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1. 发明申请

WO2009126306A8 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：用于检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A8
公开(公告)日：2010-01-14
申请号：PCT/US2009002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY INC , GU TING-LEI , WU JIONG , KANE SUSAN , HAACK HERBERT , WIELER JAMES , CAI JUN-MING , RIMKUNAS VICTORIA , YU JIAN
发明人： GU TING-LEI , WU JIONG , KANE SUSAN , HAACK HERBERT , WIELER JAMES , CAI JUN-MING , RIMKUNAS VICTORIA , YU JIAN
IPC分类号： A61K48/00
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

2. 发明申请

WO2006086111A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2006086111A3
公开(公告)日：2009-04-16
申请号：PCT/US2006000979
申请日：2006-01-12
申请人： CELL SIGNALING TECHNOLOGY INC , GOSS VALERIE , MORITZ ALBRECHT , GU TING-LEI , LEE KIMBERLY , POLAKIEWICZ ROBERTO
发明人： GOSS VALERIE , MORITZ ALBRECHT , GU TING-LEI , LEE KIMBERLY , POLAKIEWICZ ROBERTO
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C07K14/47 , C07K16/18 , C07K16/40 , C07K16/44
摘要： The invention discloses 424 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的424个新的磷酸化位点和人类白血病的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质作为使用试剂用于此目的的方法。所鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，细胞骨架蛋白，细胞代谢酶，G蛋白/ GTP酶激活/鸟嘌呤核苷酸交换因子蛋白，免疫球蛋白超家族蛋白，抑制蛋白，脂质激酶，核DNA 修复/ RNA结合/转录蛋白，丝氨酸/苏氨酸蛋白激酶，酪氨酸激酶，蛋白磷酸酶和翻译/转运蛋白。

3. 发明申请

WO2008036337A8 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008036337A8
公开(公告)日：2008-07-03
申请号：PCT/US2007020343
申请日：2007-09-18
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
发明人： HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
IPC分类号： A61K39/395
CPC分类号： C07K16/44
摘要： The invention discloses 443 novel phosphorylation sites identified in leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在白血病中鉴定的443个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

4. 发明申请

WO2007133689A3 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133689A3
公开(公告)日：2008-06-26
申请号：PCT/US2007011420
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY INC , GUO AILAN , LI YU , GU TING-LEI , MITCHELL JEFFREY , HORNBECK PETER
发明人： GUO AILAN , LI YU , GU TING-LEI , MITCHELL JEFFREY , HORNBECK PETER
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活子，翻译起始复合蛋白，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。

5. 发明申请

WO2008021542A3 LYSINE ACTEYLATION SITES 审中-公开
公开(公告)号：WO2008021542A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/018367
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GU, Ting-lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
发明人： HORNBECK, Peter , GU, Ting-lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
IPC分类号： A61K38/00
摘要： The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

6. 发明申请

WO2008008998A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测信号通路中的蛋白质磷酸化的试剂
公开(公告)号：WO2008008998A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073534
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C07K16/18 , C07K16/32 , C07K16/40 , G01N33/60 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白质和途径中鉴定的新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽）用于选择性检测和定量这些磷酸化位点/ 蛋白质以及为此目的使用试剂的方法。在所鉴定的磷酸化位点中存在发生在以下蛋白质类型中的位点：衔接子/支架蛋白质，粘附/细胞外基质蛋白质，凋亡蛋白质，钙结合蛋白质，细胞周期调节蛋白质，分子伴侣蛋白质，染色质，DNA结合/修复/ 细胞骨架蛋白，内质网或高尔基蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr） RNA结合蛋白，转录调节因子，肿瘤抑制蛋白，泛素缀合系统蛋白和功能未知的蛋白。

7. 发明申请

WO2007133689A2 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133689A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011420
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY, INC. , GUO, Ailan , LI, Yu , GU, Ting-lei , MITCHELL, Jeffrey , HORNBECK, Peter
发明人： GUO, Ailan , LI, Yu , GU, Ting-lei , MITCHELL, Jeffrey , HORNBECK, Peter
IPC分类号： B21D11/10
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活因子，翻译起始复合蛋白，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。

8. 发明申请

WO2007064743A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2007064743A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/045760
申请日：2006-11-29
申请人： CELL SIGNALING TECHNOLOGY, INC. , POLAKIEWICZ, Roberto , LEE, Kimberly , GU, Ting-lei , GOSS, Valerie
发明人： POLAKIEWICZ, Roberto , LEE, Kimberly , GU, Ting-lei , GOSS, Valerie
IPC分类号： G01N33/574
CPC分类号： G01N33/57426
摘要： The invention discloses nearly 123 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: protein kinases, adaptor/scaffold proteins, phosphatase/phospholipases, G proteins/GTPase activating proteins/guanine nucleotide exchange factors, cellular metabolism enzymes, DNA binding proteins, cytoskeletal proteins, cell cycle regulation proteins, proteases, RNA binding proteins, transcription proteins, translation initiation complex proteins, transferases, ubiquitin conjugating system proteins, vesicle proteins, actin binding proteins, apoptosis proteins, chemokine proteins, enzyme proteins extra cellular matrix proteins, helicases, hydrolases, immunoglobin superfamily proteins, inhibitor proteins, isomerases, ligases, lipid binding proteins, methyltransferases, motor proteins, receptor proteins, and chaperone proteins.
摘要翻译：本发明公开了在信号转导蛋白中识别的近123个新的磷酸化位点和人类白血病的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白，如以及使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：蛋白激酶，衔接子/支架蛋白，磷酸酶/磷脂酶，G蛋白/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子，细胞代谢酶，DNA结合蛋白，细胞骨架蛋白，细胞循环调节蛋白，蛋白酶，RNA结合蛋白，转录蛋白，翻译起始复合蛋白，转移酶，泛素缀合系统蛋白，囊泡蛋白，肌动蛋白结合蛋白，凋亡蛋白，趋化因子蛋白，酶蛋白超细胞基质蛋白，解旋酶，水解酶，免疫球蛋白超家族蛋白，抑制蛋白，异构酶，连接酶，脂质结合蛋白，甲基转移酶，运动蛋白，受体蛋白和伴侣蛋白。

9. 发明申请

WO2007027957A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2007027957A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034126
申请日：2006-08-30
申请人： CELL SIGNALING TECHNOLOGY, INC. , POLAKIEWICZ, Roberto , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
发明人： POLAKIEWICZ, Roberto , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C07B59/008 , C07K16/3061 , C07K16/44 , G01N33/6803 , G01N33/6842 , G01N2333/9121
摘要： The invention discloses nearly 480 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, acetyltransferases, actin binding proteins, adhesion proteins, apoptosis proteins, calcium-binding proteins, cell cycle regulation proteins, cell surface proteins, channel proteins, chaperone proteins, contractile proteins, cytokine proteins, cytoskeletal proteins, G protein regulators and GTPase activating proteins, guanine nucleotide exchange factors, helicase proteins, immunoglobulin superfamily proteins, inhibitor proteins, protein kinases, lipid kinases, ligases, lipid binding proteins, methytransferases, motor proteins, oxidoreductases, phosphotases, phosphodiesterases, phospholipases, proteases, receptor proteins, trascription factors, transferases, translation/transporter proteins, and ubiquitin conjugating system proteins.
摘要翻译：本发明公开了在信号转导蛋白中识别的近480个新的磷酸化位点和人类白血病的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如以及使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：衔接子/支架蛋白，乙酰转移酶，肌动蛋白结合蛋白，粘附蛋白，凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，细胞表面蛋白，通道蛋白，伴侣蛋白鸟嘌呤核苷酸交换因子，解旋酶蛋白，免疫球蛋白超家族蛋白，抑制蛋白，蛋白激酶，脂质激酶，连接酶，脂质结合蛋白，甲基转移酶，运动蛋白，肌动蛋白，氧化还原酶，磷酸二酯酶，磷脂酶，蛋白酶，受体蛋白，trascription因子，转移酶，翻译/转运蛋白和泛素缀合系统蛋白。

10. 发明申请

WO2007027906A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
公开(公告)号：WO2007027906A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/034050
申请日：2006-08-31
申请人： CELL SIGNALING TECHNOLOGY, INC. , POLAKIEWICZ, Roberto , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： POLAKIEWICZ, Roberto , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
摘要： The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.

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