-12-22
申请号：PCT/EP2011/060058
申请日：2011-06-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE , LONZA AG , GIRAUD, Matthieu , MCGARRITY, John , RENAULT, Jean-Hugues , BOUDESOCQUES, Leslie
发明人： GIRAUD, Matthieu , MCGARRITY, John , RENAULT, Jean-Hugues , BOUDESOCQUES, Leslie
IPC分类号： C07K5/06 , C07K14/415 , C07K14/47
CPC分类号： C07K5/06026 , B01D15/1892 , B01D15/422 , C07K5/06043 , C07K5/06052 , G01N30/42
摘要： The invention relates to the use of centrifugal partition chromatography in an ion exchange displacement mode for the implementation of a purification process of at least one product to be purified from a substrate containing it, said product to be purified being an amphoteric product or an amphoteric convertible product.
摘要翻译：本发明涉及离子分配色谱法在离子交换置换模式中的用途，用于从含有其的底物中纯化至少一种待纯化的产物的纯化方法，待纯化的产物是两性产物或两性可转换产品。

2. 发明申请

WO2008131932A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ETHENYLPHENYL ALCOHOLS 审中-公开
标题翻译：制备光学活性亚乙基醇的方法
公开(公告)号：WO2008131932A1
公开(公告)日：2008-11-06
申请号：PCT/EP2008/003374
申请日：2008-04-25
申请人： LONZA AG , MCGARRITY, John , BAPPERT, Erhard , BELSER, Thomas
发明人： MCGARRITY, John , BAPPERT, Erhard , BELSER, Thomas
IPC分类号： C07D215/18
CPC分类号： C07D215/18
摘要： Optically active ethenylphenyl-alcohols of formula (I) or its mirror image, wherein R 1 is unsubstituted or substituted heteroaryl and R 2 is phenyl or substituted aryl, are prepared by asymmetric hydrogenation of the corresponding ketones applying hydrogen gas in the presence of specific platinum metal complex catalysts.
摘要翻译：式（I）的光学活性乙烯基苯基醇或其镜像，其中R 1是未取代或取代的杂芳基和R 2是苯基或取代的芳基，其通过不对称在特定的铂金属络合物催化剂的存在下氢化相应的使用氢气的酮。

3. 发明申请

WO2005080370A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS 审中-公开
标题翻译：制备纯化1-取代的3-氨基醇的方法
公开(公告)号：WO2005080370A1
公开(公告)日：2005-09-01
申请号：PCT/EP2005/001781
申请日：2005-02-21
申请人： LONZA AG , MICHEL, Dominique , METTLER, Hanspeter , MCGARRITY, John
发明人： MICHEL, Dominique , METTLER, Hanspeter , MCGARRITY, John
IPC分类号： C07D333/20
CPC分类号： C07C213/00 , C07B2200/07 , C07D333/22
摘要： Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(-)- and (R)-(+)-3- N -methylamino-l-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of formula (II), wherein R 1 is selected from the group consisting of 2-thienyl, 2-furanyl and phenyl, each optionally substituted with one or more halogen atoms and/or one or more C 1-4 -alkoxy groups, and wherein R 2 is C 1-4 -alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, and wherein the corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Furthermore provided are salts of a carboxylic acid with said aminoketones and the aminoalcohols obtained by asymmetriacally hydrogenating said aminoketones, respectively.
摘要翻译：提供了制备对映体纯的1-取代-3-氨基醇，特别是（S） - （ - ） - 和（R） - （+） - 3-N-甲基氨基-1-（2-噻吩基） -1-丙醇，通过用式（II）的氨基酮不对称氢化羧酸盐，其中R 1选自2-噻吩基，2-呋喃基和苯基，各自任选被一个或多个更多的卤素原子和/或一个或多个C 1-4 - 烷氧基，并且其中R 2是C 1-4 - 烷基或苯基，各自任选被一个或多个卤素原子和/或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，并且其中相应的氨基醇通过其盐的随后水解获得。此外，还提供了羧酸与所述氨基酮和通过不对称地氢化所述氨基酮而获得的氨基醇的盐。

4. 发明申请

WO2008095678A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS 审中-公开
标题翻译：制备光学活性2-氨基-1-苯乙醇的方法
公开(公告)号：WO2008095678A1
公开(公告)日：2008-08-14
申请号：PCT/EP2008/000877
申请日：2008-02-05
申请人： LONZA AG , MCGARRITY, John , LI, Wenge
发明人： MCGARRITY, John , LI, Wenge
IPC分类号： C07C213/00 , C07C215/08 , C07C215/20 , C07C215/60 , C07F15/00 , C07F9/547
CPC分类号： C07C213/00 , C07F9/65683 , C07C215/60
摘要： Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R 1 is C 1-6 alkyl or aryl-substituted C 1-6 alkyl and R 2 through R 6 are independently hydrogen, hydroxy or C 1-6 alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoaceto-phenones in the presence of a rhodium complex catalyst comprising a chiral diphosphine ligand, wherein each phosphorus atom is part of a heterocyclic ring system which contains at least one chiral carbon atom directly bound to the phosphorus atom.
摘要翻译：式（I）的光学活性2-氨基-1-苯基乙醇或其镜像，其中R 1是C 1-6烷基或芳基取代的C 1 -C 6烷基， 1-6个C 1-6烷基和R 2至R 6独立地是氢，羟基或C 1-6烷氧基，或其盐通过在包含手性二膦配体的铑配合物催化剂存在下对应的2-氨基乙酰苯酚的不对称氢化制备，其中每个磷原子是含有至少一个与磷原子。

5. 发明申请

WO2008077560A1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-AMINO-1-PHENYLETHANOLS 审中-公开
标题翻译：制备光学活性2-氨基-1-苯乙醇的方法
公开(公告)号：WO2008077560A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/011180
申请日：2007-12-19
申请人： LONZA AG , MCGARRITY, John , ZANOTTI-GEROSA, Antonio
发明人： MCGARRITY, John , ZANOTTI-GEROSA, Antonio
IPC分类号： C07C213/00 , C07C215/60
CPC分类号： C07C213/00 , C07B2200/07 , C07C215/60
摘要： Optically active 2-amino-l-phenylethanols of formula (I) or its mirror image, wherein R 1 is hydrogen, C 1-6 alkyl or aryl-substituted C 1-6 alkyl and R 2 through R 6 are independently hydrogen, hydroxy or C 1-6 alkoxy, or salts thereof are prepared by asymmetric hydrogenation of the corresponding 2-aminoacetophenones in the presence of a ruthenium complex catalyst comprising a chiral phosphine ligand.
摘要翻译：式（I）的光学活性2-氨基-1-苯基乙醇或其镜像，其中R 1是氢，C 1-6 - 烷基或芳基取代的C 1 - C 1-6烷基和R 2至R 6独立地是氢，羟基或C 1-6烷氧基，或其盐通过在包含手性膦配体的钌络合物催化剂的存在下不对称氢化相应的2-氨基苯乙酮来制备。

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