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1. 发明申请

WO2011008749A3 PHYSIOLOGICAL VIBRATION DETECTION IN AN IMPLANTED MEDICAL DEVICE 审中-公开
标题翻译：植入式医疗器械中的生理振动检测
公开(公告)号：WO2011008749A3
公开(公告)日：2011-03-10
申请号：PCT/US2010041818
申请日：2010-07-13
申请人： CARDIAC PACEMAKERS INC , TERNES DAVID J , SIEJKO KRZYSZTOF Z , RUBLE STEPHEN , HAMANN JASON J
发明人： TERNES DAVID J , SIEJKO KRZYSZTOF Z , RUBLE STEPHEN , HAMANN JASON J
IPC分类号： A61N1/36 , A61B5/024 , A61B5/08 , A61B5/11 , A61B7/00 , A61B7/04 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B7/00 , A61B7/003 , A61B2562/0219 , A61N1/3601 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment of an implantable system configured to be implanted in a patient includes an accelerometer, a neural stimulator, and a controller. The neural stimulator is configured to deliver neural stimulation to a neural target. The controller is configured to use the accelerometer to detect laryngeal vibration or coughing, and is configured to deliver a programmed neural stimulation therapy using the neural stimulator and using detected laryngeal vibration or detected coughing as an input to the programmed neural stimulation therapy.
摘要翻译：被配置为植入患者中的可植入系统的实施例包括加速度计，神经刺激器和控制器。神经刺激器被配置为将神经刺激递送到神经靶标。控制器被配置为使用加速度计来检测喉部振动或咳嗽，并且被配置为使用神经刺激器递送编程的神经刺激治疗，并使用检测到的喉部振动或检测到的咳嗽作为编程的神经刺激疗法的输入。

2. 发明申请

WO2011159545A3 NEUROSTIMULATION SYSTEM WITH CONTROL USING EVOKED RESPONSES 审中-公开
标题翻译：使用反应灵敏度控制的神经元系统
公开(公告)号：WO2011159545A3
公开(公告)日：2012-03-15
申请号：PCT/US2011039764
申请日：2011-06-09
申请人： CARDIAC PACEMAKERS INC , HINCAPIE ORDONEZ JUAN GABRIEL , TERNES DAVID J , HAMANN JASON J , RUBLE STEPHEN
发明人： HINCAPIE ORDONEZ JUAN GABRIEL , TERNES DAVID J , HAMANN JASON J , RUBLE STEPHEN
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4058 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36135 , A61N1/36167
摘要： A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
摘要翻译：神经刺激系统提供捕获验证和刺激强度调节，以确保迷走神经刺激在调节患者体内的一个或多个目标功能方面的有效性。在各种实施例中，对迷走神经施加刺激，并且检测诱发反应以验证刺激捕获迷走神经并调节控制刺激强度的一个或多个刺激参数。

3. 发明申请

WO2015084924A3 STIMULATION SYSTEM ADJUSTED FOR INDUCED CARDIAC CONDUCTION CHANGES 审中-公开
标题翻译：刺激系统调整诱导心脏导管变化
公开(公告)号：WO2015084924A3
公开(公告)日：2015-07-23
申请号：PCT/US2014068300
申请日：2014-12-03
申请人： CARDIAC PACEMAKERS INC
发明人： STAHMANN JEFFREY E , RUBLE STEPHEN B , TERNES DAVID J
IPC分类号： A61N1/365 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36139 , A61N1/36114 , A61N1/365 , A61N1/37288
摘要： An implantable system delivers a plurality of electrical stimulation therapies to a patient and controls the delivery such that a physiologic change induced by at least one of the therapies is detected and used to adjust one or more of the therapies. In various embodiments, the implantable system delivers a cardiac rhythm management (CRM) therapy such as a pacing therapy and a neural stimulation (NS) therapy such as an autonomic modulation therapy (AMT). In various embodiments, the physiologic change includes a change in a cardiac conduction interval that may be detected within a detection window following delivery of the pacing or NS therapy.
摘要翻译：可植入系统向患者传送多个电刺激疗法并控制递送，使得检测由至少一种疗法引起的生理变化并用于调整一种或多种疗法。在各种实施例中，可植入系统递送心律管理（CRM）治疗，例如起搏治疗和神经刺激（NS）治疗，例如自主调节疗法（AMT）。在各种实施方案中，生理变化包括可以在递送起搏或NS治疗之后的检测窗口内检测到的心脏传导间期的变化。

4. 发明申请

WO2016126654A2 SENSING WINDOW MANAGEMENT OF MULTIPOINT PACING 审中-公开
标题翻译：多点感光窗口管理
公开(公告)号：WO2016126654A2
公开(公告)日：2016-08-11
申请号：PCT/US2016016086
申请日：2016-02-02
申请人： CARDIAC PACEMAKERS INC
发明人： TERNES DAVID J , LINDER WILLIAM J
IPC分类号： A61N1/32 , A61N1/368
CPC分类号： A61N1/3686 , A61N1/056 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： An apparatus for coupling to a plurality of electrodes implantable at a plurality of tissue sites of a heart chamber of a subject. The apparatus including a stimulus circuit configured to provide an electrical cardiac pacing stimulation to the plurality of electrodes, a switching circuit configured to select electrodes of the plurality of electrodes for electrical coupling to the stimulus circuit, and a control circuit including a heart rate sub-circuit configured to determine heart rate; and a pacing site activation sub-circuit configured to selectively change which electrodes of the plurality of electrodes are used to provide the electrical cardiac pacing stimulation therapy according to the determined heart rate.
摘要翻译：一种用于耦合到可植入物体的心室的多个组织部位的多个电极的装置。所述装置包括被配置为向所述多个电极提供电心脏起搏刺激的刺激电路，被配置为选择所述多个电极中的电极以与所述刺激电路电耦合的开关电路，以及包括心率子步骤的控制电路，电路配置以确定心率; 以及起搏位置激活子电路，其被配置为根据所确定的心率选择性地改变所述多个电极中的哪些电极用于提供所述心脏起搏刺激治疗。

5. 发明申请

WO2011008747A3 REMOTE SENSING IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：在植入式医疗设备中的遥感
公开(公告)号：WO2011008747A3
公开(公告)日：2011-03-10
申请号：PCT/US2010041815
申请日：2010-07-13
申请人： CARDIAC PACEMAKERS INC , TERNES DAVID J , SIEJKO KRZYSZTOF Z , RUBLE STEPHEN , HAMANN JASON J
发明人： TERNES DAVID J , SIEJKO KRZYSZTOF Z , RUBLE STEPHEN , HAMANN JASON J
IPC分类号： A61N1/05 , A61B5/024 , A61B5/11 , A61B7/00 , A61B7/04 , A61N1/36 , A61N1/362
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate information using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译：一个实施例使用加速计来感测心音，并且使用感测到的心音确定心率信息。一个实施例使用加速度计来感测呼吸活动。一个实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，之后是刺激关闭部分。电连接到植入的神经刺激装置的电极用于远程检测心脏活动。远程检测到的心脏活动用于在刺激开启部分期间检测心率信息并且在刺激关闭部分期间检测心率信息。检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激装置执行的神经刺激治疗，和/或用于提供患者病症的诊断信息。

6. 发明申请

WO2015095024A2 SYSTEM AND METHOD FOR LOCATING NEURAL TISSUE 审中-公开
标题翻译：用于定位神经组织的系统和方法
公开(公告)号：WO2015095024A2
公开(公告)日：2015-06-25
申请号：PCT/US2014070299
申请日：2014-12-15
申请人： CARDIAC PACEMAKERS INC
发明人： MOKELKE ERIC A , TERNES DAVID J , SHUROS ALLAN C , CAO HONG
IPC分类号： A61B5/00
CPC分类号： A61B5/04001 , A61B5/0538 , A61B5/4893 , A61B5/6848 , A61B18/1206 , A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/124 , A61B2562/046 , A61N1/0551 , A61N1/36128 , A61N1/36139 , A61N1/36185
摘要： An example of a system comprises a patch of electrodes for placement on tissue containing neural tissue, and a tissue tester configured to measure an electrical characteristic of tissue. The tissue tester may include a test controller and switches. The test controller and the switches may be configured to connect different combinations of the electrodes to create subsets of two or more electrodes to measure the electrical characteristic of tissue using the subsets. The test controller may be configured to measure an electrical characteristic of tissue using the subsets within the set of electrodes placed on the tissue, and compare measurements of the electrical characteristic and identify a neural target for a therapy based on the comparison of the measurements of the electrical characteristic for tissue at the neural target relative to adjacent non-neural tissue.
摘要翻译：系统的示例包括用于放置在含有神经组织的组织上的电极片，以及被配置为测量组织的电特性的组织测试器。组织测试器可以包括测试控制器和开关。测试控制器和开关可以被配置为连接电极的不同组合以产生两个或更多个电极的子集，以使用子集来测量组织的电特性。测试控制器可以被配置为使用放置在组织上的电极组内的子集来测量组织的电特性，并且比较电特性的测量并且基于对所述组合的测量的比较来识别用于治疗的神经靶标相对于相邻非神经组织的神经靶标组织的电特性。

7. 发明申请

WO2011159527A3 AUTOMATIC NEURAL STIMULATION TITRATION SWEEP 审中-公开
标题翻译：自动神经刺激ATION ATION
公开(公告)号：WO2011159527A3
公开(公告)日：2012-02-09
申请号：PCT/US2011039549
申请日：2011-06-08
申请人： CARDIAC PACEMAKERS INC , HINCAPIE ORDONEZ JUAN GABRIEL , RUBLE STEPHEN , HAMANN JASON J , MOKELKE ERIC A , ARCOT-KRISHNAMURTHY SHANTHA , STALSBERG KEVIN JOHN , TERNES DAVID J
发明人： HINCAPIE ORDONEZ JUAN GABRIEL , RUBLE STEPHEN , HAMANN JASON J , MOKELKE ERIC A , ARCOT-KRISHNAMURTHY SHANTHA , STALSBERG KEVIN JOHN , TERNES DAVID J
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译：各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。神经刺激输出电路被配置为递送神经刺激。控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。控制器被配置为与传感器电路通信。存储器具有存储在其中的指令，可由控制器电路操作。说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数刺激并提供理想的安全余量以防止对神经组织的损伤。

8. 发明申请

WO2011008748A3 REMOTE PACE DETECTION IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可移植医疗器械中的远程检测
公开(公告)号：WO2011008748A3
公开(公告)日：2011-11-17
申请号：PCT/US2010041816
申请日：2010-07-13
申请人： CARDIAC PACEMAKERS INC , TERNES DAVID J , BAKER KENNETH L
发明人： TERNES DAVID J , BAKER KENNETH L
IPC分类号： G06F19/00 , A61N1/36
CPC分类号： A61N1/36139 , A61B5/024 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/37211 , A61N1/37288 , G06F19/3406 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H40/67
摘要： A system embodiment for stimulating a neural target comprises a neural stimulator, a pace detector, and a controller. The neural stimulator is electrically connected to at least one electrode, and is configured to deliver a neural stimulation signal through the at least one electrode to stimulate the neural target. The pace detector is configured to use at least one electrode to sense cardiac activity and distinguish paced cardiac activity in the sensed cardiac activity from non-paced cardiac activity in the sensed cardiac activity. The controller is configured to control a programmed neural stimulation therapy using the neural stimulator and using detected paced cardiac activity as an input for the neural stimulation therapy.
摘要翻译：用于刺激神经目标的系统实施例包括神经刺激器，步速检测器和控制器。神经刺激器电连接到至少一个电极，并且被配置为通过至少一个电极传送神经刺激信号以刺激神经靶标。步速检测器被配置为使用至少一个电极来感测心脏活动并且将感测到的心脏活动中的心跳活动与感觉到的心脏活动中的非节奏心脏活动区分开。控制器被配置为使用神经刺激器来控制编程的神经刺激治疗，并使用检测到的起搏心脏活动作为神经刺激治疗的输入。

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