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1. 发明申请

WO2009090403A1 HYDROGEL CO-POLYMER COMPOSITION AND ITS USES, FOR EXAMPLE AS A WOUND DRESSING 审中-公开
标题翻译： HYDROGEL共聚合物组合物及其用途，例如作为一个创造性的连接
公开(公告)号：WO2009090403A1
公开(公告)日：2009-07-23
申请号：PCT/GB2009/000128
申请日：2009-01-16
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , BOOTE, Nicholas
发明人： MUNRO, Hugh, Semple , BOOTE, Nicholas
IPC分类号： A61L15/58 , A61L24/06 , C08F220/58
CPC分类号： A61K31/795 , A61L15/60 , A61L26/0014 , A61L26/008 , C08F220/58
摘要： The present invention provides a hydrogel composition, preferably for the treatment of wounds, comprising a hydrophilic co-polymer carrying multiple pendant anionic groups, wherein the polymer is derived from a first monomer and a second monomer, wherein both monomers have an octanohwater partition coefficient LogP value of less than 0, and, the LogP value of the first monomer is greater (more positive) than the second monomer. Preferably the difference between the LogP value for the two monomers is at least 0.1, preferably at least 0.2. The difference between the LogP value for the two monomers is preferably less than 2. The weight ratio (w/w) of the first monomer/second monomer in the hydrogel composition is preferably equal to or more than about 1. The pendant anionic groups may be sulphonyl groups, e.g. sulphonic acid groups or salts thereof. The anionic group in both first and second monomers may be in salt form and the counterion for both monomers is preferably the same.
摘要翻译：本发明提供一种水凝胶组合物，优选用于治疗伤口，其包含携带多个侧阴离子基团的亲水性共聚物，其中该聚合物衍生自第一单体和第二单体，其中两种单体具有八氢水分配系数LogP 值小于0，第一单体的LogP值比第二单体大（更正）。优选地，两种单体的LogP值之间的差异为至少0.1，优选至少为0.2。两个单体的LogP值之间的差值优选小于2.水凝胶组合物中第一单体/第二单体的重量比（w / w）优选等于或大于约1.侧阴离子基团可以是磺酰基，例如磺酸基或其盐。第一和第二单体中的阴离子基团可以是盐形式，两个单体的抗衡离子优选相同。

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