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1. 发明申请

WO2017044839A1 IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER 审中-公开
标题翻译：可植入氧气发生器和运输机
公开(公告)号：WO2017044839A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/051090
申请日：2016-09-09
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA , DOHENY EYE INSTITUTE
发明人： TAI, Yu-Chong , SCIANMARELLO, Nicholas E. , MURALI, Karthik , HUMAYUN, Mark S. , RIBEIRO, Ramiro Magalhaes
IPC分类号： A61F2/14 , A61F9/00 , A61M5/00 , A61M5/142 , A61M31/00 , A61M35/00
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules
摘要翻译：描述了可植入医疗装置。可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。小分子发生器包括电解质储存器和一组电极。电解质储存器的第一部分对于预定类别的小分子是不可渗透的。电解液储存器的第二部分对小分子是可渗透的。该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。至少一部分小分子扩散剂对小分子是可渗透的

2. 发明申请

WO2019226682A1 MINIATURE FIXED AND ADJUSTABLE FLOW RESTRICTOR FOR THE BODY 审中-公开
公开(公告)号：WO2019226682A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033369
申请日：2019-05-21
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： TAI, Yu-Chong , SHAPERO, Aubrey M. , SCIANMARELLO, Nicholas E. , HUMAYUN, Mark S.
IPC分类号： B01L3/00 , G02C7/04 , C12M1/36 , C12M3/00 , G01N33/50 , G02C7/00 , G02C7/02
摘要： A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

3. 发明申请

WO2018208401A1 IMPLANTABLE EXTRACOMPARTMENTAL PRESSURE SENSOR 审中-公开
公开(公告)号：WO2018208401A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/026705
申请日：2018-04-09
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： RODGER, Damien C. , TAI, Yu-Chong , HUMAYUN, Mark S. , SHAPERO, Aubrey M. , AGARWAL, Abhinav , EMAMI, Azita
IPC分类号： A61B3/10 , A61B5/00 , A61M5/00
摘要： A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.

4. 发明申请

WO2019241212A1 EYE TREATMENT DEVICE HAVING A RING LIKE SHAPE 审中-公开
公开(公告)号：WO2019241212A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036498
申请日：2019-06-11
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： TAI, Yu-Chong , SCIANMARELLO, Nicholas E. , COOK, Colin A. , HUMAYUN, Mark S.
IPC分类号： A61K9/00
摘要： An eye treatment apparatus is described. The apparatus includes an annular body that has a hollow optical zone in its center. An inner perimeter of the annular body surrounds the optical zone. The inner perimeter has a diameter that corresponds to a diameter of the eye's cornea. An outer perimeter of the annular body has a diameter such that the annular body can extend to underneath the eye lid in an open eye position when the eye treatment apparatus is in operation. In this way, the apparatus can be worn on the eye, where the hollow optical zone substantially corresponds to the cornea and does not interfere with the field of vision. The annular body also includes a storage chamber that stores therapeutic liquid for an eye. An outlet is coupled with the storage chamber such that, in operation, the therapeutic liquid can be dispensed to the eye.

5. 发明申请

WO2016061125A1 CONTACT LENS WITH METERED LIQUID SYSTEM 审中-公开
标题翻译：具有计量液体系统的接触镜
公开(公告)号：WO2016061125A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055368
申请日：2015-10-13
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： TAI, Yu-Chong , SCIANMARELLO, Nicholas E. , DEBOER, Charles M.T. , HUMAYUN, Mark S.
IPC分类号： G02C7/04
CPC分类号： G02C7/049 , A61K9/0051 , G02C7/04 , G02C7/041 , G02C7/085
摘要： A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
摘要翻译：描述了具有与流量调节器连接到通道的液体储存器的隐形眼镜流体输送装置。本文描述了其他眼睛水合和可变屈光力隐形眼镜。还描述了具有通过流量调节器连接到通道的液体储存容器的可植入液体输送装置。这些装置和装置可用于受试者内特定的靶向递送治疗液体。在一些实施例中，装置包括致动室，其提供将流体释放到目标区域（例如眼睛）中的驱动力。本文所述的致动室可以包含相变材料或渗透室或其组合以驱动流体的释放。

6. 发明申请

WO2020167649A1 TEAR FLOW MEASUREMENT DEVICE 审中-公开
公开(公告)号：WO2020167649A1
公开(公告)日：2020-08-20
申请号：PCT/US2020/017480
申请日：2020-02-10
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： TAI, Yu-Chong , SCIANMARELLO, Nicholas E. , HUMAYUN, Mark S.
IPC分类号： G01N1/10 , A61B3/00 , A61B5/00 , A61B10/00 , A61B10/02 , G01N33/48
摘要： A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

7. 发明申请

WO2009097561A1 WOUND CLOSING COMPOUNDS WITH ADDITIVES 审中-公开
标题翻译：封闭化合物与添加剂
公开(公告)号：WO2009097561A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032700
申请日：2009-01-30
申请人： DOHENY EYE INSTITUTE , AGRAWAL, Rajat , ELIOTT, Dean , HUMAYUN, Mark S.
发明人： AGRAWAL, Rajat , ELIOTT, Dean , HUMAYUN, Mark S.
IPC分类号： A61K9/14
CPC分类号： A61L24/06 , A61L26/0014 , C08L33/26
摘要： According to one embodiment of the present invention, there is provided a polyacrylamide or derivative thereof, such as poly-N-isopropyl acrylamide (pNIPAM) for use in the closure of wounds. Also provided is a composition comprising a polyacrylamide or derivative thereof in an amount effective for closing a wound, at least in part, and one or more pharmaceutically acceptable carriers. The a polyacrylamide or derivative thereof may be used in the composition according to the invention in various concentrations and may be combined with other therapeutic compounds. In another embodiment, a method for treating a wound with the compounds and compositions described herein is provided. The method comprises administering to a mammal a polyacrylamide or derivative thereof in an amount effective to close at least a part of a wound.
摘要翻译：根据本发明的一个实施方案，提供了用于闭合伤口的聚丙烯酰胺或其衍生物，例如聚-N-异丙基丙烯酰胺（pNIPAM）。还提供了包含聚丙烯酰胺或其衍生物的组合物，该组合物的量有效地用于封闭伤口，至少部分和一种或多种药学上可接受的载体。聚丙烯酰胺或其衍生物可以以各种浓度用于根据本发明的组合物中，并且可以与其它治疗化合物组合使用。在另一个实施方案中，提供了用本文所述的化合物和组合物治疗伤口的方法。该方法包括以有效闭合伤口的至少一部分的量向哺乳动物施用聚丙烯酰胺或其衍生物。

8. 发明申请

WO2020113202A1 DOUBLE-BLINDED, RANDOMIZED TRIAL OF AUGMENTED REALITY LOW-VISION MOBILITY AND GRASP AID 审中-公开
公开(公告)号：WO2020113202A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/063924
申请日：2019-12-02
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： HUMAYUN, Mark S. , ANGELOPOULOS, Anastasios
IPC分类号： G06T19/00 , G06T19/20 , G02B27/01 , G06T7/50 , G06T7/90
摘要： An augmented reality system for providing depth perspective includes a sensor system that provides spatial data of objects in a surrounding environment of a user. A computer processor system calculates spatial information of the objects from the spatial data received the sensor system. The computer processor system determines a depth-to-color mapping in which distance of objects from the user is mapped to a predetermined viewable representation. The system also includes a head mountable display that displays the depth-to-color mapping to the user. Characteristically, distances of the objects from the user are rendered to allow at least partial viewability of the object by the user. A method utilizing the augmented reality system is also provided.

9. 发明申请

WO2022159607A1 NON-INVASIVE ULTRASOUND NEUROMODULATION FOR VISION RESTORATION FROM RETINAL DISEASES 审中-公开
公开(公告)号：WO2022159607A1
公开(公告)日：2022-07-28
申请号：PCT/US2022/013163
申请日：2022-01-20
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： HUMAYUN, Mark S. , ZHOU, Qifa , QIAN, Xuejun , THOMAS, Biju , LU, Gengxi
IPC分类号： A61F9/08 , A61N7/00 , G06V10/10 , G06V20/10
摘要： Retinal disease is responsible for many instances of vision impairment. Often, individuals with vision impaired due to retinal disease continue to have functioning retinal neurons. Thus, systems, methods, and devices to stimulate retinal neurons may restore sight for vision-impaired individuals. Systems, methods, and devices provided herein direct ultrasound energy into retinal neurons and modulate phase and amplitude of ultrasound energy in time and space domains in order to variously stimulate various retinal neurons, generating neural responses consistent with visual reproduction of intended images.

10. 发明申请

WO2020051097A1 CRYOPRESERVATION OF CELL-SEEDED SUBSTRATES AND RELATED METHODS 审中-公开
公开(公告)号：WO2020051097A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/049230
申请日：2019-08-30
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： ARNOLD, Cassidy , HUMAYUN, Mark S. , ZHU, Danhong , MITRA, Debbie , PENNINGTON, Britney O. , BAILEY, Jeffrey K. , FAYNUS, Mohamed A. , JOHNSON, Lincoln V. , CLEGG, Dennis O. , HINTON, David R.
IPC分类号： C12N5/079 , A01N1/02
摘要： Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.

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