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1. 发明申请

WO2004047912A3 IMPLANTABLE MEDICAL DEVICE HAVING A CONTROLLED DIAGNOSTIC FUNCTION 审中-公开
公开(公告)号：WO2004047912A3
公开(公告)日：2004-06-10
申请号：PCT/US2003/037945
申请日：2003-11-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAZAR, Scott, Thomas, , KENKNIGHT, Bruce, H.
IPC分类号： A61N1/372
摘要： Methods and systems for providing an implantable medical device with a controlled diagnostic function adapted to convert from a monitoring mode to a therapeutic mode upon sensing an actionable cardiovascular event are disclosed. A preferred embodiment uses an interactive control module to selectively control a plurality of gated circuits that turn the sensing, therapeutic and communications functions of the device on and off to conserve battery power and extend the life of the device. Some embodiments of a system disclosed herein also can be configured as a component of an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.

2. 发明申请

WO2003075744A3 OPTIMIZING IMPLANTED MEDICAL DEVICE PERFORMANCE 审中-公开
公开(公告)号：WO2003075744A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006851
申请日：2003-03-06
申请人： CARDIAC PACEMAKERS, INC.
发明人： KENKNIGHT, Bruce, H. , LOVETT, Eric, G. , SWEENEY, Robert, J. , MAZAR, Scott, T. , MANICKA, Yatheendhar
IPC分类号： A61N1/08
摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as in interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic interfaces with a clinical programmer for use by a physician.

3. 发明申请

WO2005030325A1 DEMAND-BASED CARDIAC FUNCTION THERAPY 审中-公开
标题翻译：基于需求的心脏功能治疗
公开(公告)号：WO2005030325A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031062
申请日：2004-09-23
申请人： CARDIAC PACEMAKERS, INC. , KENKNIGHT, Bruce, H. , ZHU, Qingsheng
发明人： KENKNIGHT, Bruce, H. , ZHU, Qingsheng
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A method and device for delivering cardiac function therapy on a demand basis. An implantable device for delivering cardiac function therapy (200) is programmed to suspend such therapy (201) at periodic intervals or upon command from an external programmer. Measurements related to hemodynamic performance are then taken using one or more sensing modalities incorporated into the device (203) . Based upon these measurements, the device uses a decision algorithm to determine whether further delivery of the cardiac function therapy is warranted (206).
摘要翻译：一种用于在需求的基础上提供心脏功能治疗的方法和装置。用于递送心脏功能治疗（200）的可植入装置被编程为以周期性间隔或者来自外部编程器的命令暂停这种治疗（201）。然后使用结合到装置（203）中的一个或多个感测模式来进行与血液动力学性能相关的测量。基于这些测量，该装置使用决策算法来确定是否需要进一步递送心脏功能治疗（206）。

4. 发明申请

WO2004012815A1 SYSTEMS PREDICTING CONGESTIVE HEART FAILURE 审中-公开
标题翻译：系统预测心理失常
公开(公告)号：WO2004012815A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/024597
申请日：2003-08-06
申请人： CARDIAC PACEMAKERS, INC.
发明人： GIROUARD, Steven, D. , STAHMANN, Jeffrey, E. , SWEENEY, Robert, J. , KENKNIGHT, Bruce, H.
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61B5/4842
摘要： This document describes, among other things, systems, devices, and methods for predicting how the status of the patient's congestive heart failure (CHF) condition will progress in the future. In one example, a therapy is provided or adjusted at least in part in response to the prediction.
摘要翻译：该文件尤其描述了用于预测患者未来充血性心力衰竭（CHF）状况如何进展的系统，装置和方法。在一个示例中，至少部分地响应于预测提供或调整治疗。

5. 发明申请

WO1998013102A1 SYSTEM TO REDUCE DEFIBRILLATION REQUIREMENTS 审中-公开
标题翻译：减少破坏要求的制度
公开(公告)号：WO1998013102A1
公开(公告)日：1998-04-02
申请号：PCT/US1997017233
申请日：1997-09-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： CARDIAC PACEMAKERS, INC. , KENKNIGHT, Bruce, H.
IPC分类号： A61N01/39
CPC分类号： A61N1/3962
摘要： A hybrid tachyarrhythmia therapy utilizes a combination of two therapies: pacing therapy (optionally followed by therapy employing waveforms having morphologies congruent to defibrillation waveforms but at reduced strength); and defibrillation (including cardioversion) therapy. The two therapies are applied in either a temporally concident, or an immediately sequential, fashion. At least one pacing pulse that influences only a localized portion of selected cardiac tissue is applied, prior to or coincident with at least one defibrillation-level shock. The defibrillation shock strength (voltage and/or energy) required to terminate the tachyarrhythmia is less than would be required in the absence of the critically coupled pacing pulses. The therapy may be applied to atrial or ventricular tachyarrhythmias. A variety of electrode configurations and defibrillation pulse schemes may be employed.
摘要翻译：混合性快速性心律失常治疗采用两种疗法的组合：起搏治疗（可选地采用具有与除颤波形一致的形态的波形但具有减弱的强度）; 和除颤（包括心脏复律）治疗。这两种疗法以时间上的一致性或立即顺序的方式使用。至少一个起搏脉冲只影响所选择的心脏组织的局部部分，在与至少一个除颤级别的休克之前或之前一起应用。终止快速性心律失常所需的除颤冲击强度（电压和/或能量）小于在不存在关键起搏脉冲的情况下所需要的。该治疗可应用于心房或室性快速性心律失常。可以采用各种电极配置和除颤脉冲方案。

6. 发明申请

WO2004050180A2 METHOD AND APPARATUS FOR CELL AND ELECTRICAL THERAPY OF LIVING TISSUE 审中-公开
标题翻译：用于活组织的细胞和电疗法的方法和设备
公开(公告)号：WO2004050180A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038085
申请日：2003-11-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： GIROUARD, Steven, D. , SALO, Rodney, W. , KENKNIGHT, Bruce, H.
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the exogenous cells are conditioned in vitro before their administration into tissue. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD or DDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译：一种用于活组织的细胞和电疗法的方法，包括将外源细胞施用到受损组织的区域中并施加电能。在一个应用中，外源细胞在其施用于组织之前在体外进行条件化。在一个应用中，组合的细胞和电疗法在体内应用于受损的心脏组织。在这种应用中，微创手术用于应用细胞治疗，电疗通过植入式脉冲发生器提供。在一个应用中，植入式起搏器用于VDD或DDD模式，与房室内固有延迟相比，房室延迟保持相对较短。

7. 发明申请

WO2005018737A1 DISORDERED BREATHING MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：异常呼吸管理系统和方法
公开(公告)号：WO2005018737A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/026883
申请日：2004-08-18
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey, E. , LEE, Kent , HARTLEY, Jesse, W. , NI, Quan , HATLESTAD, John, D. , LOVETT, Eric, G. , KENKNIGHT, Bruce, H.
IPC分类号： A61N1/362
CPC分类号： A61B5/4818 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/0421 , A61B5/0422 , A61B5/0464 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/053 , A61B5/0809 , A61B5/0816 , A61B5/0836 , A61B5/087 , A61B5/103 , A61B5/1116 , A61B5/1118 , A61B5/113 , A61B5/1135 , A61B5/145 , A61B5/4035 , A61B5/4812 , A61B5/4815 , A61B2562/0219 , A61M16/026 , A61M16/0666 , A61M16/10 , A61M2016/0021 , A61M2016/0036 , A61M2016/0039 , A61M2016/0042 , A61M2202/0208 , A61M2205/3303 , A61M2205/3306 , A61M2205/3375 , A61M2205/3561 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/10 , A61M2230/202 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/435 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/3601 , A61N1/362 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/36535 , A61N1/36557 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/37 , G06F19/00 , G06F19/3418
摘要： An approach to providing disordered breathing therapy includes sensing conditions affecting the patient and adapting a therapy to mitigate the disordered breathing based on the sensed conditions. The therapy may be adapted to enhance therapy effectiveness, to provide therapy that reduces an impact of the therapy on the patient, or to achieve other therapeutic goals, Cardiac electrical therapy to mitigate the disordered breathing may include various cardiac pacing regimens and/or delivery of non-excitatory electrical stimulation to the heart.
摘要翻译：提供无序呼吸治疗的方法包括影响患者的感测状况，并根据感测到的病症适应治疗以减轻无序呼吸。治疗可以适应于增强治疗有效性，以提供减少治疗对患者的影响或实现其他治疗目标的治疗，心脏电疗法以减轻无序呼吸可包括各种心脏起搏方案和/或递送非兴奋性电刺激心脏。

8. 发明申请

WO2005000396A1 IMPLANTABLE CARDIAC RHYTHM MANAGEMENT SYSTEM HAVING MULTIPLE THERAPY MODALITIES 审中-公开
标题翻译：具有多种治疗方式的可持续心脏健康管理系统
公开(公告)号：WO2005000396A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/018684
申请日：2004-06-12
申请人： CARDIAC PACEMAKERS, INC. , SPINELLI, Julio , ZHU, Qingsheng , KENKNIGHT, Bruce, H. , YU, Yinghong , DING, Jiang
发明人： SPINELLI, Julio , ZHU, Qingsheng , KENKNIGHT, Bruce, H. , YU, Yinghong , DING, Jiang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
摘要翻译：一种用于提供多种治疗方式的心律管理系统。例如，系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。可以使用各种手动和自动方法来选择操作模式。此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

9. 发明申请

WO2003041797A3 SYSTEM FOR DETERMINING CHANGES IN HEART FAILURE STATUS 审中-公开
公开(公告)号：WO2003041797A3
公开(公告)日：2003-05-22
申请号：PCT/US2002/036821
申请日：2002-11-15
申请人： CARDIAC PACEMAKERS, INC.
发明人： ZHU, Qingsheng , SPINELLI, Julio, C. , KENKNIGHT, Bruce, H. , WARREN, Jay, A.
IPC分类号： A61N1/37
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.

10. 发明申请

WO2002087694A1 APPARATUS AND METHOD FOR REVERSAL OF MYOCARDIAL REMODELING WITH ELECTRICAL STIMULATION 审中-公开
标题翻译：装置和方法用于电刺激的肌肉重塑
公开(公告)号：WO2002087694A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/012950
申请日：2002-04-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： KRAMER, Andrew, P. , SALO, Rodney, W. , SPINELLI, Julio, C. , KENKNIGHT, Bruce, H.
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译：用电刺激治疗逆转心室重构的装置和方法。通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

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