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1. 发明申请

WO2012058233A2 SCANNING PROJECTIVE LENSLESS MICROSCOPE SYSTEM 审中-公开
标题翻译：扫描投影无线显微镜系统
公开(公告)号：WO2012058233A2
公开(公告)日：2012-05-03
申请号：PCT/US2011057735
申请日：2011-10-25
申请人： CALIFORNIA INST OF TECHN , ZHENG GUOAN , YANG SAMUEL , LEE SEUNG AH , YANG CHANGHUEI
发明人： ZHENG GUOAN , YANG SAMUEL , LEE SEUNG AH , YANG CHANGHUEI
IPC分类号： G01B9/04 , G01N21/00 , G02B21/00
CPC分类号： H04N7/183 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H2001/0447
摘要： A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.
摘要翻译：一种扫描投影镜头无显微镜装置，包括一个样品表面，一个带有光元件的扫描照明源，在样品表面外部的光检测器和一个处理器。扫描照明源将光元件扫描到多个扫描位置以向样品表面上的物体提供照明。光检测器对与多个扫描位置对应的子像素偏移投影对象图像序列进行采样。处理器基于子像素移位的投影图像的序列和感兴趣的平面上的投影的运动矢量来构建对象的高分辨率图像。

2. 发明申请

WO2011119678A3 SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING 审中-公开
标题翻译：超分辨率光学显微镜2D和3D成像
公开(公告)号：WO2011119678A3
公开(公告)日：2012-02-02
申请号：PCT/US2011029542
申请日：2011-03-23
申请人： CALIFORNIA INST OF TECHN , ZHENG GUOAN , YANG CHANGHUEI , YANG SAMUEL , LEE SEUNG AH
发明人： ZHENG GUOAN , YANG CHANGHUEI , YANG SAMUEL , LEE SEUNG AH
IPC分类号： G01N21/49 , G01N35/00 , G02B21/32
CPC分类号： H04N5/349 , G01N15/147 , G01N15/1484 , G02B21/0008 , G02B21/36 , G06T3/4053
摘要： A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.
摘要翻译：超分辨率光流体显微镜装置包括限定具有纵向轴线的流体通道的主体并且包括靠近流体通道的表面层。表面层具有二维光检测器阵列，其构造成当物体移动通过流体通道时，接收通过流体通道的光并采样一系列子像素偏移的投影框。超分辨率光流体显微镜装置还包括与二维光检测器阵列电子通信的处理器。处理器被配置为使用超分辨率算法，并且基于子像素偏移的投影帧的序列和对象的运动矢量来生成对象的高分辨率图像。

3. 发明申请

WO2012119114A2 E-PETRI DISHES, DEVICES, AND SYSTEMS 审中-公开
标题翻译：电子PETRI DISHES，设备和系统
公开(公告)号：WO2012119114A2
公开(公告)日：2012-09-07
申请号：PCT/US2012027575
申请日：2012-03-02
申请人： CALIFORNIA INST OF TECHN , ZHENG GUOAN , YANG SAMUEL , LEE SEUNG AH , PANG SHUO , YANG CHANGHUEI
发明人： ZHENG GUOAN , YANG SAMUEL , LEE SEUNG AH , PANG SHUO , YANG CHANGHUEI
IPC分类号： H01J37/22 , H01J37/244
CPC分类号： G02B21/367 , G02B21/0008 , G02B21/24
摘要： An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.
摘要翻译：一种电子培养皿，包括具有样本表面的透明层和被配置为对位于样本表面上的样本的亚像素偏移的投影图像的序列进行采样的光检测器。子像素偏移与由照明源提供的多个照明角度的光相关联的投影图像。

4. 发明申请

WO2012119094A2 LIGHT GUIDED PIXEL 审中-公开
标题翻译：光指示像素
公开(公告)号：WO2012119094A2
公开(公告)日：2012-09-07
申请号：PCT/US2012027522
申请日：2012-03-02
申请人： CALIFORNIA INST OF TECHN , LEE SEUNG AH , ZHENG GUOAN , JUDKEWITZ BENJAMIN , PANG SHUO , WU JIGANG , YANG CHANGHUEI
发明人： LEE SEUNG AH , ZHENG GUOAN , JUDKEWITZ BENJAMIN , PANG SHUO , WU JIGANG , YANG CHANGHUEI
IPC分类号： G02B6/42 , G02B6/10
CPC分类号： H01L27/14629 , H01L27/14621
摘要： A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.
摘要翻译：具有引导层和光检测器层的光引导像素。引导层具有光导。光检测器层具有接收光导通路的光检测元件。光导可以包括用于将发射引导到光检测元件的滤光器。

5. 发明申请

WO2012145566A2 TALBOT-ILLUMINATED IMAGING DEVICES, SYSTEMS, AND METHODS FOR FOCAL PLANE TUNING 审中-公开
标题翻译：用于FOCAL PLANE TUNING的TALBOT-ILLUMINATED成像装置，系统和方法
公开(公告)号：WO2012145566A2
公开(公告)日：2012-10-26
申请号：PCT/US2012034339
申请日：2012-04-20
申请人： CALIFORNIA INST OF TECHN , WU JIGANG , PANG SHUO , LI ZHENG , ZHENG GUOAN , YANG CHANGHUEI
发明人： WU JIGANG , PANG SHUO , LI ZHENG , ZHENG GUOAN , YANG CHANGHUEI
IPC分类号： G02B21/36 , G02B21/06
CPC分类号： G02B21/086 , G02B21/0044 , G02B21/244 , G02B21/361 , G02B27/4227
摘要： A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate scan array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.
摘要翻译：一种用于焦平面调谐的Talbot照明成像系统，该装置包括Talbot元件，可调谐照明源，扫描机构，光检测器和处理器。元件在焦平面上产生聚焦光斑的扫描阵列。可调谐照明源通过调节入射到Talbot元件的光的波长将焦平面移动到感兴趣的平面。扫描机构沿扫描方向扫描聚焦光点阵列上的物体。光检测器确定随着对象扫描光点阵列而与聚焦光点阵列相关联的时变光数据。处理器基于时变数据构建对象的图像。

6. 发明申请

WO2011060101A3 TURBIDITY SUPPRESSION BY OPTICAL PHASE CONJUGATION USING A SPATIAL LIGHT MODULATOR 审中-公开
标题翻译：用光调制器实现光学相位共轭抑制浊度
公开(公告)号：WO2011060101A3
公开(公告)日：2011-11-24
申请号：PCT/US2010056274
申请日：2010-11-10
申请人： CALIFORNIA INST OF TECHN , YANG CHANGHUEI , CUI MENG
发明人： YANG CHANGHUEI , CUI MENG
IPC分类号： G01N15/06 , G01N21/59 , G01N33/483
CPC分类号： G02B21/0056 , A61B5/0059 , A61B5/0066 , G01N21/1717 , G01N21/4795 , G01N21/6456 , G01N2021/1708 , G01N2021/1727 , G02B21/00 , G02B21/0004 , G02B21/0068 , G02B21/0092 , Y10T29/49826
摘要： A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light.
摘要翻译： 1.一种透过混浊介质的光的检测器，包括：一个或多个数字光学相位共轭（DOPC）装置，其中所述DOPC装置包括（1）传感器，用于检测已经透过混浊介质并输入到传感器; （2）空间光调制器（SLM），用于响应于传感器检测到的输入光输出作为输入光的光学相位共轭的输出光。

7. 发明申请

WO2008112416A3 OPTOFLUIDIC MICROSCOPE DEVICE 审中-公开
标题翻译：光学显微镜装置
公开(公告)号：WO2008112416A3
公开(公告)日：2008-11-13
申请号：PCT/US2008054908
申请日：2008-02-25
申请人： CALIFORNIA INST OF TECHN , YANG CHANGHUEI , PSALTIS DEMETRI
发明人： YANG CHANGHUEI , PSALTIS DEMETRI
IPC分类号： G01N21/00 , B32B27/04
CPC分类号： G01N21/6458 , B82Y30/00
摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light transmissive regions of different sizes may be used to image the object.
摘要翻译：公开了一种光流体显微镜装置。该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。可以使用不同尺寸的透光区域对物体进行成像。

8. 发明申请

WO2011106327A3 HIGH RESOLUTION IMAGING DEVICES WITH WIDE FIELD AND EXTENDED FOCUS 审中-公开
标题翻译：高分辨率成像装置，具有宽域和扩展焦点
公开(公告)号：WO2011106327A3
公开(公告)日：2011-12-29
申请号：PCT/US2011025762
申请日：2011-02-22
申请人： CALIFORNIA INST OF TECHN , PAVANI SRI RAMA PRASANNA , YANG CHANGHUEI , WU JIGANG
发明人： PAVANI SRI RAMA PRASANNA , YANG CHANGHUEI , WU JIGANG
IPC分类号： G01B11/24 , G01N21/00
CPC分类号： H04N13/0207 , G02B21/16 , G02B21/361 , G02B27/2242 , G02B27/2285 , H04N13/0221 , H04N13/0253
摘要： Embodiments of the present invention relate to a high-resolution imaging device with wide field and extended focus comprising a beam generator for generating a plurality of nondiffracting beams and a scanning mechanism for moving the plurality of nondiffracting beams relative to the object to illuminate a volume of the object. The high-resolution imaging device also comprises surface element and a body having a light detector layer outside the surface element. The light detector layer has a light detector configured to measure light data associated with the plurality of nondiffracting beams illuminating the volume of the object. In some cases, the high-resolution imaging device also includes a lens inside of the light detector layer. The lens is configured to focus the light on the light detector surface.
摘要翻译：本发明的实施例涉及一种具有广场和扩展焦点的高分辨率成像装置，包括用于产生多个非衍射光束的光束发生器和用于相对于物体移动多个非衍射光束的扫描机构，物体。高分辨率成像装置还包括表面元件和在表面元件外部具有光检测器层的主体。光检测器层具有光检测器，其被配置为测量与照射物体的体积的多个非衍射光束相关联的光数据。在一些情况下，高分辨率成像装置还包括在光检测器层内部的透镜。镜头被配置为将光聚焦在光检测器表面上。

9. 发明申请

WO2011060097A3 ACOUSTIC ASSISTED PHASE CONJUGATE OPTICAL TOMOGRAPHY 审中-公开
标题翻译：声学辅助相位共轭光学层析成像
公开(公告)号：WO2011060097A3
公开(公告)日：2011-10-20
申请号：PCT/US2010056270
申请日：2010-11-10
申请人： CALIFORNIA INST OF TECHN , CUI MENG , WANG YING MIN , YANG CHANGHUEI , DI MARZIO CHARLES
发明人： CUI MENG , WANG YING MIN , YANG CHANGHUEI , DI MARZIO CHARLES
IPC分类号： A61B8/00 , A61B8/13
CPC分类号： G02B21/0056 , A61B5/0059 , A61B5/0066 , G01N21/1717 , G01N21/4795 , G01N21/6456 , G01N2021/1708 , G01N2021/1727 , G02B21/00 , G02B21/0004 , G02B21/0068 , G02B21/0092 , Y10T29/49826
摘要： A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.
摘要翻译：一种用于对包含一种或多种荧光剂的样品进行成像的光学显微镜，包括用于产生聚焦在样品中的焦点处的声波的源，其中声波频移通过焦点的光的频率，由此产生频率移动光束; 至少一个空间光调制器（SLM），所述空间光调制器被定位成用作为所述频移光束的光相位共轭的输出光束照射所述样本，其中所述输出光束是从所述第一参考光束的所述第一参考光束的一个或多个像素反射 SLM，并且像素用于调制第一参考光束以创建输出光束; 以及检测器，其被定位成检测由激发样品中的焦点处的荧光剂的输出光束所生成的荧光，从而对样品成像。

10. 发明申请

WO2009111573A3 OPTOFLUIDIC MICROSCOPE DEVICE WITH PHOTOSENSOR ARRAY 审中-公开
标题翻译：带有光电传感器阵列的光学显微镜装置
公开(公告)号：WO2009111573A3
公开(公告)日：2010-01-07
申请号：PCT/US2009036045
申请日：2009-03-04
申请人： CALIFORNIA INST OF TECHN , CUI XIQUAN , HENG XIN , LEE LAP MAN , YANG CHANGHUEI
发明人： CUI XIQUAN , HENG XIN , LEE LAP MAN , YANG CHANGHUEI
IPC分类号： B81B7/02
CPC分类号： G01N21/53 , G01N21/6458
摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.
摘要翻译：本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。可以使用的一种技术消除了覆盖光检测器层的孔径层。其他技术保留孔径层，反转光源和光检测器的相对位置，使得光在通过流体通道之前通过孔层，到达光检测器。另一种技术增加了用于控制移动通过流体通道的物体运动的光学镊子。另一种技术增加了光纤束将光从透光区域转移到远程光检测器。另一种技术在流体通道的端部添加两个电极，以产生能够通过流体通道移动物体同时抑制旋转的电场。这些技术可以单独使用或组合使用以提高OFM设备的能力。

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