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1. 发明申请

WO2003099116A1 A METHOD FOR DELINEATING AN ABLATION LESION 审中-公开
标题翻译：一种消除疝气的方法
公开(公告)号：WO2003099116A1
公开(公告)日：2003-12-04
申请号：PCT/US2002/034797
申请日：2002-10-31
申请人： CASE WESTERN RESERVE UNIVERSITY , LAZEBNIK, Roee, S. , WILSON, David, L. , LEWIN, Jonathan, S.
发明人： LAZEBNIK, Roee, S. , WILSON, David, L. , LEWIN, Jonathan, S.
IPC分类号： A61B5/05
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T2207/10088 , G06T2207/20116 , G06T2207/30096
摘要： A method for delineating an ablation lesion (10) having concentric inner (12) and outer (14) lesion regions using magnetic resonance (MR) information is provided. The method includes providing a deformable model having parameters defining concentric inner and outer ellipsoid surfaces, generating boundaries from the MR information, and fitting the model parameters to the boundaries so that the model delineates the inner (11) and outer (14) lesion regions. The lesion boundaries can be generated by manually segmenting the lesion using the MR information. The lesion boundaries can also be generated by automatically segmenting the lesion using the MR information. The lesion boundaries can also be generated by automatically segmenting the lesion using the MR information. The fitting step can include minimizing an objective function f(Ø) defining the sum of squared distances di in (Ø in ) and dj out (Ø out ) from boundary surface points to the ellipsoid surfaces defined by the model parameters. Alternatively, the fitting step can include minimizing an objective function E(Ø) accounting for model position with respect to MR imaging grayscale edges.
摘要翻译：提供了使用磁共振（MR）信息描绘具有同心的内部（12）和外部（14）损伤区域的消融损伤（10）的方法。该方法包括提供具有定义同心的内椭圆表面的参数的可变形模型，从MR信息生成边界，以及将模型参数拟合到边界，使得模型描绘内部（11）和外部（14）损伤区域。可以通过使用MR信息手动分割病变来产生损伤边界。也可以通过使用MR信息自动分割病变来产生损伤边界。也可以通过使用MR信息自动分割病变来产生损伤边界。拟合步骤可以包括最小化定义从模型参数限定的边界表面点到椭圆表面的平方距离di（inin）和dj（out）（Øout）之和的目标函数f（Ø）。或者，拟合步骤可以包括最小化与MR成像灰度边缘相关的模型位置的目标函数E（Ø）。

2. 发明申请

WO2003096884A3 SYSTEMS AND METHODS FOR ASSESSING BLOOD FLOW IN A TARGET TISSUE 审中-公开
公开(公告)号：WO2003096884A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/015656
申请日：2003-05-19
申请人： CASE WESTERN RESERVE UNIVERSITY , JESBERGER, John , DUERK, Jeffrey, L. , LEWIN, Jonathan, S.
发明人： JESBERGER, John , DUERK, Jeffrey, L. , LEWIN, Jonathan, S.
IPC分类号： A61B5/055
摘要： A method is provided for determining an analog for blood flow in a target tissue of a subject comprising: a baseline set of MR images prior to injection of a contrast agent into the vasculature of a subject (10), acquiring a set of MR images after injection of a contrast agent into the vasculature of the subject (30), computing two or more concentration values from the set of images (40), computing a derivative of concentration values (50), computing the maximum value of the derivative curve (60) to provide a value which is an analog for blood flow. A system for determining an analog for blood flow in a target tissue of a subject, comprising: input logic for acquiring a baseline set of MR images prior to injection of a contrast agent into the vasculature of the subject; logic for computing two or more concentration values from the set of images, logic for computing a derivative of concentration; and logic for computing the maximum value of the derivative curve to output an analog for blood flow.

3. 发明申请

WO2005120585A1 DUAL FUNCTION POLYMER MICELLES 审中-公开
标题翻译：双功能聚合物胶
公开(公告)号：WO2005120585A1
公开(公告)日：2005-12-22
申请号：PCT/US2005/019308
申请日：2005-06-02
申请人： CASE WESTERN RESERVE UNIVERSITY , AI, Hua , DUERK, Jeffrey, L. , FLASK, Chris , GAO, Jinming , LEWIN, Jonathan, S. , SHUAI, Xintao , WEINBERG, Brent
发明人： AI, Hua , DUERK, Jeffrey, L. , FLASK, Chris , GAO, Jinming , LEWIN, Jonathan, S. , SHUAI, Xintao , WEINBERG, Brent
IPC分类号： A61K49/00
CPC分类号： A61K49/1809 , A61K9/1075 , A61K47/62 , A61K47/6907 , A61K49/126 , A61K49/1806 , A61K51/065 , A61K51/1237
摘要： The invention relates to micelles that are elaborated with functionality useful for imaging and/or selectively targeting tissue, e.g., in the delivery of hydrophobic agents.
摘要翻译：本发明涉及具有用于成像和/或选择性靶向组织的功能的功能的胶束，例如在疏水剂的递送中。

4. 发明申请

WO2003098267A1 CHEMICAL SPECIES SUPPRESSION IN MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：化学物质抑制磁共振成像
公开(公告)号：WO2003098267A1
公开(公告)日：2003-11-27
申请号：PCT/US2003/015241
申请日：2003-05-15
申请人： CASE WESTERN RESERVE UNIVERSITY , FLASK, Christopher, A. , LEWIN, Jonathan, S. , MORIGUCHI, Hisamoto , HILLEBRAND, Claudia , DUERK, Jeffrey, L. , DALE, Brian, M.
发明人： FLASK, Christopher, A. , LEWIN, Jonathan, S. , MORIGUCHI, Hisamoto , HILLEBRAND, Claudia , DUERK, Jeffrey, L. , DALE, Brian, M.
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/4824 , G01R33/5607
摘要： A new improved method for chemical species suppression MRI (10) including the steps of: (12) generating at least one pulse sequence using a first TE for a first data set having a first trajectory, and a second TE for a second data set having a second trajectory, (14) acquiring the first data set and the second data set without chemical species suppression wherein a substantial majority of the second trajectory covers k-space that is not covered by the first trajectory, (16) combining the first and second data sets to suppress the second chemical species, present in both data sets, and (18) generating an MRI image that shows the unsuppressed chemical species while suppressing the chemical species of the preceding step.
摘要翻译：一种用于化学物质抑制MRI（10）的新的改进方法，包括以下步骤：（12）使用具有第一轨迹的第一数据集的第一TE生成至少一个脉冲序列，以及具有第二数据集的第二TE （14）获取所述第一数据集和所述第二数据集而不进行化学物质抑制，其中所述第二轨迹的绝大部分覆盖未被所述第一轨迹覆盖的k空间，（16）将所述第一和第二轨迹组合用于抑制存在于两个数据集中的第二化学物质的数据集，和（18）产生显示未被抑制的化学物质同时抑制前述步骤的化学物质的MRI图像。

5. 发明申请

WO2004104611A2 MRI PROBE DESIGN AND TRACKING, AND EFFICIENT MRI RECONSTRUCTION AND DEBLURRING 审中-公开
标题翻译： MRI探索设计与追踪，高效MRI重建与治疗
公开(公告)号：WO2004104611A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/014128
申请日：2004-05-05
申请人： CASE WESTERN RESERVE UNIVERSITY , WONG, Eddy, Y. , HILLENBRAND, Claudia, M. , LEWIN, Jonathan, S. , DUERK, Jeffrey, L. , ELGORT, Daniel, R. , FLASK, Chris , WACKER, Frank, K. , DALE, Brian, M. , MORIGUCHI, Hisamoto
发明人： WONG, Eddy, Y. , HILLENBRAND, Claudia, M. , LEWIN, Jonathan, S. , DUERK, Jeffrey, L. , ELGORT, Daniel, R. , FLASK, Chris , WACKER, Frank, K. , DALE, Brian, M. , MORIGUCHI, Hisamoto
IPC分类号： G01R33/28
CPC分类号： G01R33/287 , G01R33/34084 , G01R33/4824 , G01R33/5608 , G01R33/561 , G01R33/5611 , G01R33/563
摘要： A probe suitable for attachment to, or incorporation in, a medical interventional device, such as a catheter, and which may be employed for tracking, imaging, or both, includes a first material having an MR resonance frequency distinct from a resonance frequency of a second material adjacent to the first material.
摘要翻译：适于附着或并入医疗介入装置（例如导管）中并且可用于跟踪，成像或两者的探针包括具有与共振频率不同的MR共振频率的第一材料与第一材料相邻的第二材料。

6. 发明申请

WO2003100465A1 KEYHOLE DIXON METHOD FOR FASTER FAT SUPPRESSION IN MRI 审中-公开
标题翻译：用于MRI中快速抑制的KEYHOLE DIXON方法
公开(公告)号：WO2003100465A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/009949
申请日：2003-03-31
申请人： CASE WESTERN RESERVE UNIVERSITY , FLASK, Christopher, A. , SALEM, Kyle, A. , LEWIN, Jonathan, S. , DUERK, Jeffrey, L.
发明人： FLASK, Christopher, A. , SALEM, Kyle, A. , LEWIN, Jonathan, S. , DUERK, Jeffrey, L.
IPC分类号： G01V3/00
CPC分类号： G01R33/4828
摘要： A method (10) of generating a magnetic resonance imaging (MRI) image by selectively suppressing one of two chemically shifted species. The method includes acquiring full data set (12) and a partial data set (14) with the TE set such that the magnetization of the second chemical species is 180° out of phase from its orientation in the first data set. The full (12) and partial (14) data sets are combined (16) to generate in MRI image that is perceptually equivalent to a multi-point Dixon image. The invention includes acquiring the minimum amount of data in the partial data set to generate an MRI image that is perceptually equivalent to a multi-point Dixon image.
摘要翻译：一种通过选择性地抑制两种化学位移物质之一来产生磁共振成像（MRI）图像的方法（10）。该方法包括获取具有TE集的全部数据集（12）和部分数据集（14），使得第二化学物质的磁化与其在第一数据集中的取向相位相差180°。整个（12）和部分（14）数据集合（16）在MRI图像中生成，其在感知上等同于多点狄克逊图像。本发明包括获取部分数据集中的最小数据量以产生感知上等同于多点Dixon图像的MRI图像。

7. 发明申请

WO2003098548A2 METHOD TO CORRECT MAGNETIC FIELD/PHASE VARIATIONS IN PROTON RESONANCE FREQUENCY SHIFT THERMOMETRY IN MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于校正磁共振成像中的原子共振频率移位热电偶的磁场/相位变化的方法
公开(公告)号：WO2003098548A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/015251
申请日：2003-05-15
申请人： CASE WESTERN RESERVE UNIVERSITY , LEWIN, Jonathan, S. , BARKAUSKAS, Kestutis , DUERK, Jeffrey, L.
发明人： LEWIN, Jonathan, S. , BARKAUSKAS, Kestutis , DUERK, Jeffrey, L.
IPC分类号： G06T5/00
CPC分类号： G01R33/022 , G01R33/4804 , G01R33/565 , G01R33/56563
摘要： PRF shift MRI data is acquired. The PRF shift MRI data may include signals affected by both a desired PRF shift and an undesired PRF shift. Thus, example systems and methods describe manipulating the PRF shift MRI data to make it substantially free of the effects of the undesired PRF shift, which facilitates displaying certain MRI images based on the desired PRF shift. It is emphasized that this abstract is provided to comply with the rule requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.37 CFR 1.73(b).
摘要翻译：获取PRF位移MRI数据。 PRF移位MRI数据可以包括受期望的PRF偏移和不期望的PRF偏移影响的信号。因此，示例系统和方法描述了操纵PRF移位MRI数据以使其基本上不受不期望的PRF偏移的影响，这有助于基于期望的PRF偏移来显示某些MRI图像。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定申请的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义.37 CFR 1.73（b）。

8. 发明申请

WO2004097387A3 DIXON TECHNIQUES IN SPIRAL TRAJECTORIES WITH OFF-RESONANCE CORRECTION 审中-公开
公开(公告)号：WO2004097387A3
公开(公告)日：2004-11-11
申请号：PCT/US2004/012858
申请日：2004-04-26
申请人： CASE WESTERN RESERVE UNIVERSITY , MORIGUCHI, Hisamoto , LEWIN, Jonathan, S. , DUERK, Jeffrey, L.
发明人： MORIGUCHI, Hisamoto , LEWIN, Jonathan, S. , DUERK, Jeffrey, L.
IPC分类号： G01R33/565
摘要： Spiral imaging has recently gained acceptance for rapid MR data acquisition. One of the main disadvantages of spiral imaging, however, is blurring artifacts due to off-resonance effects. Dixon techniques have been developed as methods of water-fat signal decomposition in rectilinear sampling schemes, and they can produce unequivocal water-fat signal decomposition even in the presence of B 0 inhomogeneity. Three-point and two-point Dixon techniques can be extended to conventional spiral and variable-density spiral data acquisitions for unambiguous water-fat decomposition with off-resonance blurring correction. In the spiral three-point Dixon technique, water-fat signal decomposition and image deblurring are performed based on the frequency maps that are directly derived from the acquired images. In the spiral two-point Dixon technique, several predetermined frequencies are tested to create a frequency map. The techniques can achieve more effective and more uniform fat signal suppression when compared to the conventional spiral acquisition method with SPSP pulses.

9. 发明申请

WO2003100378A2 CHEMICAL SPECIES SUPPRESSION USING RE-TRAVERSAL AROUND THE K-SPACE CENTER IN INTERLEAVED REVERSED SPIRAL IMAGING 审中-公开
标题翻译：化学物质使用反向TRAVERSAL在K空间中心在交互式反向螺旋成像中的抑制
公开(公告)号：WO2003100378A2
公开(公告)日：2003-12-04
申请号：PCT/US2003/010145
申请日：2003-04-01
申请人： CASE WESTERN RESERVE UNIVERSITY , DUERK, Jeffrey, L. , MORIGUCHI, Hisamoto , LEWIN, Jonathan, S.
发明人： DUERK, Jeffrey, L. , MORIGUCHI, Hisamoto , LEWIN, Jonathan, S.
IPC分类号： G01N
CPC分类号： G01R33/4824 , G01R33/4828 , G01R33/561
摘要： A method of suppressing a first chemical species in a subject in MR imaging includes generating a first spiral trajectory in k-space which acquires the center of the spiral, and generating a second spiral trajectory in k-space retraversing a portion of the first spiral trajectory to the center after a delay, wherein the delay is the time required for the first chemical species to rotate out of phrase with a second chemical species in the subject. The method further includes combining the first and second spiral trajectories to suppress the signal of the first chemical species in the portion of k-space defined by second spiral trajectory, and repeating the steps of generating the first and second spiral trajectories to form a plurality of trajectory interleaf pairs each covering a different portion of k-space. An MR image is generated using the trajectory interleaf pairs in which the first chemical species is suppressed relative to the second chemical species.
摘要翻译：在MR成像中抑制受试者中的第一化学物质的方法包括：产生在k空间中获取螺旋中心的第一螺旋轨迹，并且在k空间中产生第二螺旋轨迹，重新旋转第一螺旋轨迹的一部分在延迟之后到达中心，其中延迟是第一化学物质与受试者中的第二化学物质旋转出短语所需的时间。该方法还包括组合第一和第二螺旋轨迹以抑制由第二螺旋轨迹限定的k空间部分中的第一化学物质的信号，并且重复产生第一和第二螺旋轨迹以形成多个每个覆盖k空间的不同部分的轨迹插值对。使用其中相对于第二化学物质抑制第一化学物质的轨迹插入对产生MR图像。

10. 发明申请

WO2003098548A3 METHOD TO CORRECT MAGNETIC FIELD/PHASE VARIATIONS IN PROTON RESONANCE FREQUENCY SHIFT THERMOMETRY IN MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：WO2003098548A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/015251
申请日：2003-05-15
申请人： CASE WESTERN RESERVE UNIVERSITY , LEWIN, Jonathan, S. , BARKAUSKAS, Kestutis , DUERK, Jeffrey, L.
发明人： LEWIN, Jonathan, S. , BARKAUSKAS, Kestutis , DUERK, Jeffrey, L.
IPC分类号： G01R33/565
摘要： PRF shift MRI data is acquired. The PRF shift MRI data may include signals affected by both a desired PRF shift and an undesired PRF shift. Thus, example systems and methods describe manipulating the PRF shift MRI data to make it substantially free of the effects of the undesired PRF shift, which facilitates displaying certain MRI images based on the desired PRF shift. It is emphasized that this abstract is provided to comply with the rule requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.37 CFR 1.73(b).

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