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1. 发明申请

WO2008054597A9 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008054597A9
公开(公告)日：2008-07-31
申请号：PCT/US2007021086
申请日：2007-09-28
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , SPEK ERIK , POSSEMATO ANTHONY , FARNSWORTH CHARLES , BOCCALATTE FRANCESCO , YU JIAN , MITCHELL JEFFREY , RUSH JOHN , GOSS VALERIE , GU TING-LEI , LI YU , STOKES MATTHEW
发明人： HORNBECK PETER , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , SPEK ERIK , POSSEMATO ANTHONY , FARNSWORTH CHARLES , BOCCALATTE FRANCESCO , YU JIAN , MITCHELL JEFFREY , RUSH JOHN , GOSS VALERIE , GU TING-LEI , LI YU , STOKES MATTHEW
IPC分类号： G01N33/574
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新磷酸化位点，包含本发明磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新型磷酸化位点的抗体，以及上述的诊断和治疗用途。

2. 发明申请

WO2008073162A2 LYSINE ACETYLATION SITES 审中-公开
标题翻译： LYSINE乙酰化网站
公开(公告)号：WO2008073162A2
公开(公告)日：2008-06-19
申请号：PCT/US2007018275
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY INC , MITCHELL JEFFREY , HORNBECK PETER , GU TING-LEI , GUO AILAN , FARNSWORTH CHARLES , LI YU
发明人： MITCHELL JEFFREY , HORNBECK PETER , GU TING-LEI , GUO AILAN , FARNSWORTH CHARLES , LI YU
IPC分类号： A61K38/17
CPC分类号： C07K16/44 , A61K38/00 , G01N33/574 , G01N2500/04
摘要： The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在各种癌症中鉴定的332个新的乙酰化位点，包含本发明的乙酰化位点的肽（包括AQUA肽），特异性结合本发明的新型乙酰化位点的抗体，以及上述的诊断和治疗用途。

3. 发明申请

WO2008021542A2 LYSINE ACTEYLATION SITES 审中-公开
公开(公告)号：WO2008021542A2
公开(公告)日：2008-02-21
申请号：PCT/US2007018367
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GU TING-LEI , GUO AILAN , FARNSWORTH CHARLES , LI YU , MITCHELL JEFFREY
发明人： HORNBECK PETER , GU TING-LEI , GUO AILAN , FARNSWORTH CHARLES , LI YU , MITCHELL JEFFREY
IPC分类号： A61K39/395
CPC分类号： C07K16/44 , C07B59/008 , C07K14/47
摘要： The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在各种癌症中鉴定的322个新的乙酰化位点，包含本发明的乙酰化位点的肽（包括AQUA肽），特异性结合本发明的新乙酰化位点的抗体，以及上述的诊断和治疗用途。

4. 发明申请

WO2007133689A3 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133689A3
公开(公告)日：2008-06-26
申请号：PCT/US2007011420
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY INC , GUO AILAN , LI YU , GU TING-LEI , MITCHELL JEFFREY , HORNBECK PETER
发明人： GUO AILAN , LI YU , GU TING-LEI , MITCHELL JEFFREY , HORNBECK PETER
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活子，翻译起始复合蛋白，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。

5. 发明申请

WO2008054597A3 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008054597A3
公开(公告)日：2008-10-09
申请号：PCT/US2007021086
申请日：2007-09-28
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , SPEK ERIK , POSSEMATO ANTHONY , FARNSWORTH CHARLES , BOCCALATTE FRANCESCO , YU JIAN , MITCHELL JEFFREY , RUSH JOHN , GOSS VALERIE , GU TING-LEI , LI YU , STOKES MATTHEW
发明人： HORNBECK PETER , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , SPEK ERIK , POSSEMATO ANTHONY , FARNSWORTH CHARLES , BOCCALATTE FRANCESCO , YU JIAN , MITCHELL JEFFREY , RUSH JOHN , GOSS VALERIE , GU TING-LEI , LI YU , STOKES MATTHEW
IPC分类号： A61K39/00 , C07K2/00 , G01N33/574
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

6. 发明申请

WO2007133702A3 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133702A3
公开(公告)日：2008-11-27
申请号：PCT/US2007011444
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY INC , GUO AILAN , GU TING-LEI , MITCHELL JEFFREY , HORNBECK PETER
发明人： GUO AILAN , GU TING-LEI , MITCHELL JEFFREY , HORNBECK PETER
IPC分类号： G01N33/574 , C07K16/18 , C12N15/06 , G01N33/53
CPC分类号： G01N33/68 , C07K16/18 , C07K16/44 , G01N33/6842
摘要： The invention discloses 432 novel acetylatiop sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, lsomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, lnhibtor proteins, Lipid Binding proteins and Lyases.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的432种新的乙酰基部位，以及人类蛋白质乙酰化信号传导途径的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化部位/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：乙酰转移酶，适配器/支架蛋白，肌动蛋白结合蛋白，粘附蛋白，细胞凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，细胞表面蛋白，DNA结合蛋白，DNA 复制蛋白，通道蛋白，伴侣蛋白，细胞代谢酶，细胞骨架蛋白，DNA修复蛋白，内质网蛋白，酶蛋白，G蛋白和GTP酶活化蛋白，鸟嘌呤核苷酸交换因子，Helicase蛋白，lsomerase蛋白，Extracelluar基质蛋白，水解酶，连接酶蛋白，脂质激酶，抑制蛋白，脂质结合蛋白和裂解酶。

7. 发明申请

WO2012162373A8 ROS KINASE IN LUNG CANCER 审中-公开
标题翻译： ROS在肺癌中发生
公开(公告)号：WO2012162373A8
公开(公告)日：2016-05-19
申请号：PCT/US2012039108
申请日：2012-05-23
申请人： CELL SIGNALING TECHNOLOGY INC , RIMKUNAS VICTORIA MCGUINNESS , HAACK HERBERT , GU TING-LEI , GUO AILAN , POSSEMATO ANTHONY PAUL , CROSBY KATHERINE ELEANOR , TUCKER MEGHAN ANN , REEVES CYNTHIA
发明人： RIMKUNAS VICTORIA MCGUINNESS , HAACK HERBERT , GU TING-LEI , GUO AILAN , POSSEMATO ANTHONY PAUL , CROSBY KATHERINE ELEANOR , TUCKER MEGHAN ANN , REEVES CYNTHIA
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N2333/912
摘要： The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., a lung cancer).
摘要翻译：本发明提供在哺乳动物肺癌中鉴定存在具有ROS激酶活性的多肽。在一些实施方案中，具有ROS激酶活性的多肽是编码ROS编码多核苷酸和编码第二（非ROS）多肽的多核苷酸之间融合的结果。描述了ROS的三种不同的融合配偶体，即由FIG基因编码的蛋白质，SLC34A2基因和CD74基因。本发明使得能够测定生物样品中具有ROS激酶活性的多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及抑制癌症进展的方法（例如肺癌）。

8. 发明申请

WO2009051846A2 TRANSLOCATION AND MUTANT ROS KINASE IN HUMAN NON-SMALL CELL LUNG CARCINOMA 审中-公开
标题翻译：人类非小细胞肺癌转移和突变ROS激酶
公开(公告)号：WO2009051846A2
公开(公告)日：2009-04-23
申请号：PCT/US2008011968
申请日：2008-10-20
申请人： CELL SIGNALING TECHNOLOGY INC , GU TING-LEI , GUO AILAN
发明人： GU TING-LEI , GUO AILAN
IPC分类号： C07K14/73
CPC分类号： C12Q1/6886 , A61K2039/505 , C07K14/70539 , C07K14/82 , C07K16/40 , C07K2319/00 , C12N9/12 , C12N9/99 , C12N15/1137 , C12Q1/68 , C12Q1/6813 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Y207/10001
摘要： In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of the new fusion protein enables new methods for determining the presence of these mutant ROS kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.
摘要翻译：根据本发明，在人非小细胞肺癌（NSCLC）中的新基因易位（5q32,6q22），其导致将CD74的一部分与原癌基因酪氨酸蛋白激酶ROS前体（ROS）结合的融合蛋白，激酶现已被鉴定。预期CD74-ROS融合蛋白将驱动NSCLC肿瘤亚组的增殖和存活。因此，本发明部分地提供分离的多核苷酸和编码所公开的突变型ROS激酶多肽的载体，用于检测其的探针，分离的突变多肽，重组多肽和用于检测融合和截短的多肽的试剂。所公开的新融合蛋白的鉴定使得能够确定生物样品中这些突变型ROS激酶多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及抑制以突变型多核苷酸为特征的癌症进展的方法或多肽，其也由本发明提供。

9. 发明申请

WO2008009004A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测信号通路中的蛋白质磷酸化的试剂
公开(公告)号：WO2008009004A3
公开(公告)日：2008-10-30
申请号：PCT/US2007073542
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
发明人： HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
IPC分类号： G01N33/53 , A61K38/00 , C07K16/00
CPC分类号： G01N33/57426 , C07B59/008 , C07K14/47 , C07K16/44 , G01N33/6842 , G01N2458/15
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白质和途径中鉴定的新的磷酸化位点，并提供用于选择性检测和定量这些磷酸化位点/蛋白质的磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），以及使用用于此目的的试剂。在所鉴定的磷酸化位点中存在发生在以下蛋白质类型中的位点：衔接子/支架蛋白质，粘附/细胞外基质蛋白质，凋亡蛋白质，钙结合蛋白质，细胞周期调节蛋白质，分子伴侣蛋白质，染色质，DNA结合/修复/ 细胞骨架蛋白，内质网或高尔基蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr） RNA结合蛋白，转录调节因子，肿瘤抑制蛋白，泛素缀合系统蛋白和功能未知的蛋白。

10. 发明申请

WO2008036337A8 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008036337A8
公开(公告)日：2008-07-03
申请号：PCT/US2007020343
申请日：2007-09-18
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
发明人： HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
IPC分类号： A61K39/395
CPC分类号： C07K16/44
摘要： The invention discloses 443 novel phosphorylation sites identified in leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在白血病中鉴定的443个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

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