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1. 发明申请

WO2007047794A2 HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
标题翻译：具有电子充电器的电磁室
公开(公告)号：WO2007047794A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040777
申请日：2006-10-19
申请人： CARDIOMEMS, INC. , O'BRIEN, David , COURCIMAULT, Christophe , YOU, Liang , JOUNG, Yeun-Ho , ALLEN, Mark
发明人： O'BRIEN, David , COURCIMAULT, Christophe , YOU, Liang , JOUNG, Yeun-Ho , ALLEN, Mark
IPC分类号： G01L9/00
CPC分类号： G01L9/0073
摘要： An exemplary pressure cavity is disclosed that is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The exemplary pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from ambient pressure in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g., intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.
摘要翻译：公开了一种示例性的压力腔，其是耐用的，稳定的和生物相容的并且以这样的方式配置，使得其构成微微至纳升级体积。示例性压力腔与外部环境气密密封，同时保持与其他装置通信的能力。微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力和返回信息。设置在其中的压力腔和传感器部件与环境压力密封，以减少传感器内的漂移和不稳定性。传感器设计用于恶劣和生物环境，例如体内植入和体内使用。另外，采用新颖的制造方法来构造传感器。

2. 发明申请

WO2008066569A2 HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
标题翻译：带电子馈线的密封室
公开(公告)号：WO2008066569A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/011612
申请日：2007-05-15
申请人： CARDIOMEMS, INC. , O'BRIEN, David , COURCIMAULT, Christophe , YOU, Liang
发明人： O'BRIEN, David , COURCIMAULT, Christophe , YOU, Liang
IPC分类号： G01L9/12
CPC分类号： G01L9/0042 , G01L9/0075
摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.
摘要翻译：压力腔是耐用的，稳定的和生物相容性的，并且以这样的方式配置，使得它构成微微至纳升级的体积。压力腔与外部环境密封，同时保持与其他设备通信的能力。微机械密封传感器配置为通过与外部电子设备的直接电接触来接收电源并返回信息。设置在其中的压力腔和传感器部件与环境气密密封以减少传感器内的漂移和不稳定性。该传感器设计用于恶劣和生物环境，例如体内植入和体内使用。此外，采用新颖的制造方法构建传感器。

3. 发明申请

WO2007061841A2 CAPACITOR ELECTRODE FORMED ON SURFACE OF INTEGRATED CIRCUIT CHIP 审中-公开
标题翻译：集成电路芯片表面形成电容器电极
公开(公告)号：WO2007061841A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044670
申请日：2006-11-17
申请人： CARDIOMEMS, INC. , O'BRIEN, David , YOU, Liang
发明人： O'BRIEN, David , YOU, Liang
IPC分类号： G01L9/12
CPC分类号： G01L9/0075
摘要： A sensor has a sensor housing defining a cavity therein. A first wall partially defining the cavity is deflectable under a physiologically relevant range of pressures. An integrated circuit chip bearing electronics is fixedly mounted within the cavity. A capacitor comprises first and second capacitor plates in generally parallel, spaced-apart relation. The first capacitor plate is physically coupled to the deflectable wall so as to move as the wall deflects, and the second capacitor plate is carried by the chip. The second capacitor plate is in electrical communication with the input pad of the chip.
摘要翻译：传感器具有在其中限定空腔的传感器外壳。部分地限定空腔的第一壁在生理学上相关的压力范围内是可偏转的。集成电路芯片轴承电子器件固定地安装在腔内。电容器包括大致平行且间隔开的关系的第一和第二电容器板。第一电容器板物理耦合到可偏转壁，以便当壁偏转时移动，并且第二电容器板由芯片承载。第二电容器板与芯片的输入焊盘电连通。

4. 发明申请

WO2006086114A3 METHOD OF MANUFACTURING A HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
公开(公告)号：WO2006086114A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/001101
申请日：2006-01-13
申请人： CARDIOMEMS, INC. , O'BRIAN, David , CROS, Florent , PARK, Jin Woo , FONSECA, Michael , YOU, Liang , ALLEN, Mark
发明人： O'BRIAN, David , CROS, Florent , PARK, Jin Woo , FONSECA, Michael , YOU, Liang , ALLEN, Mark
IPC分类号： H01L21/66 , H01L21/00 , H01L21/44 , H01L21/50 , H01L23/02
摘要： A method of manufacturing a hermetically-sealed chamber with an electrical feedthrough includes the step of hermetically fixing an electrode to a substrate in a predetermined location on the substrate. A passage is formed through the substrate through the predetermined location such that at least a portion of the electrode is exposed to the passage. The passage is then at least partially filled with an electrically conductive material. A housing is then formed including the substrate such that the housing defines a chamber, with the electrode being disposed within the housing and the chamber being hermetically sealed. The electrode within the chamber can be placed in electrical communication with an exterior electrical component by way of the electrically conductive material in the passage.

5. 发明申请

WO2006086113A3 HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
公开(公告)号：WO2006086113A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/001095
申请日：2006-01-13
申请人： CARDIOMEMS, INC. , O'BRIAN, David , CROS, Florent , PARK, Jin Woo , FONSECA, Michael , YOU, Liang , ALLEN, Mark
发明人： O'BRIAN, David , CROS, Florent , PARK, Jin Woo , FONSECA, Michael , YOU, Liang , ALLEN, Mark
IPC分类号： G01L7/00
摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

6. 发明申请

WO2005116236A2 METHODS FOR TREATING CANCER USING ANTI-WNT2 MONOCLONAL ANTIBODIES AND SIRNA 审中-公开
标题翻译：使用抗WNT2单克隆抗体和SIRNA治疗癌症的方法
公开(公告)号：WO2005116236A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/017047
申请日：2005-05-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , YOU, Liang , HE, Biao , XU, Zhidong , JABLONS, David, M.
发明人： YOU, Liang , HE, Biao , XU, Zhidong , JABLONS, David, M.
IPC分类号： C12P21/06
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C12N15/113 , C12N2310/14 , A61K2300/00
摘要： This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
摘要翻译：本发明涉及抑制过表达Wnt2的细胞，特别是癌细胞生长的方法。所述方法包括使细胞与结合Wnt2mRNA或Wnt2蛋白的试剂接触，干扰Wnt2信号传导或抑制Wnt2蛋白与另一种蛋白质如卷曲毛发受体的结合。

7. 发明申请

WO2004032838A2 METHODS FOR TREATING CANCER BY INHIBITING WNT SIGNALING 审中-公开
标题翻译：通过抑制WNT信号来治疗癌症的方法
公开(公告)号：WO2004032838A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031384
申请日：2003-10-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
发明人： HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
IPC分类号： A61K
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/56 , C07K2317/73
摘要： This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor.
摘要翻译：本发明涉及抑制过表达Wnt蛋白的癌细胞生长的方法。该方法包括使细胞与抑制Wnt蛋白与卷曲蛋白受体结合的试剂接触。

8. 发明申请

WO2007067814A3 TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES 审中-公开
公开(公告)号：WO2007067814A3
公开(公告)日：2007-06-14
申请号：PCT/US2006/047231
申请日：2006-12-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HE, Biao , FUJII, Naoaki , YOU, Liang , XU, Zhidong , JABLONS, David M.
发明人： HE, Biao , FUJII, Naoaki , YOU, Liang , XU, Zhidong , JABLONS, David M.
IPC分类号： A61K31/415 , C07D231/06
摘要： This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.

9. 发明申请

WO2005023199A2 SOCS-3 PROMOTER METHYLATION IN CANCER 审中-公开
标题翻译： SOCS-3促性腺激素在癌症中的表达
公开(公告)号：WO2005023199A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029037
申请日：2004-09-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
发明人： HE, Biao , YOU, Liang , XU, Zhidong , JABLONS, David, M.
IPC分类号： A61K
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , G01N33/5011 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/00 , G01N2800/52 , C12Q2523/125
摘要： This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
摘要翻译：本发明提供了用于诊断和治疗SOCS-3表达降低的癌症的组合物和方法。

10. 发明申请

WO2012003493A2 PROTEIN KINASE CK2 GENE MUTATIONS, AMPLIFICATIONS AND POLYMORPHISMS IN HUMAN CANCERS AND METHODS OF USE 审中-公开
标题翻译：蛋白激酶CK2基因突变，人类癌症中的放大和多态性及其使用方法
公开(公告)号：WO2012003493A2
公开(公告)日：2012-01-05
申请号：PCT/US2011/042876
申请日：2011-07-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , YOU, Liang , XU, Zhidong , HE, Biao , JABLONS, David
发明人： YOU, Liang , XU, Zhidong , HE, Biao , JABLONS, David
IPC分类号： C12Q1/68 , C12N15/54 , C12N9/12 , C07K16/40
CPC分类号： C12Q1/6886 , C12N9/1205 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178 , C12Y207/11001 , G01N33/6893
摘要： The present disclosure provides methods and compositions for diagnosis and for providing a prognosis of a cancer patient by assessing CK2 alpha 1 pseudogene (CSNK2A1P) status. The present disclosure also provides polypeptide, polynucleotide, host cell, and transgenic animal compositions associated with CSNK2A1P.
摘要翻译：本公开提供用于诊断和通过评估CK2α1假基因（CSNK2A1P）状态来提供癌症患者的预后的方法和组合物。本公开还提供了与CSNK2A1P相关的多肽，多核苷酸，宿主细胞和转基因动物组合物。

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