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1. 发明申请

WO2005002669A3 TACHYARRHYTHMIA DETECTION AND DISCRIMINATION BASED ON CURVATURE PARAMETERS 审中-公开
标题翻译：基于曲线参数的TACHYARRHYTHMIA检测和辨别
公开(公告)号：WO2005002669A3
公开(公告)日：2005-05-12
申请号：PCT/US2004020723
申请日：2004-06-28
申请人： CARDIAC PACEMAKERS INC , SWEENEY ROBERT J , RICCI CARLOS
发明人： SWEENEY ROBERT J , RICCI CARLOS
IPC分类号： A61B5/0245 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/39 , G06K9/00 , G06F17/00
CPC分类号： G06K9/00523 , A61B5/0245 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61B5/7264 , A61N1/362 , A61N1/3962
摘要： Estimating a frequency of a sampled cardiac rhythm signal and classifying the rhythm. The received signal is sampled and transformed into a curvature series. A lobe in the curvature series corresponds to a characteristic point in the sampled series. Characteristic points are selected based on a time of a lobe in the curvature series and, in one embodiment, an amplitude of the signal at the time of the lobe. A frequency of the sampled series is estimated by autocorrelating a function of the series of the characteristic points. In one embodiment, the function is a time difference function. The rhythm is classified by plotting the timewise proximity of characteristic points derived from an atrial signal with characteristic points derived from a ventricular signal. Regions of the plot are associated with a particular rhythm and the grouping of the data corresponds to the classification.
摘要翻译：估计采样心律信号的频率并对节律进行分类。接收到的信号被采样并转换成曲率系列。曲率系列中的凸角对应于采样系列中的特征点。基于曲率序列中的波瓣的时间选择特征点，并且在一个实施例中，选择在波瓣时的信号的幅度。通过自相关一系列特征点的函数来估计采样序列的频率。在一个实施例中，该功能是时差功能。通过绘制从心房信号得到的特征点与从心室信号得到的特征点的时间接近，分类节律。地块的区域与特定节奏相关联，数据分组对应于分类。

2. 发明申请

WO2012005988A3 CARDIAC CONTRACTION DETECTION USING INFORMATION INDICATIVE OF LEAD MOTION 审中-公开
标题翻译：使用指示铅运动的信息进行心脏辅助检查
公开(公告)号：WO2012005988A3
公开(公告)日：2012-03-15
申请号：PCT/US2011041854
申请日：2011-06-24
申请人： CARDIAC PACEMAKERS INC , SWEENEY ROBERT J , SHUROS ALLAN C , SIEJKO KRZYSZTOF Z , OLSON DAVID C , INGLE FRANK
发明人： SWEENEY ROBERT J , SHUROS ALLAN C , SIEJKO KRZYSZTOF Z , OLSON DAVID C , INGLE FRANK
IPC分类号： A61N1/365 , A61B5/026 , A61B5/11
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译：描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由于一个心脏。该装置可以包括处理器电路，其被配置为确定在所获得的指示可植入引线的移动的信息中包括的指定间隔期间是否发生心脏机械收缩。处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。

3. 发明申请

WO2007133873A2 HEART FAILURE MANAGEMENT SYSTEM 审中-公开
标题翻译：心脏失败管理系统
公开(公告)号：WO2007133873A2
公开(公告)日：2007-11-22
申请号：PCT/US2007066543
申请日：2007-04-12
申请人： CARDIAC PACEMAKERS INC , LIBBUS IMAD , SIEJKO KRZYSZTOF Z , BROCKWAY MARINA , SWEENEY ROBERT J
发明人： LIBBUS IMAD , SIEJKO KRZYSZTOF Z , BROCKWAY MARINA , SWEENEY ROBERT J
IPC分类号： A61N1/365
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。控制器连接到刺激器和传感器的数量。控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。本文提供了其它方面和实施例。

4. 发明申请

WO2008027242A3 CONTROLLED TITRATION OF NEUROSTIMULATION THERAPY 审中-公开
标题翻译：神经病理疗治疗的控制
公开(公告)号：WO2008027242A3
公开(公告)日：2009-05-07
申请号：PCT/US2007018411
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS INC , BROCKWAY MARINA V , LIBBUS IMAD , SIEJKO KRZYSZTOF Z , SWEENEY ROBERT J
发明人： BROCKWAY MARINA V , LIBBUS IMAD , SIEJKO KRZYSZTOF Z , SWEENEY ROBERT J
IPC分类号： A61N1/36
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译：本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。

5. 发明申请

WO0209582A2 METHOD AND APPARATUS FOR A MORPHOLOGY-PRESERVING SMOOTHING FILTER 审中-公开
标题翻译：用于形态保存滤光片的方法和装置
公开(公告)号：WO0209582A2
公开(公告)日：2002-02-07
申请号：PCT/US0141440
申请日：2001-07-26
申请人： CARDIAC PACEMAKERS INC
发明人： LOVETT ERIC G , SWEENEY ROBERT J
IPC分类号： A61B5/04 , A61B5/0428 , A61N1/39 , H03H17/02 , H03H21/00 , A61B5/00
CPC分类号： H03H21/0043 , A61B5/04017 , A61B5/0428 , A61B5/7203 , A61N1/3956 , H03H17/026
摘要： A method and apparatus for implementing a signal morphology preservation smoothing scheme. The smoothing scheme includes generating an output signal representative of a filtered version of the input signal, wherein the output signal is generated by adaptively removing low amplitude, high frequency noise components while simultaneously preserving signal morphology of the input signal. The smoothing scheme includes comparison of a distance metric against a distance threshold to determine whether an initial smoothed version of the input signal would be oversmoothed or undersmoothed. Then the smoothing scheme appropriately increments, decrements, or maintains the initial level of smoothing to generate an optimal smoothed signal representative of the output signal.
摘要翻译：一种实现信号形态保存平滑方案的方法和装置。平滑方案包括产生表示输入信号的滤波版本的输出信号，其中通过自适应地去除低幅度高频噪声分量而产生输出信号，同时保持输入信号的信号形态。平滑方案包括距离度量与距离阈值的比较，以确定输入信号的初始平滑版本是否将被过度平缓或不足够的。然后平滑方案适当地增加，减少或维持平滑的初始水平，以产生表示输出信号的最佳平滑信号。

6. 发明申请

WO03075744A2 OPTIMIZING IMPLANTED MEDICAL DEVICE PERFORMANCE 审中-公开
标题翻译：优化植入式医疗器械性能
公开(公告)号：WO03075744A2
公开(公告)日：2003-09-18
申请号：PCT/US0306851
申请日：2003-03-06
申请人： CARDIAC PACEMAKERS INC
发明人： KENKNIGHT BRUCE H , LOVETT ERIC G , SWEENEY ROBERT J , MAZAR SCOTT T , MANICKA YATHEENDHAR
IPC分类号： A61B20060101 , A61N1/08 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/372 , A61B
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/37211 , A61N1/37235 , A61N1/37282
摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as in interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic interfaces with a clinical programmer for use by a physician.
摘要翻译：一种用于基于包括上下文信息的数据来调整植入装置的性能的装置和方法。上下文信息，包括关于植入装置的操作和性能数据以及具有植入装置的患者，由便携式电子装置存储。在一个实施例中，便携式电子设备适用于电池操作并且包括个人数字助理（PDA）。便携式电子设备适于在与植入设备进行无线通信的接口中使用。在一个实施例中，便携式电子接口与医师使用的临床程序员接口。

7. 发明申请

WO0141870A3 CLASSIFYING TACHYARRHYTHMIA EPISODES AS ASSOCIATED OR DISASSOCIATED 审中-公开
标题翻译：分类为相关或分散的TACHYARRHYTHMIA EPISODES
公开(公告)号：WO0141870A3
公开(公告)日：2001-12-13
申请号：PCT/US0042528
申请日：2000-12-01
申请人： CARDIAC PACEMAKERS INC
发明人： HSU WILLIAM , SWEENEY ROBERT J , LOVETT ERIC G
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3702 , A61N1/3622
摘要： A method and system for classifying tachyarrhythmia episodes as associated or disassociated. Primary and auxiliary depolarizations are detected from different cardiac regions during a tachycardia episode. A first time interval is positioned to surround each of one or more primary depolarizations, including auxiliary depolarizations that occur in the first time interval. The auxiliary depolarizations occurring in the first time interval are then counted. Based on the number and the location of the auxiliary depolarizations counted in the first time intervals, the one or more primary depolarizations and the auxiliary depolarizations of the tachycardia episode are classified as disassociated or associated.
摘要翻译：一种将快速性心律失常发作分类为相关或不相关的方法和系统。在心动过速发作期间，从不同的心脏区域检测到初级和辅助去极化。第一时间间隔定位成围绕一个或多个主去极化中的每一个，包括在第一时间间隔中发生的辅助去极化。然后计算在第一时间间隔内发生的辅助去极化。根据在第一次间隔中计数的辅助去极化的数量和位置，心动过速发作的一次或多次初次去极化和辅助去极化被分类为分离或相关联。

8. 发明申请

WO0240094A2 CURVATURE-BASED FEATURE SELECTION FOR ELECTROPHYSIOLOGIC SIGNALS 审中-公开
标题翻译：电视信号的基于曲线的特征选择
公开(公告)号：WO0240094A2
公开(公告)日：2002-05-23
申请号：PCT/US0145763
申请日：2001-10-26
申请人： CARDIAC PACEMAKERS INC
发明人： SWEENEY ROBERT J , LOVETT ERIC G
IPC分类号： A61B5/0452 , A61N1/362 , G06F17/00 , G06K9/00 , A61N1/00
CPC分类号： G06K9/00523 , A61B5/04525 , A61B5/7264 , A61N1/362
摘要： A method for curvature based complex identification and classification comprises sensing a cardiac signal and computing curvatures at sample points on the sensed cardiac signal, extracting features from the computed curvatures, comparing the extracted features with a set of predetermined templates, and classifying the sensed cardiac signal based on the outcome of the comparison.
摘要翻译：一种用于基于曲率的复合物识别和分类的方法包括：感测心脏信号并计算感测到的心脏信号上的采样点处的曲率，从计算的曲率中提取特征，将提取的特征与一组预定模板进行比较，以及将感测的心脏信号基于比较的结果。

9. 发明申请

WO0176687A3 ULTRASONICALLY ACTIVATED ELECTRODES 审中-公开
标题翻译：超声波激活电极
公开(公告)号：WO0176687A3
公开(公告)日：2002-03-21
申请号：PCT/US0110961
申请日：2001-04-04
申请人： CARDIAC PACEMAKERS INC
发明人： SWEENEY ROBERT J
IPC分类号： A61N1/05 , A61N1/378
CPC分类号： A61N1/3787 , A61N1/056
摘要： An implantable electrode, where the electrode comprises a first piezoelectric element which converts mechanical energy into electrical energy, and a cathode and an anode, where electrical energy generated by the first piezoelectric element causes a pacing level energy pulse to be delivered between the anode and the cathode. The mechanical energy for stimulating the piezoelectric element originates from a source external to the implantable electrode. In one embodiment, the external source is from a transmitter that is located on, or integrated into, either a cardiac lead and/or the implantable pulse generator. The electrode further includes an implantable housing into which is integrated the first piezoelectric element and on which is mounted the anode and the cathode. The housing also contains pacing control circuitry, which is coupled to the first piezoelectric element, the anode and the cathode. In one embodiment, the pacing control circuitry serves to receive the electrical energy generated by the first piezoelectric element and control the delivery of pacing level energy pulse between the anode and the cathode.
摘要翻译：一种可植入电极，其中电极包括将机械能转换为电能的第一压电元件以及阴极和阳极，其中由第一压电元件产生的电能使起搏电平能量脉冲在阳极和阴极。用于刺激压电元件的机械能源自可植入电极外部的源。在一个实施例中，外部源来自位于心脏引线和/或可植入脉冲发生器上或集成到心脏引线和/或可植入脉冲发生器中的发射器。电极还包括可植入壳体，其中集成有第一压电元件，并在其上安装阳极和阴极。外壳还包含起搏控制电路，其连接到第一压电元件，阳极和阴极。在一个实施例中，起搏控制电路用于接收由第一压电元件产生的电能并且控制在阳极和阴极之间的起搏电平能量脉冲的传递。

10. 发明申请

WO0062858A3 ULTRASOUND FOR AUTOCAPTURE OR OTHER APPLICATIONS 审中-公开
标题翻译：超声波用于自动化或其他应用
公开(公告)号：WO0062858A3
公开(公告)日：2001-03-08
申请号：PCT/US0010570
申请日：2000-04-19
申请人： CARDIAC PACEMAKERS INC
发明人： SWEENEY ROBERT J
IPC分类号： A61N1/365 , A61B8/08
CPC分类号： A61N1/36528
摘要： A cardiac rhythm management system provides ultrasound autocapture capability for determining whether a stimulation has evoked a desired response from the heart, and for adjusting an energy of the stimulation based on the observed response from the heart. A first ultrasound element is disposed on a lead in the heart. A second ultrasound element is disposed elsewhere in the heart or in the implanted device. An autocapture determination circuit determines whether motion of the heart chamber indicates a contraction in response to the stimulation, and adjusts the stimulation energy to provide only that energy which is needed to obtain capture. This saves energy, prolonging the life of the implanted device, minimizing the risk and expense to patient associated with early explantation and replacement of the implanted device. Other applications include using ultrasound for (1) determining the strength of heart contractions (2) determining dissociation between electrical and mechanical heart activity, (3) determining the volume of the heart, (4) determining the origin of sensed intrinsic electrical heart activity signals, (5) recognizing particular arrhythmias (6) disrupting cell membranes for lowering stimulation threshold, (7) controlling the delivery of a steroid, and (8) obtaining blood flow information.
摘要翻译：心脏节律管理系统提供超声自动俘获能力，用于确定刺激是否已经引起来自心脏的期望的响应，并且用于基于来自心脏的观察到的响应来调整刺激的能量。第一超声元件设置在心脏中的引线上。第二超声元件设置在心脏或植入装置中的别处。自动捕获确定电路确定心室的运动是否响应于刺激指示收缩，并且调整刺激能量以仅提供获得捕获所需的能量。这节省了能量，延长了植入装置的寿命，使与患者早期移植和置换植入装置相关联的风险和费用最小化。其他应用包括使用超声波（1）确定心脏收缩的强度（2）确定电气和机械心脏活动之间的离解，（3）确定心脏的体积，（4）确定感测的内在电气心脏活动信号的起源（5）识别特定的心律失常（6）破坏细胞膜降低刺激阈值，（7）控制类固醇的输送，（8）获得血流信息。

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