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1. 发明申请

WO2014130567A1 ANTIMICROBIAL HYDROGEL POLYMERS 审中-公开
标题翻译：抗微生物氢化聚合物
公开(公告)号：WO2014130567A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/017187
申请日：2014-02-19
申请人： CAREFUSION 2200, INC. , FIRST WATER LIMITED
发明人： TUFTS, Scott A. , BALTEZOR, Michael J. , ORTIZ, Moises , FLORES, Jesus , DEVENS, Jennifer Raeder , MUNRO, Hugh Semple , BOOTE, Nicholas
IPC分类号： A61L15/42
CPC分类号： A61L15/44 , A61L15/24 , A61L15/46 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L2300/206 , A61L2300/404 , A61L2300/602 , C08L39/04
摘要： The present invention relates generally to antimicrobial hydrogel polymers, and dressings comprising one or more hydrogel-forming hydrophilic polymers, where the hydrogels and dressings further comprise one or more antimicrobial agents that are released from the hydrogel in a controlled manner. The hydrogels and dressings may be used for medical, veterinary, and/or cosmetic applications. The dressings may be applied, for example, as would dressings, surgical dressings, and percutaneous site dressings. In certain aspects of the invention, the dressings may be beneficially used in methods of accelerating would healing, preventing and/or reducing the incidence of wound infection, and reducing scarring associated with wounds.
摘要翻译：本发明一般涉及抗微生物水凝胶聚合物和包含一种或多种形成水凝胶的亲水性聚合物的敷料，其中水凝胶和敷料还包含以受控方式从水凝胶中释放的一种或多种抗微生物剂。水凝胶和敷料可用于医疗，兽医和/或化妆品应用。敷料可以应用于例如敷料，手术敷料和经皮部位敷料。在本发明的某些方面，敷料可以有利地用于加速愈合，预防和/或减少伤口感染的发生率和减少与伤口相关的瘢痕形成的方法。

2. 发明申请

WO2017089831A1 DRESSING SYSTEM 审中-公开
标题翻译：敷料系统
公开(公告)号：WO2017089831A1
公开(公告)日：2017-06-01
申请号：PCT/GB2016/053727
申请日：2016-11-28
申请人： EDIXOMED LIMITED , FIRST WATER LIMITED
发明人： MUNRO, Hugh , BOOTE, Nicholas
IPC分类号： A61K9/70 , A61K31/167 , A61L15/44 , A61L26/00
CPC分类号： A61K9/7007 , A61K31/167 , A61L15/44 , A61L26/0066 , A61L2300/114 , A61L2300/402
摘要： The present invention relates to skin dressings that are useful in the treatment of conditions associated with tissue ischaemia and skin lesions including those that are infected, such as burns and surgical wounds and chronic wounds such as but not limited5 to diabetic foot ulcers and venous leg ulcers. The skin dressings are also useful to effect transdermal delivery of pharmaceutically active agents.
摘要翻译：本发明涉及用于治疗与组织缺血和皮肤损伤相关的病症的皮肤敷料，所述病症包括那些被感染的病症，例如烧伤和手术伤口以及慢性伤口，例如但不限于糖尿病足溃疡和腿部静脉性溃疡。皮肤敷料也可用于药物活性剂的透皮递送。

3. 发明申请

WO2009090403A1 HYDROGEL CO-POLYMER COMPOSITION AND ITS USES, FOR EXAMPLE AS A WOUND DRESSING 审中-公开
标题翻译： HYDROGEL共聚合物组合物及其用途，例如作为一个创造性的连接
公开(公告)号：WO2009090403A1
公开(公告)日：2009-07-23
申请号：PCT/GB2009/000128
申请日：2009-01-16
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , BOOTE, Nicholas
发明人： MUNRO, Hugh, Semple , BOOTE, Nicholas
IPC分类号： A61L15/58 , A61L24/06 , C08F220/58
CPC分类号： A61K31/795 , A61L15/60 , A61L26/0014 , A61L26/008 , C08F220/58
摘要： The present invention provides a hydrogel composition, preferably for the treatment of wounds, comprising a hydrophilic co-polymer carrying multiple pendant anionic groups, wherein the polymer is derived from a first monomer and a second monomer, wherein both monomers have an octanohwater partition coefficient LogP value of less than 0, and, the LogP value of the first monomer is greater (more positive) than the second monomer. Preferably the difference between the LogP value for the two monomers is at least 0.1, preferably at least 0.2. The difference between the LogP value for the two monomers is preferably less than 2. The weight ratio (w/w) of the first monomer/second monomer in the hydrogel composition is preferably equal to or more than about 1. The pendant anionic groups may be sulphonyl groups, e.g. sulphonic acid groups or salts thereof. The anionic group in both first and second monomers may be in salt form and the counterion for both monomers is preferably the same.
摘要翻译：本发明提供一种水凝胶组合物，优选用于治疗伤口，其包含携带多个侧阴离子基团的亲水性共聚物，其中该聚合物衍生自第一单体和第二单体，其中两种单体具有八氢水分配系数LogP 值小于0，第一单体的LogP值比第二单体大（更正）。优选地，两种单体的LogP值之间的差异为至少0.1，优选至少为0.2。两个单体的LogP值之间的差值优选小于2.水凝胶组合物中第一单体/第二单体的重量比（w / w）优选等于或大于约1.侧阴离子基团可以是磺酰基，例如磺酸基或其盐。第一和第二单体中的阴离子基团可以是盐形式，两个单体的抗衡离子优选相同。

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